{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T03:23:03Z","timestamp":1789096983849,"version":"build-2803163510"},"reference-count":30,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["bbmt.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biology of Blood and Marrow Transplantation"],"published-print":{"date-parts":[[2018,3]]},"DOI":"10.1016\/j.bbmt.2017.11.013","type":"journal-article","created":{"date-parts":[[2017,12,2]],"date-time":"2017-12-02T05:10:47Z","timestamp":1512191447000},"page":"501-506","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"title":["Augmenting Total Body Irradiation with a Cranial Boost before Stem Cell Transplantation Protects Against Post-Transplant Central Nervous System Relapse in Acute Lymphoblastic Leukemia"],"prefix":"10.1016","volume":"24","author":[{"given":"Robert W.","family":"Gao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn E.","family":"Dusenbery","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela R.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1294-3391","authenticated-orcid":false,"given":"Jianling","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbmt.2017.11.013_bib0010","doi-asserted-by":"crossref","first-page":"2625","DOI":"10.1200\/JCO.2009.27.0421","article-title":"Outcomes for children and adolescents with cancer: challenges for the twenty-first century","volume":"28","author":"Smith","year":"2010","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.bbmt.2017.11.013_bib0015","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1002\/cncr.23169","article-title":"Trends in childhood cancer incidence in the U.S. (1992-2004)","volume":"112","author":"Linabery","year":"2008","journal-title":"Cancer"},{"key":"10.1016\/j.bbmt.2017.11.013_bib0020","series-title":"Adult Acute Lymphocytic Leukemia: Biology and Treatment","first-page":"77","article-title":"Acute lymphoblastic leukemia: epidemiology","author":"Hourigan","year":"2011"},{"key":"10.1016\/j.bbmt.2017.11.013_bib0025","doi-asserted-by":"crossref","first-page":"2730","DOI":"10.1056\/NEJMoa0900386","article-title":"Treating childhood acute lymphoblastic leukemia without cranial irradiation","volume":"360","author":"Pui","year":"2009","journal-title":"N Engl J Med"},{"key":"10.1016\/j.bbmt.2017.11.013_bib0030","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1038\/sj.leu.2402489","article-title":"BFM-oriented treatment for children with acute lymphoblastic leukemia without cranial irradiation and treatment reduction for standard risk patients: results of DCLSG protocol ALL-8 (1991-1996)","volume":"16","author":"Kamps","year":"2002","journal-title":"Leukemia"},{"key":"10.1016\/j.bbmt.2017.11.013_bib0035","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1182\/blood.V99.3.863","article-title":"Treatment of adult acute lymphoblastic leukemia (ALL): long-term follow-up of the GIMEMA ALL 0288 randomized study","volume":"99","author":"Annino","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2017.11.013_bib0040","doi-asserted-by":"crossref","first-page":"2788","DOI":"10.1002\/cncr.20668","article-title":"Long-term follow-up results of hyperfractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone (Hyper-CVAD), a dose-intensive regimen, in adult acute lymphocytic leukemia","volume":"101","author":"Kantarjian","year":"2004","journal-title":"Cancer"},{"key":"10.1016\/j.bbmt.2017.11.013_bib0045","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.bbmt.2015.10.016","article-title":"Implications and management of central nervous system involvement before allogeneic hematopoietic cell transplantation in acute lymphoblastic leukemia","volume":"22","author":"Aldoss","year":"2016","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.bbmt.2017.11.013_bib0050","doi-asserted-by":"crossref","first-page":"1796","DOI":"10.1002\/1097-0142(19891101)64:9<1796::AID-CNCR2820640907>3.0.CO;2-7","article-title":"Central nervous system relapses after bone marrow transplantation for acute lymphoblastic leukemia in remission","volume":"64","author":"Ganem","year":"1989","journal-title":"Cancer"},{"key":"10.1016\/j.bbmt.2017.11.013_bib0055","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1016\/j.bbmt.2008.07.002","article-title":"Central nervous system relapse of leukemia after allogeneic hematopoietic stem cell transplantation","volume":"14","author":"Oshima","year":"2008","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.bbmt.2017.11.013_bib0060","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1182\/blood.V67.1.195.195","article-title":"The risks of central nervous system relapse and leukoencephalopathy in patients receiving marrow transplants for acute leukemia","volume":"67","author":"Thompson","year":"1986","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2017.11.013_bib0065","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1016\/j.bbmt.2014.07.005","article-title":"Central nervous system relapse in adults with acute lymphoblastic leukemia after allogeneic hematopoietic stem cell transplantation","volume":"20","author":"Hamdi","year":"2014","journal-title":"Biol Blood Marrow Transpl"},{"key":"10.1016\/j.bbmt.2017.11.013_bib0070","series-title":"Levitt and Tapley's Technological Basis of Radiation Therapy: Practical Clinical Application","author":"Levitt","year":"1992"},{"key":"10.1016\/j.bbmt.2017.11.013_bib0075","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/0360-3016(92)90976-O","article-title":"Prophylactic cranial irradiation dose effects on late cognitive function in children treated for acute lymphoblastic leukemia","volume":"22","author":"Halberg","year":"1992","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.bbmt.2017.11.013_bib0080","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1080\/01621459.1958.10501452","article-title":"Nonparametric estimation from incomplete observations","volume":"53","author":"Kaplan","year":"1958","journal-title":"J Am Stat Assoc"},{"key":"10.1016\/j.bbmt.2017.11.013_bib0085","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/j.2517-6161.1972.tb00899.x","article-title":"Regression models and life-tables","volume":"34","author":"Cox","year":"1972","journal-title":"J R Stat Soc Ser