{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:56:25Z","timestamp":1787756185840,"version":"build-2784847793"},"reference-count":86,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,5,23]],"date-time":"2023-05-23T00:00:00Z","timestamp":1684800000000},"content-version":"vor","delay-in-days":841,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Transplantation and Cellular Therapy"],"published-print":{"date-parts":[[2021,2]]},"DOI":"10.1016\/j.bbmt.2020.09.033","type":"journal-article","created":{"date-parts":[[2020,10,2]],"date-time":"2020-10-02T12:13:07Z","timestamp":1601640787000},"page":"115-124","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"title":["Acute Graft-versus-Host-Disease Other Than Typical Targets: Between Myths and Facts"],"prefix":"10.1016","volume":"27","author":[{"given":"Jacopo","family":"Mariotti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olaf","family":"Penack","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Castagna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbmt.2020.09.033_bib0001","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1056\/NEJMp078166","article-title":"Hematopoietic-cell transplantation at 50","volume":"357(15)","author":"Appelbaum","year":"2007","journal-title":"N Engl J Med"},{"key":"10.1016\/j.bbmt.2020.09.033_bib0002","doi-asserted-by":"crossref","first-page":"2091","DOI":"10.1056\/NEJMoa1004383","article-title":"Reduced mortality after allogeneic hematopoietic-cell transplantation","volume":"363(22)","author":"Gooley","year":"2010","journal-title":"Bone N Engl J Med"},{"key":"10.1016\/j.bbmt.2020.09.033_bib0003","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1097\/00007890-197410000-00001","article-title":"Clinical manifestations of graft-versus-host disease in humans recipients of marrow from HLA-matched sibling donors","volume":"18","author":"Glucksberg","year":"1974","journal-title":"Transplantation"},{"key":"10.1016\/j.bbmt.2020.09.033_bib0004","first-page":"825","article-title":"1994 Consensus Conference on Acute GVHD Grading","volume":"15","author":"Przepiorka","year":"1995","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.bbmt.2020.09.033_bib0005","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.bbmt.2015.09.001","article-title":"International, Multicenter Standardization of Acute Graft-versu- Host Disease Clinical Data Collection: A Report fromthe Mount Sinai Acute GVHD International Consortium","volume":"22","author":"Harris","year":"2016","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.bbmt.2020.09.033_bib0006","doi-asserted-by":"crossref","first-page":"2256","DOI":"10.1056\/NEJMra1404711","article-title":"Renal complications of hematopoietic-cell transplantation","volume":"374","author":"Hingorani","year":"2016","journal-title":"N Engl J Med"},{"key":"10.1016\/j.bbmt.2020.09.033_bib0007","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1038\/bmt.2008.207","article-title":"Contemporary analysis of the influence of acute kidney injury after reduced intensity conditioning haematopoietic cell transplantation on long-term survival","volume":"42","author":"Lopes","year":"2008","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.bbmt.2020.09.033_bib0008","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.2169\/internalmedicine.51.7418","article-title":"Risk assessment for acute kidney injury after allogeneic hematopoietic stem cell transplantation based on Acute Kidney Injury Network criteria","volume":"51","author":"Mori","year":"2012","journal-title":"Intern Med"},{"key":"10.1016\/j.bbmt.2020.09.033_bib0009","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1038\/sj.bmt.1705835","article-title":"Risk factors and mortality predictors of hepatic veno-occlusive disease after pediatric hematopoietic stem cell transplantation","volume":"40","author":"Cheuk","year":"2007","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.bbmt.2020.09.033_bib0010","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1053\/j.seminhematol.2018.04.003","article-title":"Complement in pathophysiology and treatment of transplant-associated thrombotic microangiopathies","volume":"55","author":"Jodele","year":"2018","journal-title":"Semin Hematol"},{"key":"10.1016\/j.bbmt.2020.09.033_bib0011","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1097\/TP.0b013e3181f24e8d","article-title":"Validation