{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T05:22:10Z","timestamp":1789017730127,"version":"build-2803163510"},"reference-count":33,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bbmt.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biology of Blood and Marrow Transplantation"],"published-print":{"date-parts":[[2020,3]]},"DOI":"10.1016\/j.bbmt.2019.10.024","type":"journal-article","created":{"date-parts":[[2019,11,3]],"date-time":"2019-11-03T00:55:29Z","timestamp":1572742529000},"page":"529-539","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"title":["Incidence, Predictors, and Outcomes of Veno-Occlusive Disease\/Sinusoidal Obstruction Syndrome after Reduced-Intensity Allogeneic Hematopoietic Cell Transplantation"],"prefix":"10.1016","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9329-249X","authenticated-orcid":false,"given":"Clinton","family":"Lewis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haesook T.","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsey E.","family":"Roeker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corey","family":"Cutler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Koreth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Nikiforow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Armand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahasweta","family":"Gootpu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rizwan","family":"Romee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brett","family":"Glotzbecker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prashant","family":"Nageshwar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph H.","family":"Antin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edwin P.","family":"Alyea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Richardson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J.","family":"Soiffer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent T.","family":"Ho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.bbmt.2019.10.024_bib0001","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1038\/sj.bmt.1705899","article-title":"Hepatic veno-occlusive disease after hematopoietic stem cell transplantation: update on defibrotide and other current investigational therapies","volume":"41","author":"Ho","year":"2008","journal-title":"Bone Marrow Transplant"},{"issue":"2","key":"10.1016\/j.bbmt.2019.10.024_bib0002","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.bbmt.2009.08.024","article-title":"Hepatic veno-occlusive disease following stem cell transplantation: incidence, clinical course, and outcome","volume":"16","author":"Coppell","year":"2010","journal-title":"Biol Blood Marrow Transplant"},{"issue":"1","key":"10.1016\/j.bbmt.2019.10.024_bib0003","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1055\/s-2002-23204","article-title":"Toxic injury to hepatic sinusoids: sinusoidal obstruction syndrome (veno-occlusive disease)","volume":"22","author":"DeLeve","year":"2002","journal-title":"Semin Liver Dis"},{"issue":"1","key":"10.1016\/j.bbmt.2019.10.024_bib0004","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1002\/hep.1840040121","article-title":"Venocclusive disease of the liver after bone marrow transplantation: diagnosis, incidence, and predisposing factors","volume":"4","author":"McDonald","year":"1984","journal-title":"Hepatol Baltim Md"},{"issue":"6","key":"10.1016\/j.bbmt.2019.10.024_bib0005","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1097\/00007890-198712000-00011","article-title":"Venoocclusive disease of the liver following bone marrow transplantation","volume":"44","author":"Jones","year":"1987","journal-title":"Transplantation"},{"issue":"7","key":"10.1016\/j.bbmt.2019.10.024_bib0006","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1038\/bmt.2016.130","article-title":"Revised diagnosis and severity criteria for sinusoidal obstruction syndrome\/veno-occlusive disease in adult patients: a new classification from the European Society for Blood and Marrow Transplantation","volume":"51","author":"Mohty","year":"2016","journal-title":"Bone Marrow Transplant"},{"issue":"4","key":"10.1016\/j.bbmt.2019.10.024_bib0007","doi-asserted-by":"crossref","first-page":"255","DOI":"10.7326\/0003-4819-118-4-199302150-00003","article-title":"Veno-occlusive disease of the liver and multiorgan failure after bone marrow transplantation: a cohort study of 355 patients","volume":"118","author":"McDonald","year":"1993","journal-title":"Ann Intern Med"},{"issue":"10","key":"10.1016\/j.bbmt.2019.10.024_bib0008","first-page":"3599","article-title":"Incidence and outcome of hepatic veno-occlusive disease after blood or marrow transplantation: a prospective cohort study of the European Group for Blood and Marrow Transplantation","volume":"92","author":"Carreras","year":"1998","journal-title":"Blood"},{"issue":"11","key":"10.1016\/j.bbmt.2019.10.024_bib0009","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1016\/j.bbmt.2011.06.006","article-title":"The incidence of veno-occlusive disease following allogeneic hematopoietic stem