{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T02:21:07Z","timestamp":1788315667132,"version":"build-2803163510"},"reference-count":98,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Matlin Fund"},{"name":"Sawiris Research Fund"}],"content-domain":{"domain":["bbmt.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biology of Blood and Marrow Transplantation"],"published-print":{"date-parts":[[2018,3]]},"DOI":"10.1016\/j.bbmt.2017.10.022","type":"journal-article","created":{"date-parts":[[2017,10,16]],"date-time":"2017-10-16T17:15:49Z","timestamp":1508174149000},"page":"425-432","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"title":["Unlocking the Complex Flavors of Dysgeusia after Hematopoietic Cell Transplantation"],"prefix":"10.1016","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9484-0240","authenticated-orcid":false,"given":"Michael","family":"Scordo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunjan L.","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4029-7625","authenticated-orcid":false,"given":"Jonathan U.","family":"Peled","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elaina V.","family":"Preston","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marissa L.","family":"Buchan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel B.","family":"Epstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrei","family":"Barasch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio A.","family":"Giralt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbmt.2017.10.022_bib0010","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.oraloncology.2009.11.008","article-title":"Taste disorders in cancer patients: pathogenesis, and approach to assessment and management","volume":"46","author":"Epstein","year":"2010","journal-title":"Oral Oncol"},{"key":"10.1016\/j.bbmt.2017.10.022_bib0015","doi-asserted-by":"crossref","first-page":"2201","DOI":"10.1200\/JCO.2001.19.8.2201","article-title":"Oral mucositis and the clinical and economic outcomes of hematopoietic stem-cell transplantation","volume":"19","author":"Sonis","year":"2001","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.bbmt.2017.10.022_bib0020","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1038\/sj.bmt.1703716","article-title":"Quality of life, taste, olfactory and oral function following high-dose chemotherapy and allogeneic hematopoietic cell transplantation","volume":"30","author":"Epstein","year":"2002","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.bbmt.2017.10.022_bib0025","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/j.bbmt.2015.09.014","article-title":"The incidence and severity of oral mucositis among allogeneic hematopoietic stem cell transplantation patients: a systematic review","volume":"22","author":"Chaudhry","year":"2016","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.bbmt.2017.10.022_bib0030","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1164\/rccm.201507-1491OC","article-title":"Gut microbiota predict pulmonary infiltrates after allogeneic hematopoietic cell transplantation","volume":"194","author":"Harris","year":"2016","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.bbmt.2017.10.022_bib0035","doi-asserted-by":"crossref","first-page":"2607","DOI":"10.1182\/blood-2016-06-724005","article-title":"Strategies before, during, and after hematopoietic cell transplantation to improve T-cell immune-reconstitution","volume":"128","author":"De Koning","year":"2016","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2017.10.022_bib0040","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/s00784-010-0450-6","article-title":"Oral chronic graft-versus-host disease: report from the International Consensus Conference on clinical practice in cGVHD","volume":"15","author":"Meier","year":"2011","journal-title":"Clin Oral Investig"},{"key":"10.1016\/j.bbmt.2017.10.022_bib0045","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1038\/bmt.2009.237","article-title":"Taste disorders and oral evaluation in patients undergoing allogeneic hematopoietic SCT","volume":"45","author":"Boer","year":"2010","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.bbmt.2017.10.022_bib0050","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1016\/j.bbmt.2015.07.032","article-title":"Indications for autologous and allogeneic hematopoietic cell transplantation: guidelines from the American Society for Blood and Marrow Transplantation","volume":"21","author":"Majhail","year":"2015","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.bbmt.2017.10.022_bib0055","doi-asserted-by":"crossref","first-page":"S68","DOI":"10.1016\/j.bbmt.2015.11.360","article-title":"Increasing use of allogeneic hematopoietic cell transplantation (HCT) in patients age 70 