of recently proposed consensus criteria for thrombotic microangiopathy after allogeneic hematopoietic stem-cell transplantation","volume":"90","author":"Cho","year":"2010","journal-title":"Transplantation"},{"key":"10.1016\/j.bbmt.2020.09.033_bib0012","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.blre.2014.11.001","article-title":"A new paradigm: diagnosis and management of HSCT-associated thrombotic microangiopathy as multi-system endothelial injury","volume":"29","author":"Jodele","year":"2015","journal-title":"Blood Rev"},{"key":"10.1016\/j.bbmt.2020.09.033_bib0013","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1038\/bmt.2017.119","article-title":"Transplant-associated thrombotic microangiopathy is an endothelial complication associated with refractoriness of acute GvHD","volume":"52","author":"Zeisbrich","year":"2017","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.bbmt.2020.09.033_bib0014","doi-asserted-by":"crossref","first-page":"2619","DOI":"10.1182\/bloodadvances.2018020321","article-title":"Complement-mediated thrombotic microangiopathy as a link between endothelial damage and steroid-refractory GVHD","volume":"2","author":"Wall","year":"2018","journal-title":"Blood Adv"},{"key":"10.1016\/j.bbmt.2020.09.033_bib0015","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1182\/blood-2011-02-334821","article-title":"Steroid-refractory GVHD: T-cell attack within a vulnerable endothelial system","volume":"118","author":"Luft","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2020.09.033_bib0016","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1111\/j.1440-1827.2010.02608.x","article-title":"Renal thrombotic microangiopathy associated with chronic humoral graft versus host disease after hematopoietic stem cell transplantation","volume":"61","author":"Mii","year":"2011","journal-title":"Pathol Int"},{"key":"10.1016\/j.bbmt.2020.09.033_bib0017","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1177\/0963689717720295","article-title":"Acute renal graft-versus-host disease in a murine model of allogeneic bone marrow transplantation","volume":"26","author":"Schmid","year":"2017","journal-title":"Cell Transplant"},{"key":"10.1016\/j.bbmt.2020.09.033_bib0018","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0115399","article-title":"Acute graft-versus-host disease of the kidney in allogeneic rat bone marrow transplantation","volume":"9","author":"Higo","year":"2014","journal-title":"PLoS One"},{"issue":"5","key":"10.1016\/j.bbmt.2020.09.033_bib0019","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1038\/bmt.2015.2","article-title":"Markers of coagulation activation and acute kidney injury in patients after hematopoietic cell transplantation","volume":"50","author":"Hingorani","year":"2015","journal-title":"Bone Marrow Transplant"},{"issue":"2","key":"10.1016\/j.bbmt.2020.09.033_bib0020","doi-asserted-by":"crossref","first-page":"345","DOI":"10.2215\/CJN.02070508","article-title":"Renal thrombotic microangiopathy after hematopoietic cell transplant: role of GVHD in pathogenesis","volume":"4","author":"Changsirikulchai","year":"2009","journal-title":"Clin J Am Soc Nephrol"},{"issue":"1","key":"10.1016\/j.bbmt.2020.09.033_bib0021","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1272\/jnms.JNMS.2020_87-102","article-title":"Renal complications after hematopoietic stem cell transplantation: role of graft-versus-host disease in renal thrombotic microangiopathy","volume":"87","author":"Mii","year":"2020","journal-title":"J Nippon Med Sch"},{"key":"10.1016\/j.bbmt.2020.09.033_bib0022","doi-asserted-by":"crossref","first-page":"12","DOI":"10.2215\/CJN.01840214","article-title":"Urinary elafin and kidney injury in hematopoietic cell transplant recipients","volume":"10","author":"Hingorani","year":"2015","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1016\/j.bbmt.2020.09.033_bib0023","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3000406","article-title":"Elafin is a biomarker of graft-versus-host disease of the skin","volume":"2","author":"Paczesny","year":"2010","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.bbmt.2020.09.033_bib0024","first-page":"531","article-title":"Acute kidney injury in hematopoietic stem cell transplantation","volume":"25","author":"Wanchoo","year":"2019","journal-title":"Curr Opin Crit Care"},{"key":"10.1016\/j.bbmt.2020.09.033_bib0025","doi-asserted-by":"crossref","first-page":"e414","DOI":"10.1016\/S2352-3026(17)30108-4","article-title":"EASIX in patients with acute graft-versus-host disease:a retrospective cohort analysis","volume":"4","author":"Luft","year":"2017","journal-title":"Lancet Haematol"},{"key":"10.1016\/j.bbmt.2020.09.033_bib0026","doi-asserted-by":"crossref","first-page":"2339","DOI":"10.3389\/fimmu.2019.02339","article-title":"Acute graft-vs.