{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T19:26:10Z","timestamp":1767986770090,"version":"3.49.0"},"reference-count":51,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2015,5,1]],"date-time":"2015-05-01T00:00:00Z","timestamp":1430438400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,5,1]],"date-time":"2015-05-01T00:00:00Z","timestamp":1430438400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T00:00:00Z","timestamp":1462060800000},"content-version":"vor","delay-in-days":366,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005632","name":"National Centre for Research and Development","doi-asserted-by":"crossref","award":["N R13 0082 06"],"award-info":[{"award-number":["N R13 0082 06"]}],"id":[{"id":"10.13039\/501100005632","id-type":"DOI","asserted-by":"crossref"}]},{"name":"National Center of Science","award":["N N402 351138"],"award-info":[{"award-number":["N N402 351138"]}]}],"content-domain":{"domain":["bbmt.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biology of Blood and Marrow Transplantation"],"published-print":{"date-parts":[[2015,5]]},"DOI":"10.1016\/j.bbmt.2015.01.018","type":"journal-article","created":{"date-parts":[[2015,1,21]],"date-time":"2015-01-21T15:38:07Z","timestamp":1421854687000},"page":"829-839","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"title":["Role of Donor Activating KIR\u2013HLA Ligand\u2013Mediated NK Cell Education Status in Control of Malignancy in\u00a0Hematopoietic Cell Transplant Recipients"],"prefix":"10.1016","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3474-7597","authenticated-orcid":false,"given":"Jacek","family":"Nowak","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katarzyna","family":"Ko\u015bci\u0144ska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renata","family":"Mika-Witkowska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Rogatko-Koro\u015b","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sylwia","family":"Mizia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emilia","family":"Jasku\u0142a","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ma\u0142gorzata","family":"Polak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monika","family":"Mordak-Domaga\u0142a","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janusz","family":"Lange","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Gronkowska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wies\u0142aw Wiktor","family":"J\u0119drzejczak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u0142awomira","family":"Kyrcz-Krzemie\u0144","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miros\u0142aw","family":"Markiewicz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monika","family":"Dzier\u017cak-Miet\u0142a","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agnieszka","family":"Tomaszewska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Nasi\u0142owska-Adamska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrzej","family":"Szczepi\u0144ski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazimierz","family":"Ha\u0142aburda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrzej","family":"Hellmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Czy\u017c","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lidia","family":"Gil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mieczys\u0142aw","family":"Komarnicki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacek","family":"Wachowiak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ma\u0142gorzata","family":"Bara\u0144ska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jerzy","family":"Kowalczyk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katarzyna","family":"Drabko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jolanta","family":"Go\u017adzik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Wysocza\u0144ska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katarzyna","family":"Bogunia-Kubik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"El\u017cbieta","family":"Graczyk-Pol","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agnieszka","family":"Witkowska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Marosz-Rudnicka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaudia","family":"Nestorowicz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanna","family":"Dziopa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Urszula","family":"Szlendak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krzysztof","family":"Warzocha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrzej","family":"Lange","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbmt.2015.01.018_bib1","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1084\/jem.20100479","article-title":"Homeostatic proliferation generates long-lived natural killer cells that respond against viral infection","volume":"208","author":"Sun","year":"2011","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.bbmt.2015.01.018_bib2","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1002\/cncr.22002","article-title":"Killer cell Ig-like receptors ligand-mismatched, alloreactive natural killer cells lyse primary solid tumors","volume":"107","author":"Re","year":"2006","journal-title":"Cancer"},{"key":"10.1016\/j.bbmt.2015.01.018_bib3","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1126\/science.1068440","article-title":"Effectiveness of donor natural killer cell