years and older: a CIBMTR study of trends and outcomes","volume":"22","author":"Muffly","year":"2016","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.bbmt.2017.10.022_bib0060","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1083\/jcb.201003144","article-title":"The cell biology of taste","volume":"190","author":"Chaudhari","year":"2010","journal-title":"J Cell Biol"},{"key":"10.1016\/j.bbmt.2017.10.022_bib0065","doi-asserted-by":"crossref","first-page":"3474","DOI":"10.1523\/JNEUROSCI.4167-11.2012","article-title":"Mechanisms of taste bud cell loss after head and neck irradiation","volume":"32","author":"Nguyen","year":"2012","journal-title":"J Neurosci"},{"key":"10.1016\/j.bbmt.2017.10.022_bib0070","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/nrn1344","article-title":"Molecular mechanisms of taste-recognition memory","volume":"5","author":"Berm\u00fadez-Rattoni","year":"2004","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.bbmt.2017.10.022_bib0075","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1126\/science.1204076","article-title":"A gustotopic map of taste qualities in the mammalian brain","volume":"333","author":"Chen","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.bbmt.2017.10.022_bib0080","doi-asserted-by":"crossref","first-page":"S7","DOI":"10.1038\/486S7a","article-title":"Neuroscience: hardwired for taste","volume":"486","author":"Trivedi","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.bbmt.2017.10.022_bib0085","first-page":"575","article-title":"Taste and smell dysfunction in patients receiving chemotherapy: a review of current knowledge","volume":"9","author":"Comeau","year":"2001","journal-title":"Support Care Cancer"},{"key":"10.1016\/j.bbmt.2017.10.022_bib0090","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1007\/s00415-010-5513-8","article-title":"Chemosensory interaction: acquired olfactory impairment is associated with decreased taste function","volume":"257","author":"Landis","year":"2010","journal-title":"J Neurol"},{"key":"10.1016\/j.bbmt.2017.10.022_bib0095","article-title":"Assessment of taste disorders","author":"Barasch","year":"2016","journal-title":"BMJ Best Pract"},{"key":"10.1016\/j.bbmt.2017.10.022_bib0100","first-page":"1917","article-title":"Understanding the impact of taste changes in oncology care","volume":"24","author":"Epstein","year":"2016","journal-title":"Support Care Cancer"},{"key":"10.1016\/j.bbmt.2017.10.022_bib0105","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.ctrv.2014.11.006","article-title":"Metallic taste in cancer patients treated with chemotherapy","volume":"41","author":"IJpma","year":"2015","journal-title":"Cancer Treat Rev"},{"key":"10.1016\/j.bbmt.2017.10.022_bib0110","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.ctrv.2016.03.006","article-title":"The effects of swallowing disorders, dysgeusia, oral mucositis and xerostomia on nutritional status, oral intake and weight loss in head and neck cancer patients: a systematic review","volume":"45","author":"Bressan","year":"2016","journal-title":"Cancer Treat Rev"},{"key":"10.1016\/j.bbmt.2017.10.022_bib0115","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.critrevonc.2016.03.012","article-title":"Oral toxicity management in head and neck cancer patients treated with chemotherapy and radiation: xerostomia and trismus (Part 2). Literature review and consensus statement","volume":"102","author":"Buglione","year":"2016","journal-title":"Crit Rev Oncol Hematol"},{"key":"10.1016\/j.bbmt.2017.10.022_bib0120","first-page":"1039","article-title":"A systematic review of salivary gland hypofunction and xerostomia induced by cancer therapies: prevalence, severity and impact on quality of life","volume":"18","author":"Jensen","year":"2010","journal-title":"Support Care Cancer"},{"key":"10.1016\/j.bbmt.2017.10.022_bib0125","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s00784-002-0169-0","article-title":"Perceived taste disturbance in adults: prevalence and association with oral and psychological factors and medication","volume":"6","author":"Bergdahl","year":"2002","journal-title":"Clin Oral Investig"},{"key":"10.1016\/j.bbmt.2017.10.022_bib0130","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.14219\/jada.archive.2004.0055","article-title":"Medications' impact on oral health","volume":"135","author":"Ciancio","year":"2004","journal-title":"J Am Dent Assoc"},{"key":"10.1016\/j.bbmt.2017.10.022_bib0135","first-page":"1081","article-title":"A systematic review of dysgeusia induced by cancer therapies","volume":"18","author":"Hovan","year":"2010","journal-title":"Support Care Cancer"},{"key":"10.1016\/j.bbmt.2017.10.022_bib0140","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.ejim.2010.01.017","article-title":"Drug-induced