{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T07:21:56Z","timestamp":1768548116925,"version":"3.49.0"},"reference-count":39,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2014,9,1]],"date-time":"2014-09-01T00:00:00Z","timestamp":1409529600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,9,1]],"date-time":"2014-09-01T00:00:00Z","timestamp":1409529600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2015,9,9]],"date-time":"2015-09-09T00:00:00Z","timestamp":1441756800000},"content-version":"vor","delay-in-days":373,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006058","name":"St. Baldrick's Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006058","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008269","name":"Michigan Institute for Clinical and Health Research","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100008269","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1K23AI091623"],"award-info":[{"award-number":["1K23AI091623"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bbmt.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biology of Blood and Marrow Transplantation"],"published-print":{"date-parts":[[2014,9]]},"DOI":"10.1016\/j.bbmt.2014.05.023","type":"journal-article","created":{"date-parts":[[2014,6,2]],"date-time":"2014-06-02T09:31:44Z","timestamp":1401701504000},"page":"1426-1434","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"title":["Etanercept plus Topical Corticosteroids as Initial Therapy for Grade One Acute Graft-Versus-Host Disease after Allogeneic Hematopoietic Cell Transplantation"],"prefix":"10.1016","volume":"20","author":[{"given":"Erin","family":"Gatza","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Braun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John E.","family":"Levine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James L.M.","family":"Ferrara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuang","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tianyi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lawrence","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4538-8817","authenticated-orcid":false,"given":"Andrew","family":"Harris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6323-9623","authenticated-orcid":false,"given":"Attaphol","family":"Pawarode","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carrie","family":"Kitko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John M.","family":"Magenau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory A.","family":"Yanik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel R.","family":"Couriel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven","family":"Goldstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Connelly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pavan","family":"Reddy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophie","family":"Paczesny","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung Won","family":"Choi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbmt.2014.05.023_bib1","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1056\/NEJMra052638","article-title":"Hematopoietic stem-cell transplantation","volume":"354","author":"Copelan","year":"2006","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.bbmt.2014.05.023_bib2","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1016\/S0140-6736(09)60237-3","article-title":"Graft-versus-host disease","volume":"373","author":"Ferrara","year":"2009","journal-title":"Lancet"},{"key":"10.1016\/j.bbmt.2014.05.023_bib3","doi-asserted-by":"crossref","first-page":"2091","DOI":"10.1056\/NEJMoa1004383","article-title":"Reduced mortality after allogeneic hematopoietic-cell transplantation","volume":"363","author":"Gooley","year":"2010","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.bbmt.2014.05.023_bib4","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1182\/blood-2011-06-364265","article-title":"Risk factors for acute GVHD and survival after hematopoietic cell transplantation","volume":"119","author":"Jagasia","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2014.05.023_bib5","first-page":"2062","article-title":"Phase 3 study comparing methotrexate and tacrolimus with methotrexate and cyclosporine for prophylaxis of acute graft-versus-host disease after marrow transplantation from unrelated donors","volume":"96","author":"Nash","year":"2000","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2014.05.023_bib6","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1016\/j.bbmt.2013.02.006","article-title":"Allogeneic hematopoietic cell transplantation following minimal intensity conditioning: predicting acute graft-versus-host disease and graft-versus-tumor effects","volume":"19","author":"Storb","year":"2013","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.bbmt.2014.05.023_bib7","doi-asserted-by":"crossref","first-page":"1530","DOI":"10.1200\/JCO.2012.45.0247","article-title":"Graft-versus-host disease and graft-versus-tumor effects after allogeneic hematopoietic cell transplantation","volume":"31","author":"Storb","year":"2013","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.bbmt.2014.05.023_bib8","doi-asserted-by":"crossref","first-page":"S102","DOI":"10.1016\/j.bbmt.2012.10.028","article-title":"Graft-versus-host disease: state of the