{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T21:06:54Z","timestamp":1789160814108,"version":"build-2803163510"},"reference-count":65,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T00:00:00Z","timestamp":1786320000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["445287\/2025-0"],"award-info":[{"award-number":["445287\/2025-0"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["88881.009149\/2024-0"],"award-info":[{"award-number":["88881.009149\/2024-0"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2024\/16792-8"],"award-info":[{"award-number":["2024\/16792-8"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2026\/07951-0"],"award-info":[{"award-number":["2026\/07951-0"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain, Behavior, &amp; Immunity - Health"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.bbih.2026.101325","type":"journal-article","created":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T23:33:39Z","timestamp":1786577619000},"page":"101325","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["The carotid body in sepsis: From homeostatic defense to immunometabolic dysregulation"],"prefix":"10.1016","volume":"56","author":[{"given":"Natalia C.S.","family":"Branco","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabela S.","family":"Ferracioli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8735-4252","authenticated-orcid":false,"given":"Evelin C.","family":"C\u00e1rnio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbih.2026.101325_bib1","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1038\/nri.2015.4","article-title":"'Specialized pro-resolving mediators: endogenous regulators of infection and inflammation'","volume":"16","author":"Basil","year":"2016","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.bbih.2026.101325_bib2","doi-asserted-by":"crossref","first-page":"136","DOI":"10.3389\/fimmu.2014.00136","article-title":"The HPA - immune axis and the immunomodulatory actions of glucocorticoids in the brain","volume":"5","author":"Bellavance","year":"2014","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bbih.2026.101325_bib3","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1038\/35013070","article-title":"Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin","volume":"405","author":"Borovikova","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.bbih.2026.101325_bib4","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/s11908-003-0015-9","article-title":"Mitochondrial dysfunction in sepsis","volume":"5","author":"Brealey","year":"2003","journal-title":"Curr. Infect. Dis. Rep."},{"key":"10.1016\/j.bbih.2026.101325_bib5","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.immuni.2014.02.009","article-title":"Proresolving lipid mediators and mechanisms in the resolution of acute inflammation","volume":"40","author":"Buckley","year":"2014","journal-title":"Immunity"},{"key":"10.1016\/j.bbih.2026.101325_bib6","doi-asserted-by":"crossref","first-page":"3695","DOI":"10.1111\/bph.70093","article-title":"Interplay between inflammatory reflex and energetic metabolism in endotoxaemia: a role for haem oxygenase 1?","volume":"182","author":"C\u00e1rnio","year":"2025","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.bbih.2026.101325_bib7","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1056\/NEJM199505183322008","article-title":"The hypothalamic-pituitary-adrenal axis and immune-mediated inflammation","volume":"332","author":"Chrousos","year":"1995","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbih.2026.101325_bib8","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1152\/physiolgenomics.00121.2017","article-title":"Carotid body: a metabolic sensor implicated in insulin resistance","volume":"50","author":"Conde","year":"2018","journal-title":"Physiol. Genom."},{"key":"10.1016\/j.bbih.2026.101325_bib9","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0203487","article-title":"'Heart rate variability as predictor of mortality in sepsis: a systematic review'","volume":"13","author":"de Castilho","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.bbih.2026.101325_bib10","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/s43856-024-00447-5","article-title":"Carotid body dysregulation contributes to long COVID symptoms","volume":"4","author":"El-Medany","year":"2024","journal-title":"Commun. Med."},{"key":"10.1016\/j.bbih.2026.101325_bib11","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1007\/s00134-021-06506-y","article-title":"'Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021'","volume":"47","author":"Evans","year":"2021","journal-title":"Intensive Care Med."},{"key":"10.1016\/j.bbih.2026.101325_bib12","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/nri3843","article-title":"Fever and the thermal regulation of immunity: the immune system feels the heat","volume":"15","author":"Evans","year":"2015","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.bbih.2026.101325_bib13","doi-asserted-by":"crossref","first-page":"2757","DOI":"10.1002\/jnr.22107","article-title":"Interleukin-6 increases intracellular Ca2+ concentration and induces catecholamine secretion in rat carotid body glomus cells","volume":"87","author":"Fan","year":"2009","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.bbih.2026.101325_bib14","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1186\/s13054-026-05879-0","article-title":"The poikilothermic hypothesis of sepsis","volume":"30","author":"Fan","year":"2026","journal-title":"Crit. Care"},{"key":"10.1016\/j.bbih.2026.101325_bib15","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1113\/expphysiol.2008.041152","article-title":"Lipopolysaccharide-induced carotid body inflammation in cats: functional manifestations, histopathology and involvement of tumour necrosis factor-alpha","volume":"93","author":"Fern\u00e1ndez","year":"2008","journal-title":"Exp. Physiol."