{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T02:45:31Z","timestamp":1761101131029,"version":"build-2065373602"},"reference-count":46,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2014,3,1]],"date-time":"2014-03-01T00:00:00Z","timestamp":1393632000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,3,1]],"date-time":"2014-03-01T00:00:00Z","timestamp":1393632000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2015,4,10]],"date-time":"2015-04-10T00:00:00Z","timestamp":1428624000000},"content-version":"vor","delay-in-days":405,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005632","name":"National Centre for Research and Development","doi-asserted-by":"crossref","award":["N R13 0082 06"],"award-info":[{"award-number":["N R13 0082 06"]}],"id":[{"id":"10.13039\/501100005632","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["bbmt.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biology of Blood and Marrow Transplantation"],"published-print":{"date-parts":[[2014,3]]},"DOI":"10.1016\/j.bbmt.2013.12.558","type":"journal-article","created":{"date-parts":[[2013,12,15]],"date-time":"2013-12-15T09:47:47Z","timestamp":1387100867000},"page":"409-414","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"title":["NOD2\/CARD15 Single Nucleotide Polymorphism 13 (3020insC) is Associated with Risk of Sepsis and Single Nucleotide Polymorphism 8 (2104C&gt;T) with Herpes Viruses Reactivation in Patients after Allogeneic Hematopoietic Stem Cell Transplantation"],"prefix":"10.1016","volume":"20","author":[{"given":"Emilia","family":"Jaskula","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrzej","family":"Lange","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Slawomira","family":"Kyrcz-Krzemien","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miroslaw","family":"Markiewicz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monika","family":"Dzierzak-Mietla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wieslaw Wiktor","family":"Jedrzejczak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Przemyslaw","family":"Czajka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monika","family":"Mordak-Domagala","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janusz","family":"Lange","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Gronkowska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacek","family":"Nowak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krzysztof","family":"Warzocha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrzej","family":"Hellmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jerzy","family":"Kowalczyk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katarzyna","family":"Drabko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jolanta","family":"Gozdzik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sylwia","family":"Mizia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbmt.2013.12.558_bib1","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1093\/intimm\/dxp017","article-title":"The roles of TLRs, RLRs and NLRs in pathogen recognition","volume":"21","author":"Kawai","year":"2009","journal-title":"Int Immunol"},{"key":"10.1016\/j.bbmt.2013.12.558_bib2","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1111\/j.1365-2249.2009.03926.x","article-title":"Modulation of muramyl dipeptide stimulation of cytokine production by blood components","volume":"156","author":"van der Meer","year":"2009","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.bbmt.2013.12.558_bib3","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1038\/ni.1782","article-title":"Activation of innate immune antiviral responses by Nod2","volume":"10","author":"Sabbah","year":"2009","journal-title":"Nat Immunol"},{"key":"10.1016\/j.bbmt.2013.12.558_bib4","doi-asserted-by":"crossref","first-page":"41701","DOI":"10.1074\/jbc.M206473200","article-title":"Induction of Nod2 in myelomonocytic and intestinal epithelial cells via nuclear factor-kappa B activation","volume":"277","author":"Gutierrez","year":"2002","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.bbmt.2013.12.558_bib5","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1038\/ni.1816","article-title":"T\u00a0cell-intrinsic role of Nod2 in promoting type 1 immunity to Toxoplasma gondii. T cell-intrinsic role of Nod2 in promoting type 1 immunity to Toxoplasma gondii","volume":"10","author":"Shaw","year":"2009","journal-title":"Nat Immunol"},{"key":"10.1016\/j.bbmt.2013.12.558_bib6","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.gde.2004.04.004","article-title":"Molecular genetics of Crohn's disease","volume":"14","author":"Russell","year":"2004","journal-title":"Curr Opin Genet