taste disorders","volume":"21","author":"Naik","year":"2010","journal-title":"Eur J Intern Med"},{"key":"10.1016\/j.bbmt.2017.10.022_bib0145","first-page":"1713","article-title":"Oral mucosal changes induced by anticancer targeted therapies and immune checkpoint inhibitors","volume":"25","author":"Vigarios","year":"2017","journal-title":"Support Care Cancer"},{"key":"10.1016\/j.bbmt.2017.10.022_bib0150","first-page":"315-324","article-title":"Drug-induced taste disorders in clinical practice and preclinical safety evaluation","volume":"156","author":"Wang","year":"2017","journal-title":"Toxicol Sci"},{"key":"10.1016\/j.bbmt.2017.10.022_bib0155","first-page":"519","article-title":"Late taste disorders in bone marrow transplantation: clinical evaluation with taste solutions in autologous and allogeneic bone marrow recipients","volume":"76","author":"Marinone","year":"1991","journal-title":"Haematologica"},{"key":"10.1016\/j.bbmt.2017.10.022_bib0160","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1111\/j.1600-0714.1992.tb00966.x","article-title":"Alterations in taste acuity associated with allogeneic bone marrow transplantation","volume":"21","author":"Mattsson","year":"1992","journal-title":"J Oral Pathol Med"},{"key":"10.1016\/j.bbmt.2017.10.022_bib0165","author":"Pasquini"},{"key":"10.1016\/j.bbmt.2017.10.022_bib0170","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1016\/j.bbmt.2015.02.005","article-title":"Impact of conditioning regimen on outcomes for patients with lymphoma undergoing high-dose therapy with autologous hematopoietic cell transplantation","volume":"21","author":"Chen","year":"2015","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.bbmt.2017.10.022_bib0175","first-page":"3979","article-title":"Evaluation of the risk factors associated with high-dose chemotherapy-induced dysgeusia in patients undergoing autologous hematopoietic stem cell transplantation: possible usefulness of cryotherapy in dysgeusia prevention","volume":"24","author":"Okada","year":"2016","journal-title":"Support Care Cancer"},{"key":"10.1016\/j.bbmt.2017.10.022_bib0180","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.bbmt.2005.02.006","article-title":"Mucositis after allogeneic hematopoietic stem cell transplantation: a cohort study of methotrexate- and non-methotrexate-containing graft-versus-host disease prophylaxis regimens","volume":"11","author":"Cutler","year":"2005","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.bbmt.2017.10.022_bib0185","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/bmt.2012.115","article-title":"Palifermin is efficacious in recipients of TBI-based but not chemotherapy-based allogeneic hematopoietic stem cell transplants","volume":"48","author":"Goldberg","year":"2013","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.bbmt.2017.10.022_bib0190","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1016\/j.bbi.2010.03.009","article-title":"Inflammatory cytokines are associated with the development of symptom burden in patients with NSCLC undergoing concurrent chemoradiation therapy","volume":"24","author":"Wang","year":"2010","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.bbmt.2017.10.022_bib0195","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1038\/sj.bmt.1705816","article-title":"Prolonged anorexia and elevated plasma cytokine levels following myeloablative allogeneic hematopoietic cell transplant","volume":"40","author":"Malone","year":"2007","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.bbmt.2017.10.022_bib0200","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1038\/sj.bmt.1705493","article-title":"Poor oral nutrition after allogeneic stem cell transplantation correlates significantly with severe graft-versus-host disease","volume":"38","author":"Mattsson","year":"2006","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.bbmt.2017.10.022_bib0205","doi-asserted-by":"crossref","first-page":"3371","DOI":"10.1016\/j.transproceed.2013.02.144","article-title":"The impact of pretransplant hypoalbuminemia on survival in patients with leukemia who underwent allogeneic hematopoietic stem cell transplantation (alloHSCT): a nutritional problem?","volume":"45","author":"Sivgin","year":"2013","journal-title":"Transplant Proc"},{"key":"10.1016\/j.bbmt.2017.10.022_bib0210","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.bbmt.2010.07.011","article-title":"Severe hypoalbuminemia at day 90 predicts worse nonrelapse mortality and overall survival after allogeneic hematopoietic stem cell transplantation for acute myelogenous leukemia and myelodysplastic syndrome","volume":"17","author":"Kharfan-Dabaja","year":"2011","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.bbmt.2017.10.022_bib0215","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1016\/j.bbmt.2011.07.021","article-title":"Decreased