{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T22:35:33Z","timestamp":1791326133817,"version":"4.3.1"},"reference-count":44,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2008,3,1]],"date-time":"2008-03-01T00:00:00Z","timestamp":1204329600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,3,1]],"date-time":"2008-03-01T00:00:00Z","timestamp":1204329600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2015,4,10]],"date-time":"2015-04-10T00:00:00Z","timestamp":1428624000000},"content-version":"vor","delay-in-days":2596,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["bbmt.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biology of Blood and Marrow Transplantation"],"published-print":{"date-parts":[[2008,3]]},"DOI":"10.1016\/j.bbmt.2007.12.490","type":"journal-article","created":{"date-parts":[[2008,2,15]],"date-time":"2008-02-15T08:12:23Z","timestamp":1203063143000},"page":"290-300","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":66,"title":["Up-regulation of NK Cell Activating Receptors Following Allogeneic Hematopoietic Stem Cell Transplantation under a Lymphodepleting Reduced Intensity Regimen is Associated with Elevated IL-15 Levels"],"prefix":"10.1016","volume":"14","author":[{"given":"Michael","family":"Boyiadzis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarfraz","family":"Memon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesse","family":"Carson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenton","family":"Allen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miroslaw J.","family":"Szczepanski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara A.","family":"Vance","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Dean","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael R.","family":"Bishop","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald E.","family":"Gress","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frances T.","family":"Hakim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbmt.2007.12.490_bib1","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.blre.2005.10.001","article-title":"Human natural killer cell development and biology","volume":"20","author":"Farag","year":"2006","journal-title":"Blood Rev"},{"key":"10.1016\/j.bbmt.2007.12.490_bib2","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0167-5699(96)10075-X","article-title":"Implications for immunosurveillance of altered HLA class I phenotypes in human tumours","volume":"18","author":"Garrido","year":"1997","journal-title":"Immunol Today"},{"key":"10.1016\/j.bbmt.2007.12.490_bib3","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.it.2005.06.008","article-title":"Viral evasion of NK-cell activation","volume":"26","author":"Rajagopalan","year":"2005","journal-title":"Trends Immunol"},{"key":"10.1016\/j.bbmt.2007.12.490_bib4","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1182\/blood-2004-04-1422","article-title":"HLA class I, NKG2D, and natural cytotoxicity receptors regulate multiple myeloma cell recognition by natural killer cells","volume":"105","author":"Carbone","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2007.12.490_bib5","doi-asserted-by":"crossref","first-page":"5790","DOI":"10.4049\/jimmunol.175.9.5790","article-title":"NK cells infiltrating a MHC class I-deficient lung adenocarcinoma display impaired cytotoxic activity toward autologous tumor cells associated with altered NK cell-triggering receptors","volume":"175","author":"Le Maux Chansac","year":"2005","journal-title":"J Immunol"},{"key":"10.1016\/j.bbmt.2007.12.490_bib6","first-page":"6178","article-title":"Major histocompatibility complex class I-related chain A and UL16-binding protein expression on tumor cell lines of different histotypes: analysis of tumor susceptibility to NKG2D-dependent natural killer cell cytotoxicity","volume":"62","author":"Pende","year":"2002","journal-title":"Cancer Res"},{"key":"10.1016\/j.bbmt.2007.12.490_bib7","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1146\/annurev.immunol.19.1.197","article-title":"Activating receptors and coreceptors involved in human natural killer cell-mediated cytolysis","volume":"19","author":"Moretta","year":"2001","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.bbmt.2007.12.490_bib8","doi-asserted-by":"crossref","first-page":"4120","DOI":"10.1073\/pnas.0730640100","article-title":"Transforming growth factor beta 1 inhibits expression of NKp30 and NKG2D receptors: consequences for the NK-mediated killing of dendritic