{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T12:35:13Z","timestamp":1782995713041,"version":"3.54.5"},"reference-count":38,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"HHV6 Foundation"}],"content-domain":{"domain":["bbmt.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biology of Blood and Marrow Transplantation"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1016\/j.bbmt.2016.09.018","type":"journal-article","created":{"date-parts":[[2016,10,5]],"date-time":"2016-10-05T02:12:53Z","timestamp":1475633573000},"page":"2250-2255","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":37,"title":["Human Herpesvirus 6 Infection Following Haploidentical Transplantation: Immune Recovery and Outcome"],"prefix":"10.1016","volume":"22","author":[{"given":"Raffaella","family":"Greco","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lara","family":"Crucitti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maddalena","family":"Noviello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2389-3716","authenticated-orcid":false,"given":"Sara","family":"Racca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Mannina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Forcina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3596-9810","authenticated-orcid":false,"given":"Francesca","family":"Lorentino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronica","family":"Valtolina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serena","family":"Rolla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roee","family":"Dvir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mara","family":"Morelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Giglio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0499-9005","authenticated-orcid":false,"given":"Maria Chiara","family":"Barbanti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Teresa","family":"Lupo Stanghellini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Oltolini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Vago","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Scarpellini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Assanelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo G.","family":"Carrabba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Marktel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Bernardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Consuelo","family":"Corti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Clementi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacopo","family":"Peccatori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Bonini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Ciceri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbmt.2016.09.018_bib0010","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1038\/bmt.2008.162","article-title":"Management of CMV, HHV-6, HHV-7 and Kaposi sarcoma herpesvirus (HHV-8) infections in patients with hematological malignancies and after SCT","volume":"42","author":"Ljungman","year":"2008","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.bbmt.2016.09.018_bib0015","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1016\/S0140-6736(88)91883-1","article-title":"Age prevalence of antibody to human herpesvirus 6","volume":"1","author":"Briggs","year":"1988","journal-title":"Lancet"},{"key":"10.1016\/j.bbmt.2016.09.018_bib0020","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1128\/jcm.27.4.651-653.1989","article-title":"Seroepidemiology of human herpesvirus 6 infection in normal children and adults","volume":"27","author":"Okuno","year":"1989","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.bbmt.2016.09.018_bib0025","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1056\/NEJMoa042207","article-title":"A population-based study of primary human herpesvirus 6 infection","volume":"352","author":"Zerr","year":"2005","journal-title":"N Engl J Med"},{"issue":"Pt 6","key":"10.1016\/j.bbmt.2016.09.018_bib0030","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1099\/0022-1317-72-6-1401","article-title":"Latent human herpesvirus 6 infection of human monocytes\/macrophages","volume":"72","author":"Kondo","year":"1991","journal-title":"J Gen Virol"},{"key":"10.1016\/j.bbmt.2016.09.018_bib0035","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/sj.bmt.1705671","article-title":"Active CMV disease does not always correlate with viral load detection","volume":"40","author":"Ruell","year":"2007","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.bbmt.2016.09.018_bib0040","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1128\/CMR.18.1.217-245.2005","article-title":"Update on human herpesvirus 6 biology, clinical features, and therapy","volume":"18","author":"De Bolle","year":"2005","journal-title":"Clin Microbiol Rev"},{"key":"10.1016\/j.bbmt.2016.09.018_bib0045","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1128\/jcm.31.5.1262-1267.1993","article-title":"Human herpesvirus 6 DNA in peripheral blood cells and saliva from immunocompetent individuals","volume":"31","author":"Cone","year":"1993","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.bbmt.2016.09.018_bib0050","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1086\/428060","article-title":"Clinical outcomes of human herpesvirus 6 reactivation after hematopoietic stem cell