{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T20:58:25Z","timestamp":1780952305445,"version":"3.54.1"},"reference-count":39,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2015,4,10]],"date-time":"2015-04-10T00:00:00Z","timestamp":1428624000000},"content-version":"vor","delay-in-days":860,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["bbmt.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biology of Blood and Marrow Transplantation"],"published-print":{"date-parts":[[2012,12]]},"DOI":"10.1016\/j.bbmt.2012.07.011","type":"journal-article","created":{"date-parts":[[2012,7,21]],"date-time":"2012-07-21T04:53:22Z","timestamp":1342846402000},"page":"1897-1904","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"title":["Allogeneic Hematopoietic Stem Cell Transplantation in Adolescent and Adult Patients with High-Risk T Cell Acute Lymphoblastic Leukemia"],"prefix":"10.1016","volume":"18","author":[{"given":"Mohammad","family":"Bakr","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walid","family":"Rasheed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Said Y.","family":"Mohamed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fahad","family":"Al-Mohareb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naeem","family":"Chaudhri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fahad","family":"Al-Sharif","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hazza","family":"Al-Zahrani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghuzayel","family":"Al-Dawsari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abu Jafar","family":"Saleh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amr","family":"Nassar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shad","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Assem","family":"Elghazaly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syed O.","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khalid","family":"Ibrahim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wahiba","family":"Chebbo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghada M.","family":"El Gohary","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhamad H.","family":"Al Mahayni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fazal","family":"Hussain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zubeir","family":"Nurgat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tusneem Ahmed","family":"Elhassan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia U.","family":"Walter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud","family":"Aljurf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbmt.2012.07.011_bib1","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1182\/blood-2005-04-1754","article-title":"Adult T-cell acute lymphoblastic leukemia: biologic profile at presentation and correlation with response to induction treatment in patients enrolled in the GIMEMA LAL 0496 protocol","volume":"107","author":"Vitale","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2012.07.011_bib2","doi-asserted-by":"crossref","first-page":"2543","DOI":"10.1182\/blood.V96.7.2543","article-title":"New recurring cytogenetic abnormalities and association of blast cell karyotypes with prognosis in childhood T-cell acute lymphoblastic leukemia: a pediatric oncology group report of 343 cases","volume":"96","author":"Schneider","year":"2000","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2012.07.011_bib3","doi-asserted-by":"crossref","first-page":"2771","DOI":"10.1182\/blood-2003-09-3243","article-title":"Gene expression profile of adult T-cell acute lymphocytic leukemia identifies distinct subsets of patients with different response to therapy and survival","volume":"103","author":"Chiaretti","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2012.07.011_bib4","doi-asserted-by":"crossref","first-page":"3760","DOI":"10.1182\/blood-2005-04-1623","article-title":"Induction therapy for adults with acute lymphoblastic leukemia: results of more than 1500 patients from the international ALL trial: MRC UKALL XII\/ECOG E2993","volume":"106","author":"Rowe","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2012.07.011_bib5","doi-asserted-by":"crossref","first-page":"4075","DOI":"10.1200\/JCO.2004.10.050","article-title":"Outcome of treatment in adults with acute lymphoblastic leukemia: analysis of the LALA-94 trial","volume":"22","author":"Thomas","year":"2004","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.bbmt.2012.07.011_bib6","doi-asserted-by":"crossref","first-page":"2788","DOI":"10.1002\/cncr.20668","article-title":"Long-term follow-up results of hyperfractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone (Hyper-CVAD), a dose-intensive regimen, in adult acute lymphocytic leukemia","volume":"101","author":"Kantarjian","year":"2004","journal-title":"Cancer"},{"key":"10.1016\/j.bbmt.2012.07.011_bib7","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1182\/blood-2006-05-018192","article-title":"Outcome of 609 adults after relapse of acute lymphoblastic leukemia (ALL): an MRC UKALL12\/ECOG 2993 study","volume":"109","author":"Fielding","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2012.07.011_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbmt.2005.10.018","article-title":"The role of cytotoxic therapy with hematopoietic stem cell transplantation in the therapy of acute lymphoblastic leukemia in adults: an evidence-based