{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T19:48:23Z","timestamp":1790365703628,"version":"4.1.0"},"reference-count":40,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2010,2,1]],"date-time":"2010-02-01T00:00:00Z","timestamp":1264982400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,2,1]],"date-time":"2010-02-01T00:00:00Z","timestamp":1264982400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2015,4,10]],"date-time":"2015-04-10T00:00:00Z","timestamp":1428624000000},"content-version":"vor","delay-in-days":1894,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["bbmt.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biology of Blood and Marrow Transplantation"],"published-print":{"date-parts":[[2010,2]]},"DOI":"10.1016\/j.bbmt.2009.10.021","type":"journal-article","created":{"date-parts":[[2009,10,25]],"date-time":"2009-10-25T04:18:43Z","timestamp":1256444323000},"page":"273-280","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"title":["The Role of Missing Killer Cell Immunoglobulin-Like Receptor Ligands in T Cell Replete Peripheral Blood Stem Cell Transplantation from HLA-Identical Siblings"],"prefix":"10.1016","volume":"16","author":[{"given":"Johannes","family":"Clausen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigitte","family":"Kircher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jutta","family":"Auberger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petra","family":"Schumacher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanno","family":"Ulmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Hetzenauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominik","family":"Wolf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00fcnther","family":"Gastl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Nachbaur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbmt.2009.10.021_bib1","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1182\/blood.V94.1.333.413a31_333_339","article-title":"Role of natural killer cell alloreactivity in HLA-mismatched hematopoietic stem cell transplantation","volume":"94","author":"Ruggeri","year":"1999","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2009.10.021_bib2","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1126\/science.1068440","article-title":"Effectiveness of donor natural killer cell alloreactivity in mismatched hematopoietic transplants","volume":"295","author":"Ruggeri","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.bbmt.2009.10.021_bib3","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1182\/blood-2003-01-0091","article-title":"Survival advantage with\u00a0KIR ligand incompatibility in hematopoietic stem cell transplantation from unrelated donors","volume":"102","author":"Giebel","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2009.10.021_bib4","doi-asserted-by":"crossref","first-page":"644","DOI":"10.4049\/jimmunol.172.1.644","article-title":"Determinants of antileukemia effects of allogeneic NK cells","volume":"172","author":"Leung","year":"2004","journal-title":"J Immunol"},{"key":"10.1016\/j.bbmt.2009.10.021_bib5","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1111\/j.1365-2141.2005.05513.x","article-title":"Comparison between antithymocyte globulin and alemtuzumab and the possible impact of KIR-ligand mismatch after dose-reduced conditioning and unrelated stem cell transplantation in patients with multiple myeloma","volume":"129","author":"Kroger","year":"2005","journal-title":"Br J Haematol"},{"key":"10.1016\/j.bbmt.2009.10.021_bib6","doi-asserted-by":"crossref","first-page":"2594","DOI":"10.1182\/blood-2004-04-1441","article-title":"Genotypic inhibitory killer immunoglobulin-like receptor ligand incompatibility enhances the long-term antileukemic effect of unmodified allogeneic hematopoietic stem cell transplantation in patients with myeloid leukemias","volume":"105","author":"Beelen","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2009.10.021_bib7","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1016\/j.bbmt.2006.04.008","article-title":"KIR ligands and prediction of relapse after unrelated donor hematopoietic cell transplantation for hematologic malignancy","volume":"12","author":"Hsu","year":"2006","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.bbmt.2009.10.021_bib8","doi-asserted-by":"crossref","first-page":"2860","DOI":"10.1182\/blood-2003-11-3893","article-title":"Role of KIR ligand incompatibility in hematopoietic stem cell transplantation using unrelated donors","volume":"103","author":"Bornhauser","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2009.10.021_bib9","doi-asserted-by":"crossref","first-page":"3825","DOI":"10.1182\/blood-2002-04-1197","article-title":"Evaluation of KIR ligand incompatibility in mismatched unrelated donor hematopoietic transplants. Killer immunoglobulin-like receptor","volume":"100","author":"Davies","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2009.10.021_bib10","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1111\/j.1399-0039.2005.00396.x","article-title":"Natural killer cell HLA-C epitopes and killer cell immunoglobulin-like receptors both influence outcome of mismatched unrelated donor bone marrow transplants","volume":"65","author":"De Santis","year":"2005","journal-title":"Tissue Antigens"},{"key":"10.1016\/j.bbmt.2009.10.021_bib11","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1016\/j.bbmt.2006.05.007","article-title":"The effect of KIR ligand incompatibility on the outcome of unrelated donor transplantation: a report from the Center for International Blood and Marrow Transplant Research, the European Blood and Marrow Transplant Registry, and the Dutch Registry","volume":"12","author":"Farag","year":"2006","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.bbmt.2009.10.021_bib12","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1097\/01.tp.0000235859.24513.43","article-title":"Low