{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T12:11:42Z","timestamp":1791288702202,"version":"4.3.0"},"reference-count":40,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T00:00:00Z","timestamp":1396310400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T00:00:00Z","timestamp":1396310400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2015,4,10]],"date-time":"2015-04-10T00:00:00Z","timestamp":1428624000000},"content-version":"vor","delay-in-days":374,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100005189","name":"Leukemia and Lymphoma Society","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100005189","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["bbmt.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biology of Blood and Marrow Transplantation"],"published-print":{"date-parts":[[2014,4]]},"DOI":"10.1016\/j.bbmt.2013.12.562","type":"journal-article","created":{"date-parts":[[2014,1,3]],"date-time":"2014-01-03T11:31:14Z","timestamp":1388748674000},"page":"480-489","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":47,"title":["Differential Effects of Epigenetic Modifiers on the Expansion and Maintenance of Human Cord Blood Stem\/Progenitor Cells"],"prefix":"10.1016","volume":"20","author":[{"given":"Nadim","family":"Mahmud","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Petro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sudhakar","family":"Baluchamy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinmin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona","family":"Taioli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald","family":"Lavelle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3116-4545","authenticated-orcid":false,"given":"John G.","family":"Quigley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Montha","family":"Suphangul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroto","family":"Araki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbmt.2013.12.562_bib1","series-title":"Wintrobe\u2019s clinical hematology","first-page":"79","article-title":"Origin and development of blood cells","author":"Koury","year":"2009"},{"key":"10.1016\/j.bbmt.2013.12.562_bib2","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1038\/nature07038","article-title":"Intrinsic and extrinsic control of haematopoietic stem-cell self-renewal","volume":"453","author":"Zon","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.bbmt.2013.12.562_bib3","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1016\/j.exphem.2009.05.012","article-title":"Cord blood stem cell expansion is permissive to epigenetic regulation and environmental cues","volume":"37","author":"Araki","year":"2009","journal-title":"Exp Hematol"},{"key":"10.1016\/j.bbmt.2013.12.562_bib4","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1056\/NEJM200106143442402","article-title":"Hematopoietic engraftment and survival in adult recipients of umbilical-cord blood from unrelated donors","volume":"344","author":"Laughlin","year":"2001","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.bbmt.2013.12.562_bib5","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1111\/j.1365-2141.2009.07883.x","article-title":"Improving outcomes of cord blood transplantation: HLA matching, cell dose and other graft- and transplantation-related factors","volume":"147","author":"Rocha","year":"2009","journal-title":"Br J Haematol"},{"key":"10.1016\/j.bbmt.2013.12.562_bib6","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1126\/science.1191536","article-title":"Aryl hydrocarbon receptor antagonists promote the expansion of human hematopoietic stem cells","volume":"329","author":"Boitano","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.bbmt.2013.12.562_bib7","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/nm.2080","article-title":"Notch-mediated expansion of human cord blood progenitor cells capable of rapid myeloid reconstitution","volume":"16","author":"Delaney","year":"2010","journal-title":"Nat Med"},{"key":"10.1016\/j.bbmt.2013.12.562_bib8","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.stem.2011.02.003","article-title":"Prostaglandin E2 enhances human cord blood stem cell xenotransplants and shows long-term safety in preclinical nonhuman primate transplant models","volume":"8","author":"Goessling","year":"2011","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.bbmt.2013.12.562_bib9","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1038\/nm.2119","article-title":"Pleiotrophin regulates the expansion and regeneration of hematopoietic stem cells","volume":"16","author":"Himburg","year":"2010","journal-title":"Nat Med"},{"key":"10.1016\/j.bbmt.2013.12.562_bib10","doi-asserted-by":"crossref","first-page":"2305","DOI":"10.1056\/NEJMoa1207285","article-title":"Cord-blood engraftment with ex\u00a0vivo mesenchymal-cell coculture","volume":"367","author":"de Lima","year":"2012","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.bbmt.2013.12.562_bib11","doi-asserted-by":"crossref","first-page":"2733","DOI":"10.1182\/blood-2009-03-213496","article-title":"Combined epigenetic therapy with the histone methyltransferase EZH2 inhibitor 3-deazaneplanocin A and the histone deacetylase inhibitor panobinostat against human AML