{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T19:40:16Z","timestamp":1790192416458,"version":"4.1.0"},"reference-count":33,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2004,5,1]],"date-time":"2004-05-01T00:00:00Z","timestamp":1083369600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2004,5,1]],"date-time":"2004-05-01T00:00:00Z","timestamp":1083369600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2004,5,1]],"date-time":"2004-05-01T00:00:00Z","timestamp":1083369600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2004,5,1]],"date-time":"2004-05-01T00:00:00Z","timestamp":1083369600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2004,5,1]],"date-time":"2004-05-01T00:00:00Z","timestamp":1083369600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2004,5,1]],"date-time":"2004-05-01T00:00:00Z","timestamp":1083369600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Behavioural Brain Research"],"published-print":{"date-parts":[[2004,5]]},"DOI":"10.1016\/j.bbr.2003.08.018","type":"journal-article","created":{"date-parts":[[2003,10,29]],"date-time":"2003-10-29T20:37:35Z","timestamp":1067459855000},"page":"209-217","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":56,"title":["Effects of hypothermia and hyperthermia on attentional and spatial learning deficits following neonatal hypoxia-ischemic insult in rats"],"prefix":"10.1016","volume":"151","author":[{"given":"Kenichi","family":"Mishima","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoaki","family":"Ikeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuya","family":"Yoshikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoya","family":"Aoo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuaki","family":"Egashira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi X.","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsuyomu","family":"Ikenoue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsunori","family":"Iwasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michihiro","family":"Fujiwara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbr.2003.08.018_BIB1","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1007\/BF00713529","article-title":"The influence of hypothermia on hypoglycemia-induced brain damage in the rat","volume":"83","author":"Agardh","year":"1992","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.bbr.2003.08.018_BIB2","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/S0006-8993(00)02151-X","article-title":"Quantitative evaluation of extracellular glutamate concentration in postischemic glutamate re-uptake, dependent on brain temperature, in the rat following severe global brain ischemia","volume":"864","author":"Asai","year":"2000","journal-title":"Brain Res."},{"key":"10.1016\/j.bbr.2003.08.018_BIB3","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1542\/peds.107.3.480","article-title":"Neurodevelopmental outcome of infants treated with head cooling and mild hypothermia after perinatal asphyxia","volume":"107","author":"Battin","year":"2001","journal-title":"Pediatrics"},{"key":"10.1016\/j.bbr.2003.08.018_BIB4","doi-asserted-by":"crossref","first-page":"4146","DOI":"10.1523\/JNEUROSCI.16-13-04146.1996","article-title":"Increased expression of IL-1 converting enzyme in hippocampus after ischemia: selective localization in microglia","volume":"16","author":"Bhat","year":"1996","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbr.2003.08.018_BIB5","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1161\/01.STR.29.1.203","article-title":"Transient increase of manganese-superoxide dismutase in remote brain areas after focal photothrombotic cortical lesion","volume":"29","author":"Bidmon","year":"1998","journal-title":"Stroke"},{"key":"10.1016\/j.bbr.2003.08.018_BIB6","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/0165-3806(91)90003-2","article-title":"Unilateral hypoxic-ischemic injury in neonatal rat results in a persistent increase in the density of striatal tyrosine hydroxylase immunoperoxidase staining","volume":"58","author":"Burke","year":"1991","journal-title":"Brain Res. Dev. Brain Res."},{"key":"10.1016\/j.bbr.2003.08.018_BIB7","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1038\/jcbfm.1987.127","article-title":"Small differences in intraischemic brain temperature critically determine the extent of ischemic neuronal injury","volume":"7","author":"Busto","year":"1987","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.bbr.2003.08.018_BIB8","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1038\/jcbfm.1991.13","article-title":"Marked protection by moderate hypothermia after experimental traumatic brain injury","volume":"11","author":"Clifton","year":"1991","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.bbr.2003.08.018_BIB9","doi-asserted-by":"crossref","first-page":"7250","DOI":"10.1523\/JNEUROSCI.15-11-07250.1995","article-title":"Delayed postischemic hypothermia: a six month survival study using behavioral and histological assessments of neuroprotection","volume":"15","author":"Colbourne","year":"1995","journal-title":"J. Neurosci."