number of donor activating killer immunoglobulin-like receptors (KIR) genes, but not KIR-ligand mismatch, prevents relapse and improves disease-free survival in leukemia patients after in vivo T-cell depleted unrelated stem cell transplantation","volume":"82","author":"Kroger","year":"2006","journal-title":"Transplantation"},{"key":"10.1016\/j.bbmt.2009.10.021_bib13","doi-asserted-by":"crossref","first-page":"4370","DOI":"10.1182\/blood-2005-04-1644","article-title":"KIR reconstitution is altered by T cells in the graft and correlates with clinical outcomes after unrelated donor transplantation","volume":"106","author":"Cooley","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2009.10.021_bib14","doi-asserted-by":"crossref","first-page":"4878","DOI":"10.1182\/blood-2004-12-4825","article-title":"Improved outcome in HLA-identical sibling hematopoietic stem-cell transplantation for acute myelogenous leukemia predicted by KIR and HLA genotypes","volume":"105","author":"Hsu","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2009.10.021_bib15","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1182\/blood-2003-02-0438","article-title":"The impact of donor KIR and patient HLA-C genotypes on outcome following HLA-identical sibling hematopoietic stem cell transplantation for myeloid leukemia","volume":"103","author":"Cook","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2009.10.021_bib16","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1111\/j.1365-2141.2005.05797.x","article-title":"Homozygosity for human leucocyte antigen-C ligands of KIR2DL1 is associated with increased risk of relapse after human leucocyte antigen-Cmatched unrelated donor haematopoietic stem cell transplantation","volume":"131","author":"Giebel","year":"2005","journal-title":"Br J Haematol"},{"key":"10.1016\/j.bbmt.2009.10.021_bib17","doi-asserted-by":"crossref","first-page":"5058","DOI":"10.1182\/blood-2007-01-065383","article-title":"Missing KIR ligands are associated with less relapse and increased graft-versus-host disease (GVHD) following unrelated donor allogeneic HCT","volume":"109","author":"Miller","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2009.10.021_bib18","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/sj.bmt.1705609","article-title":"Survival of AML patients receiving HLA-matched sibling donor allogeneic bone marrow transplantation correlates with HLA-Cw ligand groups for killer immunoglobulin-like receptors","volume":"39","author":"Sobecks","year":"2007","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.bbmt.2009.10.021_bib19","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1038\/sj.bmt.1705954","article-title":"Influence of killer immunoglobulin-like receptor\/HLA ligand matching on achievement of T-cell complete donor chimerism in related donor nonmyeloablative allogeneic hematopoietic stem cell transplantation","volume":"41","author":"Sobecks","year":"2008","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.bbmt.2009.10.021_bib20","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1111\/j.1365-2249.2007.03360.x","article-title":"Impact of natural killer cell dose and donor killer-cell immunoglobulin-like receptor (KIR) genotype on outcome following human leucocyte antigenidentical haematopoietic stem cell transplantation","volume":"148","author":"Clausen","year":"2007","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.bbmt.2009.10.021_bib21","doi-asserted-by":"crossref","first-page":"3918","DOI":"10.4049\/jimmunol.178.6.3918","article-title":"Relevance of C1 and C2 epitopes for hemopoietic stem cell transplantation: role for sequential acquisition of HLA-Cspecific inhibitory killer Ig-like receptor","volume":"178","author":"Fischer","year":"2007","journal-title":"J Immunol"},{"key":"10.1016\/j.bbmt.2009.10.021_bib22","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/bmt.2008.432","article-title":"KIR genes and KIR ligands affect occurrence of acute GVHD after unrelated, 12\/12 HLA-matched, hematopoietic stem cell transplantation","volume":"44","author":"Ludajic","year":"2009","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.bbmt.2009.10.021_bib23","doi-asserted-by":"crossref","first-page":"3875","DOI":"10.1182\/blood-2008-09-177055","article-title":"Breaking tolerance to self, circulating natural killer cells expressing inhibitory KIR for non-self HLA exhibit effector function after T cell depleted allogeneic hematopoietic cell transplantation","volume":"113","author":"Yu","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2009.10.021_bib24","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1182\/blood-2008-02-137521","article-title":"Human leukocyte antigens A23, A24, and A32 but not A25 are ligands for KIR3DL1","volume":"112","author":"Stern","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2009.10.021_bib25","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.bbmt.2004.06.009","article-title":"Suppression of natural killer cells in the presence of CD34+ blood progenitor cells and peripheral blood lymphocytes","volume":"10","author":"Clausen","year":"2004","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.bbmt.2009.10.021_bib26","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1038\/bmt.2008.398","article-title":"Cytolytic activity of NK cell clones against acute childhood precursor-B-cell leukaemia is influenced by HLA class I expression on blasts and the differential KIR phenotype of NK clones","volume":"43","author":"Feuchtinger","year":"2009","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.bbmt.2009.10.021_bib27","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0065-230X(01)83005-0","article-title":"MHC antigens and tumor escape from immune surveillance","volume":"83","author":"Garrido","year":"2001","journal-title":"Adv Cancer