{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T08:46:46Z","timestamp":1791362806922,"version":"4.3.1"},"reference-count":36,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"vor","delay-in-days":366,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007054","name":"Meso Scale Diagnostics","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004330","name":"GlaxoSmithKline","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004330","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008373","name":"Takeda Pharmaceutical Company","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008373","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004336","name":"Novartis","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004336","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008897","name":"Janssen Pharmaceuticals","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008897","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100019721","name":"Roche Espa\u00f1a","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019721","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004324","name":"Astellas Pharma US","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004324","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004337","name":"Roche","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004337","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bbmt.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biology of Blood and Marrow Transplantation"],"published-print":{"date-parts":[[2019,9]]},"DOI":"10.1016\/j.bbmt.2019.05.023","type":"journal-article","created":{"date-parts":[[2019,5,29]],"date-time":"2019-05-29T02:45:53Z","timestamp":1559097953000},"page":"1825-1831","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":51,"title":["Thrombopoietin Receptor Agonists for Severe Thrombocytopenia after Allogeneic Stem Cell Transplantation: Experience of the Spanish Group of Hematopoietic Stem Cell Transplant"],"prefix":"10.1016","volume":"25","author":[{"given":"Leyre","family":"Bento","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Mar\u00eda","family":"Bastida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Garc\u00eda-Cadenas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Estefania","family":"Garc\u00eda-Torres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Rivera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9147-3692","authenticated-orcid":false,"given":"Anna","family":"Bosch-Vilaseca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"De Miguel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Esther","family":"Mart\u00ednez-Mu\u00f1oz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesc","family":"Fern\u00e1ndez-Avil\u00e9s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Rold\u00e1n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anabelle","family":"Chinea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucrecia","family":"Y\u00e1\u00f1ez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Zudaire","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos Pinho","family":"Vaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ildefonso","family":"Espigado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"L\u00f3pez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Valc\u00e1rcel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Duarte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Cabrera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Concepci\u00f3n","family":"Herrera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Ram\u00f3n","family":"Gonz\u00e1lez-Porras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Guti\u00e9rrez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Solano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonia","family":"Sampol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbmt.2019.05.023_bib0001","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1038\/leu.2011.257","article-title":"Significantly worse survival of patients with NIH-defined chronic graft-versus-host disease and thrombocytopenia or progressive onset type: results of a prospective study","volume":"26","author":"Kuzmina","year":"2012","journal-title":"Leukemia"},{"key":"10.1016\/j.bbmt.2019.05.023_bib0002","doi-asserted-by":"crossref","first-page":"1678","DOI":"10.1016\/j.bbmt.2016.06.003","article-title":"Risk factors and impact of secondary failure of platelet recovery after allogeneic stem cell transplantation","volume":"22","author":"Akahoshi","year":"2016","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.bbmt.2019.05.023_bib0003","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1038\/sj.bmt.1701499","article-title":"Prolonged isolated thrombocytopenia after hematopoietic stem cell transplantation: morphologic correlation","volume":"22","author":"Bielski","year":"1998","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.bbmt.2019.05.023_bib0004","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1182\/blood.V65.2.368.368","article-title":"Isolated thrombocytopenia after allogeneic bone marrow transplantation: existence of transient and chronic thrombocytopenic syndromes","volume":"65","author":"First","year":"1985","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2019.05.023_bib0005","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1053\/bbmt.2001.v7.pm11302549","article-title":"Secondary failure of platelet recovery after hematopoietic stem cell transplantation","volume":"7","author":"Bruno","year":"2001","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.bbmt.2019.05.023_bib0006","doi-asserted-by":"crossref","first-page":"2237","DOI":"10.1056\/NEJMoa073275","article-title":"Eltrombopag