{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T04:58:32Z","timestamp":1787979512732,"version":"build-2784847793"},"reference-count":53,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008980","name":"Medical College of Wisconsin","doi-asserted-by":"publisher","award":["K23 HL123601-01"],"award-info":[{"award-number":["K23 HL123601-01"]}],"id":[{"id":"10.13039\/100008980","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bbmt.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biology of Blood and Marrow Transplantation"],"published-print":{"date-parts":[[2017,3]]},"DOI":"10.1016\/j.bbmt.2016.12.628","type":"journal-article","created":{"date-parts":[[2016,12,22]],"date-time":"2016-12-22T03:15:55Z","timestamp":1482376555000},"page":"498-504","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":120,"title":["Alternative Donor Transplantation with High-Dose Post-Transplantation Cyclophosphamide for Refractory Severe Aplastic Anemia"],"prefix":"10.1016","volume":"23","author":[{"given":"Amy E.","family":"DeZern","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianna","family":"Zahurak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather","family":"Symons","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth","family":"Cooke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard J.","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A.","family":"Brodsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbmt.2016.12.628_bib0010","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1016\/S0140-6736(05)66515-4","article-title":"Aplastic anaemia","volume":"365","author":"Brodsky","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.bbmt.2016.12.628_bib0015","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1182\/blood-2011-12-274019","article-title":"How I treat acquired aplastic anemia","volume":"120","author":"Scheinberg","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2016.12.628_bib0020","doi-asserted-by":"crossref","first-page":"489","DOI":"10.3324\/haematol.12855","article-title":"The epidemiology of acquired aplastic anemia","volume":"93","author":"Young","year":"2008","journal-title":"Haematologica"},{"key":"10.1016\/j.bbmt.2016.12.628_bib0025","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/S0031-3955(02)00031-7","article-title":"Bone marrow failure syndromes in children","volume":"49","author":"Alter","year":"2002","journal-title":"Pediatr Clin North Am"},{"key":"10.1016\/j.bbmt.2016.12.628_bib0030","series-title":"Acquired Bone Marrow Failure","author":"Young","year":"1995"},{"key":"10.1016\/j.bbmt.2016.12.628_bib0035","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1182\/asheducation-2007.1.29","article-title":"Diagnosis, genetics, and management of inherited bone marrow failure syndromes","author":"Alter","year":"2007","journal-title":"Hematology Am Soc Hematol Educ Program"},{"key":"10.1016\/j.bbmt.2016.12.628_bib0040","doi-asserted-by":"crossref","first-page":"1872","DOI":"10.1056\/NEJMra0902908","article-title":"Myelodysplastic syndromes","volume":"361","author":"Tefferi","year":"2009","journal-title":"N Engl J Med"},{"key":"10.1016\/j.bbmt.2016.12.628_bib0045","first-page":"7233","article-title":"Absence of the wild-type allele predicts poor prognosis in adult de novo acute myeloid leukemia with normal cytogenetics and the internal tandem duplication of FLT3: a cancer and leukemia group B study","volume":"61","author":"Whitman","year":"2001","journal-title":"Cancer Res"},{"key":"10.1016\/j.bbmt.2016.12.628_bib0050","doi-asserted-by":"crossref","first-page":"1868","DOI":"10.3324\/haematol.2014.108977","article-title":"Myelodysplastic syndrome evolving from aplastic anemia treated with immunosuppressive therapy: efficacy of hematopoietic stem cell transplantation","volume":"99","author":"Kim","year":"2014","journal-title":"Haematologica"},{"key":"10.1016\/j.bbmt.2016.12.628_bib0055","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1182\/asheducation.V2012.1.292.3798310","article-title":"Aplastic anemia: therapeutic updates in immunosuppression and transplantation","volume":"2012","author":"Scheinberg","year":"2012","journal-title":"Hematology Am Soc Hematol Educ Program"},{"key":"10.1016\/j.bbmt.2016.12.628_bib0060","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1182\/asheducation-2010.1.43","article-title":"Alternative donor transplantation for aplastic anemia","volume":"2010","author":"Eapen","year":"2010","journal-title":"Hematology Am Soc Hematol Educ Program"},{"key":"10.1016\/j.bbmt.2016.12.628_bib0065","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1053\/bbmt.2001.v7.pm11215697","article-title":"Cyclophosphamide and antithymocyte globulin to condition patients with aplastic anemia for allogeneic marrow transplantations: the experience in four