alloreactivity in mismatched hematopoietic transplants","volume":"295","author":"Ruggeri","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.bbmt.2015.01.018_bib4","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1182\/blood-2006-07-038687","article-title":"Donor natural killer cell allorecognition of missing self in haploidentical hematopoietic transplantation for acute myeloid leukemia: challenging its predictive value","volume":"110","author":"Ruggeri","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2015.01.018_bib5","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1038\/leu.2008.365","article-title":"KIR-ligand incompatibility in the graft-versus-host direction improves outcomes after umbilical cord blood transplantation for acute leukemia","volume":"23","author":"Willemze","year":"2009","journal-title":"Leukemia"},{"key":"10.1016\/j.bbmt.2015.01.018_bib6","doi-asserted-by":"crossref","first-page":"3119","DOI":"10.1182\/blood-2008-06-164103","article-title":"Anti-leukemia activity of alloreactive NK cells in KIR ligand-mismatched haploidentical HSCT for pediatric patients: evaluation of the functional role of activating KIR and redefinition of inhibitory KIR specificity","volume":"113","author":"Pende","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2015.01.018_bib7","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1182\/blood-2003-01-0091","article-title":"Survival advantage with KIR ligand incompatibility in hematopoietic stem cell transplantation from unrelated donors","volume":"102","author":"Giebel","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2015.01.018_bib8","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1006\/smim.2000.0212","article-title":"HLA class I recognition by killer cell Ig-like receptors","volume":"12","author":"Long","year":"2000","journal-title":"Semin Immunol"},{"key":"10.1016\/j.bbmt.2015.01.018_bib9","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1034\/j.1600-065X.2001.1810119.x","article-title":"Inhibition of natural killer cell activation signals by killer cell immunoglobulin-like receptors (CD158)","volume":"181","author":"Long","year":"2001","journal-title":"Immunol Rev"},{"key":"10.1016\/j.bbmt.2015.01.018_bib10","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1038\/nature03847","article-title":"Licensing of natural killer cells by host major histocompatibility complex class I molecules","volume":"436","author":"Kim","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.bbmt.2015.01.018_bib11","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.smim.2008.10.002","article-title":"The genetic and evolutionary balances in human NK cell receptor diversity","volume":"20","author":"Parham","year":"2008","journal-title":"Semin Immunol"},{"key":"10.1016\/j.bbmt.2015.01.018_bib12","doi-asserted-by":"crossref","first-page":"2557","DOI":"10.1084\/jem.20091010","article-title":"KIR2DS4 is a product of gene conversion with KIR3DL2 that introduced specificity for HLA-A*11 while diminishing avidity for HLA-C","volume":"206","author":"Graef","year":"2009","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.bbmt.2015.01.018_bib13","doi-asserted-by":"crossref","first-page":"4778","DOI":"10.4049\/jimmunol.1301580","article-title":"Large spectrum of HLA-C recognition by killer Ig-like receptor (KIR)2DL2 and KIR2DL3 and restricted C1 SPECIFICITY of KIR2DS2: dominant impact of KIR2DL2\/KIR2DS2 on KIR2D NK cell repertoire formation","volume":"191","author":"David","year":"2013","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.bbmt.2015.01.018_bib14","doi-asserted-by":"crossref","first-page":"854","DOI":"10.4049\/jimmunol.179.2.854","article-title":"KIR2DS1-positive NK cells mediate alloresponse against the C2 HLA-KIR ligand group in\u00a0vitro","volume":"179","author":"Chewning","year":"2007","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.bbmt.2015.01.018_bib15","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1056\/NEJMoa1200503","article-title":"HLA-C-dependent prevention of leukemia relapse by donor activating KIR2DS1","volume":"367","author":"Venstrom","year":"2012","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.bbmt.2015.01.018_bib16","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1038\/319675a0","article-title":"Selective rejection of H-2-deficient lymphoma variants suggests alternative immune defence strategy","volume":"319","author":"Karre","year":"1986","journal-title":"Nature"},{"key":"10.1016\/j.bbmt.2015.01.018_bib17","doi-asserted-by":"crossref","first-page":"6565","DOI":"10.4049\/jimmunol.174.11.6565","article-title":"Missing self, NK cells, and the White Album","volume":"174","author":"Lanier","year":"2005","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.bbmt.2015.01.018_bib18","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/0167-5699(90)90097-S","article-title":"In search of the \u2018missing self\u2019: MHC molecules and NK cell recognition","volume":"11","author":"Ljunggren","year":"1990","journal-title":"Immunol Today"},{"key":"10.1016\/j.bbmt.2015.01.018_bib19","doi-asserted-by":"crossref","first-page":"4416","DOI":"10.1182\/blood-2004-08-3156","article-title":"A\u00a0subset of natural killer cells achieves self-tolerance without expressing inhibitory receptors specific for self-MHC molecules","volume":"105","author":"Fernandez","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2015.01.018_bib20","doi-asserted-by":"crossref","first-page":"3981","DOI":"10.4049\/jimmunol.1301159","article-title":"Cutting