{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T18:51:03Z","timestamp":1772563863516,"version":"3.50.1"},"reference-count":24,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,6,26]],"date-time":"2020-06-26T00:00:00Z","timestamp":1593129600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["bbmt.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biology of Blood and Marrow Transplantation"],"published-print":{"date-parts":[[2020,10]]},"DOI":"10.1016\/j.bbmt.2020.06.019","type":"journal-article","created":{"date-parts":[[2020,6,26]],"date-time":"2020-06-26T13:13:04Z","timestamp":1593177184000},"page":"1894-1899","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["Volume of Gadolinium Enhancement and Successful Repair of the Blood-Brain Barrier in Cerebral Adrenoleukodystrophy"],"prefix":"10.1016","volume":"26","author":[{"given":"Troy C.","family":"Lund","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle","family":"Ng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul J.","family":"Orchard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel J.","family":"Loes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerald V.","family":"Raymond","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashish","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Kenny-Jung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David R.","family":"Nascene","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbmt.2020.06.019_bib0001","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1007\/s11910-014-0486-0","article-title":"X-linked adrenoleukodystrophy: pathogenesis and treatment","volume":"14","author":"Engelen","year":"2014","journal-title":"Curr Neurol Neurosci Rep"},{"key":"10.1016\/j.bbmt.2020.06.019_bib0002","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1055\/s-2000-9236","article-title":"X-linked adrenoleukodystrophy: overview and prognosis as a function of age and brain magnetic resonance imaging abnormality. A study involving 372 patients","volume":"31","author":"Moser","year":"2000","journal-title":"Neuropediatrics"},{"key":"10.1016\/j.bbmt.2020.06.019_bib0003","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.1182\/blood-2011-01-329235","article-title":"Outcomes after allogeneic hematopoietic cell transplantation for childhood cerebral adrenoleukodystrophy: the largest single-institution cohort report","volume":"118","author":"Miller","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2020.06.019_bib0004","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1182\/blood-2018-11-887240","article-title":"Successful donor engraftment and repair of the blood-brain barrier in cerebral adrenoleukodystrophy","volume":"133","author":"Orchard","year":"2019","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2020.06.019_bib0005","doi-asserted-by":"crossref","first-page":"367","DOI":"10.3174\/ajnr.A4500","article-title":"Intensity of MRI gadolinium enhancement in cerebral adrenoleukodystrophy: a biomarker for inflammation and predictor of outcome following transplantation in higher risk patients","volume":"37","author":"Miller","year":"2016","journal-title":"AJNR Am J Neuroradiol"},{"key":"10.1016\/j.bbmt.2020.06.019_bib0006","doi-asserted-by":"crossref","first-page":"e32218","DOI":"10.1371\/journal.pone.0032218","article-title":"Elevated cerebral spinal fluid cytokine levels in boys with cerebral adrenoleukodystrophy correlates with MRI severity","volume":"7","author":"Lund","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.bbmt.2020.06.019_bib0007","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1186\/1742-2094-8-144","article-title":"Chitotriosidase as a biomarker of cerebral adrenoleukodystrophy","volume":"8","author":"Orchard","year":"2011","journal-title":"J Neuroinflammation"},{"key":"10.1016\/j.bbmt.2020.06.019_bib0008","first-page":"1761","article-title":"Adrenoleukodystrophy: a scoring method for brain MR observations","volume":"15","author":"Loes","year":"1994","journal-title":"AJNR Am J Neuroradiol"},{"key":"10.1016\/j.bbmt.2020.06.019_bib0009","doi-asserted-by":"crossref","first-page":"1860","DOI":"10.1056\/NEJM199006283222607","article-title":"Reversal of early neurologic and neuroradiologic manifestations of X-linked adrenoleukodystrophy by bone marrow transplantation","volume":"322","author":"Aubourg","year":"1990","journal-title":"N Engl J Med"},{"key":"10.1016\/j.bbmt.2020.06.019_bib0010","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1148\/radiology.137.3.7444053","article-title":"A new CT pattern in adrenoleukodystrophy","volume":"137","author":"Di Chiro","year":"1980","journal-title":"Radiology"},{"key":"10.1016\/j.bbmt.2020.06.019_bib0011","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1212\/WNL.27.9.884","article-title":"CT scanning and diagnosis of adrenoleukodystrophy","volume":"27","author":"Greenberg","year":"1977","journal-title":"Neurology"},{"key":"10.1016\/j.bbmt.2020.06.019_bib0012","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1148\/radiology.165.2.3659373","article-title":"Adrenoleukodystrophy: correlating MR imaging with CT","volume":"165","author":"Kumar","year":"1987","journal-title":"Radiology"},{"key":"10.1016\/j.bbmt.2020.06.019_bib0013","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/BF02011036","article-title":"Contribution of MRI to the diagnosis of cerebral lesions of adrenoleukodystrophy","volume":"21","author":"Pasco","year":"1991","journal-title":"Pediatr Radiol"},{"key":"10.1016\/j.bbmt.2020.06.019_bib0014","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/BF00593329","article-title":"MR imaging of adrenoleukodystrophy","volume":"33","author":"Uchiyama","year":"1991","journal-title":"Neuroradiology"},{"key":"10.1016\/j.bbmt.2020.06.019_bib0015","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1084\/jem.20051342","article-title":"Dystroglycan is selectively cleaved at the parenchymal basement membrane at sites of leukocyte extravasation in experimental autoimmune encephalomyelitis","volume":"203","author":"Agrawal","year":"2006","journal-title":"J Exp Med"},{"key":"10.1016\/j.bbmt.2020.06.019_bib0016","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1002\/ana.21391","article-title":"Is microglial apoptosis an early pathogenic change in cerebral X-linked adrenoleukodystrophy","volume":"63","author":"Eichler","year":"2008","journal-title":"Ann Neurol"},{"key":"10.1016\/j.bbmt.2020.06.019_bib0017","doi-asserted-by":"crossref","DOI":"10.1002\/glia.23598","article-title":"Microglia damage precedes major myelin breakdown in X-linked adrenoleukodystrophy and metachromatic leukodystrophy","author":"Bergner","year":"2019","journal-title":"Glia"},{"key":"10.1016\/j.bbmt.2020.06.019_bib0018","doi-asserted-by":"crossref","first-page":"2676","DOI":"10.1093\/brain\/aws206","article-title":"Hypoperfusion predicts lesion progression in cerebral X-linked adrenoleukodystrophy","volume":"135","author":"Musolino","year":"2012","journal-title":"Brain"},{"key":"10.1016\/j.bbmt.2020.06.019_bib0019","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/5840286","article-title":"Autologous hematopoietic cell transplantation in multiple sclerosis: changing paradigms in the era of novel agents","volume":"2019","author":"Gavriilaki","year":"2019","journal-title":"Stem Cells Int"},{"key":"10.1016\/j.bbmt.2020.06.019_bib0020","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1056\/NEJMoa1700554","article-title":"Hematopoietic stem-cell gene therapy for cerebral adrenoleukodystrophy","volume":"377","author":"Eichler","year":"2017","journal-title":"N Engl J Med"},{"key":"10.1016\/j.bbmt.2020.06.019_bib0021","doi-asserted-by":"crossref","DOI":"10.1093\/brain\/awy127","article-title":"Impaired plasticity of macrophages in X-linked adrenoleukodystrophy","author":"Weinhofer","year":"2018","journal-title":"Brain"},{"key":"10.1016\/j.bbmt.2020.06.019_bib0022","doi-asserted-by":"crossref","first-page":"15018","DOI":"10.1073\/pnas.1205858109","article-title":"Brain conditioning is instrumental for successful microglia reconstitution following hematopoietic stem cell transplantation","volume":"109","author":"Capotondo","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.bbmt.2020.06.019_bib0023","doi-asserted-by":"crossref","first-page":"3557","DOI":"10.1073\/pnas.0306431101","article-title":"Human CD34+ cells differentiate into microglia and express recombinant therapeutic protein","volume":"101","author":"Asheuer","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.bbmt.2020.06.019_bib0024","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1126\/science.1171242","article-title":"Hematopoietic stem cell gene therapy with a lentiviral vector in X-linked adrenoleukodystrophy","volume":"326","author":"Cartier","year":"2009","journal-title":"Science"}],"container-title":["Biology of Blood and Marrow Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1083879120303736?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1083879120303736?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T15:11:36Z","timestamp":1761059496000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1083879120303736"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10]]},"references-count":24,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["S1083879120303736"],"URL":"https:\/\/doi.org\/10.1016\/j.bbmt.2020.06.019","relation":{},"ISSN":["1083-8791"],"issn-type":[{"value":"1083-8791","type":"print"}],"subject":[],"published":{"date-parts":[[2020,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Volume of Gadolinium Enhancement and Successful Repair of the Blood-Brain Barrier in Cerebral Adrenoleukodystrophy","name":"articletitle","label":"Article Title"},{"value":"Biology of Blood and Marrow Transplantation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbmt.2020.06.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 American Society for Transplantation and Cellular Therapy. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}