{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T12:10:56Z","timestamp":1790511056716,"version":"4.1.0"},"reference-count":43,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2015,7,1]],"date-time":"2015-07-01T00:00:00Z","timestamp":1435708800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,7,1]],"date-time":"2015-07-01T00:00:00Z","timestamp":1435708800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"vor","delay-in-days":366,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["bbmt.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biology of Blood and Marrow Transplantation"],"published-print":{"date-parts":[[2015,7]]},"DOI":"10.1016\/j.bbmt.2015.04.010","type":"journal-article","created":{"date-parts":[[2015,4,13]],"date-time":"2015-04-13T13:01:43Z","timestamp":1428930103000},"page":"1215-1222","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"title":["Peripheral Blood CD38 Bright CD8+ Effector Memory T Cells Predict Acute Graft-versus-Host Disease"],"prefix":"10.1016","volume":"21","author":[{"given":"Pooja","family":"Khandelwal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Lane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijaya","family":"Chaturvedi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika","family":"Owsley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stella M.","family":"Davies","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Marmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra H.","family":"Filipovich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael B.","family":"Jordan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca A.","family":"Marsh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbmt.2015.04.010_bib1","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1016\/S0140-6736(09)60237-3","article-title":"Graft-versus-host disease","volume":"373","author":"Ferrara","year":"2009","journal-title":"Lancet"},{"key":"10.1016\/j.bbmt.2015.04.010_bib2","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1038\/bmt.2012.143","article-title":"Biomarkers for acute GVHD: can we predict the unpredictable?","volume":"48","author":"Chen","year":"2013","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.bbmt.2015.04.010_bib3","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1111\/bjh.12142","article-title":"Advances in predicting acute GVHD","volume":"160","author":"Harris","year":"2013","journal-title":"Br J Haematol"},{"key":"10.1016\/j.bbmt.2015.04.010_bib4","first-page":"185","article-title":"Serum concentration of the soluble interleukin-2 receptor for monitoring acute graft-versus-host disease","volume":"17","author":"Miyamoto","year":"1996","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.bbmt.2015.04.010_bib5","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1038\/bmt.2010.165","article-title":"Biomarkers of immune activation to screen for severe, acute GVHD","volume":"46","author":"August","year":"2011","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.bbmt.2015.04.010_bib6","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.bbmt.2008.04.002","article-title":"Plasma elevations of tumor necrosis factor-receptor-1 at day 7 postallogeneic transplant correlate with graft-versus-host disease severity and overall survival in pediatric patients","volume":"14","author":"Kitko","year":"2008","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.bbmt.2015.04.010_bib7","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1016\/j.bbmt.2010.05.001","article-title":"Diarrhea during the conditioning regimen is correlated with the occurrence of severe acute graft-versus-host disease through systemic release of inflammatory cytokines","volume":"16","author":"Liu","year":"2010","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.bbmt.2015.04.010_bib8","doi-asserted-by":"crossref","first-page":"3365","DOI":"10.1182\/blood-2013-06-510586","article-title":"Plasma microRNA signature as a noninvasive biomarker for acute graft-versus-host disease","volume":"122","author":"Xiao","year":"2013","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2015.04.010_bib9","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1182\/blood-2004-02-0518","article-title":"Proteomics applied to the clinical follow-up of patients after allogeneic hematopoietic stem cell transplantation","volume":"104","author":"Kaiser","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2015.04.010_bib10","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1038\/bmt.2010.300","article-title":"Plasma levels of IL-7 and IL-15 after reduced intensity conditioned allo-SCT and relationship to acute GVHD","volume":"46","author":"Thiant","year":"2011","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.bbmt.2015.04.010_bib11","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1038\/bmt.2010.13","article-title":"Plasma levels of IL-7 and IL-15 in the first month after myeloablative BMT are predictive biomarkers of both acute GVHD and relapse","volume":"45","author":"Thiant","year":"2010","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.bbmt.2015.04.010_bib12","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1182\/blood-2008-02-138867","article-title":"Change in plasma tumor necrosis factor receptor 1 levels in the first week after myeloablative allogeneic transplantation correlates with severity and incidence of GVHD and