cells","volume":"114","author":"Fiskus","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2013.12.562_bib12","doi-asserted-by":"crossref","first-page":"2341","DOI":"10.1002\/cncr.23463","article-title":"Evolution of decitabine development: accomplishments, ongoing investigations, and future strategies","volume":"112","author":"Jabbour","year":"2008","journal-title":"Cancer"},{"key":"10.1016\/j.bbmt.2013.12.562_bib13","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1002\/cncr.22891","article-title":"Valproic acid for the treatment of myeloid malignancies","volume":"110","author":"Kuendgen","year":"2007","journal-title":"Cancer"},{"key":"10.1016\/j.bbmt.2013.12.562_bib14","doi-asserted-by":"crossref","first-page":"6417","DOI":"10.1158\/0008-5472.CAN-07-0572","article-title":"Effects of chromatin-modifying agents on CD34+ cells from patients with idiopathic myelofibrosis","volume":"67","author":"Shi","year":"2007","journal-title":"Cancer Res"},{"key":"10.1016\/j.bbmt.2013.12.562_bib15","doi-asserted-by":"crossref","first-page":"5972","DOI":"10.1182\/blood-2010-02-269696","article-title":"Sequential treatment of CD34+ cells from patients with primary myelofibrosis with chromatin-modifying agents eliminate JAK2V617F-positive NOD\/SCID marrow repopulating cells","volume":"116","author":"Wang","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2013.12.562_bib16","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.exphem.2005.10.002","article-title":"Expansion of human umbilical cord blood SCID-repopulating cells using chromatin-modifying agents","volume":"34","author":"Araki","year":"2006","journal-title":"Exp Hematol"},{"key":"10.1016\/j.bbmt.2013.12.562_bib17","series-title":"Stem Cell Transplantation","first-page":"27","article-title":"Alteration of Hematopoietic Stem Cell Fates by Chromatin-Modifying Agents","author":"Mahmud","year":"2006"},{"key":"10.1016\/j.bbmt.2013.12.562_bib18","doi-asserted-by":"crossref","first-page":"3570","DOI":"10.1182\/blood-2006-07-035287","article-title":"Chromatin-modifying agents permit human hematopoietic stem cells to undergo multiple cell divisions while retaining their repopulating potential","volume":"109","author":"Araki","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2013.12.562_bib19","doi-asserted-by":"crossref","first-page":"4102","DOI":"10.1182\/blood-2003-07-2431","article-title":"Modification of hematopoietic stem cell fate by 5aza 2'deoxycytidine and trichostatin A","volume":"103","author":"Milhem","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2013.12.562_bib20","doi-asserted-by":"crossref","first-page":"827A","DOI":"10.1182\/blood.V116.21.827.827","article-title":"Valproic acid results in maintenance but not expansion of transplantable hematopoietic stem cells from human umbilical cord blood","volume":"116","author":"Araki","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2013.12.562_bib21","doi-asserted-by":"crossref","first-page":"2537","DOI":"10.1158\/0008-5472.CAN-04-3011","article-title":"Valproic acid stimulates proliferation and self-renewal of hematopoietic stem cells","volume":"65","author":"Bug","year":"2005","journal-title":"Cancer Res"},{"key":"10.1016\/j.bbmt.2013.12.562_bib22","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1158\/0008-5472.CAN-04-3063","article-title":"Histone deacetylase inhibitor valproic acid enhances the cytokine-induced expansion of human hematopoietic stem cells","volume":"65","author":"De Felice","year":"2005","journal-title":"Cancer Res"},{"key":"10.1016\/j.bbmt.2013.12.562_bib23","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1111\/j.1600-0609.2008.01169.x","article-title":"Valproic acid enhances the engraftability of human umbilical cord blood hematopoietic stem cells expanded under serum-free conditions","volume":"82","author":"Seet","year":"2009","journal-title":"Eur J Haematol"},{"key":"10.1016\/j.bbmt.2013.12.562_bib24","doi-asserted-by":"crossref","first-page":"9836","DOI":"10.1073\/pnas.94.18.9836","article-title":"Expansion in\u00a0vitro of transplantable human cord blood stem cells demonstrated using a quantitative assay of their lympho-myeloid repopulating activity in nonobese diabetic-scid\/scid mice","volume":"94","author":"Conneally","year":"1997","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.bbmt.2013.12.562_bib25","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.4049\/jimmunol.126.4.1614","article-title":"Limiting dilution assays for the determination of immunocompetent cell frequencies. I. Data analysis","volume":"126","author":"Taswell","year":"1981","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.bbmt.2013.12.562_bib26","doi-asserted-by":"crossref","first-page":"5717","DOI":"10.1038\/onc.2008.181","article-title":"p300 provides a corepressor function by cooperating with YY1 and HDAC3 to repress c-Myc","volume":"27","author":"Sankar","year":"2008","journal-title":"Oncogene"},{"key":"10.1016\/j.bbmt.2013.12.562_bib27","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1186\/1471-2407-10-562","article-title":"Ras-association domain family 1C protein promotes breast cancer cell migration and attenuates apoptosis","volume":"10","author":"Reeves","year":"2010","journal-title":"BMC