-host disease-associated endothelial activation in vitro is prevented by defibrotide","volume":"10","author":"Martinez-Sanchez","year":"2019","journal-title":"Front Immunol"},{"issue":"10","key":"10.1016\/j.bbmt.2020.09.033_bib0027","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1007\/s00277-015-2440-x","article-title":"The incidence, risk factors, and outcomes of primary poor graft function after unmanipulated haploidentical stem cell transplantation","volume":"94","author":"Sun","year":"2015","journal-title":"Ann Hematol"},{"key":"10.1016\/j.bbmt.2020.09.033_bib0028","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1080\/146532400539260","article-title":"CD34(+) immunoselected cells for poor graft function following allogeneic BMT","volume":"2","author":"Mohty","year":"2000","journal-title":"Cytotherapy"},{"key":"10.1016\/j.bbmt.2020.09.033_bib0029","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1016\/j.bbmt.2014.04.015","article-title":"Association between an impaired bone marrow vascular microenvironment and prolonged isolated thrombocytopenia after allogeneic hematopoietic stem cell transplantation","volume":"20","author":"Kong","year":"2014","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.bbmt.2020.09.033_bib0030","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1038\/sj.bmt.1704428","article-title":"Failure of trilineage blood cell reconstitution after initial neutrophil engraftment in patients undergoing allogeneic hematopoietic cell transplantation\u2014frequency and outcomes","volume":"33","author":"Lee","year":"2004","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.bbmt.2020.09.033_bib0031","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1046\/j.1365-2141.2001.02468.x","article-title":"Factors influencing haematological recovery after allogeneic haemopoietic stem cell transplants: graft-versus-host disease, donor type, cytomegalovirus infections and cell dose","volume":"112","author":"Dominietto","year":"2001","journal-title":"Br J Haematol"},{"key":"10.1016\/j.bbmt.2020.09.033_bib0032","unstructured":"The Japan Society for Hematopoietic Cell Transplantation Office of Nationwide Survey. Annual Report of Nationwide Survey, 2003. Nagiya, Japan: Nagoya University Daiko Medical Center 2003."},{"key":"10.1016\/j.bbmt.2020.09.033_bib0033","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1053\/bbmt.2001.v7.pm11302549","article-title":"Secondary failure of platelet recovery after hematopoietic stem cell transplantation","volume":"7","author":"Bruno","year":"2001","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.bbmt.2020.09.033_bib0034","first-page":"935","article-title":"Boost of CD34+-selected peripheral blood cells without further conditioning in patients with poor graft function following allogeneic stem cell transplantation","volume":"91","author":"Larocca","year":"2006","journal-title":"Haematologica"},{"key":"10.1016\/j.bbmt.2020.09.033_bib0035","first-page":"4","article-title":"Analysis of risk factors for secondary cytopenia after allogeneic hematopoietic stem cell transplantation","volume":"35","author":"Lin","year":"2014","journal-title":"Zhonghua Xue Ye Xue Za Zhi"},{"key":"10.1016\/j.bbmt.2020.09.033_bib0036","first-page":"86","article-title":"reconstitution after allogeneic stem cell transplantation: the impact of stem cell source and graft-versus-host disease","volume":"90","author":"Abrahamsen","year":"2005","journal-title":"Haematologica"},{"issue":"suppl 1","key":"10.1016\/j.bbmt.2020.09.033_bib0037","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.bbmt.2005.10.015","article-title":"Immune reconstitution: from stem cells to lymphocytes","volume":"12","author":"Crooks","year":"2006","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.bbmt.2020.09.033_bib0038","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1182\/blood-2013-11-539031","article-title":"Bone marrow T-cell infiltration during acute GVHD is associated with delayed B-cell recovery and function after HSCT","volume":"124","author":"Mensen","year":"2014","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2020.09.033_bib0039","doi-asserted-by":"crossref","unstructured":"Pollack MS, Speeg KV, Callander NS, et al. Severe, late-onset graft-versus-host disease in a liver transplant recipient documented by chimerism analysis. Hum Immunol. 