{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T18:32:05Z","timestamp":1768674725146,"version":"3.49.0"},"reference-count":31,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"vor","delay-in-days":366,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["bbmt.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biology of Blood and Marrow Transplantation"],"published-print":{"date-parts":[[2019,3]]},"DOI":"10.1016\/j.bbmt.2018.10.008","type":"journal-article","created":{"date-parts":[[2018,10,12]],"date-time":"2018-10-12T02:39:20Z","timestamp":1539311960000},"page":"556-561","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Immune Reconstitution and Infection Patterns after Early Alemtuzumab and Reduced Intensity Transplantation for Nonmalignant Disorders in Pediatric Patients"],"prefix":"10.1016","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6751-5808","authenticated-orcid":false,"given":"Sima T.","family":"Bhatt","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6902-0876","authenticated-orcid":false,"given":"Jeffrey J.","family":"Bednarski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Berg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathryn","family":"Trinkaus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa","family":"Murray","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Hayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ginny","family":"Schulz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monica","family":"Hente","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Grimley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ka Wah","family":"Chan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naynesh","family":"Kamani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Jacobsohn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Nieder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory","family":"Hale","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lolie","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberta","family":"Adams","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jignesh","family":"Dalal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3030-8420","authenticated-orcid":false,"given":"Michael A.","family":"Pulsipher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Haut","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9816-5126","authenticated-orcid":false,"given":"Sonali","family":"Chaudhury","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey","family":"Davis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Jaroscak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Andreansky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Willert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shalini","family":"Shenoy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbmt.2018.10.008_bib0001","first-page":"1918","article-title":"Impact of bone marrow transplantation for symptomatic sickle cell disease: an interim report. Multicenter investigation of bone marrow transplantation for sickle cell disease","volume":"95","author":"Walters","year":"2000","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2018.10.008_bib0002","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1038\/sj.bmt.1703839","article-title":"National Marrow Donor P, International Bone Marrow Transplant R, Working Party on Inborn Errors EBMTG. Hematopoietic cell transplantation for inherited metabolic diseases: an overview of outcomes and practice guidelines","volume":"31","author":"Peters","year":"2003","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.bbmt.2018.10.008_bib0003","doi-asserted-by":"crossref","DOI":"10.1038\/sj.bmt.1704066","article-title":"Paediatric allogeneic bone marrow transplantation for homozygous beta-thalassaemia, the Dutch experience","volume":"31","author":"Ball","year":"2003","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.bbmt.2018.10.008_bib0004","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1111\/j.1399-3062.2009.00414.x","article-title":"Infectious complications associated with alemtuzumab use for allogeneic hematopoietic stem cell transplantation: comparison with anti-thymocyte globulin","volume":"11","author":"Park","year":"2009","journal-title":"Transpl Infect Dis"},{"key":"10.1016\/j.bbmt.2018.10.008_bib0005","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1182\/blood.V91.3.756","article-title":"Nonmyeloablative stem cell transplantation and cell therapy as an alternative to conventional bone marrow transplantation with lethal cytoreduction for the treatment of malignant and nonmalignant hematologic diseases","volume":"91","author":"Slavin","year":"1998","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2018.10.008_bib0006","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1038\/sj.bmt.1703150","article-title":"Reduced-intensity conditioning reduces the risk of severe infections after allogeneic peripheral blood stem cell transplantation","volume":"28","author":"Martino","year":"2001","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.bbmt.2018.10.008_bib0007","doi-asserted-by":"crossref","first-page":"2419","DOI":"10.1182\/blood.V96.7.2419","article-title":"In vivo CAMPATH-1H prevents graft-versus-host disease following nonmyeloablative stem cell transplantation","volume":"96","author":"Kottaridis","year":"2000","journal-title":"Blood."