{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:45:04Z","timestamp":1791895504246,"version":"4.3.4"},"reference-count":82,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T00:00:00Z","timestamp":1789171200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004472","name":"Bank of Sweden Tercentenary Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004472","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain, Behavior, & Immunity - Health"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.bbih.2026.101365","type":"journal-article","created":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T17:43:16Z","timestamp":1789666996000},"page":"101365","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Fast and slow gene expression changes in blood following acute social stress"],"prefix":"10.1016","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2546-9203","authenticated-orcid":false,"given":"Hampus","family":"Gr\u00f6nvall","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvia","family":"Abdelhalim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fara","family":"Tabrizi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sini","family":"Ezer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gamze","family":"Yazgeldi Gunaydin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"Arner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rgen","family":"Ros\u00e9n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shintaro","family":"Katayama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juha","family":"Kere","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fredrik","family":"\u00c5hs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lea","family":"Mikkola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbih.2026.101365_bib1","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.ynstr.2016.11.001","article-title":"The trier social stress test: principles and practice","volume":"6","author":"Allen","year":"2017","journal-title":"Neurobiol. Stress"},{"key":"10.1016\/j.bbih.2026.101365_bib2","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1038\/s41593-023-01435-z","article-title":"IL-12 sensing in neurons induces neuroprotective CNS tissue adaptation and attenuates neuroinflammation in mice","volume":"26","author":"Andreadou","year":"2023","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.bbih.2026.101365_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.xpro.2023.102357","article-title":"Optimized single-cell RNA sequencing protocol to study early genome activation in mammalian preimplantation development","volume":"4","author":"Boskovic","year":"2023","journal-title":"STAR Protoc."},{"key":"10.1016\/j.bbih.2026.101365_bib4","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/j.bbi.2004.12.003","article-title":"Psychological stress activates interleukin-1\u03b2 gene expression in human mononuclear cells","volume":"19","author":"Brydon","year":"2005","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbih.2026.101365_bib5","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1186\/s12884-021-04225-2","article-title":"Chemokine profile in women with moderate to severe anxiety and depression during pregnancy","volume":"21","author":"Camacho-Arroyo","year":"2021","journal-title":"BMC Pregnancy Childbirth"},{"key":"10.1016\/j.bbih.2026.101365_bib6","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1038\/s41583-023-00729-2","article-title":"Central regulation of stress-evoked peripheral immune responses","volume":"24","author":"Chan","year":"2023","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.bbih.2026.101365_bib7","series-title":"edgeR: Empirical Analysis of Digital Gene Expression Data in R","author":"Chen","year":"2025"},{"key":"10.1016\/j.bbih.2026.101365_bib8","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1262\/jrd.20239","article-title":"Alteration in anxiety with relation to the volume of the locus ceruleus in progranulin-deficient mice","volume":"55","author":"Chiba","year":"2009","journal-title":"J. Reprod. Dev."},{"key":"10.1016\/j.bbih.2026.101365_bib9","doi-asserted-by":"crossref","first-page":"15653","DOI":"10.1073\/pnas.0507901102","article-title":"Altered cortical glutamatergic and GABAergic signal transmission with glial involvement in depression","volume":"102","author":"Choudary","year":"2005","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.bbih.2026.101365_bib10","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1007\/s43440-024-00656-8","article-title":"Drugs with glutamate-based mechanisms of action in psychiatry","volume":"76","author":"Chrobak","year":"2024","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.bbih.2026.101365_bib11","doi-asserted-by":"crossref","DOI":"10.1093\/gigascience\/giab008","article-title":"Twelve years of SAMtools and BCFtools","volume":"10","author":"Danecek","year":"2021","journal-title":"GigaScience"},{"key":"10.1016\/j.bbih.2026.101365_bib12","doi-asserted-by":"crossref","DOI":"10.1126\/science.adh3707","article-title":"Systems biology dissection of PTSD and MDD across brain regions, cell types, and blood","volume":"384","author":"Daskalakis","year":"2024","journal-title":"Science"},{"key":"10.1016\/j.bbih.2026.101365_bib13","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.bbi.2022.07.158","article-title":"Childhood trauma and LPS-stimulated inflammation in adulthood: results from the Netherlands study of depression and anxiety","volume":"106","author":"de Koning","year":"2022","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbih.2026.101365_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.jad.2025.120067","article-title":"Proteomic profiling of human plasma for anxiety and depression: discovery of potential biomarkers and mechanistic insights","volume":"391","author":"Ding","year":"2025","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.bbih.2026.101365_bib15","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1007\/s12026-023-09409-w","article-title":"Acute stress transiently activates macrophages and chemokines in cervical lymph nodes","volume":"72","author":"Dohi","year":"2024","journal-title":"Immunol. Res."