2005;66:28-31.","DOI":"10.1016\/j.humimm.2004.09.014"},{"key":"10.1016\/j.bbmt.2020.09.033_bib0040","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.5858\/2008-0679-RS.1","article-title":"Solid organ transplant-associated acute graft versus host disease","volume":"134","author":"Zhang","year":"2010","journal-title":"Arch Pathol Lab Med"},{"key":"10.1016\/j.bbmt.2020.09.033_bib0041","doi-asserted-by":"crossref","first-page":"5401","DOI":"10.1182\/blood-2009-11-253559","article-title":"Bone marrow graft-versus-host disease: early destruction of hematopoietic niche after MHC-mismatched hematopoietic stem cell transplantation","volume":"115","author":"Shono","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2020.09.033_bib0042","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0104607","article-title":"Dysfunction of bone marrow vascular niche in acute graft-versus-host disease after MHC-haploidentical bone marrow transplantation","volume":"9","author":"Yao","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.bbmt.2020.09.033_bib0043","doi-asserted-by":"crossref","first-page":"118","DOI":"10.3389\/fimmu.2016.00118","article-title":"Bone marrow GvHD after allogeneic hematopoietic stem cell transplantation","volume":"7","author":"Szyska","year":"2016","journal-title":"Front Immunol"},{"key":"10.1016\/j.bbmt.2020.09.033_bib0044","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1038\/bmt.2011.179","article-title":"Romiplostim (AMG531, Nplate) for secondary failure of platelet recovery after allo-SCT","volume":"46","author":"Calmettes","year":"2011","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.bbmt.2020.09.033_bib0045","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.bbmt.2013.11.034","article-title":"CD34(+)-selected stem cell boost without further conditioning for poor graft function after allogeneic stem cell transplantation in patients with hematological malignancies","volume":"20","author":"Klyuchnikov","year":"2014","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.bbmt.2020.09.033_bib0046","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1016\/j.bbmt.2014.05.016","article-title":"CD34 selected cells for the treatment of poor graft function after allogeneic stem cell transplantation","volume":"20","author":"Stasia","year":"2014","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.bbmt.2020.09.033_bib0047","doi-asserted-by":"crossref","first-page":"2988","DOI":"10.1182\/blood-2016-03-702803","article-title":"Atorvastatin enhances endothelial cell function in posttransplant poor graft function","volume":"128","author":"Shi","year":"2016","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2020.09.033_bib0048","first-page":"42","article-title":"Clinical use of statins in hematopoietic stem cell transplantation: old drugs and new horizons","volume":"10","author":"Mohammadi","year":"2016","journal-title":"Int J Hematol Oncol Stem Cell Res"},{"key":"10.1016\/j.bbmt.2020.09.033_bib0049","doi-asserted-by":"crossref","first-page":"2852","DOI":"10.1093\/brain\/awq245","article-title":"Neurological manifestations of chronic graft-versus-host disease after allogeneic haematopoietic stem cell transplantation: report from the Consensus Conference on Clinical Practice in chronic graft-versus-host disease","volume":"133","author":"Grauer","year":"2010","journal-title":"Brain"},{"key":"10.1016\/j.bbmt.2020.09.033_bib0050","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1038\/bmt.2009.323","article-title":"Cerebral angiitis in four patients with chronic GVHD","volume":"45","author":"Sostak","year":"2010","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.bbmt.2020.09.033_bib0051","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.2169\/internalmedicine.48.2003","article-title":"Encephalomyelitis mimicking multiple sclerosis associated