edge: NK cell licensing modulates adhesion to target cells","volume":"191","author":"Thomas","year":"2013","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.bbmt.2015.01.018_bib21","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/978-1-60761-362-6_4","article-title":"Assessing licensing of NK cells","volume":"612","author":"Jonsson","year":"2010","journal-title":"Methods Mol Biol"},{"key":"10.1016\/j.bbmt.2015.01.018_bib22","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0065-2776(08)01002-X","article-title":"Natural killer cell tolerance licensing and other mechanisms","volume":"101","author":"Jonsson","year":"2009","journal-title":"Adv Immunol"},{"key":"10.1016\/j.bbmt.2015.01.018_bib23","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1182\/blood-2009-09-245746","article-title":"Education of human natural killer cells by activating killer cell immunoglobulin-like receptors","volume":"115","author":"Fauriat","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2015.01.018_bib24","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1038\/bmt.2012.66","article-title":"The EBMT activity survey: 1990-2010","volume":"47","author":"Passweg","year":"2012","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.bbmt.2015.01.018_bib25","first-page":"225","volume":"Vol. 21","author":"Nowak","year":"2012"},{"key":"10.1016\/j.bbmt.2015.01.018_bib26","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.1084\/jem.20100570","article-title":"Mature natural killer cells reset their responsiveness when exposed to an altered MHC environment","volume":"207","author":"Joncker","year":"2010","journal-title":"J\u00a0Exp Med"},{"issue":"Database issue","key":"10.1016\/j.bbmt.2015.01.018_bib27","first-page":"D1222","article-title":"The IMGT\/HLA database","volume":"41","author":"Robinson","year":"2013","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.bbmt.2015.01.018_bib28","volume":"Vol. 2014","author":"Dorak","year":"2014"},{"key":"10.1016\/j.bbmt.2015.01.018_bib29","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1182\/blood-2008-01-132902","article-title":"The reactivity of Bw4+ HLA-B and HLA-A alleles with KIR3DL1: implications for patient and donor suitability for haploidentical stem cell transplantations","volume":"112","author":"Foley","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2015.01.018_bib30","doi-asserted-by":"crossref","first-page":"E176","DOI":"10.1002\/ajh.23802","article-title":"Donor NK cell licensing in control of malignancy in hematopoietic stem cell transplant recipients","volume":"89","author":"Nowak","year":"2014","journal-title":"Am J Hematol"},{"key":"10.1016\/j.bbmt.2015.01.018_bib31","first-page":"526","article-title":"Repertoire of\u00a0MHC-KIR ligands in the Polish population","volume":"75","author":"Nowak","year":"2010","journal-title":"Tissue Antigens"},{"key":"10.1016\/j.bbmt.2015.01.018_bib32","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1111\/j.1399-0039.2007.00991.x","article-title":"Allele and extended haplotype polymorphism of HLA-A, -C, -B, -DRB1 and -DQB1 loci in Polish population and genetic affinities to other populations","volume":"71","author":"Nowak","year":"2008","journal-title":"Tissue Antigens"},{"key":"10.1016\/j.bbmt.2015.01.018_bib33","doi-asserted-by":"crossref","first-page":"3969","DOI":"10.4049\/jimmunol.180.6.3969","article-title":"Synergistic polymorphism at two positions distal to the ligand-binding site makes KIR2DL2 a stronger receptor for HLA-C than KIR2DL3","volume":"180","author":"Moesta","year":"2008","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.bbmt.2015.01.018_bib34","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1034\/j.1600-065X.2001.1810105.x","article-title":"Structure of killer cell immunoglobulin-like receptors and their recognition of the class I MHC molecules","volume":"181","author":"Boyington","year":"2001","journal-title":"Immunol Rev"},{"key":"10.1016\/j.bbmt.2015.01.018_bib35","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1084\/jem.20051884","article-title":"Roles for HLA and KIR polymorphisms in natural killer cell repertoire selection and modulation of effector function","volume":"203","author":"Yawata","year":"2006","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.bbmt.2015.01.018_bib36","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1097\/01.tp.0000235859.24513.43","article-title":"Low number of donor activating killer immunoglobulin-like receptors (KIR) genes but not KIR-ligand mismatch prevents relapse and improves disease-free survival in leukemia patients after in\u00a0vivo T-cell depleted unrelated stem cell transplantation","volume":"82","author":"Kr\u00f6ger","year":"2006","journal-title":"Transplantation"},{"key":"10.1016\/j.bbmt.2015.01.018_bib37","doi-asserted-by":"crossref","first-page":"2255","DOI":"10.1016\/j.molimm.2007.11.014","article-title":"Activating KIRs exert a crucial role on relapse and overall survival after HLA-identical sibling transplantation","volume":"45","author":"Schellekens","year":"2008","journal-title":"Mol Immunol"},{"key":"10.1016\/j.bbmt.2015.01.018_bib38","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1084\/jem.191.8.1341","article-title":"Nonstochastic coexpression of activation receptors on murine natural killer