cell transplantation has diminished and the outcome improved over the last decade","volume":"17","author":"Carreras","year":"2011","journal-title":"Biol Blood Marrow Transplant"},{"issue":"11","key":"10.1016\/j.bbmt.2019.10.024_bib0010","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1038\/bmt.2014.168","article-title":"Incidence and risk factors for moderate-to-severe veno-occlusive disease of the liver after allogeneic stem cell transplantation using a reduced intensity conditioning regimen","volume":"49","author":"Tsirigotis","year":"2014","journal-title":"Bone Marrow Transplant"},{"issue":"3","key":"10.1016\/j.bbmt.2019.10.024_bib0011","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.bbmt.2015.09.024","article-title":"Hepatic veno-occlusive disease after hematopoietic stem cell transplantation: risk factors and stratification, prophylaxis, and treatment","volume":"22","author":"Dalle","year":"2016","journal-title":"Biol Blood Marrow Transplant"},{"issue":"3","key":"10.1016\/j.bbmt.2019.10.024_bib0012","first-page":"9","article-title":"Treatment of severe veno-occlusive disease with defibrotide: compassionate use results in response without significant toxicity in a high-risk population","volume":"92","author":"Richardson","year":"1998","journal-title":"Blood"},{"issue":"7","key":"10.1016\/j.bbmt.2019.10.024_bib0013","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/j.bbmt.2010.02.009","article-title":"Defibrotide for the treatment of severe hepatic veno-occlusive disease and multiorgan failure after stem cell transplantation: a multicenter, randomized, dose-finding trial","volume":"16","author":"Richardson","year":"2010","journal-title":"Biol Blood Marrow Transplant"},{"issue":"4","key":"10.1016\/j.bbmt.2019.10.024_bib0014","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1177\/2040620712441943","article-title":"Safety and efficacy of defibrotide for the treatment of severe hepatic veno-occlusive disease","volume":"3","author":"Richardson","year":"2012","journal-title":"Ther Adv Hematol"},{"issue":"2","key":"10.1016\/j.bbmt.2019.10.024_bib0015","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1038\/sj.bmt.1704329","article-title":"Defibrotide in the treatment of children with veno-occlusive disease (VOD): a retrospective multicentre study demonstrates therapeutic efficacy upon early intervention","volume":"33","author":"Corbacioglu","year":"2004","journal-title":"Bone Marrow Transplant"},{"issue":"15, suppl","key":"10.1016\/j.bbmt.2019.10.024_bib0016","doi-asserted-by":"crossref","first-page":"7047","DOI":"10.1200\/JCO.2017.35.15_suppl.7047","article-title":"Timing of initiation of defibrotide (DF) post-diagnosis of hepatic veno-occlusive disease\/sinusoidal obstruction syndrome (VOD\/SOS) after hematopoietic stem cell transplantation (HSCT): final data from an expanded-access protocol","volume":"35","author":"Grupp","year":"2017","journal-title":"J Clin Oncol"},{"issue":"12","key":"10.1016\/j.bbmt.2019.10.024_bib0017","doi-asserted-by":"crossref","first-page":"4425","DOI":"10.1182\/blood-2008-07-169342","article-title":"Sirolimus is associated with veno-occlusive disease of the liver after myeloablative allogeneic stem cell transplantation","volume":"112","author":"Cutler","year":"2008","journal-title":"Blood"},{"issue":"8","key":"10.1016\/j.bbmt.2019.10.024_bib0018","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1016\/j.bbmt.2010.02.016","article-title":"Prediction of veno-occlusive disease using biomarkers of endothelial injury","volume":"16","author":"Cutler","year":"2010","journal-title":"Biol Blood Marrow Transplant"},{"issue":"9","key":"10.1016\/j.bbmt.2019.10.024_bib0019","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1038\/sj.bmt.1700760","article-title":"Changes in hemostatic parameters in hepatic veno-occlusive disease following bone marrow transplantation","volume":"19","author":"Park","year":"1997","journal-title":"Bone Marrow Transplant"},{"issue":"8","key":"10.1016\/j.bbmt.2019.10.024_bib0020","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1038\/sj.bmt.1702624","article-title":"Predictive markers for hepatic veno-occlusive disease after hematopoietic stem cell transplantation in adults: a prospective single center study","volume":"26","author":"Tanikawa","year":"2000","journal-title":"Bone Marrow Transplant"},{"issue":"6","key":"10.1016\/j.bbmt.2019.10.024_bib0021","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1182\/blood.V67.6.1773.1773","article-title":"Thrombocytopenia in venocclusive disease after bone marrow transplantation or chemotherapy","volume":"67","author":"Rio","year":"1986","journal-title":"Blood"},{"issue":"10","key":"10.1016\/j.bbmt.2019.10.024_bib0022","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1111\/j.1432-2277.2005.00204.x","article-title":"Altered metabolism of tacrolimus in hepatic veno-occlusive disease","volume":"18","author":"Mori","year":"2005","journal-title":"Transpl Int"},{"issue":"1","key":"10.1016\/j.bbmt.2019.10.024_bib0023","doi-asserted-by":"crossref","first-page":"55","DOI":"10.5045\/br.2013.48.1.55","article-title":"Hepatic