{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T16:45:47Z","timestamp":1791305147272,"version":"4.3.1"},"reference-count":37,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["bbmt.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biology of Blood and Marrow Transplantation"],"published-print":{"date-parts":[[2018,9]]},"DOI":"10.1016\/j.bbmt.2018.05.018","type":"journal-article","created":{"date-parts":[[2018,5,29]],"date-time":"2018-05-29T12:58:47Z","timestamp":1527598727000},"page":"1814-1822","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"title":["A Comparison of the Conditioning Regimens BEAM and FEAM for Autologous Hematopoietic Stem Cell Transplantation in Lymphoma: An Observational Study on 1038 Patients From Fondazione Italiana Linfomi"],"prefix":"10.1016","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2582-3500","authenticated-orcid":false,"given":"Jacopo","family":"Olivieri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Mosna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Pelosini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelo","family":"Fama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Rattotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margherita","family":"Giannoccaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Carli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Chiara","family":"Tisi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Ferrero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Sgherza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Maria","family":"Mazzone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dario","family":"Marino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Calimeri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giacomo","family":"Loseto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Saraceni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriella","family":"Tomei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona","family":"Sica","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Perali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katia","family":"Codeluppi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atto","family":"Billio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Attilio","family":"Olivieri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"Orciuolo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rossella","family":"Matera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piero Maria","family":"Stefani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Borghero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Ghione","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Cascavilla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Lanza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1355-1587","authenticated-orcid":false,"given":"Patrizia","family":"Chiusolo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Finotto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Federici","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filippo","family":"Gherlinzoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Centurioni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renato","family":"Fanin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Zaja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.bbmt.2018.05.018_bib0010","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1182\/blood.V52.1.85.85","article-title":"Successful engraftment of cryopreserved autologous bone marrow in patients with malignant lymphoma","volume":"52","author":"Appelbaum","year":"1978","journal-title":"Blood"},{"issue":"2","key":"10.1016\/j.bbmt.2018.05.018_bib0015","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1007\/BF00256170","article-title":"Very high dose chemotherapy with autologous bone marrow rescue in adult patients with resistant relapsed lymphoma","volume":"16","author":"Anderson","year":"1986","journal-title":"Cancer Chemother Pharmacol"},{"issue":"8852","key":"10.1016\/j.bbmt.2018.05.018_bib0020","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1016\/0140-6736(93)92411-L","article-title":"Dose intensification with autologous bone-marrow transplantation in relapsed and resistant Hodgkin's disease: results of a BNLI randomised trial","volume":"341","author":"Linch","year":"1993","journal-title":"Lancet"},{"issue":"3","key":"10.1016\/j.bbmt.2018.05.018_bib0025","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1200\/JCO.1995.13.3.588","article-title":"BEAM chemotherapy and autologous bone marrow transplantation for patients with relapsed or refractory non-Hodgkin's lymphoma","volume":"13","author":"Mills","year":"1995","journal-title":"J Clin Oncol"},{"issue":"1","key":"10.1016\/j.bbmt.2018.05.018_bib0030","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/s00277-007-0360-0","article-title":"BEAC or BEAM high-dose chemotherapy followed by autologous stem cell transplantation in non-Hodgkin's lymphoma patients: comparative analysis of efficacy and toxicity","volume":"87","author":"Jo","year":"2008","journal-title":"Ann Hematol"},{"issue":"7","key":"10.1016\/j.bbmt.2018.05.018_bib0035","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1080\/1042819031000083028","article-title":"BEAC or BEAM for high-dose therapy in patients with non-Hodgkin's lymphoma? A single centre analysis on toxicity and efficacy","volume":"44","author":"Jantunen","year":"2003","journal-title":"Leuk Lymphoma"},{"issue":"4","key":"10.1016\/j.bbmt.2018.05.018_bib0040","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/sj.bmt.1702795","article-title":"Autologous