{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T02:07:53Z","timestamp":1788228473870,"version":"build-2803163510"},"reference-count":30,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2012,9,1]],"date-time":"2012-09-01T00:00:00Z","timestamp":1346457600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,9,1]],"date-time":"2012-09-01T00:00:00Z","timestamp":1346457600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2015,4,10]],"date-time":"2015-04-10T00:00:00Z","timestamp":1428624000000},"content-version":"vor","delay-in-days":951,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute (NCI)","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung and Blood Institute (NHLBI)","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases (NIAID)","doi-asserted-by":"crossref","award":["5U01HL069294"],"award-info":[{"award-number":["5U01HL069294"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000050","name":"NHLBI","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"crossref"}]},{"name":"NCI"},{"DOI":"10.13039\/100000006","name":"Office of Naval Research","doi-asserted-by":"crossref","award":["N00014-06-1-0704"],"award-info":[{"award-number":["N00014-06-1-0704"]}],"id":[{"id":"10.13039\/100000006","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000006","name":"Office of Naval Research","doi-asserted-by":"crossref","award":["N00014-08-1-0058"],"award-info":[{"award-number":["N00014-08-1-0058"]}],"id":[{"id":"10.13039\/100000006","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Allos, Inc."},{"DOI":"10.13039\/100002429","name":"Amgen, Inc.","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100002429","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Angioblast"},{"name":"Anonymous donation to the Medical College of Wisconsin; Ariad"},{"DOI":"10.13039\/100007501","name":"Blue Cross and Blue Shield Association","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100007501","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Buchanan Family Foundation"},{"DOI":"10.13039\/100006436","name":"Celgene Corporation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100006436","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Children's Leukemia Research Association"},{"name":"Fresenius-Biotech North America, Inc."},{"name":"Gamida Cell Teva Joint Venture Ltd."},{"DOI":"10.13039\/100004328","name":"Genentech, Inc.","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100004328","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Genzyme Corporation"},{"DOI":"10.13039\/100005189","name":"The Leukemia & Lymphoma Society","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100005189","id-type":"DOI","asserted-by":"crossref"}]},{"name":"The Medical College of Wisconsin"},{"name":"Millennium Pharmaceuticals, Inc."},{"name":"Milliman USA, Inc."},{"name":"Miltenyi Biotec, Inc."},{"name":"National Marrow Donor Program"},{"name":"Optum Healthcare Solutions, Inc."},{"DOI":"10.13039\/100009155","name":"Otsuka America Pharmaceutical, Inc.","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100009155","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100010293","name":"Seattle Genetics","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100010293","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100009996","name":"Sigma-Tau Pharmaceuticals","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100009996","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Soligenix, Inc."},{"DOI":"10.13039\/501100012112","name":"Swedish Orphan Biovitrum","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100012112","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100007163","name":"THERAKOS, Inc.","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100007163","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100004382","name":"Wellpoint, Inc.","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100004382","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["bbmt.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biology of Blood and Marrow Transplantation"],"published-print":{"date-parts":[[2012,9]]},"DOI":"10.1016\/j.bbmt.2012.02.007","type":"journal-article","created":{"date-parts":[[2012,2,28]],"date-time":"2012-02-28T15:32:24Z","timestamp":1330443144000},"page":"1401-1406","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["HLA-Matched Sibling Transplantation for Severe Aplastic Anemia: Impact of HLA DR15 Antigen Status on Engraftment, Graft-versus-Host Disease, and Overall Survival"],"prefix":"10.1016","volume":"18","author":[{"given":"Minoo","family":"Battiwalla","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeanette","family":"Carreras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. Joachim","family":"Deeg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mouhab","family":"Ayas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajinder P.S.","family":"Bajwa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biju","family":"George","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vikas","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"Pasquini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hubert","family":"Schrezenmeier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakob R.","family":"Passweg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirk R.","family":"Schultz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Eapen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbmt.2012.02.007_bib1","author":"Middleton"},{"key":"10.1016\/j.bbmt.2012.02.007_bib2","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1111\/j.1365-2141.1986.tb07494.x","article-title":"Increased frequency of DR2 in patients with aplastic anaemia and increased DR sharing in their parents","volume":"63","author":"Chapuis","year":"1986","journal-title":"Br J Haematol"},{"key":"10.1016\/j.bbmt.2012.02.007_bib3","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1002\/ajh.2830400319","article-title":"HLA-DR2 predicts a favorable response to cyclosporine therapy in patients with bone marrow failure","volume":"40","author":"Nakao","year":"1992","journal-title":"Am J Hematol"},{"key":"10.1016\/j.bbmt.2012.02.007_bib4","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1182\/blood.V84.3.923.923","article-title":"An increased HLA DR2 frequency is seen in aplastic anemia patients","volume":"84","author":"Nimer","year":"1994","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2012.02.007_bib5","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1182\/blood.V100.5.1570.h81702001570_1570_1574","article-title":"HLA-DR15 (DR2) is overrepresented in myelodysplastic syndrome and aplastic anemia and predicts a response to immunosuppression in myelodysplastic syndrome","volume":"100","author":"Saunthararajah","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2012.02.007_bib6","first-page":"350","article-title":"Aplastic anemia is associated with HLA-DRB1*1501 in northern Han Chinese","volume":"71","author":"Shao","year":"2000","journal-title":"Int J Hematol"},{"key":"10.1016\/j.bbmt.2012.02.007_bib7","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.humimm.2008.04.009","article-title":"Association of human leukocyte antigen-DRB1 alleles with disease susceptibility and severity of aplastic anemia in Korean patients","volume":"69","author":"Song","year":"2008","journal-title":"Hum Immunol"},{"key":"10.1016\/j.bbmt.2012.02.007_bib8","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.exphem.2006.09.002","article-title":"Roles of DRB1 *1501 and DRB1 *1502 in the pathogenesis of aplastic anemia","volume":"35","author":"Sugimori","year":"2007","journal-title":"Exp Hematol"},{"key":"10.1016\/j.bbmt.2012.02.007_bib9","doi-asserted-by":"crossref","first-page":"2425","DOI":"10.1182\/blood-2004-05-1839","article-title":"Diazepam-binding inhibitor-related protein 1: a candidate autoantigen in acquired aplastic anemia patients harboring a minor population of paroxysmal nocturnal hemoglobinuria-type cells","volume":"104","author":"Feng","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2012.02.007_bib10","first-page":"772","article-title":"HLA-DRB1*15 and pediatric aplastic anemia","volume":"87","author":"Oguz","year":"2002","journal-title":"Haematologica"},{"key":"10.1016\/j.bbmt.2012.02.007_bib11","first-page":"251","article-title":"Increased expression of HLA DR2 in acquired aplastic anemia and its impact on response to immunosuppressive therapy","volume":"54","author":"Usman","year":"2004","journal-title":"J\u00a0Pak Med Assoc"},{"key":"10.1016\/j.bbmt.2012.02.007_bib12","doi-asserted-by":"crossref","first-page":"2055","DOI":"10.1182\/blood.V86.5.2055a.bloodjournal8652055a","article-title":"HLA-DR frequency in Turkish aplastic anemia patients and the impact of HLA-DR2 positivity in response rate in patients receiving immunosuppressive therapy","volume":"86","author":"Ilhan","year":"1995","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2012.02.007_bib13","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.bbmt.2006.12.439","article-title":"HLA DR15 and immunobiologic outcomes","volume":"13","author":"Battiwalla","year":"2007","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.bbmt.2012.02.007_bib14","doi-asserted-by":"crossref","first-page":"1970","DOI":"10.1182\/blood-2005-05-1958","article-title":"Human leukocyte antigen (HLA) DR15 is associated with reduced incidence of acute GVHD in HLA-matched allogeneic transplantation but does not impact chronic GVHD incidence","volume":"107","author":"Battiwalla","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2012.02.007_bib15","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.bbmt.2006.12.442","article-title":"HLA-DR15, reduced relapse rate and improved survival after HLA identical sibling hemopoietic stem cell transplantation","volume":"13","author":"Davidson","year":"2007","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.bbmt.2012.02.007_bib16","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1016\/j.bbmt.2006.07.001","article-title":"Human leukocyte antigen DR15 is associated with reduced relapse rate and improved survival after human leukocyte antigen-identical sibling hematopoietic stem cell transplantation","volume":"12","author":"Stern","year":"2006","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.bbmt.2012.02.007_bib17","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1016\/j.bbmt.2010.06.003","article-title":"Tumor