transplantation","volume":"40","author":"Zerr","year":"2005","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.bbmt.2016.09.018_bib0055","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1182\/blood.V78.5.1381.1381","article-title":"Human herpesvirus-6 infection in bone marrow transplantation","volume":"78","author":"Yoshikawa","year":"1991","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2016.09.018_bib0060","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1046\/j.1365-2141.2003.04048.x","article-title":"Human herpesvirus 6: relevance of infection in the immunocompromised host","volume":"120","author":"Clark","year":"2003","journal-title":"Br J Haematol"},{"key":"10.1016\/j.bbmt.2016.09.018_bib0065","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1097\/QCO.0b013e3283553362","article-title":"Human herpesvirus 6 (HHV-6) disease in the setting of transplantation","volume":"25","author":"Zerr","year":"2012","journal-title":"Curr Opin Infect Dis"},{"key":"10.1016\/j.bbmt.2016.09.018_bib0070","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1111\/j.1365-2141.2000.02422.x","article-title":"High levels of human herpesvirus 6 DNA in peripheral blood leucocytes are correlated to platelet engraftment and disease in allogeneic stem cell transplant patients","volume":"111","author":"Ljungman","year":"2000","journal-title":"Br J Haematol"},{"key":"10.1016\/j.bbmt.2016.09.018_bib0075","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1056\/NEJM199307153290302","article-title":"Human herpesvirus 6 in lung tissue from patients with pneumonitis after bone marrow transplantation","volume":"329","author":"Cone","year":"1993","journal-title":"N Engl J Med"},{"key":"10.1016\/j.bbmt.2016.09.018_bib0080","doi-asserted-by":"crossref","first-page":"5341","DOI":"10.1182\/blood.V87.12.5341.bloodjournal87125341","article-title":"Human herpesvirus 6: infection and disease following autologous and allogeneic bone marrow transplantation","volume":"87","author":"Kadakia","year":"1996","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2016.09.018_bib0085","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1086\/314581","article-title":"Human herpesvirus 6 infections after bone marrow transplantation: clinical and virologic manifestations","volume":"179","author":"Cone","year":"1999","journal-title":"J Infect Dis"},{"key":"10.1016\/j.bbmt.2016.09.018_bib0090","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1093\/infdis\/167.3.735","article-title":"Human herpesvirus-6 (HHV-6) infection in allogeneic bone marrow transplant recipients: evidence of a marrow-suppressive role for HHV-6 in vivo","volume":"167","author":"Drobyski","year":"1993","journal-title":"J Infect Dis"},{"key":"10.1016\/j.bbmt.2016.09.018_bib0095","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1086\/322642","article-title":"Human herpesvirus 6 reactivation and encephalitis in allogeneic bone marrow transplant recipients","volume":"33","author":"Zerr","year":"2001","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.bbmt.2016.09.018_bib0100","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.jcv.2008.08.008","article-title":"Human herpesvirus type 6 reactivation after haematopoietic stem cell transplantation","volume":"43","author":"de Pagter","year":"2008","journal-title":"J Clin Virol"},{"key":"10.1016\/j.bbmt.2016.09.018_bib0105","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1111\/j.1600-6143.2009.02685.x","article-title":"Prevalence of human herpesvirus-6 chromosomal integration (CIHHV-6) in Italian solid organ and allogeneic stem cell transplant patients","volume":"9","author":"Potenza","year":"2009","journal-title":"Am J Transplant"},{"key":"10.1016\/j.bbmt.2016.09.018_bib0110","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1002\/rmv.715","article-title":"Chromosomally integrated human herpesvirus 6: questions and answers","volume":"22","author":"Pellett","year":"2012","journal-title":"Rev Med Virol"},{"key":"10.1016\/j.bbmt.2016.09.018_bib0115","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1016\/j.bbmt.2011.12.579","article-title":"Early human herpesvirus type 6 reactivation after allogeneic stem cell transplantation: a large-scale clinical study","volume":"18","author":"Dulery","year":"2012","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.bbmt.2016.09.018_bib0120","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1086\/339411","article-title":"Human herpesvirus 6 viremia in bone marrow transplant recipients: clinical features and risk factors","volume":"185","author":"Yoshikawa","year":"2002","journal-title":"J Infect Dis"},{"key":"10.1016\/j.bbmt.2016.09.018_bib0125","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1038\/leu.2014.180","article-title":"Sirolimus-based graft-versus-host disease prophylaxis promotes the in vivo expansion of regulatory T cells and permits peripheral blood stem cell transplantation from haploidentical donors","volume":"29","author":"Peccatori","year":"2015","journal-title":"Leukemia"},{"key":"10.1016\/j.bbmt.2016.09.018_bib0130","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1016\/j.bbmt.2015.04.025","article-title":"Post-transplantation cyclophosphamide and sirolimus after haploidentical hematopoietic stem cell transplantation using a treosulfan-based myeloablative conditioning and peripheral blood stem