with chronic graft-versus-host disease after allogeneic bone marrow transplantation","volume":"48","author":"Matsuo","year":"2009","journal-title":"Intern Med"},{"key":"10.1016\/j.bbmt.2020.09.033_bib0052","doi-asserted-by":"crossref","first-page":"e8303","DOI":"10.1097\/MD.0000000000008303","article-title":"Case report: central nervous system involvement of human graft versus host disease: report of 7 cases and a review of literature","volume":"96","author":"Ruggiu","year":"2017","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.bbmt.2020.09.033_bib0053","doi-asserted-by":"crossref","first-page":"1994","DOI":"10.1212\/01.WNL.0000038948.09158.A7","article-title":"CNS angiitis in graft vs host disease","volume":"59","author":"Ma","year":"2002","journal-title":"Neurology"},{"key":"10.1016\/j.bbmt.2020.09.033_bib0054","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1002\/ajh.21518","article-title":"Possible graft-versus-host disease involving the central nervous system soon after cord blood transplantation","volume":"84","author":"Yamamoto","year":"2009","journal-title":"Am J Hematol"},{"key":"10.1016\/j.bbmt.2020.09.033_bib0055","first-page":"1290","article-title":"Reversible leukoencephalopathy associated with graft-versus-host disease: MR findings","volume":"17","author":"Provenzale","year":"1996","journal-title":"AJNR Am J Neuroradiol"},{"key":"10.1016\/j.bbmt.2020.09.033_bib0056","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1038\/bmt.2017.239","article-title":"Neurologic complications after allogeneic hematopoietic stem cell transplantation: risk factors and impact","volume":"53","author":"Dowling","year":"2018","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.bbmt.2020.09.033_bib0057","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1016\/j.bbmt.2009.07.013","article-title":"Early and late neurological complications after reduced-intensity conditioning allogeneic stem cell transplantation","volume":"15","author":"Barba","year":"2009","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.bbmt.2020.09.033_bib0058","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1038\/sj.bmt.1702140","article-title":"Neuropathological findings after bone marrow transplantation: an autopsy study of 180 cases","volume":"25","author":"Bleggi-Torres","year":"2000","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.bbmt.2020.09.033_bib0059","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1212\/01.WNL.0000046522.38465.79","article-title":"Prospective evaluation of neurological complications after allogeneic bone marrow transplantation","volume":"60","author":"Sostak","year":"2003","journal-title":"Neurology"},{"key":"10.1016\/j.bbmt.2020.09.033_bib0060","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1038\/sj.bmt.1704749","article-title":"Life-threatening neurological complications after bone marrow transplantation in children","volume":"35","author":"Uckan","year":"2005","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.bbmt.2020.09.033_bib0061","doi-asserted-by":"crossref","first-page":"1906","DOI":"10.1182\/blood-2012-09-456590","article-title":"The central nervous system is a target of acute graft versus host disease in mice","volume":"121","author":"Hartrampf","year":"2013","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2020.09.033_bib0062","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.coi.2018.09.008","article-title":"Bettelli E. Regulation of lymphocyte trafficking in central nervous system autoimmunity","volume":"55","author":"Oukka","year":"2018","journal-title":"Curr Opin Immunol"},{"key":"10.1016\/j.bbmt.2020.09.033_bib0063","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1164\/rccm.2007-413ST","article-title":"An official American Thoracic Society research statement: noninfectious lung injury after hematopoietic stem cell transplantation: idiopathic pneumonia syndrome","volume":"183","author":"Panoskaltsis-Mortari","year":"2011","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.bbmt.2020.09.033_bib0064","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1097\/CCO.0b013e32835dc8a5","article-title":"Management of noninfectious lung injury following hematopoietic cell transplantation","volume":"25","author":"Yanik","year":"2013","journal-title":"Curr Opin