{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,14]],"date-time":"2026-06-14T06:33:28Z","timestamp":1781418808959,"version":"3.54.1"},"reference-count":23,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2015,10,1]],"date-time":"2015-10-01T00:00:00Z","timestamp":1443657600000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K23 AI083880"],"award-info":[{"award-number":["K23 AI083880"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bbmt.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biology of Blood and Marrow Transplantation"],"published-print":{"date-parts":[[2014,10]]},"DOI":"10.1016\/j.bbmt.2014.06.025","type":"journal-article","created":{"date-parts":[[2014,6,25]],"date-time":"2014-06-25T04:03:49Z","timestamp":1403669029000},"page":"1626-1633","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":49,"title":["Clostridium Difficile Infection after Allogeneic Hematopoietic Stem Cell Transplant: Strain Diversity and Outcomes Associated with NAP1\/027"],"prefix":"10.1016","volume":"20","author":[{"given":"Mini","family":"Kamboj","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Kaltsas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao-Ting","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dick","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saliangi","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Sheahan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kent","family":"Sepkowitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann A.","family":"Jakubowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Genovefa","family":"Papanicolaou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbmt.2014.06.025_bib1","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1093\/cid\/cir1035","article-title":"Epidemiology and outcomes of Clostridium difficile infections in hematopoietic stem cell transplant recipients","volume":"54","author":"Alonso","year":"2012","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.bbmt.2014.06.025_bib2","doi-asserted-by":"crossref","first-page":"E82","DOI":"10.1111\/j.1399-0012.2010.01331.x","article-title":"Recent epidemiology of Clostridium difficile infection during hematopoietic stem cell transplantation","volume":"25","author":"Chopra","year":"2011","journal-title":"Clin Transplant"},{"key":"10.1016\/j.bbmt.2014.06.025_bib3","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1086\/668023","article-title":"Hospital-onset Clostridium difficile infection rates in persons with cancer or hematopoietic stem cell transplant: a C3IC network report","volume":"33","author":"Kamboj","year":"2012","journal-title":"Infect Control Hosp Epidemiol"},{"key":"10.1016\/j.bbmt.2014.06.025_bib4","doi-asserted-by":"crossref","first-page":"2442","DOI":"10.1056\/NEJMoa051639","article-title":"A\u00a0predominantly clonal multi-institutional outbreak of Clostridium difficile-associated diarrhea with high morbidity and mortality","volume":"353","author":"Loo","year":"2005","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.bbmt.2014.06.025_bib5","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1093\/clinids\/18.2.181","article-title":"Clostridium difficile colonization and diarrhea at a tertiary care hospital","volume":"18","author":"Samore","year":"1994","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.bbmt.2014.06.025_bib6","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1016\/j.bbmt.2012.02.010","article-title":"Clostridium difficile infection after allogeneic hematopoietic stem cell transplantation: incidence, risk factors, and outcome","volume":"18","author":"Willems","year":"2012","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.bbmt.2014.06.025_bib7","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1503\/cmaj.1041104","article-title":"Clostridium difficile-associated diarrhea in a region of Quebec from 1991 to 2003: a changing pattern of disease severity","volume":"171","author":"Pepin","year":"2004","journal-title":"Can Med Assoc J"},{"key":"10.1016\/j.bbmt.2014.06.025_bib8","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1503\/cmaj.1040957","article-title":"Clostridium difficile infection in hospitals: a brewing storm","volume":"171","author":"Valiquette","year":"2004","journal-title":"Can Med Assoc J"},{"key":"10.1016\/j.bbmt.2014.06.025_bib9","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1097\/TP.0b013e31824d34de","article-title":"Clostridium difficile colitis: increasing incidence, risk factors, and outcomes in solid organ transplant recipients","volume":"93","author":"Boutros","year":"2012","journal-title":"Transplantation"},{"key":"10.1016\/j.bbmt.2014.06.025_bib10","doi-asserted-by":"crossref","first-page":"2631","DOI":"10.1016\/j.transproceed.2010.04.057","article-title":"Outcomes of patients who develop symptomatic Clostridium difficile infection after solid organ transplantation","volume":"42","author":"Mitu-Pretorian","year":"2010","journal-title":"Transplant Proc"},{"key":"10.1016\/j.bbmt.2014.06.025_bib11","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1038\/bmt.2008.317","article-title":"Clostridium difficile-associated disease in human stem cell transplant recipients: coming epidemic or false