Dev"},{"key":"10.1016\/j.bbmt.2013.12.558_bib7","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.1016\/j.bcp.2010.07.016","article-title":"The protein Nod2: an innate receptor more complex than previously assumed","volume":"80","author":"Lecat","year":"2010","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.bbmt.2013.12.558_bib8","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1097\/01.MIB.0000225332.83861.5f","article-title":"Functional consequences of NOD2 (CARD15) mutations","volume":"12","author":"Abraham","year":"2006","journal-title":"Inflamm Bowel Dis"},{"key":"10.1016\/j.bbmt.2013.12.558_bib9","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1371\/journal.ppat.0010034","article-title":"NOD2 and toll-like receptors are nonredundant recognition systems of Mycobacterium tuberculosis","volume":"1","author":"Ferwerda","year":"2005","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.bbmt.2013.12.558_bib10","doi-asserted-by":"crossref","first-page":"5509","DOI":"10.1074\/jbc.C200673200","article-title":"Host recognition of bacterial muramyl dipeptide mediated through NOD2. Implications for Crohn's disease","volume":"278","author":"Inohara","year":"2003","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.bbmt.2013.12.558_bib11","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1155\/2012\/180391","article-title":"NOD2 Polymorphisms and Their Impact on Haematopoietic Stem Cell Transplant Outcome","volume":"2012","author":"Mayor","year":"2012","journal-title":"Bone Marrow Res"},{"key":"10.1016\/j.bbmt.2013.12.558_bib12","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1038\/bmt.2010.166","article-title":"Toll-like receptor 9, NOD2 and IL23R gene polymorphisms influenced outcome in AML patients transplanted from HLA-identical sibling donors","volume":"46","author":"Elmaagacli","year":"2011","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.bbmt.2013.12.558_bib13","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1182\/blood-2011-05-356451","article-title":"NOD2\/CARD15 gene polymorphisms affect outcome in pediatric allogeneic stem cell transplantation","volume":"118","author":"Kreyenberg","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2013.12.558_bib14","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1111\/j.1744-313X.2008.00795.x","article-title":"The role of genetic variants of NOD2\/CARD15, a receptor of the innate immune system, in GvHD and complications following related and unrelated donor haematopoietic stem cell transplantation","volume":"35","author":"Holler","year":"2008","journal-title":"Int J Immunogenet"},{"key":"10.1016\/j.bbmt.2013.12.558_bib15","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1038\/bmt.2008.9","article-title":"No impact of NOD2\/CARD15 on outcome after SCT","volume":"41","author":"Sairafi","year":"2008","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.bbmt.2013.12.558_bib16","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1016\/j.bbmt.2009.08.001","article-title":"Polymorphism of interleukin-23 receptor gene but not of NOD2\/CARD15 is associated with graft-versus-host disease after hematopoietic stem cell transplantation in children","volume":"15","author":"Gruhn","year":"2009","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.bbmt.2013.12.558_bib17","doi-asserted-by":"crossref","first-page":"3625","DOI":"10.1182\/blood-2009-09-243840","article-title":"Insufficient evidence for association of NOD2\/CARD15 or other inflammatory bowel disease-associated markers on GVHD incidence or other adverse outcomes in T-replete, unrelated donor transplantation","volume":"115","author":"Nguyen","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2013.12.558_bib18","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1016\/S0140-6736(02)08590-2","article-title":"Association of NOD2 (CARD 15) genotype with clinical course of Crohn's disease: a cohort study","volume":"359","author":"Hampe","year":"2002","journal-title":"Lancet"},{"key":"10.1016\/j.bbmt.2013.12.558_bib19","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1016\/j.bbmt.2009.06.008","article-title":"Interferon gamma 13-CA-repeat homozygous genotype and a low proportion of CD4(+) lymphocytes are independent risk factors for cytomegalovirus reactivation with a high number of copies in hematopoietic stem cell transplantation recipients","volume":"15","author":"Jaskula","year":"2009","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.bbmt.2013.12.558_bib20","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/cc2428","article-title":"Statistics review 8: qualitative data \u2013 tests of association","volume":"8","author":"Bewick","year":"2004","journal-title":"Crit Care"},{"key":"10.1016\/j.bbmt.2013.12.558_bib21","doi-asserted-by":"crossref","first-page":"180391","DOI":"10.1155\/2012\/180391","article-title":"NOD2 Polymorphisms and Their Impact on Haematopoietic Stem Cell Transplant Outcome","volume":"2012","author":"Mayor","year":"2012","journal-title":"Bone Marrow Res."