{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T21:18:15Z","timestamp":1761513495438,"version":"build-2065373602"},"reference-count":33,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2014,12,1]],"date-time":"2014-12-01T00:00:00Z","timestamp":1417392000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,12,1]],"date-time":"2014-12-01T00:00:00Z","timestamp":1417392000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R01CA102282"],"award-info":[{"award-number":["R01CA102282"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Millennium Company"}],"content-domain":{"domain":["bbmt.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biology of Blood and Marrow Transplantation"],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1016\/j.bbmt.2014.07.022","type":"journal-article","created":{"date-parts":[[2014,7,23]],"date-time":"2014-07-23T16:05:28Z","timestamp":1406131528000},"page":"1899-1904","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"title":["Therapeutic Benefit of Bortezomib on Acute Graft-versus-Host Disease Is Tissue Specific and Is Associated with Interleukin-6 Levels"],"prefix":"10.1016","volume":"20","author":[{"given":"Chien-Chun Steven","family":"Pai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui-Hua","family":"Hsiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingyi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Hagino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph","family":"Tellez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"Mall","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruce R.","family":"Blazar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arta","family":"Monjazeb","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehrdad","family":"Abedi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William J.","family":"Murphy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbmt.2014.07.022_bib1","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1038\/nri2000","article-title":"Graft-versus-host disease","volume":"7","author":"Shlomchik","year":"2007","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.bbmt.2014.07.022_bib2","doi-asserted-by":"crossref","first-page":"5249","DOI":"10.1182\/blood-2009-11-255422","article-title":"Blockade of interleukin-23 signaling results in targeted protection of the colon and allows for separation of graft-versus-host and graft-versus-leukemia responses","volume":"115","author":"Das","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2014.07.022_bib3","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1146\/annurev.immunol.25.022106.141606","article-title":"Immunobiology of allogeneic hematopoietic stem cell transplantation","volume":"25","author":"Welniak","year":"2007","journal-title":"Ann Rev Immunol"},{"key":"10.1016\/j.bbmt.2014.07.022_bib4","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1007\/s12185-011-0803-1","article-title":"Implications of TNF-alpha in the pathogenesis and management of GVHD","volume":"93","author":"Levine","year":"2011","journal-title":"Int J Hematol"},{"key":"10.1016\/j.bbmt.2014.07.022_bib5","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1038\/nri3212","article-title":"Advances in graft-versus-host disease biology and therapy","volume":"12","author":"Blazar","year":"2012","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.bbmt.2014.07.022_bib6","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1093\/intimm\/dxq030","article-title":"IL-6: from its discovery to clinical applications","volume":"22","author":"Kishimoto","year":"2010","journal-title":"Int Immunol"},{"key":"10.1016\/j.bbmt.2014.07.022_bib7","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1182\/blood-2009-01-197178","article-title":"Blockade of interleukin-6 signaling augments regulatory T-cell reconstitution and attenuates the severity of graft-versus-host disease","volume":"114","author":"Chen","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2014.07.022_bib8","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1158\/1078-0432.CCR-10-1198","article-title":"Interleukin-6 modulates graft-versus-host responses after experimental allogeneic bone marrow transplantation","volume":"17","author":"Tawara","year":"2011","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.bbmt.2014.07.022_bib9","doi-asserted-by":"crossref","first-page":"2752","DOI":"10.1038\/jid.2012.226","article-title":"IL-6 blockade attenuates the development of murine sclerodermatous chronic graft-versus-host disease","volume":"132","author":"Le Huu","year":"2012","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.bbmt.2014.07.022_bib10","doi-asserted-by":"crossref","first-page":"e602","DOI":"10.1200\/JCO.2010.29.1682","article-title":"Effectiveness and safety of tocilizumab, an anti-interleukin-6 receptor monoclonal antibody, in a patient with refractory GI graft-versus-host disease","volume":"28","author":"Gergis","year":"2010","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.bbmt.2014.07.022_bib11","doi-asserted-by":"crossref","first-page":"1862","DOI":"10.1016\/j.bbmt.2011.07.001","article-title":"Tocilizumab for the treatment of steroid refractory graft-versus-host disease","volume":"17","author":"Drobyski","year":"2011","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.bbmt.2014.07.022_bib12","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1182\/blood-2012-04-403733","article-title":"Proteasome inhibitors in multiple myeloma: 10 years later","volume":"120","author":"Moreau","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2014.07.022_bib13","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1159\/000330067","article-title":"Anti-inflammatory and immunomodulatory effects of bortezomib in various in\u00a0vivo models","volume":"88","author":"Tung","year":"2011","journal-title":"Pharmacology"},{"key":"10.1016\/j.bbmt.2014.07.022_bib14","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1016\/j.bcp.2009.10.006","article-title":"Proteasome inhibition up-regulates inflammatory gene transcription induced by an atypical pathway of NF-kappaB activation","volume":"79","author":"Cullen","year":"2010","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.bbmt.2014.07.022_bib15","doi-asserted-by":"crossref","first-page":"975","DOI":"10.3324\/haematol.2008.005017","article-title":"Treatment with bortezomib of human CD4+ T cells preserves natural regulatory T cells and allows the emergence of a distinct suppressor T-cell population","volume":"94","author":"Blanco","year":"2009","journal-title":"Haematologica"},{"key":"10.1016\/j.bbmt.2014.07.022_bib16","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1111\/j.1365-2249.2008.03818.x","article-title":"Sensitization of human breast cancer cells to natural killer cell-mediated cytotoxicity by proteasome