centers","volume":"7","author":"Storb","year":"2001","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.bbmt.2016.12.628_bib0070","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.hoc.2009.01.005","article-title":"Diagnosis and treatment of acquired aplastic anemia","volume":"23","author":"Bacigalupo","year":"2009","journal-title":"J Hematol Oncol Clin North Am"},{"key":"10.1016\/j.bbmt.2016.12.628_bib0075","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1182\/asheducation.V2012.1.223.3798305","article-title":"Matched and mismatched unrelated donor transplantation: is the outcome the same as for matched sibling donor transplantation?","volume":"2012","author":"Bacigalupo","year":"2012","journal-title":"Hematology Am Soc Hematol Educ Program"},{"key":"10.1016\/j.bbmt.2016.12.628_bib0080","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1056\/NEJMoa1103975","article-title":"Horse versus rabbit antithymocyte globulin in acquired aplastic anemia","volume":"365","author":"Scheinberg","year":"2011","journal-title":"N Engl J Med"},{"key":"10.1016\/j.bbmt.2016.12.628_bib0085","article-title":"Long-term issues after immunosuppressive therapy for aplastic anemia","author":"de Fontebrune","year":"2016","journal-title":"Curr Drug Targets"},{"key":"10.1016\/j.bbmt.2016.12.628_bib0090","doi-asserted-by":"crossref","first-page":"1818","DOI":"10.1182\/blood-2013-10-534743","article-title":"Eltrombopag restores trilineage hematopoiesis in refractory severe aplastic anemia that can be sustained on discontinuation of drug","volume":"123","author":"Desmond","year":"2014","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2016.12.628_bib0095","doi-asserted-by":"crossref","first-page":"3561","DOI":"10.1182\/blood-2013-05-498279","article-title":"Management of the refractory aplastic anemia patient: what are the options?","volume":"122","author":"Marsh","year":"2013","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2016.12.628_bib0100","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1111\/j.1365-2141.2009.07842.x","article-title":"Guidelines for the diagnosis and management of aplastic anaemia","volume":"147","author":"Marsh","year":"2009","journal-title":"Br J Haematol"},{"key":"10.1016\/j.bbmt.2016.12.628_bib0105","doi-asserted-by":"crossref","first-page":"3152","DOI":"10.1200\/JCO.2014.60.4777","article-title":"Outcomes of nonmyeloablative HLA-haploidentical blood or marrow transplantation with high-dose post-transplantation cyclophosphamide in older adults","volume":"33","author":"Kasamon","year":"2015","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.bbmt.2016.12.628_bib0110","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1097\/MOH.0b013e32833eaf1b","article-title":"High-dose cyclophosphamide for graft-versus-host disease prevention","volume":"17","author":"Luznik","year":"2010","journal-title":"Curr Opin Hematol"},{"key":"10.1016\/j.bbmt.2016.12.628_bib0115","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/j.bbmt.2008.03.005","article-title":"HLA-haploidentical bone marrow transplantation for hematologic malignancies using nonmyeloablative conditioning and high-dose, posttransplantation cyclophosphamide","volume":"14","author":"Luznik","year":"2008","journal-title":"Biol Blood Marrow Transplant"},{"issue":"1 suppl","key":"10.1016\/j.bbmt.2016.12.628_bib0120","doi-asserted-by":"crossref","first-page":"S6","DOI":"10.1016\/j.bbmt.2012.10.007","article-title":"HCT for nonmalignant disorders","volume":"19","author":"Tisdale","year":"2013","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.bbmt.2016.12.628_bib0125","doi-asserted-by":"crossref","first-page":"4285","DOI":"10.1182\/blood-2012-07-438408","article-title":"HLA-haploidentical bone marrow transplantation with posttransplant cyclophosphamide expands the donor pool for patients with sickle cell disease","volume":"120","author":"Bolanos-Meade","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2016.12.628_bib0130","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1182\/blood.V48.1.63.63","article-title":"Severe aplastic anemia: a prospective study of the effect of early marrow transplantation on acute mortality","volume":"48","author":"Camitta","year":"1976","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2016.12.628_bib0135","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/S0091-679X(04)75031-1","article-title":"Telomere length measurements using fluorescence in situ hybridization and flow cytometry","volume":"75","author":"Baerlocher","year":"2004","journal-title":"Methods Cell Biol"},{"key":"10.1016\/j.bbmt.2016.12.628_bib0140","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1111\/bjh.13297","article-title":"Outcome of aplastic anaemia in children. A study by the Severe Aplastic Anaemia and Paediatric Disease Working Parties of the European Group Blood and Bone Marrow