Res"},{"key":"10.1016\/j.bbmt.2009.10.021_bib28","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1007\/s00262-008-0601-7","article-title":"Role of the inhibitory KIR ligand HLA-Bw4 and HLA-C expression levels in the recognition of leukemic cells by natural killer cells","volume":"58","author":"Verheyden","year":"2008","journal-title":"Cancer Immunol Immunother"},{"key":"10.1016\/j.bbmt.2009.10.021_bib29","doi-asserted-by":"crossref","first-page":"6010","DOI":"10.4049\/jimmunol.181.9.6010","article-title":"Estimation of the size of the alloreactive NK cell repertoire: studies in individuals homozygous for the group A KIR haplotype","volume":"181","author":"Fauriat","year":"2008","journal-title":"J Immunol"},{"key":"10.1016\/j.bbmt.2009.10.021_bib30","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1002\/eji.200425089","article-title":"Recognition of HLA-A3 and HLA-A11 by KIR3DL2 is peptide-specific","volume":"34","author":"Hansasuta","year":"2004","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.bbmt.2009.10.021_bib31","doi-asserted-by":"crossref","first-page":"2369","DOI":"10.1182\/blood-2008-03-143727","article-title":"MHC class Ispecific inhibitory receptors and their ligands structure diverse human NK-cell repertoires toward a balance of missing self-response","volume":"112","author":"Yawata","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2009.10.021_bib32","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.transproceed.2005.11.091","article-title":"Impact of activating killer immunoglobulin-like receptor genotype on outcome of unrelated donor hematopoietic cell transplantation","volume":"38","author":"Giebel","year":"2006","journal-title":"Transplant Proc"},{"key":"10.1016\/j.bbmt.2009.10.021_bib33","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1038\/sj.leu.2403839","article-title":"A defined donor-activating natural killer cell receptor genotype protects against leukemic relapse after related HLA-identical hematopoietic stem cell transplantation","volume":"19","author":"Verheyden","year":"2005","journal-title":"Leukemia"},{"key":"10.1016\/j.bbmt.2009.10.021_bib34","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1182\/blood-2005-03-1039","article-title":"Donor KIR genotype has a major influence on the rate of cytomegalovirus reactivation following T-cell replete stem cell transplantation","volume":"107","author":"Cook","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2009.10.021_bib35","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1038\/sj.bmt.1705468","article-title":"Activating KIR genes are associated with CMV reactivation and survival after nonT-cell depleted HLA-identical sibling bone marrow transplantation for malignant disorders","volume":"38","author":"Chen","year":"2006","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.bbmt.2009.10.021_bib36","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1097\/01.tp.0000285918.72930.35","article-title":"The activating killer cell immunoglobulin-like receptors as important determinants of acute graft-versus-host disease in hematopoietic stem cell transplantation for acute myelogenous leukemia","volume":"84","author":"Kim","year":"2007","journal-title":"Transplantation"},{"key":"10.1016\/j.bbmt.2009.10.021_bib37","doi-asserted-by":"crossref","first-page":"3631","DOI":"10.1016\/j.molimm.2008.04.016","article-title":"KIR2DS5 is associated with leukemia-free survival after HLA-identical stem cell transplantation in chronic myeloid leukemia patients","volume":"45","author":"Van der Meer","year":"2008","journal-title":"Mol Immunol"},{"key":"10.1016\/j.bbmt.2009.10.021_bib38","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.humimm.2006.12.007","article-title":"Studies on the expression of the deleted KIR2DS4\u2217003 gene product and distribution of KIR2DS4 deleted and nondeleted versions in different populations","volume":"68","author":"Middleton","year":"2007","journal-title":"Hum Immunol"},{"key":"10.1016\/j.bbmt.2009.10.021_bib39","doi-asserted-by":"crossref","first-page":"1852","DOI":"10.3324\/haematol.13033","article-title":"The relationship between circulating natural killer cells after reduced-intensity conditioning hematopoietic stem cell transplantation and relapse-free survival and graft-versus-host disease","volume":"93","author":"Dunbar","year":"2008","journal-title":"Haematologica"},{"key":"10.1016\/j.bbmt.2009.10.021_bib40","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/j.bbmt.2009.01.018","article-title":"What is the role for donor natural killer cells after nonmyeloablative conditioning?","volume":"15","author":"Baron","year":"2009","journal-title":"Biol Blood Marrow Transplant"}],"container-title":["Biology of Blood and Marrow Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1083879109004923?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1083879109004923?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T14:35:17Z","timestamp":1761057317000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1083879109004923"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,2]]},"references-count":40,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2010,2]]}},"alternative-id":["S1083879109004923"],"URL":"https:\/\/doi.org\/10.1016\/j.bbmt.2009.10.021","relation":{},"ISSN":["1083-8791"],"issn-type":[{"value":"1083-8791","type":"print"}],"subject":[],"published":{"date-parts":[[2010,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Role of Missing Killer Cell Immunoglobulin-Like Receptor Ligands in T Cell Replete Peripheral Blood Stem Cell Transplantation from HLA-Identical Siblings","name":"articletitle","label":"Article Title"},{"value":"Biology of Blood and Marrow Transplantation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbmt.2009.10.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 American Society for Blood and Marrow Transplantation. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}