survival","volume":"112","author":"Choi","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2015.04.010_bib13","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1038\/bmt.2009.360","article-title":"Elevations of tumor necrosis factor receptor 1 at day 7 and acute graft-versus-host disease after allogeneic hematopoietic cell transplantation with nonmyeloablative conditioning","volume":"45","author":"Willems","year":"2010","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.bbmt.2015.04.010_bib14","first-page":"675","article-title":"Three biomarker panel at day 7 and 14 can predict development of grade II-IV acute graft-versus-host disease","volume":"116","author":"Paczesny","year":"2010","journal-title":"[ASH Annual Meeting Abstracts] Blood"},{"key":"10.1016\/j.bbmt.2015.04.010_bib15","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1056\/NEJMoa1213299","article-title":"ST2 as a marker for risk of therapy-resistant graft-versus-host disease and death","volume":"369","author":"Vander Lugt","year":"2013","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.bbmt.2015.04.010_bib16","doi-asserted-by":"crossref","first-page":"5938","DOI":"10.4049\/jimmunol.0802212","article-title":"Central memory CD8+ T cells induce graft-versus-host disease and mediate graft-versus-leukemia","volume":"182","author":"Zheng","year":"2009","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.bbmt.2015.04.010_bib17","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1016\/j.bbmt.2011.03.007","article-title":"Activation and expansion of CD8(+) T effector cells in patients with chronic graft-versus-host disease","volume":"17","author":"Grogan","year":"2011","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.bbmt.2015.04.010_bib18","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.bbmt.2012.12.003","article-title":"Lymphocyte phenotype during therapy for acute graft-versus-host disease: a brief report from BMT CTN 0302","volume":"19","author":"Bolanos-Meade","year":"2013","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.bbmt.2015.04.010_bib19","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.trsl.2007.06.003","article-title":"Pathophysiology of acute graft-versus-host disease: recent advances","volume":"150","author":"Sun","year":"2007","journal-title":"Transl Res"},{"key":"10.1016\/j.bbmt.2015.04.010_bib20","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1146\/annurev.immunol.22.012703.104702","article-title":"Central memory and effector memory T cell subsets: function, generation, and maintenance","volume":"22","author":"Sallusto","year":"2004","journal-title":"Ann Rev Immunol"},{"key":"10.1016\/j.bbmt.2015.04.010_bib21","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1038\/44385","article-title":"Two subsets of memory T lymphocytes with distinct homing potentials and effector functions","volume":"401","author":"Sallusto","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.bbmt.2015.04.010_bib22","doi-asserted-by":"crossref","first-page":"2476","DOI":"10.1182\/blood-2007-08-109678","article-title":"Effector memory CD4+ T cells mediate graft-versus-leukemia without inducing graft-versus-host disease","volume":"111","author":"Zheng","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2015.04.010_bib23","doi-asserted-by":"crossref","first-page":"6547","DOI":"10.4049\/jimmunol.179.10.6547","article-title":"Naive and memory T cells induce different types of graft-versus-host disease","volume":"179","author":"Dutt","year":"2007","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.bbmt.2015.04.010_bib24","doi-asserted-by":"crossref","first-page":"3230","DOI":"10.1182\/blood-2010-10-312751","article-title":"CD8+CD44(hi) but not CD4+CD44(hi) memory T cells mediate potent graft antilymphoma activity without GVHD","volume":"117","author":"Dutt","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2015.04.010_bib25","doi-asserted-by":"crossref","first-page":"3115","DOI":"10.1182\/blood-2006-04-016410","article-title":"Inability of memory T cells to induce graft-versus-host disease is a result of an abortive alloresponse","volume":"109","author":"Chen","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2015.04.010_bib26","doi-asserted-by":"crossref","first-page":"3970","DOI":"10.1182\/blood-2003-09-3135","article-title":"Dendritic cell-activated CD44hiCD8+ T cells are defective in mediating acute graft-versus-host disease but retain graft-versus-leukemia activity","volume":"103","author":"Zhang","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2015.04.010_bib27","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.bbmt.2014.01.002","article-title":"Immune cell subset counts associated with graft-versus-host disease","volume":"20","author":"Podgorny","year":"2014","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.bbmt.2015.04.010_bib28","doi-asserted-by":"crossref","first-page":"2216","DOI":"10.1182\/blood.V82.7.2216.2216","article-title":"Prediction of graft-versus-host disease by phenotypic analysis of early immune reconstitution after CD6-depleted allogeneic bone marrow transplantation","volume":"82","author":"Soiffer","year":"1993","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2015.04.010_bib29","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1182\/blood.V63.6.1416.1416","article-title":"T\u00a0lymphocyte repopulation and differentiation after bone marrow transplantation. Early shifts in the ratio between T4+ and T8+ T lymphocytes correlate with the occurrence of acute graft-versus-host