Cancer"},{"key":"10.1016\/j.bbmt.2013.12.562_bib28","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/j.stem.2010.08.012","article-title":"Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA","volume":"7","author":"Warren","year":"2010","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.bbmt.2013.12.562_bib29","doi-asserted-by":"crossref","first-page":"e38","DOI":"10.1093\/nar\/gnh032","article-title":"A\u00a0simple method for estimating global DNA methylation using bisulfite PCR of repetitive DNA elements","volume":"32","author":"Yang","year":"2004","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.bbmt.2013.12.562_bib30","doi-asserted-by":"crossref","first-page":"3473A","DOI":"10.1182\/blood.V112.11.3473.3473","article-title":"Possible epigenetic regulation of functionally opposing groups of genes involved in ex\u00a0vivo expansion of cord blood stem cells","volume":"112","author":"Baluchamy","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2013.12.562_bib31","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1634\/stemcells.2005-0276","article-title":"Gene-expression profiling of CD34+ hematopoietic cells expanded in a collagen I matrix","volume":"24","author":"Oswald","year":"2006","journal-title":"Stem Cells"},{"key":"10.1016\/j.bbmt.2013.12.562_bib32","doi-asserted-by":"crossref","first-page":"20012","DOI":"10.1073\/pnas.1116110108","article-title":"Human bone marrow hematopoietic stem cells are increased in frequency and myeloid-biased with age","volume":"108","author":"Pang","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.bbmt.2013.12.562_bib33","doi-asserted-by":"crossref","first-page":"e56334","DOI":"10.1371\/journal.pone.0056334","article-title":"MicroRNAs distinguish cytogenetic subgroups in pediatric AML and contribute to complex regulatory networks in AML-relevant pathways","volume":"8","author":"Daschkey","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.bbmt.2013.12.562_bib34","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1084\/jem.193.7.873","article-title":"Histone acetylation determines the developmentally regulated accessibility for T cell receptor gamma gene recombination","volume":"193","author":"Agata","year":"2001","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.bbmt.2013.12.562_bib35","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/j.immuni.2004.11.004","article-title":"Enhanced self-renewal of hematopoietic stem cells mediated by the polycomb gene product Bmi-1","volume":"21","author":"Iwama","year":"2004","journal-title":"Immunity"},{"key":"10.1016\/j.bbmt.2013.12.562_bib36","doi-asserted-by":"crossref","first-page":"2170","DOI":"10.1182\/blood-2005-09-3585","article-title":"The Polycomb group gene Ezh2 prevents hematopoietic stem cell exhaustion","volume":"107","author":"Kamminga","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2013.12.562_bib37","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1182\/blood-2009-03-209734","article-title":"Repression of BMI1 in normal and leukemic human CD34(+) cells impairs self-renewal and induces apoptosis","volume":"114","author":"Rizo","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2013.12.562_bib38","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1189\/jlb.1008647","article-title":"The endogenous Toll-like receptor 4 agonist S100A8\/S100A9 (calprotectin) as innate amplifier of infection, autoimmunity, and cancer","volume":"86","author":"Ehrchen","year":"2009","journal-title":"J\u00a0Leuk Biol"},{"key":"10.1016\/j.bbmt.2013.12.562_bib39","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1002\/jcb.22686","article-title":"The expression of functional Toll-like receptor 4 is associated with proliferation and maintenance of stem cell phenotype in endothelial progenitor cells (EPCs)","volume":"111","author":"He","year":"2010","journal-title":"J\u00a0Cell Biochem"},{"key":"10.1016\/j.bbmt.2013.12.562_bib40","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1038\/nature09135","article-title":"Quiescent haematopoietic stem cells are activated by IFN-gamma in response to chronic infection","volume":"465","author":"Baldridge","year":"2010","journal-title":"Nature"}],"container-title":["Biology of Blood and Marrow Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S108387911301152X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S108387911301152X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T14:47:11Z","timestamp":1761058031000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S108387911301152X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4]]},"references-count":40,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,4]]}},"alternative-id":["S108387911301152X"],"URL":"https:\/\/doi.org\/10.1016\/j.bbmt.2013.12.562","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.718220185.793519951","asserted-by":"object"}]},"ISSN":["1083-8791"],"issn-type":[{"value":"1083-8791","type":"print"}],"subject":[],"published":{"date-parts":[[2014,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Differential Effects of Epigenetic Modifiers on the Expansion and Maintenance of Human Cord Blood Stem\/Progenitor Cells","name":"articletitle","label":"Article Title"},{"value":"Biology of Blood and Marrow Transplantation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbmt.2013.12.562","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 American Society for Blood and Marrow Transplantation. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}