cells","volume":"100","author":"Castriconi","year":"2003","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.bbmt.2007.12.490_bib9","doi-asserted-by":"crossref","first-page":"5541","DOI":"10.4049\/jimmunol.175.8.5541","article-title":"Inhibition of NK cell activity through TGF-beta 1 by down-regulation of NKG2D in a murine model of head and neck cancer","volume":"175","author":"Dasgupta","year":"2005","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.bbmt.2007.12.490_bib10","doi-asserted-by":"crossref","first-page":"7596","DOI":"10.1158\/0008-5472.CAN-04-1627","article-title":"RNA interference targeting transforming growth factor-beta enhances NKG2D-mediated antiglioma immune response, inhibits glioma cell migration and invasiveness, and abrogates tumorigenicity in vivo","volume":"64","author":"Friese","year":"2004","journal-title":"Cancer Res"},{"key":"10.1016\/j.bbmt.2007.12.490_bib11","doi-asserted-by":"crossref","first-page":"7335","DOI":"10.4049\/jimmunol.172.12.7335","article-title":"Elevated TGF-beta1 secretion and down-modulation of NKG2D underlies impaired NK cytotoxicity in cancer patients","volume":"172","author":"Lee","year":"2004","journal-title":"J Immunol"},{"key":"10.1016\/j.bbmt.2007.12.490_bib12","doi-asserted-by":"crossref","first-page":"3860","DOI":"10.1182\/blood-2003-04-1200","article-title":"Reconstitution of dendritic and natural killer-cell subsets after allogeneic stem cell transplantation: effects of endogenous flt3 ligand","volume":"103","author":"Chklovskaia","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2007.12.490_bib13","doi-asserted-by":"crossref","first-page":"3239","DOI":"10.1182\/blood.V79.12.3239.bloodjournal79123239","article-title":"CD16- CD56+ natural killer cells after bone marrow transplantation","volume":"79","author":"Jacobs","year":"1992","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2007.12.490_bib14","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1089\/152581600319630","article-title":"Natural killer (NK) and T cell-associated surface marker expression following allogeneic and autologous bone marrow transplantation (BMT)","volume":"9","author":"Nagler","year":"2000","journal-title":"J Hematother Stem Cell Res"},{"key":"10.1016\/j.bbmt.2007.12.490_bib15","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.molimm.2004.07.019","article-title":"Human natural killer cells undergoing in vivo differentiation after allogeneic bone marrow transplantation: analysis of the surface expression and function of activating NK receptors","volume":"42","author":"Vitale","year":"2005","journal-title":"Mol Immunol"},{"key":"10.1016\/j.bbmt.2007.12.490_bib16","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1038\/sj.bmt.1704084","article-title":"A comparison of T-, B- and NK-cell reconstitution following conventional or nonmyeloablative conditioning and transplantation with bone marrow or peripheral blood stem cells from human leucocyte antigen identical sibling donors","volume":"32","author":"Petersen","year":"2003","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.bbmt.2007.12.490_bib17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s002770050246","article-title":"Association of natural killer cell immune recovery with a graft-versus-leukemia effect independent of graft-versus-host disease following allogeneic bone marrow transplantation","volume":"74","author":"Jiang","year":"1997","journal-title":"Ann Hematol"},{"key":"10.1016\/j.bbmt.2007.12.490_bib18","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1182\/blood-2006-07-036228","article-title":"A subpopulation of human peripheral blood NK cells that lacks inhibitory receptors for self-MHC is developmentally immature","volume":"110","author":"Cooley","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2007.12.490_bib19","doi-asserted-by":"crossref","first-page":"3824","DOI":"10.1182\/blood-2006-04-020198","article-title":"Coordinated acquisition of inhibitory and activating receptors and functional properties by developing human natural killer cells","volume":"108","author":"Grzywacz","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2007.12.490_bib20","doi-asserted-by":"crossref","first-page":"1530","DOI":"10.1182\/blood-2006-10-048173","article-title":"The unexpected effect of cyclosporin A on CD56+CD16- and CD56+CD16+ natural killer cell subpopulations","volume":"110","author":"Wang","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2007.12.490_bib21","doi-asserted-by":"crossref","first-page":"3730","DOI":"10.1182\/blood-2002-08-2568","article-title":"Reconstitution