{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T09:28:50Z","timestamp":1769851730982,"version":"3.49.0"},"reference-count":45,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2012,9,1]],"date-time":"2012-09-01T00:00:00Z","timestamp":1346457600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,9,1]],"date-time":"2012-09-01T00:00:00Z","timestamp":1346457600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2015,4,10]],"date-time":"2015-04-10T00:00:00Z","timestamp":1428624000000},"content-version":"vor","delay-in-days":951,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["bbmt.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biology of Blood and Marrow Transplantation"],"published-print":{"date-parts":[[2012,9]]},"DOI":"10.1016\/j.bbmt.2012.02.016","type":"journal-article","created":{"date-parts":[[2012,3,17]],"date-time":"2012-03-17T02:45:53Z","timestamp":1331952353000},"page":"1430-1437","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"title":["Radiation-Free Allogeneic Conditioning with Fludarabine, Carmustine, and Thiotepa for Acute Lymphoblastic Leukemia and Other Hematologic Malignancies Necessitating Enhanced Central Nervous System Activity"],"prefix":"10.1016","volume":"18","author":[{"given":"Petros","family":"Christopoulos","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hartmut","family":"Bertz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriele","family":"Ihorst","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reinhard","family":"Marks","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ralph","family":"W\u00e4sch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00fcrgen","family":"Finke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbmt.2012.02.016_bib1","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1056\/NEJM197504172921605","article-title":"Bone-marrow transplantation (first of two parts)","volume":"292","author":"Thomas","year":"1975","journal-title":"N Engl J Med"},{"key":"10.1016\/j.bbmt.2012.02.016_bib2","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1038\/sj.bmt.1704518","article-title":"Allogeneic myeloablative transplantation for patients aged 50 years and over","volume":"34","author":"Yanada","year":"2004","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.bbmt.2012.02.016_bib3","doi-asserted-by":"crossref","first-page":"3204","DOI":"10.1182\/blood.V90.8.3204","article-title":"Total body irradiation and acute graft-versus-host disease: the role of gastrointestinal damage and inflammatory cytokines","volume":"90","author":"Hill","year":"1997","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2012.02.016_bib4","doi-asserted-by":"crossref","first-page":"3214","DOI":"10.1182\/blood-2010-08-302109","article-title":"Comparative analysis of risk factors for acute graft-versus-host disease and for chronic graft-versus-host disease according to National Institutes of Health consensus criteria","volume":"117","author":"Flowers","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2012.02.016_bib5","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1016\/0360-3016(83)90365-6","article-title":"Acute and delayed toxicities of total body irradiation","volume":"9","author":"Deeg","year":"1983","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"Suppl 2","key":"10.1016\/j.bbmt.2012.02.016_bib6","doi-asserted-by":"crossref","first-page":"S14","DOI":"10.1038\/bmt.2008.47","article-title":"Current European practice in pediatric myeloablative conditioning","volume":"41","author":"Vettenranta","year":"2008","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.bbmt.2012.02.016_bib7","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1200\/JCO.2000.18.2.340","article-title":"Comparison of preparative regimens in transplants for children with acute lymphoblastic leukemia","volume":"18","author":"Davies","year":"2000","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.bbmt.2012.02.016_bib8","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1038\/sj.bmt.1701334","article-title":"Survival, disease-free survival and adverse effects of conditioning for allogeneic bone marrow transplantation with busulfan\/cyclophosphamide vs. total body irradiation: a meta-analysis","volume":"22","author":"Hartman","year":"1998","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.bbmt.2012.02.016_bib9","doi-asserted-by":"crossref","first-page":"2295","DOI":"10.1200\/JCO.2006.09.9861","article-title":"Chemotherapy delivery issues in central nervous system malignancy: a reality check","volume":"25","author":"Muldoon","year":"2007","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.bbmt.2012.02.016_bib10","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1182\/blood-2005-11-4666","article-title":"Central nervous system involvement in adult acute lymphoblastic leukemia at diagnosis: results from the international ALL trial MRC UKALL XII\/ECOG E2993","volume":"108","author":"Lazarus","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2012.02.016_bib11","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1016\/j.leukres.2008.04.011","article-title":"Central nervous system involvement in adult acute lymphoblastic leukemia at diagnosis and\/or at first relapse: results from the GET-LALA group","volume":"32","author":"Reman","year":"2008","journal-title":"Leuk Res"},{"key":"10.1016\/j.bbmt.2012.02.016_bib12","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1002\/1097-0142(197403)33:3<863::AID-CNCR2820330336>3.0.CO;2-1","article-title":"The incidence of central nervous system leukemia in adults with acute leukemia","volume":"33","author":"Wolk","year":"1974","journal-title":"Cancer"},{"key":"10.1016\/j.bbmt.2012.02.016_bib13","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1200\/JCO.2008.16.8021","article-title":"Natural history of CNS relapse in patients with aggressive non-Hodgkin's lymphoma: a 20-year follow-up analysis of SWOG 8516\u2014the