{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T21:06:48Z","timestamp":1789160808162,"version":"build-2803163510"},"reference-count":59,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T00:00:00Z","timestamp":1787356800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100011929","name":"Programa Operacional Tem\u00e1tico Factores de Competitividade","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011929","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["PTDC\/MED- NEU \/27946\/2017"],"award-info":[{"award-number":["PTDC\/MED- NEU \/27946\/2017"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["SAICTPAC\/0010\/2015"],"award-info":[{"award-number":["SAICTPAC\/0010\/2015"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["POCI-01-0145-FEDER-016428"],"award-info":[{"award-number":["POCI-01-0145-FEDER-016428"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["PTDC\/MEC-PSQ\/30943\/2017"],"award-info":[{"award-number":["PTDC\/MEC-PSQ\/30943\/2017"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["LA\/P\/0058\/ 2020"],"award-info":[{"award-number":["LA\/P\/0058\/ 2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["UIDB\/04539\/2020"],"award-info":[{"award-number":["UIDB\/04539\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["POCI-01-0145-FEDER-016795"],"award-info":[{"award-number":["POCI-01-0145-FEDER-016795"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["UIDP\/04539\/2020"],"award-info":[{"award-number":["UIDP\/04539\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["POCI-01-0145-FEDER-30943"],"award-info":[{"award-number":["POCI-01-0145-FEDER-30943"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["PTDC\/NEU- SCC \/7051\/2014"],"award-info":[{"award-number":["PTDC\/NEU- SCC \/7051\/2014"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100024333","name":"Rede Nacional de Espectrometria de Massa","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100024333","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004895","name":"European Social Fund Plus","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004895","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain, Behavior, & Immunity - Health"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.bbih.2026.101336","type":"journal-article","created":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T23:47:44Z","timestamp":1787701664000},"page":"101336","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Plasma IL-17A, IFN-\u03b3, and MIP-3\u03b1 profiles are associated with clinical stage transition in first-episode psychosis"],"prefix":"10.1016","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2727-8868","authenticated-orcid":false,"given":"Miguel","family":"Rosado","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catarina Morais","family":"Empadinhas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vitor","family":"Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e1tia","family":"Santa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1rio","family":"Gr\u00e3os","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Coroa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofia","family":"Morais","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Bajouco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helder","family":"Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In\u00eas","family":"Baldeiras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Artur","family":"Paiva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Macedo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuno","family":"Madeira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2087-4042","authenticated-orcid":false,"given":"Bruno","family":"Manadas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbih.2026.101336_bib1","series-title":"Diagnostic and Statistical Manual of Mental Disorders (DSM-5\u00ae)","year":"2013"},{"issue":"9995","key":"10.1016\/j.bbih.2026.101336_bib2","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/S0140-6736(14)62254-6","article-title":"Transitioning health systems for multimorbidity","volume":"386","author":"Atun","year":"2015","journal-title":"Lancet"},{"key":"10.1016\/j.bbih.2026.101336_bib3","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.bbi.2018.03.013","article-title":"Immune and metabolic alterations in first episode psychosis (FEP) patients","volume":"70","author":"Bocchio-Chiavetto","year":"2018","journal-title":"Brain Behav. Immun."},{"issue":"11","key":"10.1016\/j.bbih.2026.101336_bib4","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1016\/j.jpsychires.2012.08.016","article-title":"Elevated serum level of type-2 cytokine and low IL-17 in first episode psychosis and schizophrenia in relapse","volume":"46","author":"Borovcanin","year":"2012","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.bbih.2026.101336_bib5","doi-asserted-by":"crossref","DOI":"10.3390\/diagnostics10110926","article-title":"Type 17 immune response facilitates progression of inflammation and correlates with cognition in stable schizophrenia","volume":"10","author":"Borovcanin","year":"2020","journal-title":"Diagnostics"},{"issue":"4","key":"10.1016\/j.bbih.2026.101336_bib6","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1111\/j.1751-7893.2009.00148.x","article-title":"Review of the operational definition for first-episode psychosis","volume":"3","author":"Breitborde","year":"2009","journal-title":"Early Interv. Psychiatry"},{"issue":"6","key":"10.1016\/j.bbih.2026.101336_bib7","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1093\/schbul\/sbx056","article-title":"Lifetime prevalence and correlates of Schizophrenia-Spectrum, affective, and other non-affective psychotic disorders in the Chinese adult population","volume":"43","author":"Chang","year":"2017","journal-title":"Schizophr. Bull."