},{"key":"10.1016\/j.bbih.2026.101325_bib16","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.resp.2010.12.014","article-title":"'Lipopolysaccharide signaling in the carotid chemoreceptor pathway of rats with sepsis syndrome'","volume":"175","author":"Fern\u00e1ndez","year":"2011","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.bbih.2026.101325_bib17","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.cell.2019.01.050","article-title":"Energetic trade-offs and hypometabolic states promote disease tolerance","volume":"177","author":"Ganeshan","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.bbih.2026.101325_bib18","doi-asserted-by":"crossref","first-page":"398","DOI":"10.3389\/fphys.2014.00398","article-title":"'Glucose sensing by carotid body glomus cells: potential implications in disease'","volume":"5","author":"Gao","year":"2014","journal-title":"Front. Physiol."},{"key":"10.1016\/j.bbih.2026.101325_bib19","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2025.1643194","article-title":"The immunosuppressive mechanisms induced by sepsis and the corresponding treatment strategies","volume":"16","author":"Gao","year":"2025","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bbih.2026.101325_bib20","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/B978-0-444-64074-1.00034-3","article-title":"'Fever and hypothermia in systemic inflammation'","volume":"157","author":"Garami","year":"2018","journal-title":"Handb. Clin. Neurol."},{"key":"10.1016\/j.bbih.2026.101325_bib21","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1186\/s13054-014-0503-3","article-title":"Sepsis-associated hyperlactatemia","volume":"18","author":"Garcia-Alvarez","year":"2014","journal-title":"Crit. Care"},{"issue":"1985","key":"10.1016\/j.bbih.2026.101325_bib22","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1152\/japplphysiol.00435.2022","article-title":"Carotid body hyperexcitability underlies heat-induced hyperventilation in exercising humans","volume":"133","author":"Gibbons","year":"2022","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.bbih.2026.101325_bib23","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1007\/s00134-018-5213-x","article-title":"The ten pitfalls of lactate clearance in sepsis","volume":"45","author":"Hernandez","year":"2019","journal-title":"Intensive Care Med."},{"key":"10.1016\/j.bbih.2026.101325_bib24","doi-asserted-by":"crossref","DOI":"10.1038\/nrdp.2016.45","article-title":"'Sepsis and septic shock'","volume":"2","author":"Hotchkiss","year":"2016","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.bbih.2026.101325_bib25","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1038\/nri3552","article-title":"Sepsis-induced immunosuppression: from cellular dysfunctions to immunotherapy","volume":"13","author":"Hotchkiss","year":"2013","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.bbih.2026.101325_bib26","doi-asserted-by":"crossref","first-page":"3067","DOI":"10.1113\/JP275335","article-title":"Translating carotid body function into clinical medicine","volume":"596","author":"Iturriaga","year":"2018","journal-title":"J. Physiol."},{"key":"10.1016\/j.bbih.2026.101325_bib27","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1152\/physiol.00031.2021","article-title":"Carotid body inflammation: role in hypoxia and in the anti-inflammatory reflex","volume":"37","author":"Iturriaga","year":"2022","journal-title":"Physiology"},{"key":"10.1016\/j.bbih.2026.101325_bib28","doi-asserted-by":"crossref","first-page":"3079","DOI":"10.1113\/JP274354","article-title":"'Role of the carotid body chemoreceptors in glucose homeostasis and thermoregulation in humans'","volume":"596","author":"Joyner","year":"2018","journal-title":"J. Physiol."},{"key":"10.1016\/j.bbih.2026.101325_bib29","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.bbi.2022.03.014","article-title":"The carotid body detects circulating tumor necrosis factor-alpha to activate a sympathetic anti-inflammatory reflex","volume":"102","author":"Katayama","year":"2022","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbih.2026.101325_bib30","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.1033774","article-title":"The carotid body: a novel key player in neuroimmune interactions","volume":"13","author":"Katayama","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bbih.2026.101325_bib31","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.bbi.2018.06.005","article-title":"'Vagal afferent activation suppresses systemic inflammation via the splanchnic anti-inflammatory pathway'","volume":"73","author":"Komegae","year":"2018","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbih.2026.101325_bib32","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1016\/j.cell.2015.02.010","article-title":"'Homeostasis, inflammation, and disease susceptibility'","volume":"160","author":"Kotas","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.bbih.2026.101325_bib33","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1002\/j.2040-4603.2012.tb00399.x","article-title":"Peripheral chemoreceptors: function and plasticity of the carotid body","volume":"2","author":"Kumar","year":"2012","journal-title":"Compr. Physiol."