{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T02:07:52Z","timestamp":1788228472826,"version":"build-2803163510"},"reference-count":25,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2012,8,1]],"date-time":"2012-08-01T00:00:00Z","timestamp":1343779200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,8,1]],"date-time":"2012-08-01T00:00:00Z","timestamp":1343779200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2015,4,10]],"date-time":"2015-04-10T00:00:00Z","timestamp":1428624000000},"content-version":"vor","delay-in-days":982,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"National Institute of Health (NIH)"},{"name":"Public Health Service","award":["U24-CA76518"],"award-info":[{"award-number":["U24-CA76518"]}]},{"name":"National Cancer Institute (NCI), the National Heart, Lung and Blood Institute (NHLBI) and the National Institute of Allergy and Infectious Diseases (NIAID)","award":["5U01HL069294"],"award-info":[{"award-number":["5U01HL069294"]}]},{"name":"NHLBI and NCI","award":["HHSH234200637015C"],"award-info":[{"award-number":["HHSH234200637015C"]}]},{"DOI":"10.13039\/100000006","name":"Office of Naval Research","doi-asserted-by":"crossref","award":["N00014-10-1-0204 and N00014-1-1-0339"],"award-info":[{"award-number":["N00014-10-1-0204 and N00014-1-1-0339"]}],"id":[{"id":"10.13039\/100000006","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["bbmt.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biology of Blood and Marrow Transplantation"],"published-print":{"date-parts":[[2012,8]]},"DOI":"10.1016\/j.bbmt.2012.02.011","type":"journal-article","created":{"date-parts":[[2012,3,10]],"date-time":"2012-03-10T14:31:05Z","timestamp":1331389865000},"page":"1302-1308","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["HLA DR15 Antigen Status Does Not Impact Graft-versus-Host Disease or Survival in HLA-Matched Sibling Transplantation for Hematologic Malignancies"],"prefix":"10.1016","volume":"18","author":[{"given":"Minoo","family":"Battiwalla","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin","family":"Ellis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peigang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven Z.","family":"Pavletic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gorgun","family":"Akpek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peiman","family":"Hematti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas R.","family":"Klumpp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard T.","family":"Maziarz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bipin N.","family":"Savani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud D.","family":"Aljurf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitchell S.","family":"Cairo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William R.","family":"Drobyski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biju","family":"George","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theresa","family":"Hahn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nandita","family":"Khera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark R.","family":"Litzow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison W.","family":"Loren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wael","family":"Saber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mukta","family":"Arora","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alvaro","family":"Urbano-Ispizua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corey","family":"Cutler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary E.D.","family":"Flowers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen R.","family":"Spellman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbmt.2012.02.011_bib1","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1097\/00007890-199710150-00014","article-title":"HLA gene and haplotype frequencies in the North American population: the National Marrow Donor Program Donor Registry","volume":"64","author":"Mori","year":"1997","journal-title":"Transplantation"},{"key":"10.1016\/j.bbmt.2012.02.011_bib2","doi-asserted-by":"crossref","unstructured":"Middleton D, Menchaca L, Rood H, Komerofsky R. New allele frequency database: http:\/\/www.allelefrequencies.net. Tissue Antigens. 2003;61:403-407.","DOI":"10.1034\/j.1399-0039.2003.00062.x"},{"key":"10.1016\/j.bbmt.2012.02.011_bib3","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1111\/j.1365-2141.1990.tb06352.x","article-title":"Does HLA-DR predict response to specific immunosuppressive therapy in aplastic anaemia?","volume":"74","author":"Rugman","year":"1990","journal-title":"Br J Haematol"},{"key":"10.1016\/j.bbmt.2012.02.011_bib4","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1002\/ajh.2830400319","article-title":"HLA-DR2 predicts a favorable response to cyclosporine therapy in patients with bone marrow failure","volume":"40","author":"Nakao","year":"1992","journal-title":"Am J Hematol"},{"key":"10.1016\/j.bbmt.2012.02.011_bib5","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1111\/j.1365-2141.1986.tb07494.x","article-title":"Increased frequency of DR2 in patients with aplastic anaemia and increased DR sharing in their parents","volume":"63","author":"Chapuis","year":"1986","journal-title":"Br J Haematol"},{"key":"10.1016\/j.bbmt.2012.02.011_bib6","doi-asserted-by":"crossref","first-page":"4257","DOI":"10.1182\/blood.V84.12.4257.bloodjournal84124257","article-title":"Identification of a specific HLA class II haplotype strongly associated with susceptibility to cyclosporine-dependent aplastic anemia","volume":"84","author":"Nakao","year":"1994","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2012.02.011_bib7","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1182\/blood.V84.3.923.923","article-title":"An increased HLA DR2 frequency is seen in aplastic anemia patients","volume":"84","author":"Nimer","year":"1994","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2012.02.011_bib8","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1182\/blood.V100.5.1570.h81702001570_1570_1574","article-title":"HLA-DR15 (DR2) is overrepresented in myelodysplastic syndrome and aplastic anemia and predicts a response to immunosuppression in myelodysplastic syndrome","volume":"100","author":"Saunthararajah","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2012.02.011_bib9","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/S0140-6736(04)16736-6","article-title":"Insights