veno-occlusive disease resulting in tacrolimus toxicity after allogeneic hematopoietic stem cell transplantation","volume":"48","author":"Shin","year":"2013","journal-title":"Blood Res"},{"issue":"1","key":"10.1016\/j.bbmt.2019.10.024_bib0024","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.bbmt.2018.07.039","article-title":"Early clinical predictors of hepatic veno-occlusive disease\/sinusoidal obstruction syndrome after myeloablative stem cell transplantation","volume":"25","author":"Roeker","year":"2019","journal-title":"Biol Blood Marrow Transplant"},{"issue":"12","key":"10.1016\/j.bbmt.2019.10.024_bib0025","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1016\/j.bbmt.2009.07.004","article-title":"Defining the intensity of conditioning regimens: working definitions","volume":"15","author":"Bacigalupo","year":"2009","journal-title":"Biol Blood Marrow Transplant"},{"issue":"345","key":"10.1016\/j.bbmt.2019.10.024_bib0026","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1080\/01621459.1974.10480131","article-title":"Evaluation of response-time data involving transient states: an illustration using heart-transplant data","volume":"69","author":"Mantel","year":"1974","journal-title":"J Am Stat Assoc"},{"issue":"1","key":"10.1016\/j.bbmt.2019.10.024_bib0027","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1002\/sim.4780030106","article-title":"A non-parametric graphical representation of the relationship between survival and the occurrence of an event: application to responder versus non-responder bias","volume":"3","author":"Simon","year":"1984","journal-title":"Stat Med"},{"issue":"3","key":"10.1016\/j.bbmt.2019.10.024_bib0028","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1214\/aos\/1176350951","article-title":"A class of $K$-sample tests for comparing the cumulative incidence of a competing risk","volume":"16","author":"Gray","year":"1988","journal-title":"Ann Stat"},{"issue":"1","key":"10.1016\/j.bbmt.2019.10.024_bib0029","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/s41409-018-0233-2","article-title":"Hepatic veno-occlusive disease following sirolimus-based immune suppression","volume":"54","author":"Khimani","year":"2019","journal-title":"Bone Marrow Transplant"},{"issue":"10","key":"10.1016\/j.bbmt.2019.10.024_bib0030","doi-asserted-by":"crossref","first-page":"2072","DOI":"10.1016\/j.bbmt.2018.06.013","article-title":"Risk score for the development of veno-occlusive disease after allogeneic hematopoietic cell transplant","volume":"24","author":"Strouse","year":"2018","journal-title":"Biol Blood Marrow Transplant"},{"issue":"12","key":"10.1016\/j.bbmt.2019.10.024_bib0031","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1038\/s41409-019-0474-8","article-title":"Systematic review of defibrotide studies in the treatment of veno-occlusive disease\/sinusoidal obstruction syndrome (VOD\/SOS)","volume":"54","author":"Richardson","year":"2019","journal-title":"Bone Marrow Transplant"},{"issue":"6","key":"10.1016\/j.bbmt.2019.10.024_bib0032","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1111\/bjh.15267","article-title":"Final results from a defibrotide treatment-IND study for patients with hepatic veno-occlusive disease\/sinusoidal obstruction syndrome","volume":"181","author":"Kernan","year":"2018","journal-title":"Br J Haematol"},{"key":"10.1016\/j.bbmt.2019.10.024_bib0033","doi-asserted-by":"crossref","unstructured":"Mohty M, Malard F, Abecasis M, et al. Prophylactic, preemptive, and curative treatment for sinusoidal obstruction syndrome\/veno-occlusive disease in adult patients: a position statement from an international expert group [e-pub ahead of print]. Bone Marrow Transplant. https:\/\/doi.org\/10.1038\/s41409-019-0705-z. Accessed 22 Oct 2019.","DOI":"10.1038\/s41409-019-0705-z"}],"container-title":["Biology of Blood and Marrow Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1083879119307062?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1083879119307062?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T15:10:46Z","timestamp":1761059446000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1083879119307062"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3]]},"references-count":33,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,3]]}},"alternative-id":["S1083879119307062"],"URL":"https:\/\/doi.org\/10.1016\/j.bbmt.2019.10.024","relation":{},"ISSN":["1083-8791"],"issn-type":[{"value":"1083-8791","type":"print"}],"subject":[],"published":{"date-parts":[[2020,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Incidence, Predictors, and Outcomes of Veno-Occlusive Disease\/Sinusoidal Obstruction Syndrome after Reduced-Intensity Allogeneic Hematopoietic Cell Transplantation","name":"articletitle","label":"Article Title"},{"value":"Biology of Blood and Marrow Transplantation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbmt.2019.10.024","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Published by Elsevier Inc. on behalf of the American Society for Transplantation and Cellular Therapy","name":"copyright","label":"Copyright"}]}}