Transplant","volume":"169","author":"Dufour","year":"2015","journal-title":"Br J Haematol"},{"key":"10.1016\/j.bbmt.2016.12.628_bib0145","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/bjh.13853","article-title":"Guidelines for the diagnosis and management of adult aplastic anaemia","volume":"172","author":"Killick","year":"2016","journal-title":"Br J Haematol"},{"key":"10.1016\/j.bbmt.2016.12.628_bib0150","doi-asserted-by":"crossref","first-page":"884","DOI":"10.3324\/haematol.2015.138727","article-title":"Unrelated alternative donor transplantation for severe acquired aplastic anemia: a study from the French Society of Bone Marrow Transplantation and Cell Therapies and the EBMT Severe Aplastic Anemia Working Party","volume":"101","author":"Devillier","year":"2016","journal-title":"Haematologica"},{"key":"10.1016\/j.bbmt.2016.12.628_bib0155","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1038\/bmt.2010.213","article-title":"Post-transplantation cyclophosphamide for GVHD prophylaxis in severe aplastic anemia","volume":"46","author":"Dezern","year":"2011","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.bbmt.2016.12.628_bib0160","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1056\/NEJMsa1311707","article-title":"HLA match likelihoods for hematopoietic stem-cell grafts in the U.S. registry","volume":"371","author":"Gragert","year":"2014","journal-title":"N Engl J Med"},{"key":"10.1016\/j.bbmt.2016.12.628_bib0165","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1038\/sj.bmt.1702845","article-title":"Non-HLA barriers to unrelated donor stem cell transplantation","volume":"27","author":"Kollman","year":"2001","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.bbmt.2016.12.628_bib0170","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.bbmt.2009.01.017","article-title":"Rapid transport and infusion of hematopoietic cells is associated with improved outcome after myeloablative therapy and unrelated donor transplant","volume":"15","author":"Lazarus","year":"2009","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.bbmt.2016.12.628_bib0175","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.bbmt.2010.10.028","volume":"17","author":"Pulsipher","year":"2011","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.bbmt.2016.12.628_bib0180","doi-asserted-by":"crossref","first-page":"2136","DOI":"10.1182\/blood-2009-06-225375","article-title":"High-dose cyclophosphamide for severe aplastic anemia: long-term follow-up","volume":"115","author":"Brodsky","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2016.12.628_bib0185","doi-asserted-by":"crossref","first-page":"e367","DOI":"10.1016\/S2352-3026(15)00147-7","article-title":"Cyclophosphamide conditioning in patients with severe aplastic anaemia given unrelated marrow transplantation: a phase 1-2 dose de-escalation study","volume":"2","author":"Anderlini","year":"2015","journal-title":"Lancet Haematol"},{"key":"10.1016\/j.bbmt.2016.12.628_bib0190","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1111\/bjh.14225","article-title":"Haplo-identical transplantation for acquired severe aplastic anaemia in a multicentre prospective study","volume":"175","author":"Xu","year":"2016","journal-title":"Br J Haematol"},{"key":"10.1016\/j.bbmt.2016.12.628_bib0195","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1111\/bjh.14110","article-title":"Unmanipulated haploidentical haematopoietic stem cell transplantation for children with severe aplastic anaemia","volume":"174","author":"Zhu","year":"2016","journal-title":"Br J Haematol"},{"key":"10.1016\/j.bbmt.2016.12.628_bib0200","article-title":"Comparison of haploidentical hematopoietic stem cell transplantation and immunosuppressive therapy for the treatment of acquired severe aplastic anemia in pediatric patients","author":"Zhang","year":"2016","journal-title":"Am J Ther"},{"key":"10.1016\/j.bbmt.2016.12.628_bib0205","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1038\/bmt.2015.251","article-title":"Unmanipulated haploidentical hematopoietic cell transplantation with post-transplant cyclophosphamide in a patient with paroxysmal nocturnal hemoglobinuria and secondary aplastic anemia","volume":"51","author":"Sarmiento","year":"2016","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.bbmt.2016.12.628_bib0210","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1038\/bmt.2015.20","article-title":"Haploidentical BMT and post-transplant Cy for severe aplastic anemia: a multicenter retrospective study","volume":"50","author":"Esteves","year":"2015","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.bbmt.2016.12.628_bib0215","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1038\/bmt.2014.187","article-title":"Good outcome of haploidentical hematopoietic SCT as a salvage therapy in children and adolescents with acquired severe aplastic