for the treatment of chronic idiopathic thrombocytopenic purpura","volume":"357","author":"Bussel","year":"2007","journal-title":"N Engl J Med"},{"key":"10.1016\/j.bbmt.2019.05.023_bib0007","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1177\/2042098618769587","article-title":"Eltrombopag in immune thrombocytopenia: efficacy review and update on drug safety","volume":"9","author":"Gonzalez-Porras","year":"2018","journal-title":"Ther Adv Drug Saf"},{"key":"10.1016\/j.bbmt.2019.05.023_bib0008","doi-asserted-by":"crossref","first-page":"2227","DOI":"10.1056\/NEJMoa073255","article-title":"Eltrombopag for thrombocytopenia in patients with cirrhosis associated with hepatitis C","volume":"357","author":"McHutchison","year":"2007","journal-title":"N Engl J Med"},{"key":"10.1016\/j.bbmt.2019.05.023_bib0009","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1056\/NEJMoa1200931","article-title":"Eltrombopag and improved hematopoiesis in refractory aplastic anemia","volume":"367","author":"Olnes","year":"2012","journal-title":"N Engl J Med"},{"key":"10.1016\/j.bbmt.2019.05.023_bib0010","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1182\/blood-2014-02-553404","article-title":"Eltrombopag: a stem cell cookie?","volume":"123","author":"Marsh","year":"2014","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2019.05.023_bib0011","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/S0140-6736(08)60203-2","article-title":"Efficacy of romiplostim in patients with chronic immune thrombocytopenic purpura: a double-blind randomised controlled trial","volume":"371","author":"Kuter","year":"2008","journal-title":"Lancet"},{"key":"10.1016\/j.bbmt.2019.05.023_bib0012","doi-asserted-by":"crossref","first-page":"3163","DOI":"10.1182\/blood-2010-03-274753","article-title":"Phase 2 study of romiplostim in patients with low- or intermediate-risk myelodysplastic syndrome receiving azacitidine therapy","volume":"116","author":"Kantarjian","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2019.05.023_bib0013","doi-asserted-by":"crossref","first-page":"e34","DOI":"10.1016\/S2352-3026(17)30228-4","article-title":"Eltrombopag for advanced myelodysplastic syndromes or acute myeloid leukaemia and severe thrombocytopenia (ASPIRE): a randomised, placebo-controlled, phase 2 trial","volume":"5","author":"Mittelman","year":"2018","journal-title":"Lancet Haematol"},{"key":"10.1016\/j.bbmt.2019.05.023_bib0014","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1002\/pbc.22332","article-title":"Response of refractory immune thrombocytopenia after bone marrow transplantation to romiplostim","volume":"54","author":"Beck","year":"2010","journal-title":"Pediatr Blood Cancer"},{"key":"10.1016\/j.bbmt.2019.05.023_bib0015","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1038\/bmt.2011.179","article-title":"Romiplostim (AMG531, Nplate) for secondary failure of platelet recovery after allo-SCT","volume":"46","author":"Calmettes","year":"2011","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.bbmt.2019.05.023_bib0016","first-page":"1","article-title":"Evaluation of romiplostim for the treatment of secondary failure of platelet recovery among allogeneic hematopoietic stem cell transplant patients","volume":"0","author":"Hartranft","year":"2015","journal-title":"J Oncol Pharm Pract"},{"key":"10.1016\/j.bbmt.2019.05.023_bib0017","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/j.bbmt.2016.01.018","article-title":"Eltrombopag for treatment of thrombocytopenia after allogeneic hematopoietic cell transplantation","volume":"22","author":"Tanaka","year":"2016","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.bbmt.2019.05.023_bib0018","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1111\/ejh.13132","article-title":"Usefulness of thrombopoietin receptor agonists for persistent clinically relevant thrombocytopenia after allogeneic stem cell transplantation","volume":"101","author":"Bosch-Vilaseca","year":"2018","journal-title":"Eur J Haematol"},{"key":"10.1016\/j.bbmt.2019.05.023_bib0019","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1038\/s41409-018-0368-1","article-title":"Usefulness of eltrombopag for treating thrombocytopenia after allogeneic stem cell transplantation","volume":"54","author":"Rivera","year":"2019","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.bbmt.2019.05.023_bib0020","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1038\/s41409-019-0442-3","article-title":"Eltrombopag for post-transplant cytopenias due to poor graft function","volume":"54","author":"Marotta","year":"2019","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.bbmt.2019.05.023_bib0021","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1016\/j.bbmt.2019.01.027","article-title":"Eltrombopag for the treatment of thrombocytopenia post-allogeneic stem cell transplantation","volume":"25","author":"Yuan","year":"2019","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.bbmt.2019.05.023_bib0022","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1038\/s41409-019-0435-2","article-title":"Eltrombopag is an effective and safe therapy for refractory thrombocytopenia after haploidentical hematopoietic stem cell transplantation","volume":"54","author":"Fu","year":"2019","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.bbmt.2019.05.023_bib0023","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1002\/ajh.23225","article-title":"Use of eltrombopag, a thrombopoietin receptor agonist, in post-transplantation thrombocytopenia","volume":"87","author":"Reid","year":"2012","journal-title":"Am J