},{"key":"10.1016\/j.bbih.2026.101365_bib16","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1038\/s41573-021-00368-1","article-title":"Immune targets for therapeutic development in depression: towards precision medicine","volume":"21","author":"Drevets","year":"2022","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.bbih.2026.101365_bib17","series-title":"Visualization of Functional Enrichment Result","author":"enrichplot","year":"2025"},{"key":"10.1016\/j.bbih.2026.101365_bib18","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/j.celrep.2019.08.093","article-title":"Hippocampal subregions express distinct dendritic transcriptomes that reveal differences in mitochondrial function in CA2","volume":"29","author":"Farris","year":"2019","journal-title":"Cell Rep."},{"key":"10.1016\/j.bbih.2026.101365_bib19","doi-asserted-by":"crossref","DOI":"10.1038\/sdata.2017.151","article-title":"Clustergrammer, a web-based heatmap visualization and analysis tool for high-dimensional biological data","volume":"4","author":"Fernandez","year":"2017","journal-title":"Sci. Data"},{"key":"10.1016\/j.bbih.2026.101365_bib20","doi-asserted-by":"crossref","DOI":"10.1002\/brb3.2624","article-title":"Negative correlation between IL\u20101\u03b2, IL\u201012 and TNF\u2010\u03b3, and cortisol levels in patients with panic disorder","volume":"12","author":"Fern\u00e1ndez\u2010Serrano","year":"2022","journal-title":"Brain Behav."},{"key":"10.1016\/j.bbih.2026.101365_bib21","doi-asserted-by":"crossref","first-page":"D916","DOI":"10.1093\/nar\/gkaa1087","article-title":"GENCODE 2021","volume":"49","author":"Frankish","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bbih.2026.101365_bib22","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0114626","article-title":"Formyl peptide receptor as a novel therapeutic target for anxiety-related disorders","volume":"9","author":"Gallo","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.bbih.2026.101365_bib23","doi-asserted-by":"crossref","first-page":"1940","DOI":"10.1111\/jdv.15012","article-title":"Anxiety and depression in patients with moderate\u2010to\u2010severe psoriasis and comparison of change from baseline after treatment with guselkumab vs. adalimumab: results from the phase 3 VOYAGE 2 study","volume":"32","author":"Gordon","year":"2018","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"10.1016\/j.bbih.2026.101365_bib24","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/s41587-023-01767-y","article-title":"Dictionary learning for integrative, multimodal, and scalable single-cell analysis","volume":"42","author":"Hao","year":"2024","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.bbih.2026.101365_bib25","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.bbi.2019.06.001","article-title":"Effects of SSRIs on peripheral inflammatory cytokines in patients with generalized anxiety disorder","volume":"81","author":"Hou","year":"2019","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbih.2026.101365_bib26","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1038\/s41586-025-09083-y","article-title":"Single-cell transcriptomic and chromatin dynamics of the human brain in PTSD","volume":"643","author":"Hwang","year":"2025","journal-title":"Nature"},{"key":"10.1016\/j.bbih.2026.101365_bib27","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1038\/ni1268","article-title":"Effector and memory CD8+ T cell fate coupled by T-bet and eomesodermin","volume":"6","author":"Intlekofer","year":"2005","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.bbih.2026.101365_bib28","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1038\/mp.2015.57","article-title":"Gene expression in major depressive disorder","volume":"21","author":"Jansen","year":"2016","journal-title":"Mol. Psychiatr."},{"key":"10.1016\/j.bbih.2026.101365_bib29","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1186\/s13104-021-05635-3","article-title":"Integrated microRNA and mRNA gene expression in peripheral blood mononuclear cells in response to acute psychosocial stress: a repeated-measures within-subject pilot study","volume":"14","author":"Jurkiewicz","year":"2021","journal-title":"BMC Res. Notes"},{"key":"10.1016\/j.bbih.2026.101365_bib30","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.scib.2024.09.041","article-title":"Plasma proteomics identifies proteins and pathways associated with incident depression in 46,165 adults","volume":"70","author":"Kang","year":"2025","journal-title":"Sci. Bull."},{"key":"10.1016\/j.bbih.2026.101365_bib31","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abh2169","article-title":"A single\u2013cell type transcriptomics map of human tissues","volume":"7","author":"Karlsson","year":"2021","journal-title":"Sci. Adv."