stem cell transplantation for clinically aggressive non-Hodgkin's lymphoma: the role of preparative regimens","volume":"27","author":"Salar","year":"2001","journal-title":"Bone Marrow Transplant"},{"issue":"3","key":"10.1016\/j.bbmt.2018.05.018_bib0045","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1038\/sj.bmt.1702154","article-title":"Pulmonary toxicity following carmustine-based preparative regimens and autologous peripheral blood progenitor cell transplantation in hematological malignancies","volume":"25","author":"Alessandrino","year":"2000","journal-title":"Bone Marrow Transplant"},{"issue":"13","key":"10.1016\/j.bbmt.2018.05.018_bib0050","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1200\/JCO.2012.45.9453","volume":"31","author":"Vose","year":"2013","journal-title":"J Clin Oncol"},{"issue":"18","key":"10.1016\/j.bbmt.2018.05.018_bib0055","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1056\/NEJMp1109772","article-title":"The shortage of essential chemotherapy drugs in the United States","volume":"365","author":"Gatesman","year":"2011","journal-title":"N Engl J Med"},{"issue":"7","key":"10.1016\/j.bbmt.2018.05.018_bib0060","doi-asserted-by":"crossref","first-page":"609","DOI":"10.2146\/ajhp120563","article-title":"National survey on the effect of oncology drug shortages on cancer care","volume":"70","author":"McBride","year":"2013","journal-title":"Am J Health Syst Pharm"},{"issue":"26","key":"10.1016\/j.bbmt.2018.05.018_bib0065","doi-asserted-by":"crossref","first-page":"2461","DOI":"10.1056\/NEJMp1212468","article-title":"The impact of drug shortages on children with cancer\u2013the example of mechlorethamine","volume":"367","author":"Metzger","year":"2012","journal-title":"N Engl J Med"},{"issue":"1","key":"10.1016\/j.bbmt.2018.05.018_bib0070","first-page":"138","article-title":"Oncologic drug shortages also in Italy","volume":"16","author":"Tirelli","year":"2012","journal-title":"Eur Rev Med Pharmacol Sci"},{"issue":"24 pt 1","key":"10.1016\/j.bbmt.2018.05.018_bib0075","first-page":"6782","article-title":"Phase I clinical study of the new amino acid-linked nitrosourea, S 10036, administered on a weekly schedule","volume":"47","author":"Khayat","year":"1987","journal-title":"Cancer Res"},{"issue":"7","key":"10.1016\/j.bbmt.2018.05.018_bib0080","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1038\/bmt.2009.318","article-title":"Fotemustine plus etoposide, cytarabine and melphalan (FEAM) as a new conditioning regimen for lymphoma patients undergoing auto-SCT: a multicenter feasibility study","volume":"45","author":"Musso","year":"2010","journal-title":"Bone Marrow Transplant"},{"issue":"1","key":"10.1016\/j.bbmt.2018.05.018_bib0085","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1111\/bjh.13803","article-title":"Improved outcome of patients with relapsed\/refractory Hodgkin lymphoma with a new fotemustine-based high-dose chemotherapy regimen","volume":"172","author":"Musso","year":"2016","journal-title":"Br J Haematol"},{"issue":"5","key":"10.1016\/j.bbmt.2018.05.018_bib0090","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1200\/JCO.2006.09.2403","article-title":"International Harmonization Project on Lymphoma. Revised response criteria for malignant lymphoma","volume":"25","author":"Cheson","year":"2007","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.bbmt.2018.05.018_bib0095","series-title":"Handbook for reporting results of cancer treatment","first-page":"15","author":"World Health Organization","year":"1979"},{"issue":"4","key":"10.1016\/j.bbmt.2018.05.018_bib0100","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1093\/cid\/ciq147","article-title":"Clinical practice guideline for the use of antimicrobial agents in neutropenic patients with cancer: 2010 Update by the Infectious Diseases Society of America","volume":"52","author":"Freifeld","year":"2011","journal-title":"Clin Infect Dis"},{"issue":"18","key":"10.1016\/j.bbmt.2018.05.018_bib0105","doi-asserted-by":"crossref","first-page":"3385","DOI":"10.1002\/sim.2771","article-title":"Sample size determination for logistic regression revisited","volume":"26","author":"Demidenko","year":"2007","journal-title":"Stat Med"},{"key":"10.1016\/j.bbmt.2018.05.018_bib0110","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1080\/01621459.1999.10474144","article-title":"A proportional hazards model for the subdistribution of a competing risk","volume":"94","author":"Fine","year":"1999","journal-title":"J Am Stat Assoc"},{"issue":"6","key":"10.1016\/j.bbmt.2018.05.018_bib0115","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1016\/j.bbmt.2015.02.005","article-title":"Impact of conditioning regimen on outcomes for patients with lymphoma undergoing high-dose therapy with autologous hematopoietic cell transplantation","volume":"21","author":"Chen","year":"2015","journal-title":"Biol Blood Marrow Transplant"},{"issue":"2","key":"10.1016\/j.bbmt.2018.05.018_bib0120","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1038\/bmt.2015.273","article-title":"Thiotepa-based high-dose therapy for autologous stem cell transplantation in lymphoma: a retrospective study from the EBMT","volume":"51","author":"Sellner","year":"2016","journal-title":"Bone Marrow Transplant"},{"issue":"1","key":"10.1016\/j.bbmt.2018.05.018_bib0125","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/sj.bmt.1705544","article-title":"LACE-conditioned autologous stem cell transplantation for relapsed or refractory Hodgkin's lymphoma: treatment outcome and risk