disease","volume":"63","author":"Gratama","year":"1984","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2015.04.010_bib30","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1111\/j.1365-2249.2006.03104.x","article-title":"Activation-associated phenotype of CD3 T cells in acute graft-versus-host disease","volume":"145","author":"Paz Morante","year":"2006","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.bbmt.2015.04.010_bib31","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1002\/cyto.b.21092","article-title":"CD38 and CD157: a long journey from activation markers to multifunctional molecules","volume":"84","author":"Quarona","year":"2013","journal-title":"Cytometry B Clin Cytom"},{"key":"10.1016\/j.bbmt.2015.04.010_bib32","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1084\/jem.152.4.771","article-title":"Location of T cell and major histocompatibility complex antigens in the human thymus","volume":"152","author":"Bhan","year":"1980","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.bbmt.2015.04.010_bib33","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1016\/j.immuni.2008.02.020","article-title":"Human effector and memory CD8+ T cell responses to smallpox and yellow fever vaccines","volume":"28","author":"Miller","year":"2008","journal-title":"Immunity"},{"key":"10.1016\/j.bbmt.2015.04.010_bib34","doi-asserted-by":"crossref","first-page":"3470","DOI":"10.1182\/blood-2011-06-275610","article-title":"CD38 and chronic lymphocytic leukemia: a decade later","volume":"118","author":"Malavasi","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2015.04.010_bib35","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1093\/jnci\/djq256","article-title":"Functional role and prognostic significance of CD157 in ovarian carcinoma","volume":"102","author":"Ortolan","year":"2010","journal-title":"J\u00a0Natl Cancer Inst"},{"key":"10.1016\/j.bbmt.2015.04.010_bib36","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1111\/j.1365-3083.2009.02345.x","article-title":"Relevance of CD38 expression on CD8 T cells to evaluate antiretroviral therapy response in HIV-1-infected youths","volume":"71","author":"Rosso","year":"2010","journal-title":"Scand J Immunol"},{"key":"10.1016\/j.bbmt.2015.04.010_bib37","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1097\/00002030-200006160-00004","article-title":"Role of CD38 in HIV-1 infection: an epiphenomenon of T cell activation or an active player in virus\/host interactions?","volume":"14","author":"Savarino","year":"2000","journal-title":"AIDS"},{"key":"10.1016\/j.bbmt.2015.04.010_bib38","first-page":"99","article-title":"CD38\/CD31, a receptor\/ligand system ruling adhesion and signaling in human leukocytes","volume":"75","author":"Deaglio","year":"2000","journal-title":"Chem Immunol"},{"key":"10.1016\/j.bbmt.2015.04.010_bib39","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1097\/00007890-197410000-00001","article-title":"Clinical manifestations of graft-versus-host disease in human recipients of marrow from HL-A-matched sibling donors","volume":"18","author":"Glucksberg","year":"1974","journal-title":"Transplantation"},{"key":"10.1016\/j.bbmt.2015.04.010_bib40","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/j.bbmt.2014.01.018","article-title":"Early cytomegalovirus reactivation leaves a specific and dynamic imprint on the reconstituting T cell compartment long-term after hematopoietic stem cell transplantation","volume":"20","author":"Lugthart","year":"2014","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.bbmt.2015.04.010_bib41","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1038\/33340","article-title":"Chemokines and leukocyte traffic","volume":"392","author":"Baggiolini","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.bbmt.2015.04.010_bib42","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1126\/science.272.5258.60","article-title":"Lymphocyte homing and homeostasis","volume":"272","author":"Butcher","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.bbmt.2015.04.010_bib43","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1056\/NEJMoa1201248","article-title":"Blockade of lymphocyte chemotaxis in visceral graft-versus-host disease","volume":"367","author":"Reshef","year":"2012","journal-title":"N\u00a0Engl J Med"}],"container-title":["Biology of Blood and Marrow Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1083879115002542?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1083879115002542?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T14:51:03Z","timestamp":1761058263000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1083879115002542"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7]]},"references-count":43,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2015,7]]}},"alternative-id":["S1083879115002542"],"URL":"https:\/\/doi.org\/10.1016\/j.bbmt.2015.04.010","relation":{},"ISSN":["1083-8791"],"issn-type":[{"value":"1083-8791","type":"print"}],"subject":[],"published":{"date-parts":[[2015,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Peripheral Blood CD38 Bright CD8+ Effector Memory T Cells Predict Acute Graft-versus-Host Disease","name":"articletitle","label":"Article Title"},{"value":"Biology of Blood and Marrow Transplantation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbmt.2015.04.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 American Society for Blood and Marrow Transplantation. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}