B"},{"key":"10.1016\/j.bbmt.2017.11.013_bib0090","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1002\/(SICI)1097-0258(19970430)16:8<901::AID-SIM543>3.0.CO;2-M","article-title":"Non-parametric inference for cumulative incidence functions in competing risks studies","volume":"16","author":"Lin","year":"1997","journal-title":"Stat Med"},{"key":"10.1016\/j.bbmt.2017.11.013_bib0095","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1080\/01621459.1999.10474144","article-title":"A proportional hazards model for the subdistribution of a competing risk","volume":"94","author":"Fine","year":"1999","journal-title":"J Am Stat Assoc"},{"key":"10.1016\/j.bbmt.2017.11.013_bib0100","doi-asserted-by":"crossref","first-page":"S166","DOI":"10.1016\/j.ijrobp.2016.06.418","article-title":"Treatment of pediatric CNS leukemia with cranial or craniospinal boost in conjunction with total body irradiation as part of the conditioning regimen for bone marrow transplantation","volume":"96","author":"Grow","year":"2016","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.bbmt.2017.11.013_bib0105","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.prro.2016.06.008","article-title":"Low-dose cranial boost in high-risk adult acute lymphoblastic leukemia patients undergoing bone marrow transplant","volume":"7","author":"Su","year":"2017","journal-title":"Pract Radiat Oncol"},{"key":"10.1016\/j.bbmt.2017.11.013_bib0110","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1016\/j.ijrobp.2005.04.020","article-title":"Utility of cranial boost in addition to total body irradiation in the treatment of high risk acute lymphoblastic leukemia","volume":"63","author":"Alexander","year":"2005","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.bbmt.2017.11.013_bib0115","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/S0140-6736(88)91246-9","article-title":"Growth in children treated for acute lymphoblastic leukaemia","volume":"1","author":"Clayton","year":"1988","journal-title":"Lancet"},{"key":"10.1016\/j.bbmt.2017.11.013_bib0120","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1111\/j.1469-7610.1988.tb00757.x","article-title":"Cognitive effects of cranial irradiation in leukaemia: a survey and meta-analysis","volume":"29","author":"Cousens","year":"1988","journal-title":"J Child Psychol Psychiatry"},{"key":"10.1016\/j.bbmt.2017.11.013_bib0125","doi-asserted-by":"crossref","first-page":"2770","DOI":"10.1182\/blood.V95.9.2770.009k16_2770_2775","article-title":"Secondary neoplasms subsequent to Berlin-Frankfurt-M\u00fcnster therapy of acute lymphoblastic leukemia in childhood: significantly lower risk without cranial radiotherapy","volume":"95","author":"L\u00f6ning","year":"2000","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2017.11.013_bib0130","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1038\/sj.leu.2401962","article-title":"Long-term follow-up of the United Kingdom Medical Research Council protocols for childhood acute lymphoblastic leukaemia, 1980-1997. Medical Research Council Childhood Leukaemia Working Party","volume":"14","author":"Eden","year":"2000","journal-title":"Leukemia"},{"key":"10.1016\/j.bbmt.2017.11.013_bib0135","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1046\/j.1365-2141.2003.04738.x","article-title":"Successful treatment without cranial radiotherapy of children receiving intensified chemotherapy for acute lymphoblastic leukaemia: results of the risk-stratified randomized central nervous system trial MRC UKALL XI (ISRC TN 16757172)","volume":"124","author":"Hill","year":"2004","journal-title":"Br J Haematol"},{"key":"10.1016\/j.bbmt.2017.11.013_bib0140","doi-asserted-by":"crossref","first-page":"2223","DOI":"10.1038\/sj.leu.2401939","article-title":"Children's Cancer Group trials in childhood acute lymphoblastic leukemia: 1983-1995","volume":"14","author":"Gaynon","year":"2000","journal-title":"Leukemia"},{"key":"10.1016\/j.bbmt.2017.11.013_bib0145","doi-asserted-by":"crossref","first-page":"2286","DOI":"10.1038\/sj.leu.2401938","article-title":"Long-term results of total therapy studies 11, 12 and 13A for childhood acute lymphoblastic leukemia at St Jude Children's Research Hospital","volume":"14","author":"Pui","year":"2000","journal-title":"Leukemia"},{"key":"10.1016\/j.bbmt.2017.11.013_bib0150","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.ijrobp.2014.01.056","article-title":"Survival and neurocognitive outcomes after cranial or craniospinal irradiation plus total-body irradiation before stem cell transplantation in pediatric leukemia patients with central nervous system involvement","volume":"89","author":"Hiniker","year":"2014","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.bbmt.2017.11.013_bib0155","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1056\/NEJM199808273390907","article-title":"Acute lymphoblastic leukemia","volume":"339","author":"Pui","year":"1998","journal-title":"N Engl J Med"}],"container-title":["Biology of Blood and Marrow Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1083879117308492?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1083879117308492?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T15:01:25Z","timestamp":1761058885000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1083879117308492"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3]]},"references-count":30,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,3]]}},"alternative-id":["S1083879117308492"],"URL":"https:\/\/doi.org\/10.1016\/j.bbmt.2017.11.013","relation":{},"ISSN":["1083-8791"],"issn-type":[{"value":"1083-8791","type":"print"}],"subject":[],"published":{"date-parts":[[2018,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Augmenting Total Body Irradiation with a Cranial Boost before Stem Cell Transplantation Protects Against Post-Transplant Central Nervous System Relapse in Acute Lymphoblastic Leukemia","name":"articletitle","label":"Article Title"},{"value":"Biology of Blood and Marrow Transplantation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbmt.2017.11.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 American Society for Blood and Marrow Transplantation.","name":"copyright","label":"Copyright"}]}}