alarm?","volume":"42","author":"Bobak","year":"2008","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.bbmt.2014.06.025_bib12","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1111\/j.1399-0012.2009.01035.x","article-title":"Clostridium difficile-associated disease in allogeneic hematopoietic stem-cell transplant recipients: risk associations, protective associations, and outcomes","volume":"24","author":"Dubberke","year":"2010","journal-title":"Clin Transplant"},{"key":"10.1016\/j.bbmt.2014.06.025_bib13","first-page":"1358","article-title":"Treatment of Clostridium difficile infection","volume":"53","year":"2011","journal-title":"Med Lett"},{"key":"10.1016\/j.bbmt.2014.06.025_bib14","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1086\/519265","article-title":"A\u00a0comparison of vancomycin and metronidazole for the treatment of Clostridium difficile-associated diarrhea, stratified by disease severity","volume":"45","author":"Zar","year":"2007","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.bbmt.2014.06.025_bib15","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1038\/sj.bmt.1702627","article-title":"Clostridium difficile infection in allogeneic stem cell transplant recipients is associated with severe graft-versus-host disease and non-relapse mortality","volume":"26","author":"Chakrabarti","year":"2000","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.bbmt.2014.06.025_bib16","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1046\/j.1365-2141.1997.1112925.x","article-title":"IBMTR Severity Index for grading acute graft-versus-host disease: retrospective comparison with Glucksberg grade","volume":"97","author":"Rowlings","year":"1997","journal-title":"Br J Haematol"},{"key":"10.1016\/j.bbmt.2014.06.025_bib17","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1111\/j.1574-6968.1999.tb13629.x","article-title":"Development of a new PCR-ribotyping method for Clostridium difficile based on ribosomal RNA gene sequencing","volume":"175","author":"Bidet","year":"1999","journal-title":"FEMS Microbiol Lett"},{"key":"10.1016\/j.bbmt.2014.06.025_bib18","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1128\/JCM.01796-09","article-title":"Multilocus sequence typing of Clostridium difficile","volume":"48","author":"Griffiths","year":"2010","journal-title":"J\u00a0Clin Microbiol"},{"key":"10.1016\/j.bbmt.2014.06.025_bib19","doi-asserted-by":"crossref","first-page":"e90158","DOI":"10.1371\/journal.pone.0090158","article-title":"Clostridium difficile colonization and infection during allogeneic hematopoietic stem cell transplantation","volume":"9","author":"Kinnebrew","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.bbmt.2014.06.025_bib20","doi-asserted-by":"crossref","unstructured":"Jain T, Banavasi HVR, Urday-Cornejo V, et\u00a0al. Prospective evaluation of toxigenic and non-toxigenic strains of Clostridium difficile colonization and infection among allogenic hematopoietic stem cell transplant recipients, 2010-2012. Presented at ID week, San Francisco, October 2-6, 2013, abstract number\u00a0627.","DOI":"10.1182\/blood.V122.21.4563.4563"},{"key":"10.1016\/j.bbmt.2014.06.025_bib21","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1097\/00000658-200203000-00008","article-title":"Fulminant Clostridium difficile: an underappreciated and increasing cause of death and complications","volume":"235","author":"Dallal","year":"2002","journal-title":"Ann Surg"},{"key":"10.1016\/j.bbmt.2014.06.025_bib22","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1016\/S0140-6736(05)67420-X","article-title":"Toxin production by an emerging strain of Clostridium difficile associated with outbreaks of severe disease in North America and Europe","volume":"366","author":"Warny","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.bbmt.2014.06.025_bib23","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1093\/cid\/cis840","article-title":"Impact of the type of diagnostic assay on Clostridium difficile infection and complication rates in a mandatory reporting program","volume":"56","author":"Longtin","year":"2013","journal-title":"Clin Infect Dis"}],"container-title":["Biology of Blood and Marrow Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1083879114003759?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1083879114003759?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T14:49:43Z","timestamp":1761058183000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1083879114003759"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10]]},"references-count":23,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["S1083879114003759"],"URL":"https:\/\/doi.org\/10.1016\/j.bbmt.2014.06.025","relation":{},"ISSN":["1083-8791"],"issn-type":[{"value":"1083-8791","type":"print"}],"subject":[],"published":{"date-parts":[[2014,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Clostridium Difficile Infection after Allogeneic Hematopoietic Stem Cell Transplant: Strain Diversity and Outcomes Associated with NAP1\/027","name":"articletitle","label":"Article Title"},{"value":"Biology of Blood and Marrow Transplantation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbmt.2014.06.025","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 American Society for Blood and Marrow Transplantation. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}