Southwest Oncology Group","volume":"27","author":"Bernstein","year":"2009","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.bbmt.2012.02.016_bib14","first-page":"699","article-title":"Involvement of the central nervous system by non-Hodgkin\u2019s lymphoma in adults: a review of 36 cases","volume":"60","author":"Mead","year":"1986","journal-title":"Q J Med"},{"key":"10.1016\/j.bbmt.2012.02.016_bib15","doi-asserted-by":"crossref","first-page":"3865","DOI":"10.1200\/JCO.2006.06.2117","article-title":"High-dose chemotherapy with autologous stem-cell transplantation and hyperfractionated radiotherapy as first-line treatment of primary CNS lymphoma","volume":"24","author":"Illerhaus","year":"2006","journal-title":"J Clin Oncol"},{"issue":"1 Suppl 3","key":"10.1016\/j.bbmt.2012.02.016_bib16","first-page":"2","article-title":"High-dose N, N\u2032, N\u2032\u2032-triethylenethiophosphoramide (thiotepa) with autologous bone marrow transplantation: phase I studies","volume":"17","author":"Wolff","year":"1990","journal-title":"Semin Oncol"},{"key":"10.1016\/j.bbmt.2012.02.016_bib17","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1097\/00007890-199010000-00040","article-title":"Enhancement of T-cell\u2013depleted bone marrow allografts in mice by thiotepa","volume":"50","author":"Terenzi","year":"1990","journal-title":"Transplantation"},{"key":"10.1016\/j.bbmt.2012.02.016_bib18","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1056\/NEJM199810223391702","article-title":"Treatment of high-risk acute leukemia with T-cell\u2013depleted stem cells from related donors with one fully mismatched HLA haplotype","volume":"339","author":"Aversa","year":"1998","journal-title":"N Engl J Med"},{"key":"10.1016\/j.bbmt.2012.02.016_bib19","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1182\/blood.V88.1.353.353","article-title":"Thiotepa cyclophosphamide followed by granulocyte colony-stimulating factor mobilized allogeneic peripheral blood cells in adults with advanced leukemia","volume":"88","author":"Bacigalupo","year":"1996","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2012.02.016_bib20","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/S0145-2126(99)00112-5","article-title":"The role of thiotepa in allogeneic stem cell transplantation in patients with leukemia","volume":"23","author":"Rosales","year":"1999","journal-title":"Leuk Res"},{"key":"10.1016\/j.bbmt.2012.02.016_bib21","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/978-1-4615-0919-6_2","article-title":"Immunosuppression with limited toxicity: the characteristics of nucleoside analogs and anti-lymphocyte antibodies used in non-myeloablative hematopoietic cell transplantation","volume":"110","author":"Bashey","year":"2002","journal-title":"Cancer Treat Res"},{"key":"10.1016\/j.bbmt.2012.02.016_bib22","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1177\/106002809102500512","article-title":"Fludarabine: a review","volume":"25","author":"Hood","year":"1991","journal-title":"DICP"},{"key":"10.1016\/j.bbmt.2012.02.016_bib23","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1016\/j.bbmt.2009.08.002","article-title":"A novel GVHD prophylaxis with low-dose alemtuzumab in allogeneic sibling or unrelated donor hematopoetic cell transplantation: the feasibility of deescalation","volume":"15","author":"Bertz","year":"2009","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.bbmt.2012.02.016_bib24","unstructured":"National Cancer Institute. Common terminology criteria for adverse events (CTCAE), v. 4.0. Available from: http:\/\/evs.nci.nih.gov\/ftp1\/CTCAE\/About.html. Accessed November 1, 2011."},{"key":"10.1016\/j.bbmt.2012.02.016_bib25","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1046\/j.1365-2141.1997.1112925.x","article-title":"IBMTR Severity Index for grading acute graft-versus-host disease: retrospective comparison with Glucksberg grade","volume":"97","author":"Rowlings","year":"1997","journal-title":"Br J Haematol"},{"key":"10.1016\/j.bbmt.2012.02.016_bib26","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/0002-9343(80)90380-0","article-title":"Chronic graft-versus-host syndrome in man: a long-term clinicopathologic study of 20 Seattle patients","volume":"69","author":"Shulman","year":"1980","journal-title":"Am J Med"},{"key":"10.1016\/j.bbmt.2012.02.016_bib27","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1086\/588660","volume":"46","author":"De Pauw","year":"2008","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.bbmt.2012.02.016_bib28","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.bbmt.2008.12.497","article-title":"Reduced-intensity conditioning regimen workshop: defining the dose spectrum: report of a workshop convened by the Center for International Blood and Marrow Transplant Research","volume":"15","author":"Giralt","year":"2009","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.bbmt.2012.02.016_bib29","doi-asserted-by":"crossref","first-page":"2962","DOI":"10.1182\/blood.V90.8.2962","article-title":"Autologous versus unrelated donor allogeneic marrow transplantation for acute lymphoblastic leukemia","volume":"90","author":"Weisdorf","year":"1997","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2012.02.016_bib30","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1038\/sj.bmt.1700787","volume":"19","author":"Ringden","year":"1997","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.bbmt.2012.02.016_bib31","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1182\/blood-2007-12-128918","article-title":"Unrelated donor transplants in adults with Philadelphia-negative acute lymphoblastic leukemia in first complete remission","volume":"112","author":"Marks","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2012.02.016_bib32","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1182\/blood.V97.6.1572","article-title":"Unrelated marrow transplantation for adult patients with poor-risk