necrosis factor polymorphism affects transplantation outcome in patients with myelodysplastic syndrome but not in those with chronic myelogenous leukemia, independent of the presence of HLA-DR15","volume":"16","author":"Newell","year":"2010","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.bbmt.2012.02.007_bib18","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1097\/00007890-197410000-00001","article-title":"Clinical manifestations of graft-versus-host disease in human recipients of marrow from HLA matched sibling donors","volume":"18","author":"Glucksberg","year":"1974","journal-title":"Transplantation"},{"key":"10.1016\/j.bbmt.2012.02.007_bib19","series-title":"The Statistical Analysis of Failure Time Data","author":"Kalbfleish","year":"1980"},{"key":"10.1016\/j.bbmt.2012.02.007_bib20","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1080\/01621459.1958.10501452","article-title":"Nonparametric estimation from incomplete observations","volume":"53","author":"Kaplan","year":"1958","journal-title":"J Am Statist Assoc"},{"key":"10.1016\/j.bbmt.2012.02.007_bib21","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/j.2517-6161.1972.tb00899.x","article-title":"Regression models and life-tables","volume":"34","author":"Cox","year":"1972","journal-title":"J R Stat Soc Series B (Methodol)"},{"key":"10.1016\/j.bbmt.2012.02.007_bib22","first-page":"825","article-title":"1994 Consensus conference on acute GVHD grading","volume":"15","author":"Przepiorka","year":"1995","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.bbmt.2012.02.007_bib23","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1016\/S0889-8588(05)70111-8","article-title":"Pathophysiology and treatment of graft-versus-host disease","volume":"13","author":"Flowers","year":"1999","journal-title":"Hematol Oncol Clin North Am"},{"key":"10.1016\/j.bbmt.2012.02.007_bib24","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1111\/j.0006-341X.2005.031209.x","article-title":"Regression modeling of competing risks data based on pseudo-values of the cumulative incidence function","volume":"61","author":"Klein","year":"2005","journal-title":"Biometrics"},{"key":"10.1016\/j.bbmt.2012.02.007_bib25","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1002\/sim.2246","article-title":"Modeling competing risks in cancer studies","volume":"25","author":"Klein","year":"2006","journal-title":"Stat Med"},{"key":"10.1016\/j.bbmt.2012.02.007_bib26","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1182\/blood-2007-03-081596","article-title":"Worse outcome and more chronic GVHD with peripheral blood progenitor cells than bone marrow in HLA-matched sibling donor transplants for young patients with severe acquired aplastic anemia","volume":"110","author":"Schrezenmeier","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2012.02.007_bib27","doi-asserted-by":"crossref","first-page":"4582","DOI":"10.1182\/blood-2006-10-052308","article-title":"Bone marrow transplantation for severe aplastic anemia: a randomized controlled study of conditioning regimens","volume":"109","author":"Champlin","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2012.02.007_bib28","first-page":"858","article-title":"Bone marrow transplantation for severe aplastic anemia: has outcome improved?","volume":"90","author":"Passweg","year":"1997","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2012.02.007_bib29","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1182\/blood.V73.2.606.606","article-title":"Graft failure following bone marrow transplantation for severe aplastic anemia: risk factors and treatment results","volume":"73","author":"Champlin","year":"1989","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2012.02.007_bib30","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1016\/j.bbmt.2009.01.023","article-title":"Risk factors affecting outcome of second HLA-matched sibling donor transplantations for graft failure in severe acquired aplastic anemia","volume":"15","author":"Horan","year":"2009","journal-title":"Biol Blood Marrow Transplant"}],"container-title":["Biology of Blood and Marrow Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S108387911200095X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S108387911200095X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T14:42:40Z","timestamp":1761057760000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S108387911200095X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,9]]},"references-count":30,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2012,9]]}},"alternative-id":["S108387911200095X"],"URL":"https:\/\/doi.org\/10.1016\/j.bbmt.2012.02.007","relation":{},"ISSN":["1083-8791"],"issn-type":[{"value":"1083-8791","type":"print"}],"subject":[],"published":{"date-parts":[[2012,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"HLA-Matched Sibling Transplantation for Severe Aplastic Anemia: Impact of HLA DR15 Antigen Status on Engraftment, Graft-versus-Host Disease, and Overall Survival","name":"articletitle","label":"Article Title"},{"value":"Biology of Blood and Marrow Transplantation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbmt.2012.02.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}