},{"key":"10.1016\/j.bbih.2026.101336_bib8","series-title":"Ggbeeswarm: Categorical Scatter (Violin Point) Plots","author":"Clarke","year":"2023"},{"issue":"6","key":"10.1016\/j.bbih.2026.101336_bib9","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1093\/schbul\/sbu049","article-title":"Th17 pathway-mediated immunopathogenesis of schizophrenia: mechanisms and implications","volume":"40","author":"Debnath","year":"2014","journal-title":"Schizophr. Bull."},{"key":"10.1016\/j.bbih.2026.101336_bib10","first-page":"2349","article-title":"Orange: data mining toolbox in python","volume":"14","author":"Dem\u0161ar","year":"2013","journal-title":"J. Mach. Learn. Res."},{"key":"10.1016\/j.bbih.2026.101336_bib11","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.pnpbp.2014.01.001","article-title":"Activation of Th17 cells in drug naive, first episode schizophrenia","volume":"51","author":"Ding","year":"2014","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"issue":"1","key":"10.1016\/j.bbih.2026.101336_bib12","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1111\/acps.13416","article-title":"Inflammation in first-episode psychosis: the contribution of inflammatory biomarkers to the emergence of negative symptoms, a systematic review and meta-analysis","volume":"146","author":"Dunleavy","year":"2022","journal-title":"Acta Psychiatr. Scand."},{"issue":"6237","key":"10.1016\/j.bbih.2026.101336_bib13","doi-asserted-by":"crossref","first-page":"aaa6566","DOI":"10.1126\/science.aaa6566","article-title":"Innate lymphoid cells. Innate lymphoid cells: a new paradigm in immunology","volume":"348","author":"Eberl","year":"2015","journal-title":"Science"},{"issue":"1\u20132","key":"10.1016\/j.bbih.2026.101336_bib14","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.psychres.2014.10.007","article-title":"Increased Interleukin-17 and decreased BAFF serum levels in drug-free acute schizophrenia","volume":"225","author":"El Kissi","year":"2015","journal-title":"Psychiatry Res."},{"issue":"3","key":"10.1016\/j.bbih.2026.101336_bib15","first-page":"135","article-title":"Interleukin-17 alteration in first-episode psychosis: a meta-analysis","volume":"3","author":"Fang","year":"2018","journal-title":"Mol. Neuropsychiatry"},{"key":"10.1016\/j.bbih.2026.101336_bib16","series-title":"An R Companion to Applied Regression","author":"Fox","year":"2019"},{"key":"10.1016\/j.bbih.2026.101336_bib17","series-title":"Cardata: Companion to Applied Regression Data Sets","author":"Fox","year":"2022"},{"issue":"3","key":"10.1016\/j.bbih.2026.101336_bib18","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1002\/wps.20446","article-title":"Improving outcomes of first-episode psychosis: an overview","volume":"16","author":"Fusar-Poli","year":"2017","journal-title":"World Psychiatry"},{"issue":"2","key":"10.1016\/j.bbih.2026.101336_bib19","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.psychres.2011.08.014","article-title":"Inflammatory markers in antipsychotic-naive patients with nonaffective psychosis and deficit vs. nondeficit features","volume":"198","author":"Garcia-Rizo","year":"2012","journal-title":"Psychiatry Res."},{"issue":"3","key":"10.1016\/j.bbih.2026.101336_bib20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v040.i03","article-title":"Dates and times made easy with lubridate","volume":"40","author":"Grolemund","year":"2011","journal-title":"J. Stat. Software"},{"issue":"1","key":"10.1016\/j.bbih.2026.101336_bib21","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1186\/s12888-023-04952-0","article-title":"Sex differences in the association of treatment-resistant schizophrenia and serum interleukin-6 levels","volume":"23","author":"He","year":"2023","journal-title":"BMC Psychiatry"},{"key":"10.1016\/j.bbih.2026.101336_bib22","article-title":"Association between cytokines and suicidality in patients with psychosis: a multicentre longitudinal analysis","volume":"37","author":"Hoprekstad","year":"2024","journal-title":"Brain Behav. Immun Health"},{"issue":"1","key":"10.1016\/j.bbih.2026.101336_bib23","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1038\/s41392-023-01653-8","article-title":"Gammadelta T cells: origin and fate, subsets, diseases and immunotherapy","volume":"8","author":"Hu","year":"2023","journal-title":"Signal Transduct. Targeted Ther."},{"issue":"1","key":"10.1016\/j.bbih.2026.101336_bib24","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1111\/cns.13569","article-title":"Peripheral inflammation and blood-brain barrier disruption: effects and mechanisms","volume":"27","author":"Huang","year":"2021","journal-title":"CNS Neurosci. Ther."