{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T19:39:58Z","timestamp":1790192398097,"version":"4.1.0"},"reference-count":20,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2006,10,1]],"date-time":"2006-10-01T00:00:00Z","timestamp":1159660800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,10,1]],"date-time":"2006-10-01T00:00:00Z","timestamp":1159660800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2015,6,15]],"date-time":"2015-06-15T00:00:00Z","timestamp":1434326400000},"content-version":"vor","delay-in-days":3179,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["bbmt.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biology of Blood and Marrow Transplantation"],"published-print":{"date-parts":[[2006,10]]},"DOI":"10.1016\/j.bbmt.2006.06.008","type":"journal-article","created":{"date-parts":[[2006,10,29]],"date-time":"2006-10-29T07:04:05Z","timestamp":1162105445000},"page":"1085-1091","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Is High-Dose Chemotherapy After Primary Chemotherapy a Therapeutic Option for Patients With Primary Mediastinal Nonseminomatous Germ Cell Tumor?"],"prefix":"10.1016","volume":"12","author":[{"given":"Giuseppe Luigi","family":"Banna","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ugo","family":"De Giorgi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benvenuto","family":"Ferrari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Castagna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Alloisio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Marangolo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Rosti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armando","family":"Santoro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbmt.2006.06.008_bib1","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1200\/JCO.1997.15.2.594","article-title":"International Germ Cell Consensus Classification: a prognostic factor-based staging system for metastatic germ cell cancers","volume":"15","year":"1997","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.bbmt.2006.06.008_bib2","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1200\/JCO.1998.16.2.725","article-title":"Primary mediastinal nonseminomatous germ cell tumors: results of modern therapy including cisplatin-based chemotherapy","volume":"16","author":"Fizazi","year":"1998","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.bbmt.2006.06.008_bib3","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1093\/annonc\/mdh301","article-title":"European consensus on diagnosis and treatment of germ cell cancer: a report of the European Germ Cell Cancer Consensus Group (EGCCCG)","volume":"15","author":"Schmoll","year":"2004","journal-title":"Ann Oncol"},{"key":"10.1016\/j.bbmt.2006.06.008_bib4","doi-asserted-by":"crossref","first-page":"1864","DOI":"10.1200\/JCO.2002.07.062","article-title":"Extragonadal germ cell tumors of the mediastinum and retroperitoneum: results from an international analysis","volume":"20","author":"Bokemeyer","year":"2002","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.bbmt.2006.06.008_bib5","first-page":"95","article-title":"The status of high-dose chemotherapy with hematopoietic stem cell transplantation in patients with germ cell tumor","volume":"87","author":"De Giorgi","year":"2002","journal-title":"Haematologica"},{"key":"10.1016\/j.bbmt.2006.06.008_bib6","doi-asserted-by":"crossref","first-page":"3450","DOI":"10.1200\/JCO.1999.17.11.3450","article-title":"First-line high-dose chemotherapy compared with standard-dose PEB\/VIP chemotherapy in patients with advanced germ cell tumors: a multivariate and matched-pair analysis","volume":"17","author":"Bokemeyer","year":"1999","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.bbmt.2006.06.008_bib7","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1023\/A:1008393512723","article-title":"High-dose chemotherapy and autologous haematopoietic support in poor risk non-seminomatous germ-cell tumours: an effective first-line therapy with minimal toxicity","volume":"11","author":"Decatris","year":"2000","journal-title":"Ann Oncol"},{"key":"10.1016\/j.bbmt.2006.06.008_bib8","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1038\/sj.bmt.1704704","article-title":"First line high-dose chemotherapy for patients with poor prognosis extragonadal germ cell tumors: the experience of the European Bone Marrow Transplantation (EBMT) Solid Tumors Working Party","volume":"34","author":"Rosti","year":"2004","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.bbmt.2006.06.008_bib9","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1093\/annonc\/mdi017","article-title":"Second-line high-dose chemotherapy in patients with mediastinal and