Hematol"},{"key":"10.1016\/j.bbmt.2019.05.023_bib0024","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1111\/j.1600-0609.2012.01832.x","article-title":"Response of complex immune-mediated thrombocytopenia to romiplostim in the setting of allogeneic stem cell transplantation for chronic myelogenous leukemia","volume":"89","author":"Bollag","year":"2012","journal-title":"Eur J Haematol"},{"key":"10.1016\/j.bbmt.2019.05.023_bib0025","first-page":"260","article-title":"Romiplostim for delayed platelet recovery and secondary thrombocytopenia following allogeneic stem cell transplantation","volume":"3","author":"Poon","year":"2013","journal-title":"Am J Blood Res"},{"key":"10.1016\/j.bbmt.2019.05.023_bib0026","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1177\/1078155212469640","article-title":"Romiplostim resistance in secondary failure of platelet recovery","volume":"19","author":"DeRemer","year":"2013","journal-title":"J Oncol Pharm Pract"},{"key":"10.1016\/j.bbmt.2019.05.023_bib0027","doi-asserted-by":"crossref","first-page":"E181","DOI":"10.1111\/petr.12564","article-title":"Successful treatment of secondary graft failure following unrelated cord blood transplant with hematopoietic growth factors in a pediatric patient with Fanconi anemia","volume":"19","author":"Buchbinder","year":"2015","journal-title":"Pediatr Transplant"},{"key":"10.1016\/j.bbmt.2019.05.023_bib0028","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1007\/s12185-015-1806-0","article-title":"Identification of anti-thrombopoietin receptor antibody in prolonged thrombocytopenia after allogeneic hematopoietic stem cell transplantation treated successfully with eltrombopag","volume":"102","author":"Fujimi","year":"2015","journal-title":"Int J Hematol"},{"key":"10.1016\/j.bbmt.2019.05.023_bib0029","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1007\/s12185-015-1821-1","article-title":"Romiplostim for secondary thrombocytopenia following allogeneic stem cell transplantation in children","volume":"102","author":"Maximova","year":"2015","journal-title":"Int J Hematol"},{"key":"10.1016\/j.bbmt.2019.05.023_bib0030","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1038\/bmt.2015.182","article-title":"Safety and feasibility of romiplostim treatment for patients with persistent thrombocytopenia after allogeneic stem cell transplantation","volume":"50","author":"Battipaglia","year":"2015","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.bbmt.2019.05.023_bib0031","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1182\/blood.V126.23.738.738","article-title":"Eltrombopag for post-transplant thrombocytopenia: results of phase ii randomized double blind placebo controlled trial","volume":"126","author":"Popat","year":"2015","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2019.05.023_bib0032","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1634\/stemcells.2008-0366","article-title":"Preclinical activity of eltrombopag (SB-497115), an oral, nonpeptide thrombopoietin receptor agonist","volume":"27","author":"Erickson-Miller","year":"2009","journal-title":"Stem Cells"},{"key":"10.1016\/j.bbmt.2019.05.023_bib0033","doi-asserted-by":"crossref","first-page":"2162","DOI":"10.1182\/blood.V87.6.2162.bloodjournal8762162","article-title":"Deficiencies in progenitor cells of multiple hematopoietic lineages and defective megakaryocytopoiesis in mice lacking the thrombopoietic receptor c-Mpl","volume":"87","author":"Alexander","year":"1996","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2019.05.023_bib0034","doi-asserted-by":"crossref","first-page":"2043","DOI":"10.1182\/blood-2018-11-884486","article-title":"Eltrombopag maintains human hematopoietic stem and progenitor cells under inflammatory conditions mediated by IFN\u03b3","volume":"133","author":"Alvarado","year":"2019","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2019.05.023_bib0035","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1056\/NEJMoa1613878","article-title":"Eltrombopag added to standard immunosuppression for aplastic anemia","volume":"376","author":"Townsley","year":"2017","journal-title":"N Engl J Med"},{"key":"10.1016\/j.bbmt.2019.05.023_bib0036","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1038\/s41409-019-0452-1","article-title":"Nationwide survey in France on the use of romiplostim in patients with refractory severe aplastic anemia","volume":"54","author":"Zhao","year":"2019","journal-title":"Bone Marrow Transplant"}],"container-title":["Biology of Blood and Marrow Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1083879119303349?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1083879119303349?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T15:07:25Z","timestamp":1761059245000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1083879119303349"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9]]},"references-count":36,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["S1083879119303349"],"URL":"https:\/\/doi.org\/10.1016\/j.bbmt.2019.05.023","relation":{},"ISSN":["1083-8791"],"issn-type":[{"value":"1083-8791","type":"print"}],"subject":[],"published":{"date-parts":[[2019,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Thrombopoietin Receptor Agonists for Severe Thrombocytopenia after Allogeneic Stem Cell Transplantation: Experience of the Spanish Group of Hematopoietic Stem Cell Transplant","name":"articletitle","label":"Article Title"},{"value":"Biology of Blood and Marrow Transplantation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbmt.2019.05.023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 American Society for Transplantation and Cellular Therapy. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}