},{"key":"10.1016\/j.bbih.2026.101325_bib34","doi-asserted-by":"crossref","DOI":"10.1186\/cc13106","article-title":"The impact of body temperature abnormalities on the disease severity and outcome in patients with severe sepsis: an analysis from a multicenter, prospective survey of severe sepsis","volume":"17","author":"Kushimoto","year":"2013","journal-title":"Crit. Care"},{"key":"10.1016\/j.bbih.2026.101325_bib35","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/s40779-022-00422-y","article-title":"'Sepsis-induced immunosuppression: mechanisms, diagnosis and current treatment options'","volume":"9","author":"Liu","year":"2022","journal-title":"Milit. Med. Res."},{"key":"10.1016\/j.bbih.2026.101325_bib36","doi-asserted-by":"crossref","first-page":"4405","DOI":"10.2147\/JIR.S459185","article-title":"'Lactate and Lactylation in Sepsis: a Comprehensive Review'","volume":"17","author":"Liu","year":"2024","journal-title":"J. Inflamm. Res."},{"key":"10.1016\/j.bbih.2026.101325_bib38","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1113\/EP085559","article-title":"The splanchnic anti-inflammatory pathway: could it be the efferent arm of the inflammatory reflex?","volume":"101","author":"Martelli","year":"2016","journal-title":"Exp. Physiol."},{"key":"10.1016\/j.bbih.2026.101325_bib37","doi-asserted-by":"crossref","first-page":"R235","DOI":"10.1152\/ajpregu.00298.2018","article-title":"Anti-inflammatory reflex action of splanchnic sympathetic nerves is distributed across abdominal organs","volume":"316","author":"Martelli","year":"2019","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.bbih.2026.101325_bib39","doi-asserted-by":"crossref","first-page":"R1085","DOI":"10.1152\/ajpregu.00259.2014","article-title":"'Reflex control of inflammation by the splanchnic anti-inflammatory pathway is sustained and independent of anesthesia'","volume":"307","author":"Martelli","year":"2014","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.bbih.2026.101325_bib40","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1152\/japplphysiol.01094.2015","article-title":"'Lipopolysaccharide exposure during the early postnatal period adversely affects the structure and function of the developing rat carotid body'","volume":"121","author":"Master","year":"2016","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.bbih.2026.101325_bib41","doi-asserted-by":"crossref","first-page":"4521","DOI":"10.1113\/JP283217","article-title":"Divergent splanchnic sympathetic efferent nerve pathways regulate interleukin-10 and tumour necrosis factor-\u03b1 responses to endotoxaemia","volume":"600","author":"McKinley","year":"2022","journal-title":"J. Physiol."},{"key":"10.1016\/j.bbih.2026.101325_bib42","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1038\/nature07201","article-title":"'Origin and physiological roles of inflammation'","volume":"454","author":"Medzhitov","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.bbih.2026.101325_bib43","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1038\/nature01320","article-title":"Points of control in inflammation","volume":"420","author":"Nathan","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.bbih.2026.101325_bib44","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1038\/nrendo.2012.189","article-title":"The vagus nerve and the inflammatory reflex--linking immunity and metabolism","volume":"8","author":"Pavlov","year":"2012","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.bbih.2026.101325_bib45","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1186\/cc5014","article-title":"Bench-to-bedside review: potential strategies to protect or reverse mitochondrial dysfunction in sepsis-induced organ failure","volume":"10","author":"Protti","year":"2006","journal-title":"Crit. Care"},{"key":"10.1016\/j.bbih.2026.101325_bib46","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S0306-9877(98)90022-6","article-title":"'Fever and hypothermia: two adaptive thermoregulatory responses to systemic inflammation'","volume":"50","author":"Romanovsky","year":"1998","journal-title":"Med. Hypotheses"},{"key":"10.1016\/j.bbih.2026.101325_bib47","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1126\/science.1209985","article-title":"Acetylcholine-synthesizing T cells relay neural signals in a vagus nerve circuit","volume":"334","author":"Rosas-Ballina","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.bbih.2026.101325_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbi.2026.106767","article-title":"Carotid body sensing of systemic inflammation contributes to recruitment of the splanchnic anti-inflammatory pathway","volume":"136","author":"Rosin","year":"2026","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbih.2026.101325_bib49","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0170152","article-title":"'Fever Is Associated with Reduced, Hypothermia with Increased Mortality in Septic Patients: a Meta-Analysis of Clinical Trials'","volume":"12","author":"Rumbus","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.bbih.2026.101325_bib50","doi-asserted-by":"crossref","first-page":"3638","DOI":"10.1111\/j.1460-9568.2007.05586.x","article-title":"'IL-1beta