review","volume":"12","author":"Hahn","year":"2006","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.bbmt.2012.07.011_bib9","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1038\/sj.leu.2400959","article-title":"The impact of age on outcome in lymphoblastic leukaemia: MRC UKALL X and XA compared. A report from the MRC Paediatric and Adult Working Parties","volume":"12","author":"Chessells","year":"1998","journal-title":"Leukemia"},{"key":"10.1016\/j.bbmt.2012.07.011_bib10","first-page":"540","article-title":"New approaches to acute lymphoblastic leukemia in adults: where do we go?","volume":"27","author":"Hoelzer","year":"2000","journal-title":"Semin Oncol"},{"key":"10.1016\/j.bbmt.2012.07.011_bib11","doi-asserted-by":"crossref","first-page":"3189","DOI":"10.1182\/blood-2006-10-051912","article-title":"Karyotype is an independent prognostic factor in adult acute lymphoblastic leukemia (ALL): analysis of cytogenetic data from patients treated on the Medical Research Council (MRC) UKALLXII\/Eastern Cooperative Oncology Group (ECOG) 2993 trial","volume":"109","author":"Moorman","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2012.07.011_bib12","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1038\/sj.leu.2404603","article-title":"Why and how to quantify minimal residual disease in acute lymphoblastic leukemia?","volume":"21","author":"Szczepanski","year":"2007","journal-title":"Leukemia"},{"key":"10.1016\/j.bbmt.2012.07.011_bib13","first-page":"1783","article-title":"Proposals for the immunological classification of acute leukemias","volume":"9","author":"Bene","year":"1995","journal-title":"Leukemia"},{"key":"10.1016\/j.bbmt.2012.07.011_bib14","doi-asserted-by":"crossref","first-page":"2563","DOI":"10.1182\/blood-2007-10-116186","article-title":"Impact of cytogenetics on the outcome of adult acute lymphoblastic leukemia: results of Southwest Oncology Group 9400 study","volume":"111","author":"Pullarkat","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2012.07.011_bib15","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1016\/j.bbmt.2009.06.013","article-title":"Chances of finding an HLA-matched sibling: the Saudi experience","volume":"15","author":"Jawdat","year":"2009","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.bbmt.2012.07.011_bib16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/bmt.2008.389","article-title":"Special issues related to hematopoietic SCT in the Eastern Mediterranean region and the first regional activity report","volume":"43","author":"Aljurf","year":"2009","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.bbmt.2012.07.011_bib17","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1097\/00007890-197410000-00001","article-title":"Clinical manifestations of graft-versus-host disease in human recipients of marrow from HLA-matched sibling donors","volume":"18","author":"Glucksberg","year":"1974","journal-title":"Transplantation"},{"key":"10.1016\/j.bbmt.2012.07.011_bib18","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1080\/01621459.1958.10501452","article-title":"Nonparametric estimation from incomplete observations","volume":"53","author":"Kaplan","year":"1958","journal-title":"J Am Stat Assoc"},{"key":"10.1016\/j.bbmt.2012.07.011_bib19","series-title":"The Statistical Analysis of Failure Time Data","author":"Kalbfleisch","year":"1980"},{"key":"10.1016\/j.bbmt.2012.07.011_bib20","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1080\/01621459.1999.10474144","article-title":"A proportional hazards model for the subdistribution of a competing risk","volume":"94","author":"Fine","year":"1999","journal-title":"J Am Stat Assoc"},{"key":"10.1016\/j.bbmt.2012.07.011_bib21","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/j.2517-6161.1972.tb00899.x","article-title":"Regression models and life tables","volume":"34","author":"Cox","year":"1972","journal-title":"J R Stat Soc B"},{"issue":"Suppl 1","key":"10.1016\/j.bbmt.2012.07.011_bib22","doi-asserted-by":"crossref","first-page":"S18","DOI":"10.1038\/bmt.2008.107","article-title":"Allogeneic hematopoietic cell transplantation for adults with ALL","volume":"42","author":"Larson","year":"2008","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.bbmt.2012.07.011_bib23","doi-asserted-by":"crossref","first-page":"5136","DOI":"10.1182\/blood-2009-08-231217","article-title":"T-cell acute lymphoblastic leukemia in adults: clinical features, immunophenotype, cytogenetics, and outcome from the large randomized prospective trial (UKALL XII\/ECOG 2993)","volume":"114","author":"Marks","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2012.07.011_bib24","doi-asserted-by":"crossref","first-page":"3028","DOI":"10.1182\/blood-2003-10-3560","article-title":"Better outcome of adult acute lymphoblastic leukemia after early genoidentical allogeneic bone marrow transplantation (BMT) than after late high-dose therapy and autologous BMT: a GOELAMS trial","volume":"104","author":"Hunault","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2012.07.011_bib25","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.1182\/blood-2007-10-116582","volume":"111","author":"Goldstone","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2012.07.011_bib26","doi-asserted-by":"crossref","first-page":"3447","DOI":"10.1002\/cncr.25136","article-title":"Management of adult patients with acute lymphoblastic leukemia in first complete remission: systematic review and