cells","volume":"21","author":"Cieri","year":"2015","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.bbmt.2016.09.018_bib0135","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1086\/498531","article-title":"Human herpesvirus 6 DNA in plasma after allogeneic stem cell transplantation: incidence and clinical significance","volume":"193","author":"Ogata","year":"2006","journal-title":"J Infect Dis"},{"key":"10.1016\/j.bbmt.2016.09.018_bib0140","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1111\/j.1365-2141.2004.05254.x","article-title":"Impact of human herpesvirus-6 after haematopoietic stem cell transplantation","volume":"128","author":"Hentrich","year":"2005","journal-title":"Br J Haematol"},{"key":"10.1016\/j.bbmt.2016.09.018_bib0145","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/S0140-6736(87)92088-5","article-title":"Herpesvirus immunity and acute graft-versus-host disease","volume":"1","author":"Gratama","year":"1987","journal-title":"Lancet"},{"key":"10.1016\/j.bbmt.2016.09.018_bib0150","doi-asserted-by":"crossref","first-page":"8280","DOI":"10.1128\/JVI.77.15.8280-8289.2003","article-title":"Pathogenic effects of human herpesvirus 6 in human lymphoid tissue ex vivo","volume":"77","author":"Grivel","year":"2003","journal-title":"J Virol"},{"key":"10.1016\/j.bbmt.2016.09.018_bib0155","doi-asserted-by":"crossref","first-page":"9096","DOI":"10.1073\/pnas.1305187110","article-title":"CD134 is a cellular receptor specific for human herpesvirus-6B entry","volume":"110","author":"Tang","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.bbmt.2016.09.018_bib0160","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/j.bbmt.2008.02.010","article-title":"CD134-allodepletion allows selective elimination of alloreactive human T cells without loss of virus-specific and leukemia-specific effectors","volume":"14","author":"Ge","year":"2008","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.bbmt.2016.09.018_bib0165","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1097\/INF.0000000000000824","article-title":"Reactivation of human herpesvirus 6 after pediatric stem cell transplantation: risk factors, onset, clinical symptoms and association with severity of acute graft-versus-host disease","volume":"34","author":"Verhoeven","year":"2015","journal-title":"Pediatr Infect Dis J"},{"issue":"Suppl 2","key":"10.1016\/j.bbmt.2016.09.018_bib0170","first-page":"S72","article-title":"Immune reconstitution and viral infections after stem cell transplantation","volume":"21","author":"Ljungman","year":"1998","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.bbmt.2016.09.018_bib0175","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1038\/bmt.2015.132","article-title":"Early recovery of CMV immunity after HLA-haploidentical hematopoietic stem cell transplantation as a surrogate biomarker for a reduced risk of severe infections overall","volume":"50","author":"Noviello","year":"2015","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.bbmt.2016.09.018_bib0180","doi-asserted-by":"crossref","first-page":"4776","DOI":"10.1128\/JVI.06573-11","article-title":"Human CD4+ T cell response to human herpesvirus 6","volume":"86","author":"Nastke","year":"2012","journal-title":"J Virol"},{"key":"10.1016\/j.bbmt.2016.09.018_bib0185","doi-asserted-by":"crossref","first-page":"5442","DOI":"10.1128\/JVI.00106-09","article-title":"Differential effect of human herpesvirus 6A on cell division and apoptosis among naive and central and effector memory CD4+ and CD8+ T-cell subsets","volume":"83","author":"Gupta","year":"2009","journal-title":"J Virol"},{"key":"10.1016\/j.bbmt.2016.09.018_bib0190","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.clim.2012.06.006","article-title":"First analysis of human herpesvirus 6T-cell responses: specific boosting after HHV-6 reactivation in stem cell transplantation recipients","volume":"144","author":"de Pagter","year":"2012","journal-title":"Clin Immunol"},{"key":"10.1016\/j.bbmt.2016.09.018_bib0195","doi-asserted-by":"crossref","first-page":"95","DOI":"10.3389\/fphar.2015.00095","article-title":"Improving the safety of cell therapy with the TK-suicide gene","volume":"6","author":"Greco","year":"2015","journal-title":"Front Pharmacol"}],"container-title":["Biology of Blood and Marrow Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1083879116303585?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1083879116303585?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T14:56:52Z","timestamp":1761058612000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1083879116303585"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12]]},"references-count":38,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["S1083879116303585"],"URL":"https:\/\/doi.org\/10.1016\/j.bbmt.2016.09.018","relation":{},"ISSN":["1083-8791"],"issn-type":[{"value":"1083-8791","type":"print"}],"subject":[],"published":{"date-parts":[[2016,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Human Herpesvirus 6 Infection Following Haploidentical Transplantation: Immune Recovery and Outcome","name":"articletitle","label":"Article Title"},{"value":"Biology of Blood and Marrow Transplantation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbmt.2016.09.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 American Society for Blood and Marrow Transplantation.","name":"copyright","label":"Copyright"}]}}