anemia","volume":"49","author":"Wang","year":"2014","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.bbmt.2016.12.628_bib0220","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1016\/j.bbmt.2014.06.028","article-title":"Nonmyeloablative peripheral blood haploidentical stem cell transplantation for refractory severe aplastic anemia","volume":"20","author":"Clay","year":"2014","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.bbmt.2016.12.628_bib0225","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1038\/bmt.2013.224","article-title":"Long-term outcome of HLA-haploidentical hematopoietic SCT without in vitro T-cell depletion for adult severe aplastic anemia after modified conditioning and supportive therapy","volume":"49","author":"Gao","year":"2014","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.bbmt.2016.12.628_bib0230","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1182\/blood-2016-01-636381","article-title":"Clonal hematopoiesis in acquired aplastic anemia","volume":"128","author":"Ogawa","year":"2016","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2016.12.628_bib0235","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1056\/NEJMoa1414799","article-title":"Somatic mutations and clonal hematopoiesis in aplastic anemia","volume":"373","author":"Yoshizato","year":"2015","journal-title":"N Engl J Med"},{"key":"10.1016\/j.bbmt.2016.12.628_bib0240","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.3324\/haematol.2016.149476","article-title":"Genetic features of myelodysplastic syndrome and aplastic anemia in pediatric and young adult patients","volume":"101","author":"Keel","year":"2016","journal-title":"Haematologica"},{"key":"10.1016\/j.bbmt.2016.12.628_bib0245","doi-asserted-by":"crossref","first-page":"2698","DOI":"10.1182\/blood-2014-05-574889","article-title":"Somatic mutations identify a subgroup of aplastic anemia patients who progress to myelodysplastic syndrome","volume":"124","author":"Kulasekararaj","year":"2014","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2016.12.628_bib0250","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1056\/NEJM199310143291603","article-title":"Malignant tumors occurring after treatment of aplastic anemia","volume":"329","author":"Socie","year":"1993","journal-title":"N Engl J Med"},{"key":"10.1016\/j.bbmt.2016.12.628_bib0255","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1111\/j.1600-0609.2011.01615.x","article-title":"Natural history of paroxysmal nocturnal hemoglobinuria clones in patients presenting as aplastic anemia","volume":"87","author":"Pu","year":"2011","journal-title":"Eur J Haematol"},{"key":"10.1016\/j.bbmt.2016.12.628_bib0260","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1111\/ejh.12021","article-title":"Predictors of hemoglobin response to eculizumab therapy in paroxysmal nocturnal hemoglobinuria","volume":"90","author":"DeZern","year":"2013","journal-title":"Eur J Haematol"},{"key":"10.1016\/j.bbmt.2016.12.628_bib0265","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1046\/j.1365-2141.2002.03518.x","article-title":"Aplastic anaemia with 13q-: a benign subset of bone marrow failure responsive to immunosuppressive therapy","volume":"117","author":"Ishiyama","year":"2002","journal-title":"Br J Haematol"},{"key":"10.1016\/j.bbmt.2016.12.628_bib0270","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.3324\/haematol.2011.061127","article-title":"Favorable outcome of patients who have 13q deletion: a suggestion for revision of the WHO \u201cMDS-U\u201d designation","volume":"97","author":"Hosokawa","year":"2012","journal-title":"Haematologica"}],"container-title":["Biology of Blood and Marrow Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1083879116311879?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1083879116311879?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T14:59:00Z","timestamp":1761058740000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1083879116311879"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3]]},"references-count":53,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,3]]}},"alternative-id":["S1083879116311879"],"URL":"https:\/\/doi.org\/10.1016\/j.bbmt.2016.12.628","relation":{},"ISSN":["1083-8791"],"issn-type":[{"value":"1083-8791","type":"print"}],"subject":[],"published":{"date-parts":[[2017,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Alternative Donor Transplantation with High-Dose Post-Transplantation Cyclophosphamide for Refractory Severe Aplastic Anemia","name":"articletitle","label":"Article Title"},{"value":"Biology of Blood and Marrow Transplantation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbmt.2016.12.628","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 American Society for Blood and Marrow Transplantation.","name":"copyright","label":"Copyright"}]}}