},{"issue":"1","key":"10.1016\/j.bbih.2026.101336_bib25","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.schres.2011.09.005","article-title":"A dimensional approach to the psychosis spectrum between bipolar disorder and schizophrenia: the Schizo-bipolar scale","volume":"133","author":"Keshavan","year":"2011","journal-title":"Schizophr. Res."},{"key":"10.1016\/j.bbih.2026.101336_bib26","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1146\/annurev.immunol.021908.132710","article-title":"IL-17 and Th17 cells","volume":"27","author":"Korn","year":"2009","journal-title":"Annu. Rev. Immunol."},{"issue":"5","key":"10.1016\/j.bbih.2026.101336_bib27","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1001\/archpsyc.63.5.484","article-title":"Caution regarding the use of pilot studies to guide power calculations for study proposals","volume":"63","author":"Kraemer","year":"2006","journal-title":"Arch. Gen. Psychiatry"},{"issue":"5","key":"10.1016\/j.bbih.2026.101336_bib28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v028.i05","article-title":"Building predictive models in R using the caret package","volume":"28","author":"Kuhn","year":"2008","journal-title":"J. Stat. Software"},{"issue":"8","key":"10.1016\/j.bbih.2026.101336_bib29","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1080\/j.1440-1614.2006.01860.x","article-title":"Clinical staging of psychiatric disorders: a heuristic framework for choosing earlier, safer and more effective interventions","volume":"40","author":"McGorry","year":"2006","journal-title":"Aust. N. Z. J. Psychiatr."},{"issue":"7","key":"10.1016\/j.bbih.2026.101336_bib30","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.biopsych.2011.04.013","article-title":"Meta-analysis of cytokine alterations in schizophrenia: clinical status and antipsychotic effects","volume":"70","author":"Miller","year":"2011","journal-title":"Biol. Psychiatry"},{"issue":"1","key":"10.1016\/j.bbih.2026.101336_bib31","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1038\/s41577-022-00746-9","article-title":"IL-17 and IL-17-producing cells in protection versus pathology","volume":"23","author":"Mills","year":"2023","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.bbih.2026.101336_bib32","series-title":"Tibble: Simple Data Frames","author":"M\u00fcller","year":"2025"},{"issue":"3","key":"10.1016\/j.bbih.2026.101336_bib33","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1007\/s00357-014-9161-z","article-title":"Ward's hierarchical agglomerative clustering method: which algorithms implement ward's criterion?","volume":"31","author":"Murtagh","year":"2014","journal-title":"J. Classif."},{"key":"10.1016\/j.bbih.2026.101336_bib34","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.pnpbp.2012.10.022","article-title":"The role of pro-inflammatory cytokines in the neuroinflammation and neurogenesis of schizophrenia","volume":"48","author":"Na","year":"2014","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"issue":"1","key":"10.1016\/j.bbih.2026.101336_bib35","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1111\/imr.13125","article-title":"At the crux of maternal immune activation: viruses, microglia, microbes, and IL-17A","volume":"311","author":"Otero","year":"2022","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.bbih.2026.101336_bib36","doi-asserted-by":"crossref","DOI":"10.3389\/fpsyt.2022.1072380","article-title":"IL-17 and TNF-beta: predictive biomarkers for transition to psychosis in ultra-high risk individuals","volume":"13","author":"Ouyang","year":"2022","journal-title":"Front. Psychiatr."},{"issue":"W1","key":"10.1016\/j.bbih.2026.101336_bib37","doi-asserted-by":"crossref","first-page":"W398","DOI":"10.1093\/nar\/gkae253","article-title":"MetaboAnalyst 6.0: towards a unified platform for metabolomics data processing, analysis and interpretation","volume":"52","author":"Pang","year":"2024","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bbih.2026.101336_bib38","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.jpsychires.2020.12.060","article-title":"Active psychosis and pro-inflammatory cytokines in first-episode of psychosis","volume":"134","author":"Pardo-de-Santayana","year":"2021","journal-title":"J. Psychiatr. Res."},{"issue":"12","key":"10.1016\/j.bbih.2026.101336_bib39","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1016\/S0895-4356(96)00236-3","article-title":"A simulation study of the number of events per variable in logistic regression analysis","volume":"49","author":"Peduzzi","year":"1996","journal-title":"J. Clin. Epidemiol."},{"key":"10.1016\/j.bbih.2026.101336_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.psychres.2023.115109","article-title":"A clinical staging model of psychotic disorders based on a long-term follow-up of first-admission psychosis: a validation study","volume":"322","author":"Peralta","year":"2023","journal-title":"Psychiatry Res."},{"issue":"4","key":"10.1016\/j.bbih.2026.101336_bib41","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.jpsychores.2015.06.011","article-title":"Cytokine profile in drug-naive, first episode patients with psychosis","volume":"79","author":"Petrikis","year":"2015","journal-title":"J. Psychosom. Res."