},{"key":"10.1016\/j.bbmt.2013.12.558_bib22","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1182\/blood-2003-10-3543","article-title":"Both donor and recipient NOD2\/CARD15 mutations associate with transplant-related mortality and GvHD following allogeneic stem cell transplantation","volume":"104","author":"Holler","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2013.12.558_bib23","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1200\/JCO.2007.14.1325","article-title":"NOD2\/CARD15 polymorphisms in allogeneic stem-cell transplantation from unrelated donors: T depletion matters","volume":"26","author":"Holler","year":"2008","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.bbmt.2013.12.558_bib24","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1016\/j.bbmt.2011.04.007","article-title":"Differences in T cell depletion and intestinal mucositis explain inconsistent effects of NOD2\/CARD15 polymorphisms in SCT","volume":"17","author":"van der Velden","year":"2011","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.bbmt.2013.12.558_bib25","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1007\/s00277-013-1734-0","article-title":"Impact of NOD2 polymorphisms on infectious complications following chemotherapy in patients with acute myeloid leukaemia","volume":"92","author":"Yomade","year":"2013","journal-title":"Ann Hematol"},{"key":"10.1016\/j.bbmt.2013.12.558_bib26","doi-asserted-by":"crossref","first-page":"e73","DOI":"10.1097\/PCC.0b013e3182191c2e","article-title":"Importance of NOD2\/CARD15 gene variants for susceptibility to and outcome of sepsis in Turkish children","volume":"13","author":"Tekin","year":"2012","journal-title":"Pediatr Crit Care Med"},{"key":"10.1016\/j.bbmt.2013.12.558_bib27","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1007\/s00134-007-0722-z","article-title":"Genetic variants in the NOD2\/CARD15 gene are associated with early mortality in sepsis patients","volume":"33","author":"Brenmoehl","year":"2007","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.bbmt.2013.12.558_bib28","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1189\/jlb.0805484","article-title":"Impaired dendritic cell function in Crohn's disease patients with NOD2 3020insC mutation","volume":"79","author":"Kramer","year":"2006","journal-title":"J\u00a0Leukoc Biol"},{"key":"10.1016\/j.bbmt.2013.12.558_bib29","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1126\/science.1103685","article-title":"Nod2 mutation in Crohn's disease potentiates NF-kappaB activity and IL-1beta processing","volume":"307","author":"Maeda","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.bbmt.2013.12.558_bib30","doi-asserted-by":"crossref","first-page":"1794","DOI":"10.1016\/S0140-6736(05)66582-8","article-title":"Muramyl dipeptide and toll-like receptor sensitivity in NOD2-associated Crohn's disease","volume":"365","author":"van Heel","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.bbmt.2013.12.558_bib31","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1083\/jcb.200502153","article-title":"Membrane recruitment of NOD2 in intestinal epithelial cells is essential for nuclear factor-{kappa}B activation in muramyl dipeptide recognition","volume":"170","author":"Barnich","year":"2005","journal-title":"J\u00a0Cell Biol"},{"key":"10.1016\/j.bbmt.2013.12.558_bib32","doi-asserted-by":"crossref","first-page":"40301","DOI":"10.1074\/jbc.M508538200","article-title":"A\u00a0role for Erbin in the regulation of Nod2-dependent NF-kappaB signaling","volume":"280","author":"McDonald","year":"2005","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.bbmt.2013.12.558_bib33","doi-asserted-by":"crossref","first-page":"2052","DOI":"10.1002\/eji.200425229","article-title":"NOD2 mediates anti-inflammatory signals induced by TLR2 ligands: implications for Crohn's disease","volume":"34","author":"Netea","year":"2004","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.bbmt.2013.12.558_bib34","doi-asserted-by":"crossref","first-page":"6518","DOI":"10.4049\/jimmunol.174.10.6518","article-title":"Nucleotide-binding oligomerization domain-2 modulates specific TLR pathways for the induction of cytokine release","volume":"174","author":"Netea","year":"2005","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.bbmt.2013.12.558_bib35","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/nri2937","article-title":"Recognition of herpesviruses by the innate immune