of NK cell receptor repertoire following HLA-matched hematopoietic cell transplantation","volume":"101","author":"Shilling","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2007.12.490_bib22","doi-asserted-by":"crossref","first-page":"239","DOI":"10.4049\/jimmunol.169.1.239","article-title":"Genetic control of human NK cell repertoire","volume":"169","author":"Shilling","year":"2002","journal-title":"J Immunol"},{"key":"10.1016\/j.bbmt.2007.12.490_bib23","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1080\/146532402760271127","article-title":"Innate immunity against hematological malignancies","volume":"4","author":"Ruggeri","year":"2002","journal-title":"Cytotherapy"},{"key":"10.1016\/j.bbmt.2007.12.490_bib24","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1126\/science.1068440","article-title":"Effectiveness of donor natural killer cell alloreactivity in mismatched hematopoietic transplants","volume":"295","author":"Ruggeri","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.bbmt.2007.12.490_bib25","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1111\/j.1365-2249.2007.03360.x","article-title":"Impact of natural killer cell dose and donor killer-cell immunoglobulin-like receptor (KIR) genotype on outcome following human leucocyte antigen-identical haematopoietic stem cell transplantation","volume":"148","author":"Clausen","year":"2007","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.bbmt.2007.12.490_bib26","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1111\/j.1365-2141.2004.05133.x","article-title":"Targeted pretransplant host lymphocyte depletion prior to T-cell depleted reduced-intensity allogeneic stem cell transplantation","volume":"126","author":"Bishop","year":"2004","journal-title":"Br J Haematol"},{"key":"10.1016\/j.bbmt.2007.12.490_bib27","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.bbmt.2005.04.005","article-title":"Efficacy of reduced-intensity allogeneic stem cell transplantation in chemotherapy-refractory non-hodgkin lymphoma","volume":"11","author":"Dean","year":"2005","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.bbmt.2007.12.490_bib28","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1006\/meth.1996.0037","article-title":"Measurements of Natural Killer (NK) Activity and NK-Cell Quantification","volume":"9","author":"Friberg","year":"1996","journal-title":"Methods"},{"key":"10.1016\/j.bbmt.2007.12.490_bib29","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1002\/jcla.1860040207","article-title":"Natural killer cytotoxicity in the diagnosis of immune dysfunction: criteria for a reproducible assay","volume":"4","author":"Whiteside","year":"1990","journal-title":"J Clin Lab Anal"},{"key":"10.1016\/j.bbmt.2007.12.490_bib30","doi-asserted-by":"crossref","first-page":"4370","DOI":"10.1182\/blood-2005-04-1644","article-title":"KIR reconstitution is altered by T cells in the graft and correlates with clinical outcomes after unrelated donor transplantation","volume":"106","author":"Cooley","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2007.12.490_bib31","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1097\/00043426-200312000-00011","article-title":"Elevated serum interleukin-15 level in acute graft-versus-host disease after hematopoietic cell transplantation","volume":"25","author":"Chik","year":"2003","journal-title":"J Pediatr Hematol Oncol"},{"key":"10.1016\/j.bbmt.2007.12.490_bib32","doi-asserted-by":"crossref","first-page":"3051","DOI":"10.1182\/blood-2004-07-2974","article-title":"Successful adoptive transfer and in vivo expansion of human haploidentical NK cells in patients with cancer","volume":"105","author":"Miller","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2007.12.490_bib33","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1038\/nri1901","article-title":"The biology of interleukin-2 and interleukin-15: implications for cancer therapy and vaccine design","volume":"6","author":"Waldmann","year":"2006","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.bbmt.2007.12.490_bib34","doi-asserted-by":"crossref","first-page":"2983","DOI":"10.1182\/blood.V97.10.2983","article-title":"A potential role for interleukin-7 in T-cell homeostasis","volume":"97","author":"Fry","year":"2001","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2007.12.490_bib35","doi-asserted-by":"crossref","first-page":"735","DOI":"10.4049\/jimmunol.156.2.735","article-title":"Induction