into the autoimmune nature of aplastic anaemia","volume":"364","author":"Marsh","year":"2004","journal-title":"Lancet"},{"key":"10.1016\/j.bbmt.2012.02.011_bib10","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.humimm.2008.04.009","article-title":"Association of human leukocyte antigen-DRB1 alleles with disease susceptibility and severity of aplastic anemia in Korean patients","volume":"69","author":"Song","year":"2008","journal-title":"Hum Immunol"},{"key":"10.1016\/j.bbmt.2012.02.011_bib11","first-page":"350","article-title":"Aplastic anemia is associated with HLA-DRB1*1501 in northern Han Chinese","volume":"71","author":"Shao","year":"2000","journal-title":"Int J Hematol"},{"key":"10.1016\/j.bbmt.2012.02.011_bib12","doi-asserted-by":"crossref","first-page":"3513","DOI":"10.1182\/blood.V98.13.3513","article-title":"Increased frequency of HLA-DR2 in patients with paroxysmal nocturnal hemoglobinuria and the PNH\/aplastic anemia syndrome","volume":"98","author":"Maciejewski","year":"2001","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2012.02.011_bib13","doi-asserted-by":"crossref","first-page":"2425","DOI":"10.1182\/blood-2004-05-1839","article-title":"Diazepam-binding inhibitor-related protein 1: a candidate autoantigen in acquired aplastic anemia patients harboring a minor population of paroxysmal nocturnal hemoglobinuria-type cells","volume":"104","author":"Feng","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2012.02.011_bib14","first-page":"772","article-title":"HLA-DRB1*15 and pediatric aplastic anemia","volume":"87","author":"Oguz","year":"2002","journal-title":"Haematologica"},{"key":"10.1016\/j.bbmt.2012.02.011_bib15","first-page":"251","article-title":"Increased expression of HLA DR2 in acquired aplastic anemia and its impact on response to immunosuppressive therapy","volume":"54","author":"Usman","year":"2004","journal-title":"J Pak Med Assoc"},{"key":"10.1016\/j.bbmt.2012.02.011_bib16","doi-asserted-by":"crossref","first-page":"2055","DOI":"10.1182\/blood.V86.5.2055a.bloodjournal8652055a","article-title":"HLA-DR frequency in Turkish aplastic anemia patients and the impact of HLA-DR2 positivity in response rate in patients receiving immunosuppressive therapy","volume":"86","author":"Ilhan","year":"1995","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2012.02.011_bib17","doi-asserted-by":"crossref","first-page":"1970","DOI":"10.1182\/blood-2005-05-1958","article-title":"Human leukocyte antigen (HLA) DR15 is associated with reduced incidence of acute GVHD in HLA-matched allogeneic transplantation but does not impact chronic GVHD incidence","volume":"107","author":"Battiwalla","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2012.02.011_bib18","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.bbmt.2006.12.439","article-title":"HLA DR15 and immunobiologic outcomes","volume":"13","author":"Battiwalla","year":"2007","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.bbmt.2012.02.011_bib19","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1016\/j.bbmt.2006.07.001","article-title":"Human leukocyte antigen DR15 is associated with reduced relapse rate and improved survival after human leukocyte antigen-identical sibling hematopoietic stem cell transplantation","volume":"12","author":"Stern","year":"2006","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.bbmt.2012.02.011_bib20","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.bbmt.2006.12.442","article-title":"HLA-DR15, reduced relapse rate and improved survival after HLA identical sibling hemopoietic stem cell transplantation","volume":"13","author":"Davidson","year":"2007","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.bbmt.2012.02.011_bib21","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1016\/j.bbmt.2010.06.003","article-title":"Tumor necrosis factor polymorphism affects transplantation outcome in patients with myelodysplastic syndrome but not in those with chronic myelogenous leukemia, independent of the presence of HLA-DR15","volume":"16","author":"Newell","year":"2010","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.bbmt.2012.02.011_bib22","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1046\/j.1365-2141.1997.1112925.x","article-title":"IBMTR Severity Index for grading acute graft-versus-host disease: retrospective comparison with Glucksberg grade","volume":"97","author":"Rowlings","year":"1997","journal-title":"Br J Haematol"},{"key":"10.1016\/j.bbmt.2012.02.011_bib23","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/0002-9343(80)90380-0","article-title":"Chronic graft-versus-host syndrome in man. A long-term clinicopathologic study of 20 Seattle patients","volume":"69","author":"Shulman","year":"1980","journal-title":"Am J Med"},{"key":"10.1016\/j.bbmt.2012.02.011_bib24","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1080\/01621459.1958.10501452","article-title":"Nonparametric estimation from incomplete observations","volume":"53","author":"Kaplan","year":"1958","journal-title":"J Amer Statist Assn"},{"key":"10.1016\/j.bbmt.2012.02.011_bib25","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/j.humimm.2007.04.005","article-title":"High-resolution HLA alleles and haplotypes in the United States population","volume":"68","author":"Maiers","year":"2007","journal-title":"Hum Immunol"}],"container-title":["Biology of Blood and Marrow Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1083879112001073?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1083879112001073?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T14:41:39Z","timestamp":1761057699000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1083879112001073"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8]]},"references-count":25,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2012,8]]}},"alternative-id":["S1083879112001073"],"URL":"https:\/\/doi.org\/10.1016\/j.bbmt.2012.02.011","relation":{},"ISSN":["1083-8791"],"issn-type":[{"value":"1083-8791","type":"print"}],"subject":[],"published":{"date-parts":[[2012,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"HLA DR15 Antigen Status Does Not Impact Graft-versus-Host Disease or Survival in HLA-Matched Sibling Transplantation for Hematologic Malignancies","name":"articletitle","label":"Article Title"},{"value":"Biology of Blood and Marrow Transplantation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbmt.2012.02.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}