},{"key":"10.1016\/j.bbmt.2018.10.008_bib0008","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1016\/j.exphem.2005.05.009","article-title":"Reduced-intensity conditioning containing low-dose alemtuzumab before allogeneic peripheral blood stem cell transplantation: graft-versus-host disease is decreased but T-cell reconstitution is delayed","volume":"33","author":"Dodero","year":"2005","journal-title":"Exp Hematol"},{"key":"10.1016\/j.bbmt.2018.10.008_bib0009","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.1016\/j.bbmt.2012.05.006","article-title":"Busulfan, fludarabine, and alemtuzumab as a reduced toxicity regimen for children with malignant and nonmalignant diseases improves engraftment and graft-versus-host disease without delaying immune reconstitution","volume":"18","author":"Law","year":"2012","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.bbmt.2018.10.008_bib0010","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1182\/blood.V99.3.1071","article-title":"Limiting transplantation-related mortality following unrelated donor stem cell transplantation by using a nonmyeloablative conditioning regimen","volume":"99","author":"Chakraverty","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2018.10.008_bib0011","doi-asserted-by":"crossref","first-page":"e94","DOI":"10.1097\/MPH.0000000000000272","article-title":"Late toxicity of a novel allogeneic stem cell transplant using single fraction total body irradiation for hematologic malignancies in children","volume":"37","author":"Madden","year":"2015","journal-title":"J Pediatr Hematol Oncol"},{"key":"10.1016\/j.bbmt.2018.10.008_bib0012","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.1016\/j.bbmt.2016.08.013","article-title":"A single-center experience comparing alemtuzumab, fludarabine, and melphalan reduced-intensity conditioning with myeloablative busulfan, cyclophosphamide, and antithymocyte globulin for chronic granulomatous disease","volume":"22","author":"Khandelwal","year":"2016","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.bbmt.2018.10.008_bib0013","doi-asserted-by":"crossref","first-page":"4357","DOI":"10.1182\/blood.V99.12.4357","article-title":"High incidence of cytomegalovirus infection after nonmyeloablative stem cell transplantation: potential role of Campath-1H in delaying immune reconstitution","volume":"99","author":"Chakrabarti","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2018.10.008_bib0014","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/S1083-8791(03)00192-7","article-title":"Results of minimally toxic nonmyeloablative transplantation in patients with sickle cell anemia and beta-thalassemia","volume":"9","author":"Iannone","year":"2003","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.bbmt.2018.10.008_bib0015","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1016\/j.bbmt.2015.03.019","article-title":"Hematopoietic cell transplantation using reduced-intensity conditioning is successful in children with hematologic cytopenias of genetic origin","volume":"21","author":"Kothari","year":"2015","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.bbmt.2018.10.008_bib0016","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1002\/ajh.24183","article-title":"Successful matched sibling donor marrow transplantation following reduced intensity conditioning in children with hemoglobinopathies","volume":"90","author":"King","year":"2015","journal-title":"Am J Hematol"},{"key":"10.1016\/j.bbmt.2018.10.008_bib0017","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1002\/pbc.25458","article-title":"Alemtuzumab based reduced intensity transplantation for pediatric severe aplastic anemia","volume":"62","author":"Ngwube","year":"2015","journal-title":"Pediatr Blood Cancer"},{"key":"10.1016\/j.bbmt.2018.10.008_bib0018","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.bbmt.2013.11.005","article-title":"Low-dose serotherapy improves early immune reconstitution after cord blood transplantation for primary immunodeficiencies","volume":"20","author":"Lane","year":"2014","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.bbmt.2018.10.008_bib0019","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/sj.bmt.1705584","article-title":"Immune recovery in children undergoing allogeneic stem cell transplantation:absolute CD8+ CD3+ count reconstitution is associated with survival","volume":"39","author":"Koehl","year":"2007","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.bbmt.2018.10.008_bib0020","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.bbmt.2014.11.674","article-title":"Impact of serotherapy on immune reconstitution and survival outcomes after stem cell transplantations in children: thymoglobulin versus alemtuzumab","volume":"21","author":"Willemsen","year":"2015","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.bbmt.2018.10.008_bib0021","doi-asserted-by":"crossref","first-page":"3080","DOI":"10.1182\/blood-2010-05-286856","article-title":"Impact of in vivo alemtuzumab dose before reduced intensity conditioning and HLA-identical sibling stem cell transplantation: pharmacokinetics, GVHD, and immune reconstitution","volume":"116","author":"Chakraverty","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2018.10.008_bib0022","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1038\/sj.bmt.1704795","article-title":"A novel reduced-intensity stem cell transplant regimen for nonmalignant disorders","volume":"35","author":"Shenoy","year":"2005","journal-title":"Bone Marrow Transplant."