Oncol"},{"key":"10.1016\/j.bbmt.2020.09.033_bib0065","doi-asserted-by":"crossref","first-page":"2777","DOI":"10.1182\/blood-2003-05-1597","article-title":"Risks and outcomes of idiopathic pneumonia syndrome after nonmyeloablative and conventional conditioning regimens for allogeneic hematopoietic stem cell transplantation","volume":"102","author":"Fukuda","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2020.09.033_bib0066","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1053\/j.seminhematol.2005.09.004","article-title":"The lung as a target organ of graft-versus-host disease","volume":"43","author":"Yanik","year":"2006","journal-title":"Semin Hematol"},{"key":"10.1016\/j.bbmt.2020.09.033_bib0067","first-page":"231","article-title":"Concannon A. An acute pulmonary syndrome possibly representing acute graft-versus-host disease involving the lung interstitium","volume":"8","author":"Atkinson","year":"1991","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.bbmt.2020.09.033_bib0068","first-page":"225","article-title":"Acute graft-versus-host disease and the risks for idiopathic pneumonia after marrow transplantation for severe aplastic anemia","volume":"12","author":"Crawford","year":"1993","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.bbmt.2020.09.033_bib0069","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1111\/j.1365-2141.1989.tb06314.x","article-title":"Risk factors for interstitial pneumonia following bone marrow transplantation for severe aplastic anaemia","volume":"71","author":"Weiner","year":"1989","journal-title":"Br J Haematol"},{"key":"10.1016\/j.bbmt.2020.09.033_bib0070","doi-asserted-by":"crossref","first-page":"168","DOI":"10.7326\/0003-4819-104-2-168","article-title":"Interstitial pneumonitis after bone marrow transplantation: assessment of risk factors","volume":"104","author":"Weiner","year":"1986","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.bbmt.2020.09.033_bib0071","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1097\/00007890-199704270-00006","article-title":"Idiopathic pneumonia syndrome: changing spectrum of lung injury after marrow transplantation","volume":"63","author":"Kantrow","year":"1997","journal-title":"Transplantation"},{"key":"10.1016\/j.bbmt.2020.09.033_bib0072","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.1097\/00003246-199909000-00016","article-title":"Idiopathic pneumonia after bone marrow transplantation: cytokine activation and lipopolysaccharide amplification in the bronchoalveolar compartment","volume":"27","author":"Clark","year":"1999","journal-title":"Crit Care Med"},{"key":"10.1016\/j.bbmt.2020.09.033_bib0073","doi-asserted-by":"crossref","first-page":"3073","DOI":"10.1182\/blood-2008-03-143412","article-title":"The impact of soluble tumor necrosis factor receptor etanercept on the treatment of idiopathic pneumonia syndrome after allogeneic hematopoietic stem cell transplantation","volume":"112","author":"Yanik","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2020.09.033_bib0074","doi-asserted-by":"crossref","first-page":"2417","DOI":"10.1182\/blood-2003-08-2708","article-title":"A critical role for CCR2\/MCP-1 interactions in the development of idiopathic pneumonia syndrome after allogeneic bone marrow transplantation","volume":"103","author":"Hildebrandt","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2020.09.033_bib0075","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1097\/PAP.0000000000000032","article-title":"Hematopoietic stem cell transplantation: graft versus host disease and pathology of gastrointestinal tract, liver, and lung","volume":"21","author":"Kambham","year":"2014","journal-title":"Adv Anat Pathol"},{"key":"10.1016\/j.bbmt.2020.09.033_bib0076","doi-asserted-by":"crossref","first-page":"3230","DOI":"10.1182\/blood.V88.8.3230.bloodjournal8883230","article-title":"An experimental model of idiopathic pneumonia syndrome after bone marrow transplantation, I: the roles of minor H antigens and endotoxin","volume":"88","author":"Cooke","year":"1996","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2020.09.033_bib0077","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1172\/JCI119612","article-title":"The critical early proinflammatory events associated with idiopathic pneumonia syndrome in irradiated murine allogeneic recipients are due to donor T cell infusion and potentiated by