serum albumin as a biomarker for severe acute graft-versus-host disease after reduced-intensity allogeneic hematopoietic cell transplantation","volume":"17","author":"Rezvani","year":"2011","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.bbmt.2017.10.022_bib0220","doi-asserted-by":"crossref","first-page":"4321.","DOI":"10.1182\/blood.V126.23.4321.4321","article-title":"Fluid overload as new toxicity category has a strong impact on non relapse mortality and survival in allogeneic hematopoietic stem cell transplantation","volume":"126","author":"Rondon","year":"2015","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2017.10.022_bib0225","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/j.ccc.2015.06.013","article-title":"Fluid overload","volume":"31","author":"O'Connor","year":"2015","journal-title":"Crit Care Clin"},{"key":"10.1016\/j.bbmt.2017.10.022_bib0230","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1513\/AnnalsATS.201504-187OC","article-title":"Volume overload: prevalence, risk factors, and functional outcome in survivors of septic shock","volume":"12","author":"Mitchell","year":"2015","journal-title":"Ann Am Thorac Soc."},{"key":"10.1016\/j.bbmt.2017.10.022_bib0235","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1038\/bmt.2016.310","article-title":"Revisiting nutritional support for allogeneic hematologic stem cell transplantation\u2014a systematic review","volume":"52","author":"Baumgartner","year":"2017","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.bbmt.2017.10.022_bib0240","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1016\/j.bbmt.2010.04.009","article-title":"Obesity does not preclude safe and effective myeloablative hematopoietic cell transplantation (HCT) for acute myeloid leukemia (AML) in adults","volume":"16","author":"Navarro","year":"2010","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.bbmt.2017.10.022_bib0245","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1016\/j.bbmt.2017.01.006","article-title":"Cardiovascular function in long-term hematopoietic cell transplantation survivors","volume":"23","author":"Armenian","year":"2017","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.bbmt.2017.10.022_bib0250","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1177\/0148607109341804","article-title":"ASPEN clinical guidelines: nutrition support therapy during adult anticancer treatment and in hematopoietic cell transplantation","volume":"33","author":"August","year":"2009","journal-title":"JPEN J Parenter Enteral Nutr."},{"key":"10.1016\/j.bbmt.2017.10.022_bib0255","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1097\/01.tp.0000229419.73428.ff","article-title":"Enteral feeding and early outcomes of patients undergoing allogeneic stem cell transplantation following myeloablative conditioning","volume":"82","author":"Seguy","year":"2006","journal-title":"Transplantation"},{"key":"10.1016\/j.bbmt.2017.10.022_bib0260","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.clnu.2013.07.012","article-title":"Enteral versus parenteral nutritional support in allogeneic haematopoietic stem-cell transplantation","volume":"33","author":"Gui\u00e8ze","year":"2014","journal-title":"Clin Nutr"},{"key":"10.1016\/j.bbmt.2017.10.022_bib0265","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1186\/s13063-015-0663-8","article-title":"Could enteral nutrition improve the outcome of patients with haematological malignancies undergoing allogeneic haematopoietic stem cell transplantation? A study protocol for a randomized controlled trial (the NEPHA study)","volume":"16","author":"Lemal","year":"2015","journal-title":"Trials"},{"key":"10.1016\/j.bbmt.2017.10.022_bib0270","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/2046-4053-3-9","article-title":"Association between nutritional status and the immune response in HIV+ patients under HAART: protocol for a systematic review","volume":"3","author":"Sicotte","year":"2014","journal-title":"Syst Rev"},{"key":"10.1016\/j.bbmt.2017.10.022_bib0275","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1182\/asheducation-2015.1.215","article-title":"Immune reconstitution following stem cell transplantation","volume":"2015","author":"van den Brink","year":"2015","journal-title":"Hematol Am Soc Hematol Educ Progr."