retroperitoneal primary non-seminomatous germ cell tumors: the EBMT experience","volume":"16","author":"De Giorgi","year":"2005","journal-title":"Ann Oncol"},{"key":"10.1016\/j.bbmt.2006.06.008_bib10","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1038\/sj.bjc.6600999","article-title":"First-line sequential high-dose VIP chemotherapy with autologous transplantation for patients with primary mediastinal nonseminomatous germ cell tumours: a prospective trial","volume":"89","author":"Bokemeyer","year":"2003","journal-title":"Br J Cancer"},{"key":"10.1016\/j.bbmt.2006.06.008_bib11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0197-2456(89)90015-9","article-title":"Optimal two-stage designs for phase II clinical trials","volume":"10","author":"Simon","year":"1989","journal-title":"Control Clin Trials"},{"key":"10.1016\/j.bbmt.2006.06.008_bib12","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1080\/01621459.1958.10501452","article-title":"Non parametric estimation from incomplete observations","volume":"53","author":"Kaplan","year":"1958","journal-title":"J Am Stat Assoc"},{"key":"10.1016\/j.bbmt.2006.06.008_bib13","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1038\/sj.bmt.1701622","article-title":"Peripheral blood progenitor cell (PBPC) mobilization in heavily pretreated patients with germ cell tumors: a report of 34 cases","volume":"23","author":"Dazzi","year":"1999","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.bbmt.2006.06.008_bib14","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1016\/j.jtcvs.2005.06.006","article-title":"Induction chemotherapy, surgical resection, and high-dose chemotherapy for mediastinal nonseminomatous germ-cell tumor","volume":"130","author":"Date","year":"2005","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.bbmt.2006.06.008_bib15","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1159\/000474596","article-title":"Early intensified chemotherapy with autologous bone marrow transplantation in first line treatment of poor risk non-seminomatous germ cell tumours","volume":"23","author":"Chevreau","year":"1993","journal-title":"Eur Urol"},{"key":"10.1016\/j.bbmt.2006.06.008_bib16","doi-asserted-by":"crossref","first-page":"4083","DOI":"10.1200\/JCO.2003.09.035","volume":"21","author":"Schmoll","year":"2003","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.bbmt.2006.06.008_bib17","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1200\/JCO.1998.16.2.692","volume":"16","author":"Kaye","year":"1998","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.bbmt.2006.06.008_bib18","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1023\/A:1008279222625","article-title":"Treatment of men with metastatic non-seminomatous germ cell tumours with cyclical POMB\/ACE chemotherapy","volume":"8","author":"Bower","year":"1997","journal-title":"Ann Oncol"},{"key":"10.1016\/j.bbmt.2006.06.008_bib19","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/j.bbmt.2005.07.010","article-title":"Paclitaxel-based high-dose chemotherapy with autologous stem cell rescue for relapsed germ cell cancer","volume":"11","author":"Margolin","year":"2005","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.bbmt.2006.06.008_bib20","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1200\/JCO.2003.05.155","article-title":"Intensive induction chemotherapy with CBOP\/BEP in patients with poor prognosis germ cell tumors","volume":"21","author":"Christian","year":"2003","journal-title":"J Clin Oncol"}],"container-title":["Biology of Blood and Marrow Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1083879106004101?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1083879106004101?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T14:27:22Z","timestamp":1761056842000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1083879106004101"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,10]]},"references-count":20,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2006,10]]}},"alternative-id":["S1083879106004101"],"URL":"https:\/\/doi.org\/10.1016\/j.bbmt.2006.06.008","relation":{},"ISSN":["1083-8791"],"issn-type":[{"value":"1083-8791","type":"print"}],"subject":[],"published":{"date-parts":[[2006,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Is High-Dose Chemotherapy After Primary Chemotherapy a Therapeutic Option for Patients With Primary Mediastinal Nonseminomatous Germ Cell Tumor?","name":"articletitle","label":"Article Title"},{"value":"Biology of Blood and Marrow Transplantation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbmt.2006.06.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 American Society for Blood and Marrow Transplantation. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}