cyclophosphamide","volume":"100","author":"Panoskaltsis-Mortari","year":"1997","journal-title":"J Clin Invest"},{"issue":"9","key":"10.1016\/j.bbmt.2020.09.033_bib0078","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1164\/rccm.2007-413ST","article-title":"An official American Thoracic Society research statement: noninfectious lung injury after hematopoietic stem cell transplantation: idiopathic pneumonia syndrome","volume":"183","author":"Panoskaltsis-Mortari","year":"2011","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.bbmt.2020.09.033_bib0079","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1182\/blood-2006-12-063982","article-title":"IFNgamma differentially controls the development of idiopathic pneumonia syndrome and GVHD of the gastrointestinal tract","volume":"110","author":"Burman","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2020.09.033_bib0080","doi-asserted-by":"crossref","DOI":"10.1182\/blood-2014-07-590232","article-title":"Lung parenchyma-derived IL-6 promotes IL-17A-dependent acute lung injury after allogeneic stem cell transplantation","volume":"125","author":"Varelias","year":"2015","journal-title":"Blood"},{"key":"10.1016\/j.bbmt.2020.09.033_bib0081","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1038\/bmt.2011.260","article-title":"High-dose corticosteroids with or without etanercept for the treatment of idiopathic pneumonia syndrome after allo-SCT","volume":"47","author":"Tizon","year":"2012","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.bbmt.2020.09.033_bib0082","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.bbmt.2014.09.019","article-title":"TNF-receptor inhibitor therapy for the treatment of children with idiopathic pneumonia syndrome: a joint Pediatric Blood and Marrow Transplant Consortium and Children's Oncology Group Study (ASCT0521)","volume":"21","author":"Yanik","year":"2015","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.bbmt.2020.09.033_bib0083","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1016\/j.bbmt.2014.02.026","volume":"20","author":"Yanik","year":"2014","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.bbmt.2020.09.033_bib0084","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1002\/cam4.2607","article-title":"Pretransplant active disease status and HLA class II mismatching are associated with increased incidence and severity of cytokine release syndrome after haploidentical transplantation with posttransplant cyclophosphamide","volume":"9","author":"Mariotti","year":"2020","journal-title":"Cancer Med"},{"key":"10.1016\/j.bbmt.2020.09.033_bib0085","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.1056\/NEJMoa1917635","article-title":"Ruxolitinib for glucocorticoid-refractory acute graft-versus-host disease","volume":"382","author":"Zeiser","year":"2020","journal-title":"N Engl J Med"},{"key":"10.1016\/j.bbmt.2020.09.033_bib0086","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1038\/bmt.2014.29","article-title":"Acute disseminated encephalomyelitis following allo-SCT: central nervous system manifestation of GVHD","volume":"4","author":"Harvey","year":"2014","journal-title":"Bone Marrow Transplant"}],"container-title":["Transplantation and Cellular Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1083879120306261?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1083879120306261?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T23:31:32Z","timestamp":1761089492000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1083879120306261"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2]]},"references-count":86,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,2]]}},"alternative-id":["S1083879120306261"],"URL":"https:\/\/doi.org\/10.1016\/j.bbmt.2020.09.033","relation":{},"ISSN":["2666-6367"],"issn-type":[{"value":"2666-6367","type":"print"}],"subject":[],"published":{"date-parts":[[2021,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Acute Graft-versus-Host-Disease Other Than Typical Targets: Between Myths and Facts","name":"articletitle","label":"Article Title"},{"value":"Transplantation and Cellular Therapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbmt.2020.09.033","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The American Society for Transplantation and Cellular Therapy. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}