},{"key":"10.1016\/j.bbih.2026.101365_bib32","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1186\/s12859-019-3017-9","article-title":"Guide for library design and bias correction for large-scale transcriptome studies using highly multiplexed RNAseq methods","volume":"20","author":"Katayama","year":"2019","journal-title":"BMC Bioinf."},{"key":"10.1016\/j.bbih.2026.101365_bib33","doi-asserted-by":"crossref","first-page":"W212","DOI":"10.1093\/nar\/gkz446","article-title":"ChEA3: transcription factor enrichment analysis by orthogonal omics integration","volume":"47","author":"Keenan","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bbih.2026.101365_bib34","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.jbtep.2007.02.003","article-title":"Sex differences in emotional and physiological responses to the trier social stress test","volume":"39","author":"Kelly","year":"2008","journal-title":"J. Behav. Ther. Exp. Psychiatr."},{"key":"10.1016\/j.bbih.2026.101365_bib35","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.jneuroim.2011.09.008","article-title":"T-bet deficient mice exhibit resistance to stress-induced development of depression-like behaviors","volume":"240\u2013241","author":"Kim","year":"2011","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.bbih.2026.101365_bib36","first-page":"76","article-title":"The \u2018Trier Social Stress Test\u2019 \u2013 a tool for investigating psychobiological stress responses in a laboratory setting","volume":"28","author":"Kirschbaum","year":"1993","journal-title":"Neuropsychobiology"},{"key":"10.1016\/j.bbih.2026.101365_bib37","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1111\/acps.12698","article-title":"Peripheral cytokine and chemokine alterations in depression: a meta\u2010analysis of 82 studies","volume":"135","author":"K\u00f6hler","year":"2017","journal-title":"Acta Psychiatr. Scand."},{"key":"10.1016\/j.bbih.2026.101365_bib38","doi-asserted-by":"crossref","first-page":"W207","DOI":"10.1093\/nar\/gkad347","article-title":"g:Profiler\u2014interoperable web service for functional enrichment analysis and gene identifier mapping (2023 update)","volume":"51","author":"Kolberg","year":"2023","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bbih.2026.101365_bib39","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1093\/humrep\/dew008","article-title":"Single-cell transcriptome analysis of endometrial tissue","volume":"31","author":"Krjut\u0161kov","year":"2016","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.bbih.2026.101365_bib40","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.bbi.2014.12.024","article-title":"Stress-induced modulation of NF-\u03baB activation, inflammation-associated gene expression, and cytokine levels in blood of healthy men","volume":"46","author":"Kuebler","year":"2015","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbih.2026.101365_bib41","doi-asserted-by":"crossref","DOI":"10.18637\/jss.v082.i13","article-title":"lmerTest package: tests in linear mixed effects models","volume":"82","author":"Kuznetsova","year":"2017","journal-title":"J. Stat. Software"},{"key":"10.1016\/j.bbih.2026.101365_bib42","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.jaad.2009.09.014","article-title":"Ustekinumab significantly improves symptoms of anxiety, depression, and skin-related quality of life in patients with moderate-to-severe psoriasis: results from a randomized, double-blind, placebo-controlled phase III trial","volume":"63","author":"Langley","year":"2010","journal-title":"J. Am. Acad. Dermatol."},{"key":"10.1016\/j.bbih.2026.101365_bib43","first-page":"2","volume":"1.11","author":"Lenth","year":"2017"},{"key":"10.1016\/j.bbih.2026.101365_bib44","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1038\/nri1083","article-title":"The ABCs of granule-mediated cytotoxicity: new weapons in the arsenal","volume":"3","author":"Lieberman","year":"2003","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.bbih.2026.101365_bib46","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1038\/s41380-019-0474-5","article-title":"Peripheral cytokine levels and response to antidepressant treatment in depression: a systematic review and meta-analysis","volume":"25","author":"Liu","year":"2020","journal-title":"Mol. Psychiatr."},{"key":"10.1016\/j.bbih.2026.101365_bib45","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.psyneuen.2017.04.007","article-title":"Sex differences in salivary cortisol reactivity to the Trier Social Stress Test (TSST): a meta-analysis","volume":"82","author":"Liu","year":"2017","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.bbih.2026.101365_bib47","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.nbd.2009.11.015","article-title":"Neuroimmune mechanisms of cytokine-induced depression: current theories and novel treatment strategies","volume":"37","author":"Loftis","year":"2010","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.bbih.2026.101365_bib48","doi-asserted-by":"crossref","first-page":"35","DOI":"10.37757\/mr2022.v24.n2.6","article-title":"Genome-wide mRNA expression analysis of acute psychological stress responses","volume":"24","author":"Logan","year":"2022","journal-title":"MEDICC Rev."