inhibits IK and increases [Ca2+]i in the carotid body glomus cells and increases carotid sinus nerve firings in the rat'","volume":"25","author":"Shu","year":"2007","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.bbih.2026.101325_bib51","doi-asserted-by":"crossref","first-page":"66","DOI":"10.4161\/viru.26907","article-title":"The role of mitochondrial dysfunction in sepsis-induced multi-organ failure","volume":"5","author":"Singer","year":"2014","journal-title":"Virulence"},{"key":"10.1016\/j.bbih.2026.101325_bib52","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1001\/jama.2016.0287","article-title":"The third international consensus definitions for sepsis and septic shock (Sepsis-3)","volume":"315","author":"Singer","year":"2016","journal-title":"JAMA"},{"key":"10.1016\/j.bbih.2026.101325_bib53","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1186\/s13054-021-03776-2","article-title":"Fever and hypothermia represent two populations of sepsis patients and are associated with outside temperature","volume":"25","author":"Thomas-R\u00fcddel","year":"2021","journal-title":"Crit. Care"},{"key":"10.1016\/j.bbih.2026.101325_bib54","doi-asserted-by":"crossref","first-page":"4166","DOI":"10.1038\/s41467-021-24444-7","article-title":"Lactate sensing mechanisms in arterial chemoreceptor cells","volume":"12","author":"Torres-Torrelo","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbih.2026.101325_bib55","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1038\/nature01321","article-title":"The inflammatory reflex","volume":"420","author":"Tracey","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.bbih.2026.101325_bib56","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/nri.2017.36","article-title":"The immunopathology of sepsis and potential therapeutic targets","volume":"17","author":"van der Poll","year":"2017","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.bbih.2026.101325_bib57","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.3389\/fimmu.2020.01318","article-title":"Glucocorticoids in sepsis: to be or not to be","volume":"11","author":"Vandewalle","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bbih.2026.101325_bib58","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1038\/nature01339","article-title":"'Nicotinic acetylcholine receptor alpha7 subunit is an essential regulator of inflammation'","volume":"421","author":"Wang","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.bbih.2026.101325_bib59","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1177\/002215540205001213","article-title":"Strong expression of interleukin-1 receptor type I in the rat carotid body","volume":"50","author":"Wang","year":"2002","journal-title":"J. Histochem. Cytochem."},{"key":"10.1016\/j.bbih.2026.101325_bib60","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2022.104363","article-title":"Immunopathophysiology of human sepsis","volume":"86","author":"Wiersinga","year":"2022","journal-title":"EBioMedicine"},{"key":"10.1016\/j.bbih.2026.101325_bib61","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1093\/emph\/eoaa044","article-title":"Let fever do its job: the meaning of fever in the pandemic era","volume":"9","author":"Wrotek","year":"2021","journal-title":"Evol. Med. Public Health"},{"key":"10.1016\/j.bbih.2026.101325_bib62","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.resp.2011.03.025","article-title":"Immunosensory signalling by carotid body chemoreceptors","volume":"178","author":"Zapata","year":"2011","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.bbih.2026.101325_bib63","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1038\/s41586-019-1678-1","article-title":"'Metabolic regulation of gene expression by histone lactylation'","volume":"574","author":"Zhang","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.bbih.2026.101325_bib64","article-title":"Lactate's impact on immune cells in sepsis: unraveling the complex interplay","volume":"15","author":"Zhang","year":"2024","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bbih.2026.101325_bib65","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.cytogfr.2022.07.007","article-title":"MDSCs in sepsis-induced immunosuppression and its potential therapeutic targets","volume":"69","author":"Zhang","year":"2023","journal-title":"Cytokine Growth Factor Rev."}],"container-title":["Brain, Behavior, &amp; Immunity - Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666354626001584?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666354626001584?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T20:17:01Z","timestamp":1789157821000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666354626001584"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":65,"alternative-id":["S2666354626001584"],"URL":"https:\/\/doi.org\/10.1016\/j.bbih.2026.101325","relation":{},"ISSN":["2666-3546"],"issn-type":[{"value":"2666-3546","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The carotid body in sepsis: From homeostatic defense to immunometabolic dysregulation","name":"articletitle","label":"Article Title"},{"value":"Brain, Behavior, & Immunity - Health","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbih.2026.101325","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"101325"}}