},{"issue":"Suppl 3","key":"10.1016\/j.bbmt.2017.10.022_bib0280","doi-asserted-by":"crossref","first-page":"S46","DOI":"10.1038\/sj.ejcn.1601485","article-title":"The thymus gland is a target in malnutrition","volume":"56","author":"Savino","year":"2002","journal-title":"Eur J Clin Nutr"},{"key":"10.1016\/j.bbmt.2017.10.022_bib0285","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.it.2009.04.003","article-title":"Thymic involution and immune reconstitution","volume":"30","author":"Lynch","year":"2009","journal-title":"Trends Immunol"},{"key":"10.1016\/j.bbmt.2017.10.022_bib0290","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1017\/S0029665110002545","article-title":"Nutritional imbalances and infections affect the thymus: consequences on T-cell-mediated immune responses","volume":"69","author":"Savino","year":"2010","journal-title":"Proc Nutr Soc"},{"key":"10.1016\/j.bbmt.2017.10.022_bib0295","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1002\/path.2104","article-title":"Immunosenescence of ageing","volume":"211","author":"Gruver","year":"2007","journal-title":"J Pathol"},{"key":"10.1016\/j.bbmt.2017.10.022_bib0300","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1001\/jama.286.8.944","article-title":"Should immunonutrition become routine in critically ill patients? A systematic review of the evidence","volume":"286","author":"Heyland","year":"2001","journal-title":"JAMA"},{"key":"10.1016\/j.bbmt.2017.10.022_bib0305","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0261-5614(03)00007-4","article-title":"Immunonutrition in the intensive care unit: a systematic review and consensus statement","volume":"22","author":"Montejo","year":"2003","journal-title":"Clin Nutr"},{"key":"10.1016\/j.bbmt.2017.10.022_bib0310","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1056\/NEJMoa1212722","article-title":"A randomized trial of glutamine and antioxidants in critically ill patients","volume":"368","author":"Heyland","year":"2013","journal-title":"N Engl J Med"},{"key":"10.1016\/j.bbmt.2017.10.022_bib0315","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/8071539","article-title":"Sickness-associated anorexia: mother nature's idea of immunonutrition?","volume":"2016","author":"van Niekerk","year":"2016","journal-title":"Mediators Inflamm"},{"key":"10.1016\/j.bbmt.2017.10.022_bib0320","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1016\/j.cell.2012.01.035","article-title":"The impact of the gut microbiota on human health: an integrative view","volume":"148","author":"Clemente","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.bbmt.2017.10.022_bib0325","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1172\/JCI32205","article-title":"Microbial translocation augments the function of adoptively transferred self\/tumor-specific CD8+ T cells via TLR4 signaling","volume":"117","author":"Paulos","year":"2007","journal-title":"J Clin Invest"},{"key":"10.1016\/j.bbmt.2017.10.022_bib0330","doi-asserted-by":"crossref","first-page":"16036","DOI":"10.1038\/nmicrobiol.2016.36","article-title":"Role of gut flora after bone marrow transplantation","volume":"1","author":"Peled","year":"2016","journal-title":"Nat Microbiol"},{"key":"10.1016\/j.bbmt.2017.10.022_bib0335","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1182\/blood-2014-02-554725","article-title":"The effects of intestinal tract bacterial diversity on mortality following allogeneic hematopoietic stem cell transplantation","volume":"124","author":"Taur","year":"2014","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2017.10.022_bib0340","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1016\/j.bbmt.2015.04.016","article-title":"Intestinal blautia is associated with reduced death from graft-versus-host disease","volume":"21","author":"Jenq","year":"2015","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.bbmt.2017.10.022_bib0345","doi-asserted-by":"crossref","first-page":"339ra71","DOI":"10.1126\/scitranslmed.aaf2311","article-title":"Increased GVHD-related mortality with broad-spectrum antibiotic use after allogeneic hematopoietic stem cell transplantation in human patients and mice","volume":"8","author":"Shono","year":"2016","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.bbmt.2017.10.022_bib0350","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1182\/asheducation-2016.1.119","article-title":"Role of the intestinal mucosa in acute gastrointestinal GVHD","volume":"2016","author":"Peled","year":"2016","journal-title":"Hematol Am Soc Hematol Educ Program"},{"key":"10.1016\/j.bbmt.2017.10.022_bib0355","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1093\/infdis\/jix011","article-title":"Protective factors in the intestinal microbiome against clostridium difficile infection in recipients of allogeneic hematopoietic stem cell transplantation","volume":"215","author":"Lee","year":"2017","journal-title":"J Infect Dis"},{"key":"10.1016\/j.bbmt.2017.10.022_bib0360","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1038\/nature12820","article-title":"Diet rapidly and reproducibly alters the human gut