},{"key":"10.1016\/j.bbih.2026.101365_bib49","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1038\/s41386-020-00897-0","article-title":"Beta-adrenergic blockade blunts inflammatory and antiviral\/antibody gene expression responses to acute psychosocial stress","volume":"46","author":"MacCormack","year":"2021","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.bbih.2026.101365_bib50","doi-asserted-by":"crossref","first-page":"7393","DOI":"10.1038\/s41380-021-01188-w","article-title":"Association of inflammation with depression and anxiety: evidence for symptom-specificity and potential causality from UK biobank and NESDA cohorts","volume":"26","author":"Milaneschi","year":"2021","journal-title":"Mol. Psychiatr."},{"key":"10.1016\/j.bbih.2026.101365_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.psychres.2019.112544","article-title":"Lithium and glutamine synthetase: protective effects following stress","volume":"281","author":"Mundorf","year":"2019","journal-title":"Psychiatry Res."},{"key":"10.1016\/j.bbih.2026.101365_bib52","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.biopsycho.2009.06.009","article-title":"Impact of acute psychosocial stress on peripheral blood gene expression pathways in healthy men","volume":"82","author":"Nater","year":"2009","journal-title":"Biol. Psychol."},{"key":"10.1016\/j.bbih.2026.101365_bib53","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1038\/s41590-020-0758-6","article-title":"The NK cell granule protein NKG7 regulates cytotoxic granule exocytosis and inflammation","volume":"21","author":"Ng","year":"2020","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.bbih.2026.101365_bib54","doi-asserted-by":"crossref","first-page":"3573","DOI":"10.1097\/MS9.0000000000003304","article-title":"Stress, neutrophils, and immunity: a dynamic interplay","volume":"87","author":"Obeagu","year":"2025","journal-title":"Ann. Med. Surg."},{"key":"10.1016\/j.bbih.2026.101365_bib55","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1016\/j.pharep.2018.06.001","article-title":"The association between inflammatory markers (iNOS, HO-1, IL-33, MIP-1\u03b2) and depression with and without posttraumatic stress disorder","volume":"70","author":"Og\u0142odek","year":"2018","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.bbih.2026.101365_bib56","doi-asserted-by":"crossref","first-page":"D1243","DOI":"10.1093\/nar\/gkae974","article-title":"The UCSC genome browser database: 2025 update","volume":"53","author":"Perez","year":"2024","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bbih.2026.101365_bib57","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1176\/appi.ajp.2020.20060947","article-title":"Elevated C-Reactive protein in patients with depression, independent of genetic, health, and psychosocial factors: results from the UK biobank","volume":"178","author":"Pitharouli","year":"2021","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.bbih.2026.101365_bib58","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1038\/s41586-022-04890-z","article-title":"Brain motor and fear circuits regulate leukocytes during acute stress","volume":"607","author":"Poller","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.bbih.2026.101365_bib59","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1002\/path.2440","article-title":"The human protein Atlas\u2014A tool for pathology","volume":"216","author":"Pont\u00e9n","year":"2008","journal-title":"J. Pathol."},{"key":"10.1016\/j.bbih.2026.101365_bib60","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1038\/nrn3138","article-title":"The stressed synapse: the impact of stress and glucocorticoids on glutamate transmission","volume":"13","author":"Popoli","year":"2012","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.bbih.2026.101365_bib61","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1523\/JNEUROSCI.23-02-00622.2003","article-title":"Genetic disruption of cortical interneuron development causes Region- and GABA cell type-specific deficits, epilepsy, and behavioral dysfunction","volume":"23","author":"Powell","year":"2003","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbih.2026.101365_bib62","series-title":"R: a Language and Environment for Statistical Computing","year":"2025"},{"key":"10.1016\/j.bbih.2026.101365_bib63","doi-asserted-by":"crossref","first-page":"e47","DOI":"10.1093\/nar\/gkv007","article-title":"Limma powers differential expression analyses for RNA-sequencing and microarray studies","volume":"43","author":"Ritchie","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bbih.2026.101365_bib64","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/s12974-021-02100-7","article-title":"On inflammatory hypothesis of depression: what is the role of IL-6 in the middle of the chaos?","volume":"18","author":"Roohi","year":"2021","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.bbih.2026.101365_bib65","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1042\/BST20130237","article-title":"Astrocyte glutamine synthetase: pivotal in health and disease","volume":"41","author":"Rose","year":"2013","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.bbih.2026.101365_bib66","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1038\/s41598-024-51932-9","article-title":"Evaluation of serum interleukin-12 and interleukin-4 as potential biomarkers for the diagnosis of major depressive disorder","volume":"14","author":"Sarmin","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbih.2026.101365_bib67","doi-asserted-by":"crossref","first-page":"2530","DOI":"10.1038\/npp.2016.57","article-title":"Altered stress-induced regulation of genes in monocytes in adults with a history of childhood adversity","volume":"41","author":"Schwaiger","year":"2016","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.bbih.2026.101365_bib68","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.psyneuen.2013.12.001","article-title":"Plasma IL-12 levels are suppressed in vivo by stress and surgery through endogenous release of glucocorticoids and prostaglandins but not catecholamines or opioids","volume":"42","author":"Shaashua","year":"2014","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.bbih.2026.101365_bib69","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1037\/a0035302","article-title":"From stress to inflammation and major depressive disorder: a social signal transduction theory of depression","volume":"140","author":"Slavich","year":"2014","journal-title":"Psychol. Bull."