meta-analysis","volume":"116","author":"Ram","year":"2010","journal-title":"Cancer"},{"key":"10.1016\/j.bbmt.2012.07.011_bib27","first-page":"3702","article-title":"IBMTR Histocompatibility and Stem Cell Sources Working Committee and the European Group for Blood and Marrow Transplantation (EBMT). Blood stem cells compared with bone marrow as a source of hematopoietic cells for allogeneic transplantation","volume":"95","author":"Champlin","year":"2000","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2012.07.011_bib28","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1182\/blood.V75.3.555.555","article-title":"Graft-versus-leukemia reactions after bone marrow transplantation","volume":"75","author":"Horowitz","year":"1990","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2012.07.011_bib29","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/sj.bmt.1701064","article-title":"Graft-versus-leukemia effects in T lineage and B lineage acute lymphoblastic leukemia","volume":"21","author":"Passweg","year":"1998","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.bbmt.2012.07.011_bib30","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1182\/blood-2005-11-4666","article-title":"Central nervous system involvement in adult acute lymphoblastic leukemia at diagnosis: results from the international ALL trial MRC UKALL XII\/ECOG E2993","volume":"108","author":"Lazarus","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2012.07.011_bib31","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/S1083-8791(03)00149-6","article-title":"Predictive factors for outcome of allogeneic hematopoietic cell transplantation for adult acute lymphoblastic leukemia","volume":"9","author":"Doney","year":"2003","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.bbmt.2012.07.011_bib32","doi-asserted-by":"crossref","first-page":"3072","DOI":"10.1182\/blood-2004-09-3666","article-title":"Impact of TCR status and genotype on outcome in adult T-cell acute lymphoblastic leukemia: a LALA-94 study","volume":"105","author":"Asnafi","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2012.07.011_bib33","doi-asserted-by":"crossref","first-page":"3739","DOI":"10.1200\/JCO.2007.11.5253","article-title":"Low ERG and BAALC expression identifies a new subgroup of adult acute T-lymphoblastic leukemia with a highly favorable outcome","volume":"25","author":"Baldus","year":"2007","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.bbmt.2012.07.011_bib34","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1200\/JCO.2010.30.1382","article-title":"Modern therapy of acute lymphoblastic leukemia","volume":"29","author":"Bassan","year":"2011","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.bbmt.2012.07.011_bib35","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1182\/blood-2004-05-1933","article-title":"Results of a phase 1-2 study of clofarabine in combination with cytarabine (ara-C) in relapsed and refractory acute leukemias","volume":"105","author":"Faderl","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2012.07.011_bib36","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1097\/CCO.0b013e32834bb854","article-title":"Advances in acute lymphoblastic leukemia in adults","volume":"23","author":"Ribera","year":"2011","journal-title":"Curr Opin Oncol"},{"key":"10.1016\/j.bbmt.2012.07.011_bib37","doi-asserted-by":"crossref","first-page":"2020","DOI":"10.1182\/blood-2008-02-137141","article-title":"mTOR inhibitors are synergistic with methotrexate: an effective combination to treat acute lymphoblastic leukemia","volume":"112","author":"Teachey","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2012.07.011_bib38","doi-asserted-by":"crossref","first-page":"37370","DOI":"10.1074\/jbc.M703697200","article-title":"Protein kinase A, not Epac, suppresses hedgehog activity and regulates glucocorticoid sensitivity in acute lymphoblastic leukemia cells","volume":"282","author":"Ji","year":"2007","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bbmt.2012.07.011_bib39","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1038\/leu.2009.75","article-title":"NOTCH inhibition and glucocorticoid therapy in T-cell acute lymphoblastic leukemia","volume":"23","author":"Real","year":"2009","journal-title":"Leukemia"}],"container-title":["Biology of Blood and Marrow Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S108387911200287X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S108387911200287X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T14:43:32Z","timestamp":1761057812000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S108387911200287X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12]]},"references-count":39,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["S108387911200287X"],"URL":"https:\/\/doi.org\/10.1016\/j.bbmt.2012.07.011","relation":{},"ISSN":["1083-8791"],"issn-type":[{"value":"1083-8791","type":"print"}],"subject":[],"published":{"date-parts":[[2012,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Allogeneic Hematopoietic Stem Cell Transplantation in Adolescent and Adult Patients with High-Risk T Cell Acute Lymphoblastic Leukemia","name":"articletitle","label":"Article Title"},{"value":"Biology of Blood and Marrow Transplantation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbmt.2012.07.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 American Society for Blood and Marrow Transplantation. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}