microbiome","volume":"505","author":"David","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.bbmt.2017.10.022_bib0365","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1097\/PSY.0000000000000318","article-title":"Gut microbiota and a selectively bred taste phenotype: a novel model of microbiome-behavior relationships","volume":"78","author":"Lyte","year":"2016","journal-title":"Psychosom Med"},{"key":"10.1016\/j.bbmt.2017.10.022_bib0370","first-page":"A1787","article-title":"Serial changes in oral and respiratory microbiota in patients undergoing hematopoietic stem cell transplantation: a pilot study","volume":"191","author":"Littmann","year":"2015","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.bbmt.2017.10.022_bib0375","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/odi.12224","article-title":"Microbiota and their role in the pathogenesis of oral mucositis","volume":"21","author":"Vanhoecke","year":"2015","journal-title":"Oral Dis"},{"key":"10.1016\/j.bbmt.2017.10.022_bib0380","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1177\/0022034516641890","article-title":"Host-microbiome cross-talk in oral mucositis","volume":"95","author":"Vasconcelos","year":"2016","journal-title":"J Dent Res"},{"key":"10.1016\/j.bbmt.2017.10.022_bib0385","doi-asserted-by":"crossref","first-page":"R42","DOI":"10.1186\/gb-2012-13-6-r42","article-title":"Composition of the adult digestive tract bacterial microbiome based on seven mouth surfaces, tonsils, throat and stool samples","volume":"13","author":"Segata","year":"2012","journal-title":"Genome Biol"},{"key":"10.1016\/j.bbmt.2017.10.022_bib0390","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.tripleo.2005.12.016","article-title":"Relationship between mucositis and changes in oral microflora during cancer chemotherapy","volume":"103","author":"Nape\u00f1as","year":"2007","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"10.1016\/j.bbmt.2017.10.022_bib0395","first-page":"3231","article-title":"Oral bacteria and yeasts in relationship to oral ulcerations in hematopoietic stem cell transplant recipients","volume":"20","author":"Laheij","year":"2012","journal-title":"Support Care Cancer"},{"key":"10.1016\/j.bbmt.2017.10.022_bib0400","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1002\/cncr.23299","article-title":"Symptom burden after autologous stem cell transplantation for multiple myeloma","volume":"112","author":"Campagnaro","year":"2008","journal-title":"Cancer"},{"key":"10.1016\/j.bbmt.2017.10.022_bib0405","doi-asserted-by":"crossref","first-page":"2919","DOI":"10.1002\/cncr.11382","article-title":"Are the symptoms of cancer and cancer treatment due to a shared biologic mechanism? A cytokine-immunologic model of cancer symptoms","volume":"97","author":"Cleeland","year":"2003","journal-title":"Cancer"},{"key":"10.1016\/j.bbmt.2017.10.022_bib0410","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1093\/jncimonographs\/lgm005","article-title":"Symptom burden: multiple symptoms and their impact as patient-reported outcomes","volume":"37","author":"Cleeland","year":"2007","journal-title":"J Natl Cancer Inst Monogr"},{"key":"10.1016\/j.bbmt.2017.10.022_bib0415","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1001\/archotol.1991.01870170065015","article-title":"Smell and taste disorders, a study of 750 patients from the University of Pennsylvania Smell and Taste Center","volume":"117","author":"Deems","year":"1991","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.bbmt.2017.10.022_bib0420","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S1051-2276(99)90050-X","article-title":"Mechanisms of uremic suppression of appetite","volume":"9","author":"Bergstrom","year":"1999","journal-title":"J Ren Nutr"},{"key":"10.1016\/j.bbmt.2017.10.022_bib0425","first-page":"257","article-title":"Buccal mucosal cancer patient who failed to recover taste acuity after partial oral cavity irradiation","volume":"20","author":"Saito","year":"2002","journal-title":"Radiat Med"},{"key":"10.1016\/j.bbmt.2017.10.022_bib0430","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1200\/EDBK_159514","article-title":"Patient-reported outcomes in cancer clinical trials: measuring symptomatic adverse events with the National Cancer Institute's Patient-Reported Outcomes version of the Common Terminology Criteria for Adverse Events (PRO-CTCAE)","volume":"35","author":"Kluetz","year":"2016","journal-title":"Am Soc Clin Oncol Educ Book"},{"key":"10.1016\/j.bbmt.2017.10.022_bib0435","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1097\/00000441-197611000-00006","article-title":"A double blind study of the effects of zinc sulfate on taste and smell dysfunction","volume":"272","author":"Henkin","year":"1976","journal-title":"Am J Med