inhibition","volume":"155","author":"Ames","year":"2009","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.bbmt.2014.07.022_bib17","doi-asserted-by":"crossref","first-page":"3202","DOI":"10.1200\/JCO.2012.42.0984","article-title":"Bortezomib-based graft-versus-host disease prophylaxis in HLA-mismatched unrelated donor transplantation","volume":"30","author":"Koreth","year":"2012","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.bbmt.2014.07.022_bib18","doi-asserted-by":"crossref","first-page":"3956","DOI":"10.1182\/blood-2009-07-231092","article-title":"Bortezomib, tacrolimus, and methotrexate for prophylaxis of graft-versus-host disease after reduced-intensity conditioning allogeneic stem cell transplantation from HLA-mismatched unrelated donors","volume":"114","author":"Koreth","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2014.07.022_bib19","doi-asserted-by":"crossref","first-page":"3293","DOI":"10.1182\/blood-2004-11-4526","article-title":"Differential effects of proteasome inhibition by bortezomib on murine acute graft-versus-host disease (GVHD): delayed administration of bortezomib results in increased GVHD-dependent gastrointestinal toxicity","volume":"106","author":"Sun","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2014.07.022_bib20","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.4049\/jimmunol.1102853","article-title":"IFN-gamma receptor-deficient donor T cells mediate protection from graft-versus-host disease and preserve graft-versus-tumor responses after allogeneic bone marrow transplantation","volume":"189","author":"Sun","year":"2012","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.bbmt.2014.07.022_bib21","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1182\/blood-2004-01-0328","article-title":"Recipient CD4+ T cells that survive irradiation regulate chronic graft-versus-host disease","volume":"104","author":"Anderson","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2014.07.022_bib22","doi-asserted-by":"crossref","first-page":"3133","DOI":"10.1084\/jem.20071733","article-title":"Blood-derived dermal langerin+ dendritic cells survey the skin in the steady state","volume":"204","author":"Ginhoux","year":"2007","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.bbmt.2014.07.022_bib23","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1126\/science.285.5426.412","article-title":"Prevention of graft versus host disease by inactivation of host antigen-presenting cells","volume":"285","author":"Shlomchik","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.bbmt.2014.07.022_bib24","doi-asserted-by":"crossref","first-page":"3463","DOI":"10.4049\/jimmunol.175.6.3463","article-title":"Directing transition from innate to acquired immunity: defining a role for IL-6","volume":"175","author":"Jones","year":"2005","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.bbmt.2014.07.022_bib25","doi-asserted-by":"crossref","first-page":"9589","DOI":"10.1073\/pnas.0501794102","article-title":"IL-6 trans-signaling via STAT3 directs T cell infiltration in acute inflammation","volume":"102","author":"McLoughlin","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.bbmt.2014.07.022_bib26","doi-asserted-by":"crossref","first-page":"8120","DOI":"10.1073\/pnas.0401563101","article-title":"Inhibition of acute graft-versus-host disease with retention of graft-versus-tumor effects by the proteasome inhibitor bortezomib","volume":"101","author":"Sun","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.bbmt.2014.07.022_bib27","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1182\/blood-2008-03-143461","article-title":"Differential effects of donor T-cell cytokines on outcome with continuous bortezomib administration after allogeneic bone marrow transplantation","volume":"112","author":"Sun","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2014.07.022_bib28","doi-asserted-by":"crossref","first-page":"e96252","DOI":"10.1371\/journal.pone.0096252","article-title":"Dexamethasone Palmitate Ameliorates Macrophages-Rich Graft-versus-Host Disease by Inhibiting Macrophage Functions","volume":"9","author":"Nishiwaki","year":"2014","journal-title":"PloS One"},{"key":"10.1016\/j.bbmt.2014.07.022_bib29","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.immuni.2013.10.022","article-title":"Interleukin-6 signaling drives fibrosis in unresolved inflammation","volume":"40","author":"Fielding","year":"2014","journal-title":"Immunity"},{"key":"10.1016\/j.bbmt.2014.07.022_bib30","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/S1074-7613(01)00151-0","article-title":"Il-6 and its soluble receptor orchestrate a temporal switch in the pattern of leukocyte recruitment seen during acute inflammation","volume":"14","author":"Hurst","year":"2001","journal-title":"Immunity"},{"key":"10.1016\/j.bbmt.2014.07.022_bib31","doi-asserted-by":"crossref","first-page":"3827","DOI":"10.1182\/blood-2006-12-061408","article-title":"CXCL10-CXCR3 interactions play an important role in the pathogenesis of acute graft-versus-host disease in the skin following allogeneic stem-cell transplantation","volume":"110","author":"Piper","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2014.07.022_bib32","doi-asserted-by":"crossref","first-page":"3322","DOI":"10.1182\/blood-2005-05-1860","article-title":"CCR2 is required for CD8-induced graft-versus-host disease","volume":"106","author":"Terwey","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2014.07.022_bib33","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1182\/blood-2002-09-2748","article-title":"Early changes in gene expression profiles of hepatic GVHD uncovered by oligonucleotide microarrays","volume":"102","author":"Ichiba","year":"2003","journal-title":"Blood"}],"container-title":["Biology of Blood and Marrow Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1083879114004480?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1083879114004480?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T14:48:28Z","timestamp":1761058108000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1083879114004480"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12]]},"references-count":33,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["S1083879114004480"],"URL":"https:\/\/doi.org\/10.1016\/j.bbmt.2014.07.022","relation":{},"ISSN":["1083-8791"],"issn-type":[{"type":"print","value":"1083-8791"}],"subject":[],"published":{"date-parts":[[2014,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Therapeutic Benefit of Bortezomib on Acute Graft-versus-Host Disease Is Tissue Specific and Is Associated with Interleukin-6 Levels","name":"articletitle","label":"Article Title"},{"value":"Biology of Blood and Marrow Transplantation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbmt.2014.07.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 American Society for Blood and Marrow Transplantation. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}