},{"key":"10.1016\/j.bbih.2026.101365_bib70","series-title":"Manual for the State-Trait Anxiety Inventory","first-page":"1983","author":"Spielberger","year":"1983"},{"key":"10.1016\/j.bbih.2026.101365_bib71","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.cyto.2015.01.030","article-title":"Interleukin 12 (IL-12) family cytokines: role in immune pathogenesis and treatment of CNS autoimmune disease","volume":"75","author":"Sun","year":"2015","journal-title":"Cytokine"},{"key":"10.1016\/j.bbih.2026.101365_bib72","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1111\/cns.13810","article-title":"Progranulin promotes hippocampal neurogenesis and alleviates anxiety\u2010like behavior and cognitive impairment in adult mice subjected to cerebral ischemia","volume":"28","author":"Sun","year":"2022","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.bbih.2026.101365_bib73","doi-asserted-by":"crossref","first-page":"D638","DOI":"10.1093\/nar\/gkac1000","article-title":"The STRING database in 2023: protein-protein association networks and functional enrichment analyses for any sequenced genome of interest","volume":"51","author":"Szklarczyk","year":"2023","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bbih.2026.101365_bib74","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1007\/s43440-021-00271-x","article-title":"Formyl peptide receptor 2, as an important target for ligands triggering the inflammatory response regulation: a link to brain pathology","volume":"73","author":"Tylek","year":"2021","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.bbih.2026.101365_bib75","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1038\/nri3839","article-title":"Perforin and granzymes: function, dysfunction and human pathology","volume":"15","author":"Voskoboinik","year":"2015","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.bbih.2026.101365_bib76","series-title":"ggplot2: Elegant Graphics for Data Analysis","author":"Wickham","year":"2016"},{"key":"10.1016\/j.bbih.2026.101365_bib77","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.bbi.2014.09.016","article-title":"Blood gene expression profiles suggest altered immune function associated with symptoms of generalized anxiety disorder","volume":"43","author":"Wingo","year":"2015","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbih.2026.101365_bib78","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1038\/mp.2008.59","article-title":"Polymorphisms in inflammation-related genes are associated with susceptibility to major depression and antidepressant response","volume":"13","author":"Wong","year":"2008","journal-title":"Mol. Psychiatr."},{"key":"10.1016\/j.bbih.2026.101365_bib79","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.110108","article-title":"Serum cytokines-based biomarkers in the diagnosis and monitoring of therapeutic response in patients with major depressive disorder","volume":"118","author":"Xu","year":"2023","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.bbih.2026.101365_bib80","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1017\/thg.2019.99","article-title":"The Swedish twin registry: content and management as a research infrastructure","volume":"22","author":"Zagai","year":"2019","journal-title":"Twin Res. Hum. Genet."},{"key":"10.1016\/j.bbih.2026.101365_bib81","article-title":"Imbalance between TNF\u03b1 and progranulin contributes to memory impairment and anxiety in sleep-deprived mice","volume":"7","author":"Zhang","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbih.2026.101365_bib82","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1186\/s12974-025-03408-4","article-title":"Role of FPR2 antagonism in alleviating social isolation-induced depression and protecting blood-brain barrier integrity","volume":"22","author":"Zheng","year":"2025","journal-title":"J. Neuroinflammation"}],"container-title":["Brain, Behavior, & Immunity - Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666354626001985?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666354626001985?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T11:45:33Z","timestamp":1791891933000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666354626001985"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":82,"alternative-id":["S2666354626001985"],"URL":"https:\/\/doi.org\/10.1016\/j.bbih.2026.101365","relation":{},"ISSN":["2666-3546"],"issn-type":[{"value":"2666-3546","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Fast and slow gene expression changes in blood following acute social stress","name":"articletitle","label":"Article Title"},{"value":"Brain, Behavior, & Immunity - Health","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbih.2026.101365","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"101365"}}