Sci"},{"key":"10.1016\/j.bbmt.2017.10.022_bib0440","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1080\/00016480260046517","article-title":"Double-blind, placebo-controlled trial of zinc picolinate for taste disorders","volume":"546","author":"Sakai","year":"2002","journal-title":"Acta Otolaryngol Suppl"},{"key":"10.1016\/j.bbmt.2017.10.022_bib0445","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1177\/154405910508400105","article-title":"Zinc gluconate in the treatment of dysgeusia: a randomized clinical trial","volume":"84","author":"Heckmann","year":"2005","journal-title":"J Dent Res"},{"key":"10.1016\/j.bbmt.2017.10.022_bib0450","doi-asserted-by":"crossref","first-page":"111","DOI":"10.3109\/15360288.2012.676618","article-title":"A randomized, placebo controlled trial of oral zinc for chemotherapy-related taste and smell disorders","volume":"26","author":"Lyckholm","year":"2012","journal-title":"J Pain Palliat Care Pharmacother"},{"key":"10.1016\/j.bbmt.2017.10.022_bib0455","doi-asserted-by":"crossref","first-page":"219","DOI":"10.3816\/SCT.2004.n.014","article-title":"Oral complications and management considerations in patients treated with high-dose chemotherapy","volume":"1","author":"Raber-Durlacher","year":"2004","journal-title":"Support Cancer Ther."},{"key":"10.1016\/j.bbmt.2017.10.022_bib0460","first-page":"357","article-title":"Systematic review of amifostine for the management of oral mucositis in cancer patients","volume":"21","author":"Nicolatou-Galitis","year":"2013","journal-title":"Support Care Cancer"},{"key":"10.1016\/j.bbmt.2017.10.022_bib0465","doi-asserted-by":"crossref","first-page":"2590","DOI":"10.1056\/NEJMoa040125","article-title":"Palifermin for oral mucositis after intensive therapy for hematologic cancers","volume":"351","author":"Spielberger","year":"2004","journal-title":"N Engl J Med"},{"key":"10.1016\/j.bbmt.2017.10.022_bib0470","first-page":"1069","article-title":"A systematic review with meta-analysis of the effect of low-level laser therapy (LLLT) in cancer therapy-induced oral mucositis","volume":"19","author":"Bjordal","year":"2011","journal-title":"Support Care Cancer"},{"key":"10.1016\/j.bbmt.2017.10.022_bib0475","first-page":"327","article-title":"Systematic review of oral cryotherapy for management of oral mucositis caused by cancer therapy","volume":"21","author":"Peterson","year":"2013","journal-title":"Support Care Cancer"},{"key":"10.1016\/j.bbmt.2017.10.022_bib0480","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1016\/j.bbmt.2014.02.025","article-title":"Pharmacoeconomic analysis of palifermin to prevent mucositis among patients undergoing autologous hematopoietic stem cell transplantation","volume":"20","author":"Nooka","year":"2014","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.bbmt.2017.10.022_bib0485","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1038\/bmt.2013.118","article-title":"Impact of palifermin on intestinal mucositis of HSCT recipients after BEAM","volume":"49","author":"Herbers","year":"2014","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.bbmt.2017.10.022_bib0490","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1002\/hon.2050","article-title":"Cost-effectiveness of the introduction of specialized oral care with laser therapy in hematopoietic stem cell transplantation","volume":"32","author":"Bezinelli","year":"2014","journal-title":"Hematol Oncol"},{"key":"10.1016\/j.bbmt.2017.10.022_bib0495","first-page":"2843","article-title":"A state-of-the-art review of the management and treatment of taste and smell alterations in adult oncology patients","volume":"23","author":"Thorne","year":"2015","journal-title":"Support Care Cancer"}],"container-title":["Biology of Blood and Marrow Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1083879117307814?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1083879117307814?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T15:02:14Z","timestamp":1761058934000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1083879117307814"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3]]},"references-count":98,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,3]]}},"alternative-id":["S1083879117307814"],"URL":"https:\/\/doi.org\/10.1016\/j.bbmt.2017.10.022","relation":{},"ISSN":["1083-8791"],"issn-type":[{"value":"1083-8791","type":"print"}],"subject":[],"published":{"date-parts":[[2018,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Unlocking the Complex Flavors of Dysgeusia after Hematopoietic Cell Transplantation","name":"articletitle","label":"Article Title"},{"value":"Biology of Blood and Marrow Transplantation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbmt.2017.10.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 American Society for Blood and Marrow Transplantation.","name":"copyright","label":"Copyright"}]}}