},{"key":"10.1016\/j.bbmt.2018.10.008_bib0023","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.imbio.2014.02.010","article-title":"Reference ranges of lymphocyte subsets in healthy adults and adolescents with special mention of T cell maturation subsets in adults of South Florida","volume":"219","author":"Valiathan","year":"2014","journal-title":"Immunobiology"},{"key":"10.1016\/j.bbmt.2018.10.008_bib0024","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1016\/j.exphem.2005.06.016","article-title":"Reduced-intensity conditioning regimen preserves thymic function in the early period after hematopoietic stem cell transplantation","volume":"33","author":"Jimenez","year":"2005","journal-title":"Exp Hematol"},{"key":"10.1016\/j.bbmt.2018.10.008_bib0025","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1038\/sj.leu.2404681","article-title":"Immune reconstitution after allogeneic stem cell transplantation with reduced-intensity conditioning regimens","volume":"21","author":"Jimenez","year":"2007","journal-title":"Leukemia"},{"key":"10.1016\/j.bbmt.2018.10.008_bib0026","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1038\/sj.bmt.1704205","article-title":"Immune reconstitution following reduced-intensity transplantation with cladribine, busulfan, and antithymocyte globulin: serial comparison with conventional myeloablative transplantation","volume":"32","author":"Saito","year":"2003","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.bbmt.2018.10.008_bib0027","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1182\/blood-2013-05-502385","article-title":"Impact of thymoglobulin prior to pediatric unrelated umbilical cord blood transplantation on immune reconstitution and clinical outcome","volume":"123","author":"Lindemans","year":"2014","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2018.10.008_bib0028","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1016\/j.bbmt.2009.08.006","article-title":"Incidence of Viral and fungal infections following busulfan-based reduced-intensity versus myeloablative conditioning in pediatric allogeneic stem cell transplantation recipients","volume":"15","author":"Satwani","year":"2009","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.bbmt.2018.10.008_bib0029","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1182\/blood-2003-02-0456","article-title":"Risks and outcomes of invasive fungal infections in recipients of allogeneic hematopoietic stem cell transplants after nonmyeloablative conditioning","volume":"102","author":"Fukuda","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2018.10.008_bib0030","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1038\/sj.bmt.1704164","article-title":"Cytomegalovirus infections in allogeneic stem cell recipients after reduced-intensity or myeloablative conditioning assessed by quantitative PCR and pp65-antigenemia","volume":"32","author":"Schetelig","year":"2003","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.bbmt.2018.10.008_bib0031","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/sj.bmt.1705255","article-title":"Infections after allogeneic hematopoietic stem cell transplantation with a nonmyeloablative conditioning regimen","volume":"37","author":"Frere","year":"2006","journal-title":"Bone Marrow Transplant"}],"container-title":["Biology of Blood and Marrow Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1083879118306414?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1083879118306414?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T15:07:20Z","timestamp":1761059240000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1083879118306414"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3]]},"references-count":31,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,3]]}},"alternative-id":["S1083879118306414"],"URL":"https:\/\/doi.org\/10.1016\/j.bbmt.2018.10.008","relation":{},"ISSN":["1083-8791"],"issn-type":[{"value":"1083-8791","type":"print"}],"subject":[],"published":{"date-parts":[[2019,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Immune Reconstitution and Infection Patterns after Early Alemtuzumab and Reduced Intensity Transplantation for Nonmalignant Disorders in Pediatric Patients","name":"articletitle","label":"Article Title"},{"value":"Biology of Blood and Marrow Transplantation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbmt.2018.10.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 American Society for Blood and Marrow Transplantation.","name":"copyright","label":"Copyright"}]}}