science","volume":"19","author":"Alousi","year":"2013","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.bbmt.2014.05.023_bib9","doi-asserted-by":"crossref","first-page":"4119","DOI":"10.1182\/blood-2006-12-041889","article-title":"How I treat refractory acute GVHD","volume":"109","author":"Deeg","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2014.05.023_bib10","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1097\/00007890-199408270-00008","article-title":"Treatment of moderate and severe acute GVHD after allogeneic bone marrow transplantation","volume":"58","author":"Hings","year":"1994","journal-title":"Transplantation"},{"key":"10.1016\/j.bbmt.2014.05.023_bib11","doi-asserted-by":"crossref","first-page":"2470","DOI":"10.1182\/blood-2007-09-112987","article-title":"Etanercept plus methylprednisolone as initial therapy for acute graft-versus-host disease","volume":"111","author":"Levine","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2014.05.023_bib12","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1053\/bbmt.2002.v8.pm12171485","article-title":"Response of 443 patients to steroids as primary therapy for acute graft-versus-host disease: comparison of grading systems","volume":"8","author":"MacMillan","year":"2002","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.bbmt.2014.05.023_bib13","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1182\/blood.V76.3.624.624","article-title":"Acute upper gastrointestinal graft-versus-host disease: clinical significance and response to immunosuppressive therapy","volume":"76","author":"Weisdorf","year":"1990","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2014.05.023_bib14","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1016\/j.bbmt.2010.05.019","article-title":"Graft-versus-host disease treatment: predictors of survival","volume":"16","author":"Levine","year":"2010","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.bbmt.2014.05.023_bib15","doi-asserted-by":"crossref","first-page":"5412","DOI":"10.1182\/blood-2009-12-258442","article-title":"The best endpoint for acute GVHD treatment trials","volume":"115","author":"MacMillan","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2014.05.023_bib16","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1038\/bmt.2011.41","article-title":"Prognostic value of response after upfront therapy for acute GVHD","volume":"47","author":"Saliba","year":"2012","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.bbmt.2014.05.023_bib17","doi-asserted-by":"crossref","first-page":"601953","DOI":"10.1155\/2011\/601953","article-title":"Steroid-refractory acute GVHD: predictors and outcomes","volume":"2011","author":"Westin","year":"2011","journal-title":"Adv Hematol"},{"key":"10.1016\/j.bbmt.2014.05.023_bib18","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1182\/blood-2009-03-212290","article-title":"Etanercept, mycophenolate, denileukin, or pentostatin plus corticosteroids for acute graft-versus-host disease: a randomized phase 2 trial from the Blood and Marrow Transplant Clinical Trials Network","volume":"114","author":"Alousi","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2014.05.023_bib19","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.bbmt.2008.04.002","article-title":"Plasma elevations of tumor necrosis factor-receptor-1 at day 7 postallogeneic transplant correlate with graft-versus-host disease severity and overall survival in pediatric patients","volume":"14","author":"Kitko","year":"2008","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.bbmt.2014.05.023_bib20","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1182\/blood-2008-02-138867","article-title":"Change in plasma tumor necrosis factor receptor 1 levels in the first week after myeloablative allogeneic transplantation correlates with severity and incidence of GVHD and survival","volume":"112","author":"Choi","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2014.05.023_bib21","doi-asserted-by":"crossref","first-page":"656","DOI":"10.4049\/jimmunol.164.2.656","article-title":"The p55 TNF-alpha receptor plays a critical role in T cell alloreactivity","volume":"164","author":"Hill","year":"2000","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.bbmt.2014.05.023_bib22","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/S1083-8791(03)00087-9","article-title":"Role of tumor necrosis factor-alpha in graft-versus-host disease and graft-versus-leukemia responses","volume":"9","author":"Korngold","year":"2003","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.bbmt.2014.05.023_bib23","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1345\/aph.19126","article-title":"The pharmacokinetics of etanercept in healthy volunteers","volume":"34","author":"Korth-Bradley","year":"2000","journal-title":"Ann Pharmacother"},{"key":"10.1016\/j.bbmt.2014.05.023_bib24","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1016\/j.bbmt.2012.03.013","article-title":"TNF-inhibition with etanercept for graft-versus-host disease prevention in high-risk HCT: lower TNFR1 levels correlate with better outcomes","volume":"18","author":"Choi","year":"2012","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.bbmt.2014.05.023_bib25","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1128\/JCM.42.3.1142-1148.2004","article-title":"Optimization of quantitative detection of cytomegalovirus DNA in plasma by real-time PCR","volume":"42","author":"Boeckh","year":"2004","journal-title":"J\u00a0Clin