acute lymphoblastic leukemia: strong graft-versus-leukemia effect and risk factors determining outcome","volume":"97","author":"Cornelissen","year":"2001","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2012.02.016_bib33","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1182\/blood-2010-01-264077","article-title":"The outcome of full-intensity and reduced-intensity conditioning matched sibling or unrelated donor transplantation in adults with Philadelphia chromosome-negative acute lymphoblastic leukemia in first and second complete remission","volume":"116","author":"Marks","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2012.02.016_bib34","doi-asserted-by":"crossref","first-page":"4439","DOI":"10.1182\/blood-2010-02-266551","article-title":"Reduced-intensity versus conventional myeloablative conditioning allogeneic stem cell transplantation for patients with acute lymphoblastic leukemia: a retrospective study from the European Group for Blood and Marrow Transplantation","volume":"116","author":"Mohty","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2012.02.016_bib35","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1200\/JCO.1992.10.2.237","article-title":"Radiation-free preparation for allogeneic bone marrow transplantation in adults with acute lymphoblastic leukemia","volume":"10","author":"Copelan","year":"1992","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.bbmt.2012.02.016_bib36","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1016\/j.bbmt.2007.06.001","article-title":"Allogeneic stem cell transplantation in first complete remission enhances graft-versus-leukemia effect in adults with acute lymphoblastic leukemia: antileukemic activity of chronic graft-versus-host disease","volume":"13","author":"Lee","year":"2007","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.bbmt.2012.02.016_bib37","first-page":"921","article-title":"Graft-versus-leukemia effect in allogeneic marrow transplant recipients with acute leukemia is maintained using cyclosporin A combined with methotrexate as prophylaxis. Acute Leukemia Working Party of the European Group for Blood and Marrow Transplantation","volume":"18","author":"Ringden","year":"1996","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.bbmt.2012.02.016_bib38","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1200\/JCO.1998.16.3.859","article-title":"Long-term survival in primary CNS lymphoma","volume":"16","author":"Abrey","year":"1998","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.bbmt.2012.02.016_bib39","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/jbiol73","article-title":"How chemotherapy damages the central nervous system","volume":"7","author":"Meyers","year":"2008","journal-title":"J Biol"},{"key":"10.1016\/j.bbmt.2012.02.016_bib40","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1016\/j.bbmt.2008.07.002","article-title":"Central nervous system relapse of leukemia after allogeneic hematopoietic stem cell transplantation","volume":"14","author":"Oshima","year":"2008","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.bbmt.2012.02.016_bib41","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1124\/mi.4.5.7","article-title":"Mechanisms of radiation injury to the central nervous system: implications for neuroprotection","volume":"4","author":"Wong","year":"2004","journal-title":"Mol Interv"},{"key":"10.1016\/j.bbmt.2012.02.016_bib42","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1056\/NEJM200108093450606","article-title":"Toxic leukoencephalopathy","volume":"345","author":"Filley","year":"2001","journal-title":"N Engl J Med"},{"key":"10.1016\/j.bbmt.2012.02.016_bib43","doi-asserted-by":"crossref","first-page":"2464","DOI":"10.1200\/JCO.2002.07.116","article-title":"Intensified and shortened cyclical chemotherapy for adult acute lymphoblastic leukemia","volume":"20","author":"Linker","year":"2002","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.bbmt.2012.02.016_bib44","doi-asserted-by":"crossref","first-page":"5243","DOI":"10.1182\/blood-2010-10-316083","article-title":"HHV-6 reactivation and its effect on delirium and cognitive functioning in hematopoietic cell transplantation recipients","volume":"117","author":"Zerr","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2012.02.016_bib45","first-page":"924","article-title":"Are patients with acute leukaemia, alive and well 2 years post bone marrow transplantation cured? A European survey. Acute Leukaemia Working Party of the European Group for Bone Marrow Transplantation (EBMT)","volume":"8","author":"Frassoni","year":"1994","journal-title":"Leukemia"}],"container-title":["Biology of Blood and Marrow Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1083879112001152?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1083879112001152?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T14:42:57Z","timestamp":1761057777000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1083879112001152"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,9]]},"references-count":45,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2012,9]]}},"alternative-id":["S1083879112001152"],"URL":"https:\/\/doi.org\/10.1016\/j.bbmt.2012.02.016","relation":{},"ISSN":["1083-8791"],"issn-type":[{"value":"1083-8791","type":"print"}],"subject":[],"published":{"date-parts":[[2012,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Radiation-Free Allogeneic Conditioning with Fludarabine, Carmustine, and Thiotepa for Acute Lymphoblastic Leukemia and Other Hematologic Malignancies Necessitating Enhanced Central Nervous System Activity","name":"articletitle","label":"Article Title"},{"value":"Biology of Blood and Marrow Transplantation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbmt.2012.02.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 American Society for Blood and Marrow Transplantation. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}