and regulation of IL-15 expression in murine macrophages","volume":"156","author":"Doherty","year":"1996","journal-title":"J Immunol"},{"key":"10.1016\/j.bbmt.2007.12.490_bib36","doi-asserted-by":"crossref","first-page":"5011","DOI":"10.4049\/jimmunol.167.9.5011","article-title":"Lipopolysaccharide-stimulated or granulocyte-macrophage colony-stimulating factor-stimulated monocytes rapidly express biologically active IL-15 on their cell surface independent of new protein synthesis","volume":"167","author":"Neely","year":"2001","journal-title":"J Immunol"},{"key":"10.1016\/j.bbmt.2007.12.490_bib37","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1172\/JCI119258","article-title":"A potential role for interleukin-15 in the regulation of human natural killer cell survival","volume":"99","author":"Carson","year":"1997","journal-title":"J Clin Invest"},{"key":"10.1016\/j.bbmt.2007.12.490_bib38","doi-asserted-by":"crossref","first-page":"3633","DOI":"10.1182\/blood-2001-12-0293","article-title":"In vivo evidence for a dependence on interleukin 15 for survival of natural killer cells","volume":"100","author":"Cooper","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2007.12.490_bib39","doi-asserted-by":"crossref","first-page":"4887","DOI":"10.1182\/blood-2002-11-3392","article-title":"IL-15 is an essential mediator of peripheral NK-cell homeostasis","volume":"101","author":"Ranson","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2007.12.490_bib40","doi-asserted-by":"crossref","first-page":"3439","DOI":"10.1002\/eji.200324533","article-title":"IL-21 induces both rapid maturation of human CD34+ cell precursors towards NK cells and acquisition of surface killer Ig-like receptors","volume":"33","author":"Sivori","year":"2003","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.bbmt.2007.12.490_bib41","doi-asserted-by":"crossref","first-page":"4526","DOI":"10.1073\/pnas.072065999","article-title":"Early expression of triggering receptors and regulatory role of 2B4 in human natural killer cell precursors undergoing in vitro differentiation","volume":"99","author":"Sivori","year":"2002","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.bbmt.2007.12.490_bib42","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1172\/JCI1268","article-title":"Suppression of graft-versus-host disease and amplification of graft-versus-tumor effects by activated natural killer cells after allogeneic bone marrow transplantation","volume":"101","author":"Asai","year":"1998","journal-title":"J Clin Invest"},{"key":"10.1016\/j.bbmt.2007.12.490_bib43","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1182\/blood-2005-05-1897","article-title":"Factors associated with early molecular remission after T cell-depleted allogeneic stem cell transplantation for chronic myelogenous leukemia","volume":"107","author":"Savani","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2007.12.490_bib44","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1182\/blood.V94.1.333.413a31_333_339","article-title":"Role of natural killer cell alloreactivity in HLA-mismatched hematopoietic stem cell transplantation","volume":"94","author":"Ruggeri","year":"1999","journal-title":"Blood"}],"container-title":["Biology of Blood and Marrow Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1083879107006532?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1083879107006532?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T14:33:53Z","timestamp":1761057233000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1083879107006532"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,3]]},"references-count":44,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2008,3]]}},"alternative-id":["S1083879107006532"],"URL":"https:\/\/doi.org\/10.1016\/j.bbmt.2007.12.490","relation":{},"ISSN":["1083-8791"],"issn-type":[{"value":"1083-8791","type":"print"}],"subject":[],"published":{"date-parts":[[2008,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Up-regulation of NK Cell Activating Receptors Following Allogeneic Hematopoietic Stem Cell Transplantation under a Lymphodepleting Reduced Intensity Regimen is Associated with Elevated IL-15 Levels","name":"articletitle","label":"Article Title"},{"value":"Biology of Blood and Marrow Transplantation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbmt.2007.12.490","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2008 American Society for Blood and Marrow Transplantation. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}