Microbiol"},{"key":"10.1016\/j.bbmt.2014.05.023_bib26","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1086\/323335","article-title":"Defining opportunistic invasive fungal infections in immunocompromised patients with cancer and hematopoietic stem cell transplants: an international consensus","volume":"34","author":"Ascioglu","year":"2002","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.bbmt.2014.05.023_bib27","first-page":"825","article-title":"1994 Consensus Conference on Acute GVHD Grading","volume":"15","author":"Przepiorka","year":"1995","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.bbmt.2014.05.023_bib28","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1016\/j.bbmt.2005.09.004","article-title":"National Institutes of Health consensus development project on criteria for clinical trials in chronic graft-versus-host disease: I. Diagnosis and staging working group report","volume":"11","author":"Filipovich","year":"2005","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.bbmt.2014.05.023_bib29","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1056\/NEJMoa1213299","article-title":"ST2 as a marker for risk of therapy-resistant graft-versus-host disease and death","volume":"369","author":"Vander Lugt","year":"2013","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.bbmt.2014.05.023_bib30","doi-asserted-by":"crossref","first-page":"6702","DOI":"10.1182\/blood-2011-08-375006","article-title":"Regenerating islet-derived 3-alpha is a biomarker of gastrointestinal graft-versus-host disease","volume":"118","author":"Ferrara","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2014.05.023_bib31","doi-asserted-by":"crossref","first-page":"13ra2","DOI":"10.1126\/scitranslmed.3000406","article-title":"Elafin is a biomarker of graft-versus-host disease of the skin","volume":"2","author":"Paczesny","year":"2010","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.bbmt.2014.05.023_bib32","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1080\/01621459.1958.10501452","article-title":"Nonparametric estimation from incomplete observations","volume":"53","author":"Kaplan","year":"1958","journal-title":"J\u00a0Am Stat Assoc"},{"key":"10.1016\/j.bbmt.2014.05.023_bib33","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1080\/01621459.1999.10474144","article-title":"A\u00a0proportional hazards model for the subdistribution of a competing risk","volume":"94","author":"Fine","year":"1999","journal-title":"J\u00a0Am Stat Assoc"},{"key":"10.1016\/j.bbmt.2014.05.023_bib34","unstructured":"ASBMT RFI 2013-Disease Classifications Corresponding to CIBMTR Classifications. 2013. Available at: http:\/\/c.ymcdn.com\/sites\/www.asbmt.org\/resource\/resmgr\/Docs\/ASBMT_RFI_2014_Translation_t.pdf."},{"key":"10.1016\/j.bbmt.2014.05.023_bib35","doi-asserted-by":"crossref","first-page":"2960","DOI":"10.1182\/blood-2011-10-387357","article-title":"Plasma biomarkers of lower gastrointestinal and liver acute GVHD","volume":"119","author":"Harris","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2014.05.023_bib36","doi-asserted-by":"crossref","first-page":"3854","DOI":"10.1182\/blood-2012-01-403063","article-title":"Acute graft-versus-host disease biomarkers measured during therapy can predict treatment outcomes: a Blood and Marrow Transplant Clinical Trials Network study","volume":"119","author":"Levine","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2014.05.023_bib37","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1182\/blood-2008-07-167098","article-title":"A\u00a0biomarker panel for acute graft-versus-host disease","volume":"113","author":"Paczesny","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2014.05.023_bib38","doi-asserted-by":"crossref","first-page":"S116","DOI":"10.1016\/j.bbmt.2011.10.019","article-title":"Clinical applications for biomarkers of acute and chronic graft-versus-host disease","volume":"18","author":"Levine","year":"2012","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.bbmt.2014.05.023_bib39","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1182\/blood-2012-08-355990","article-title":"Discovery and validation of graft-versus-host disease biomarkers","volume":"121","author":"Paczesny","year":"2013","journal-title":"Blood"}],"container-title":["Biology of Blood and Marrow Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1083879114003218?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1083879114003218?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T14:48:47Z","timestamp":1761058127000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1083879114003218"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9]]},"references-count":39,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2014,9]]}},"alternative-id":["S1083879114003218"],"URL":"https:\/\/doi.org\/10.1016\/j.bbmt.2014.05.023","relation":{},"ISSN":["1083-8791"],"issn-type":[{"value":"1083-8791","type":"print"}],"subject":[],"published":{"date-parts":[[2014,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Etanercept plus Topical Corticosteroids as Initial Therapy for Grade One Acute Graft-Versus-Host Disease after Allogeneic Hematopoietic Cell Transplantation","name":"articletitle","label":"Article Title"},{"value":"Biology of Blood and Marrow Transplantation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbmt.2014.05.023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 American Society for Blood and Marrow Transplantation. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}