cells","volume":"191","author":"Smith","year":"2000","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.bbmt.2015.01.018_bib39","doi-asserted-by":"crossref","first-page":"e1000254","DOI":"10.1371\/journal.pgen.1000254","article-title":"Genetic control of variegated KIR gene expression: polymorphisms of the bi-directional KIR3DL1 promoter are associated with distinct frequencies of gene expression","volume":"4","author":"Li","year":"2008","journal-title":"PLoS Genet"},{"key":"10.1016\/j.bbmt.2015.01.018_bib40","doi-asserted-by":"crossref","first-page":"3053","DOI":"10.1073\/pnas.0712229105","article-title":"HLA alleles determine differences in human natural killer cell responsiveness and potency","volume":"105","author":"Kim","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.bbmt.2015.01.018_bib41","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.humimm.2006.12.007","article-title":"Studies on the expression of the deleted KIR2DS4*003 gene product and distribution of KIR2DS4 deleted and nondeleted versions in different populations","volume":"68","author":"Middleton","year":"2007","journal-title":"Hum Immunol"},{"key":"10.1016\/j.bbmt.2015.01.018_bib42","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1146\/annurev.immunol.19.1.197","article-title":"Activating receptors and coreceptors involved in human natural killer cell-mediated cytolysis","volume":"19","author":"Moretta","year":"2001","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.bbmt.2015.01.018_bib43","doi-asserted-by":"crossref","first-page":"9","DOI":"10.3410\/M3-9","article-title":"Natural killer cell-based therapies","volume":"3","author":"Romagn\u00e9","year":"2011","journal-title":"F1000 Med Rep"},{"key":"10.1016\/j.bbmt.2015.01.018_bib44","first-page":"289","article-title":"Modulation of NKG2D-ligand cell surface expression enhances immune cell therapy of cancer","volume":"34","author":"Huang","year":"2011","journal-title":"J\u00a0Immunother"},{"key":"10.1016\/j.bbmt.2015.01.018_bib45","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/0167-5699(90)90097-S","article-title":"In search of the \u2018missing self\u2019: MHC molecules and NK cell recognition","volume":"11","author":"Ljunggren","year":"1990","journal-title":"Immunol Today"},{"key":"10.1016\/j.bbmt.2015.01.018_bib46","doi-asserted-by":"crossref","first-page":"4358","DOI":"10.4049\/jimmunol.167.8.4358","article-title":"Spatial organization of signal transduction molecules in the NK cell immune synapses during MHC class I-regulated noncytolytic and cytolytic interactions","volume":"167","author":"Vyas","year":"2001","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.bbmt.2015.01.018_bib47","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.4049\/jimmunol.178.3.1261","article-title":"Activating Ly-49 receptors regulate LFA-1-mediated adhesion by NK cells","volume":"178","author":"Osman","year":"2007","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.bbmt.2015.01.018_bib48","doi-asserted-by":"crossref","first-page":"2657","DOI":"10.1182\/blood-2009-01-201632","article-title":"Minimal requirement for induction of natural cytotoxicity and intersection of activation signals by inhibitory receptors","volume":"114","author":"Bryceson","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2015.01.018_bib49","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1038\/ni.1849","article-title":"\u2018Unlicensed\u2019 natural killer cells dominate the response to cytomegalovirus infection","volume":"11","author":"Orr","year":"2010","journal-title":"Nat Immunol"},{"key":"10.1016\/j.bbmt.2015.01.018_bib50","doi-asserted-by":"crossref","first-page":"e8379","DOI":"10.1371\/journal.pone.0008379","article-title":"Development of functional human NK cells in an immunodeficient mouse model with the ability to provide protection against tumor challenge","volume":"4","author":"Kwant-Mitchell","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.bbmt.2015.01.018_bib51","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1038\/cmi.2012.17","article-title":"Generation of natural killer cells from hematopoietic stem cells in\u00a0vitro for immunotherapy","volume":"9","author":"Luevano","year":"2012","journal-title":"Cell Mol Immunol"}],"container-title":["Biology of Blood and Marrow Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S108387911500052X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S108387911500052X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T14:51:39Z","timestamp":1761058299000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S108387911500052X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5]]},"references-count":51,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,5]]}},"alternative-id":["S108387911500052X"],"URL":"https:\/\/doi.org\/10.1016\/j.bbmt.2015.01.018","relation":{},"ISSN":["1083-8791"],"issn-type":[{"value":"1083-8791","type":"print"}],"subject":[],"published":{"date-parts":[[2015,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Role of Donor Activating KIR\u2013HLA Ligand\u2013Mediated NK Cell Education Status in Control of Malignancy in\u00a0Hematopoietic Cell Transplant Recipients","name":"articletitle","label":"Article Title"},{"value":"Biology of Blood and Marrow Transplantation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbmt.2015.01.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 American Society for Blood and Marrow Transplantation. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}