},{"issue":"11","key":"10.1016\/j.bbih.2026.101336_bib42","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1038\/nm.2514","article-title":"The neutrophil in vascular inflammation","volume":"17","author":"Phillipson","year":"2011","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbih.2026.101336_bib43","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1186\/1471-2105-12-77","article-title":"pROC: an open-source package for R and S+ to analyze and compare ROC curves","volume":"12","author":"Robin","year":"2011","journal-title":"BMC Bioinf."},{"issue":"2","key":"10.1016\/j.bbih.2026.101336_bib44","first-page":"1","article-title":"plotROC: a tool for plotting ROC curves","volume":"79","author":"Sachs","year":"2017","journal-title":"J. Statis. Software Code Snippets"},{"key":"10.1016\/j.bbih.2026.101336_bib45","series-title":"Lattice: Multivariate Data Visualization with R","author":"Sarkar","year":"2008"},{"issue":"1","key":"10.1016\/j.bbih.2026.101336_bib46","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.chc.2019.08.010","article-title":"First episode psychosis medical workup: evidence-informed recommendations and introduction to a clinically guided approach","volume":"29","author":"Skikic","year":"2020","journal-title":"Child Adolesc. Psychiatr. Clin. N. Am."},{"issue":"1","key":"10.1016\/j.bbih.2026.101336_bib47","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.schres.2009.03.005","article-title":"Schizophrenia, \u201cjust the facts\u201d 4. Clinical features and conceptualization","volume":"110","author":"Tandon","year":"2009","journal-title":"Schizophr. Res."},{"issue":"5","key":"10.1016\/j.bbih.2026.101336_bib48","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1007\/s00401-015-1402-7","article-title":"The role of IL-17 in CNS diseases","volume":"129","author":"Waisman","year":"2015","journal-title":"Acta Neuropathol."},{"issue":"4","key":"10.1016\/j.bbih.2026.101336_bib49","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1001\/jamapsychiatry.2014.2502","article-title":"Mortality in mental disorders and global disease burden implications: a systematic review and meta-analysis","volume":"72","author":"Walker","year":"2015","journal-title":"JAMA Psychiatry"},{"key":"10.1016\/j.bbih.2026.101336_bib50","series-title":"Gplots: Various R Programming Tools for Plotting Data","author":"Warnes","year":"2024"},{"key":"10.1016\/j.bbih.2026.101336_bib51","series-title":"International Statistical Classification of Diseases and Related Health Problems","year":"2019"},{"key":"10.1016\/j.bbih.2026.101336_bib52","series-title":"ggplot2: Elegant Graphics for Data Analysis","author":"Wickham","year":"2016"},{"issue":"43","key":"10.1016\/j.bbih.2026.101336_bib54","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.21105\/joss.01686","article-title":"Welcome to the tidyverse","volume":"4","author":"Wickham","year":"2019","journal-title":"J. Open Source Softw."},{"key":"10.1016\/j.bbih.2026.101336_bib55","series-title":"Dplyr: a Grammar of Data Manipulation","author":"Wickham","year":"2023"},{"key":"10.1016\/j.bbih.2026.101336_bib53","series-title":"Forcats: Tools for Working with Categorical Variables (Factors)","author":"Wickham","year":"2023"},{"key":"10.1016\/j.bbih.2026.101336_bib57","series-title":"Purrr: Functional Programming Tools","author":"Wickham","year":"2025"},{"key":"10.1016\/j.bbih.2026.101336_bib56","series-title":"Readr: Read Rectangular Text Data","author":"Wickham","year":"2024"},{"issue":"2\u20133","key":"10.1016\/j.bbih.2026.101336_bib58","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1159\/000356536","article-title":"First-episode psychosis: an inflammatory state?","volume":"21","author":"Zajkowska","year":"2014","journal-title":"Neuroimmunomodulation"},{"issue":"1","key":"10.1016\/j.bbih.2026.101336_bib59","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1186\/s12974-021-02261-5","article-title":"Sex difference in the interrelationship between TNF-alpha and oxidative stress status in first-episode drug-naive schizophrenia","volume":"18","author":"Zhu","year":"2021","journal-title":"J. Neuroinflammation"}],"container-title":["Brain, Behavior, & Immunity - Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666354626001699?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666354626001699?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T20:15:26Z","timestamp":1789157726000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666354626001699"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":59,"alternative-id":["S2666354626001699"],"URL":"https:\/\/doi.org\/10.1016\/j.bbih.2026.101336","relation":{},"ISSN":["2666-3546"],"issn-type":[{"value":"2666-3546","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Plasma IL-17A, IFN-\u03b3, and MIP-3\u03b1 profiles are associated with clinical stage transition in first-episode psychosis","name":"articletitle","label":"Article Title"},{"value":"Brain, Behavior, & Immunity - Health","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbih.2026.101336","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"101336"}}