factor analysis in 67 patients from a single centre","volume":"39","author":"Perz","year":"2007","journal-title":"Bone Marrow Transplant"},{"issue":"19","key":"10.1016\/j.bbmt.2018.05.018_bib0130","doi-asserted-by":"crossref","first-page":"3029","DOI":"10.1182\/blood-2014-08-596668","article-title":"Bendamustine, etoposide, cytarabine, melphalan, and autologous stem cell rescue produce a 72% 3-year PFS in resistant lymphoma","volume":"124","author":"Visani","year":"2014","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2018.05.018_bib0135","author":"US National Library of Medicine"},{"key":"10.1016\/j.bbmt.2018.05.018_bib0140","series-title":"Diffuse Lung Disorders: A Comprehensive Clinical-Radiological Overview","author":"Sperber","year":"2012"},{"issue":"4","key":"10.1016\/j.bbmt.2018.05.018_bib0145","doi-asserted-by":"crossref","first-page":"271","DOI":"10.3109\/10715769109088956","article-title":"Comparative study on the influence of two 2-chloroethylnitrosoureas with different carbamoylating potential towards glutathione and glutathione-related enzymes in different organs of the rat","volume":"14","author":"Stahl","year":"1991","journal-title":"Free Radic Res Commun"},{"key":"10.1016\/j.bbmt.2018.05.018_bib0150","first-page":"S71","article-title":"The outcome of Beac conditioning regimen prior to autologous stem cell transplant in non-Hodgkin lymphoma (NHL) and comparison with Beam conditioning: a Lymphoma Working Party-EBMT study: o102","volume":"52","author":"Robinson","year":"2017","journal-title":"Bone Marrow Transplant"},{"issue":"4","key":"10.1016\/j.bbmt.2018.05.018_bib0155","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1007\/s002800050586","article-title":"High-dose carmustine for high-grade gliomas in childhood","volume":"39","author":"Bouffet","year":"1997","journal-title":"Cancer Chemother Pharmacol"},{"issue":"9","key":"10.1016\/j.bbmt.2018.05.018_bib0160","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1200\/JCO.2007.13.6028","article-title":"Prospective oral mucositis audit: oral mucositis in patients receiving high-dose melphalan or BEAM conditioning chemotherapy\u2013European Blood and Marrow Transplantation Mucositis Advisory Group","volume":"26","author":"Blijlevens","year":"2008","journal-title":"J Clin Oncol"},{"issue":"2","key":"10.1016\/j.bbmt.2018.05.018_bib0165","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1046\/j.1365-2141.2000.02202.x","article-title":"Prospective evaluation of oral mucositis in patients receiving myeloablative conditioning regimens and haemopoietic progenitor rescue","volume":"110","author":"Wardley","year":"2000","journal-title":"Br J Haematol"},{"issue":"12","key":"10.1016\/j.bbmt.2018.05.018_bib0170","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD011552","article-title":"Interventions for preventing oral mucositis in patients with cancer receiving treatment: oral cryotherapy","author":"Riley","year":"2015","journal-title":"Cochrane Database Syst Rev"},{"issue":"4","key":"10.1016\/j.bbmt.2018.05.018_bib0175","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1111\/bjh.13113","article-title":"Mucosal barrier injury, fever and infection in neutropenic patients with cancer: introducing the paradigm febrile mucositis","volume":"167","author":"van der Velden","year":"2014","journal-title":"Br J Haematol"},{"issue":"2","key":"10.1016\/j.bbmt.2018.05.018_bib0180","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1038\/bmt.2014.231","article-title":"Infections by carbapenem-resistant Klebsiella pneumoniae in SCT recipients: a nationwide retrospective survey from Italy","volume":"50","author":"Girmenia","year":"2015","journal-title":"Bone Marrow Transplant"},{"issue":"7650","key":"10.1016\/j.bbmt.2018.05.018_bib0185","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1136\/bmj.39489.470347.AD","article-title":"GRADE: an emerging consensus on rating quality of evidence and strength of recommendations","volume":"336","author":"Guyatt","year":"2008","journal-title":"BMJ"},{"issue":"9302","key":"10.1016\/j.bbmt.2018.05.018_bib0190","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/S0140-6736(02)07451-2","article-title":"Bias and causal associations in observational research","volume":"359","author":"Grimes","year":"2002","journal-title":"Lancet"}],"container-title":["Biology of Blood and Marrow Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1083879118302702?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1083879118302702?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T15:03:26Z","timestamp":1761059006000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1083879118302702"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9]]},"references-count":37,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2018,9]]}},"alternative-id":["S1083879118302702"],"URL":"https:\/\/doi.org\/10.1016\/j.bbmt.2018.05.018","relation":{},"ISSN":["1083-8791"],"issn-type":[{"value":"1083-8791","type":"print"}],"subject":[],"published":{"date-parts":[[2018,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A Comparison of the Conditioning Regimens BEAM and FEAM for Autologous Hematopoietic Stem Cell Transplantation in Lymphoma: An Observational Study on 1038 Patients From Fondazione Italiana Linfomi","name":"articletitle","label":"Article Title"},{"value":"Biology of Blood and Marrow Transplantation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbmt.2018.05.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 American Society for Blood and Marrow Transplantation.","name":"copyright","label":"Copyright"}]}}