system","volume":"11","author":"Paludan","year":"2011","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.bbmt.2013.12.558_bib36","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1111\/j.1365-3083.2011.02530.x","article-title":"The impact of early viral infections and graft-versus-host disease on immune reconstitution following paediatric stem cell transplantation","volume":"73","author":"Olkinuora","year":"2011","journal-title":"Scand J Immunol"},{"key":"10.1016\/j.bbmt.2013.12.558_bib37","first-page":"349","article-title":"Pathogenesis of GVHD: role of herpes viruses","volume":"11","author":"Appleton","year":"1993","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.bbmt.2013.12.558_bib38","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1038\/bmt.2008.238","article-title":"Correlations of human herpesvirus 6B and CMV infection with acute GVHD in recipients of allogeneic haematopoietic stem cell transplantation","volume":"42","author":"Wang","year":"2008","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.bbmt.2013.12.558_bib39","doi-asserted-by":"crossref","first-page":"375075","DOI":"10.1155\/2012\/375075","article-title":"CMV serostatus of donor-recipient pairs influences the risk of CMV infection\/reactivation in HSCT patients","volume":"2012","author":"Jaskula","year":"2012","journal-title":"Bone Marrow Res"},{"key":"10.1016\/j.bbmt.2013.12.558_bib40","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1111\/tid.12003","article-title":"Infectious complications following\u00a0allogeneic stem cell transplantation: reduced-intensity vs. myeloablative conditioning regimens","volume":"15","author":"Kim","year":"2013","journal-title":"Transpl Infect Dis"},{"key":"10.1016\/j.bbmt.2013.12.558_bib41","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/sj.bmt.1704758","article-title":"Antilymphocyte\/thymocyte globulin for graft versus host disease prophylaxis: efficacy and side effects","volume":"35","author":"Bacigalupo","year":"2005","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.bbmt.2013.12.558_bib42","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1007\/s12032-010-9635-8","article-title":"Epstein-Barr virus-related lymphoproliferative disorder induced by equine anti-thymocyte globulin therapy","volume":"28","author":"Viola","year":"2011","journal-title":"Med Oncol"},{"key":"10.1016\/j.bbmt.2013.12.558_bib43","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1053\/j.seminhematol.2005.09.001","article-title":"Pathophysiology of graft-versus-host disease","volume":"43","author":"Ferrara","year":"2006","journal-title":"Semin Hematol"},{"issue":"Suppl 2","key":"10.1016\/j.bbmt.2013.12.558_bib44","doi-asserted-by":"crossref","first-page":"S58","DOI":"10.1038\/bmt.2008.56","article-title":"EBMT Paediatric Working Party. Acute GvHD: pathogenesis and classification","volume":"41","author":"Ball","year":"2008","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.bbmt.2013.12.558_bib45","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1086\/507034","article-title":"Primary Epstein-Barr virus infection with pneumonia transmitted by allogeneic bone marrow after transplantation","volume":"43","author":"Teira","year":"2006","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.bbmt.2013.12.558_bib46","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1038\/sj.bmt.1705368","article-title":"Mesenchymal stem cells are susceptible to human herpesviruses, but viral DNA cannot be detected in the healthy seropositive individual","volume":"37","author":"Sundin","year":"2006","journal-title":"Bone Marrow Transplant"}],"container-title":["Biology of Blood and Marrow Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1083879113011300?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1083879113011300?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T14:47:15Z","timestamp":1761058035000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1083879113011300"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3]]},"references-count":46,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,3]]}},"alternative-id":["S1083879113011300"],"URL":"https:\/\/doi.org\/10.1016\/j.bbmt.2013.12.558","relation":{},"ISSN":["1083-8791"],"issn-type":[{"type":"print","value":"1083-8791"}],"subject":[],"published":{"date-parts":[[2014,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"NOD2\/CARD15 Single Nucleotide Polymorphism 13 (3020insC) is Associated with Risk of Sepsis and Single Nucleotide Polymorphism 8 (2104C>T) with Herpes Viruses Reactivation in Patients after Allogeneic Hematopoietic Stem Cell Transplantation","name":"articletitle","label":"Article Title"},{"value":"Biology of Blood and Marrow Transplantation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbmt.2013.12.558","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}