},{"issue":"6","key":"10.1016\/j.bbr.2003.08.018_BIB10","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1161\/01.STR.17.6.1313","article-title":"Behavioral performance of rats following neonatal hypoxia-ischemia","volume":"17","author":"Young","year":"1986","journal-title":"Stroke"},{"key":"10.1016\/j.bbr.2003.08.018_BIB11","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1111\/j.1749-6632.1994.tb21789.x","article-title":"Induction of superoxide anion and nitric oxide production in cultured microglia","volume":"738","author":"Colton","year":"1994","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.bbr.2003.08.018_BIB12","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1161\/01.STR.21.9.1318","article-title":"Effects of normothermic versus mild hyperthermic forebrain ischemia in rats","volume":"21","author":"Dietrich","year":"1990","journal-title":"Stroke"},{"key":"10.1016\/j.bbr.2003.08.018_BIB13","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1038\/jcbfm.1993.71","article-title":"Intraischemic but not postischemic brain hypothermia protects chronically following global forebrain ischemia in rats","volume":"13","author":"Dietrich","year":"1993","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.bbr.2003.08.018_BIB14","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1203\/00006450-199512000-00014","article-title":"Selective destruction of nitric oxide synthase neurons with quisqualate reduces damage after hypoxia-ischemia in the neonatal rat","volume":"38","author":"Ferriero","year":"1995","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.bbr.2003.08.018_BIB15","first-page":"341","article-title":"Delayed ischemic hyperintensity on T1 weighted magnetic resonance images and induced manganese superoxide dismutase in mitochondria after mild focal ischemia: long-lasting oxidative stress hypothesis","volume":"31","author":"Fujioka","year":"2000","journal-title":"Stroke"},{"key":"10.1016\/j.bbr.2003.08.018_BIB16","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/0169-328X(93)90194-T","article-title":"Immediate early gene induction after neonatal hypoxia-ischemia","volume":"18","author":"Gubits","year":"1993","journal-title":"Brain Res. Mol. Brain Res."},{"key":"10.1016\/j.bbr.2003.08.018_BIB17","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1542\/peds.102.4.885","article-title":"Selective head cooling in newborn infants after perinatal asphyxia: a safety study","volume":"102","author":"Gunn","year":"1998","journal-title":"Pediatrics"},{"key":"10.1016\/j.bbr.2003.08.018_BIB18","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0166-4328(00)00287-4","article-title":"Selective and long-term learning impairment following neonatal hypoxic-ischemic brain insult in rats","volume":"118","author":"Ikeda","year":"2001","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbr.2003.08.018_BIB19","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0166-4328(95)00248-0","article-title":"Long-term effects of neonatal ischemic-hypoxic brain injury on sensorimotor and locomotor tasks in rats","volume":"78","author":"Jansen","year":"1996","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbr.2003.08.018_BIB20","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1097\/00004647-199601000-00012","article-title":"Brain temperature alters hydroxyl radical production during cerebral ischemia\/reperfusion in rats","volume":"16","author":"Kil","year":"1996","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.bbr.2003.08.018_BIB21","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1002\/ana.410280107","article-title":"The effect of mild hyperthermia and hypothermia on brain damage following 5, 10, and 15min of forebrain ischemia","volume":"28","author":"Minamisawa","year":"1990","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.bbr.2003.08.018_BIB22","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/0023-9690(81)90020-5","article-title":"Spatial localization dose not require the presence of local cues","volume":"12","author":"Morris","year":"1981","journal-title":"Learn Motiv."},{"key":"10.1016\/j.bbr.2003.08.018_BIB23","doi-asserted-by":"crossref","first-page":"7994","DOI":"10.1523\/JNEUROSCI.20-21-07994.2000","article-title":"Apoptosis has prolonged role in the neurodegeneration after hypoxic ischemia in the newborn rat","volume":"20","author":"Nakajima","year":"2000","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbr.2003.08.018_BIB24","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1161\/01.STR.29.7.1454","article-title":"A model of transient unilateral focal ischemia with reperfusion in the P7 neonatal rat","volume":"29","author":"Renolleau","year":"1998","journal-title":"Stroke"},{"key":"10.1016\/j.bbr.2003.08.018_BIB25","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1002\/ana.410090206","article-title":"The influence of immaturity on hypoxic-ischemic brain damage in the rat","volume":"9","author":"Rice","year":"1981","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.bbr.2003.08.018_BIB26","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/S0095-5108(18)30405-6","article-title":"Long-term follow-up of term neonates with perinatal asphyxia","volume":"20","author":"Robertson","year":"1993","journal-title":"Clin. Perinatol."},{"key":"10.1016\/j.bbr.2003.08.018_BIB27","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1203\/00006450-199112000-00021","article-title":"Hypoxia-ischemia stimulates hippocampal glutamate efflux in perinatal rat brain: an in vivo microdialysis study","volume":"30","author":"Silverstein","year":"1991","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.bbr.2003.08.018_BIB28","doi-asserted-by":"crossref","unstructured":"Sternau L, Thompson C, Dietrich WD, Martinez E, Busto R, Ginsberg MD. Ischemia induced neurotransmitter release: effects of mild intraischemic hypothermia. In: Globus MY-T, Dietrich WD, editors. The role of neurotransmitters in brain injury. New York: Plenum Press; 1992. p. 33\u20138.","DOI":"10.1007\/978-1-4615-3452-5_6"},{"key":"10.1016\/j.bbr.2003.08.018_BIB29","doi-asserted-by":"crossref","first-page":"F3","DOI":"10.1136\/fn.74.1.F3","article-title":"Posthypoxic cooling of neonatal rats provides protection against brain injury","volume":"74","author":"Thoresen","year":"1996","journal-title":"Arch. Dis. Child"},{"key":"10.1016\/j.bbr.2003.08.018_BIB30","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1007\/BF00293321","article-title":"The effect of focal cerebral cooling on perinatal hypoxic-ischemic brain damage","volume":"87","author":"Towfighi","year":"1994","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.bbr.2003.08.018_BIB31","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/S0387-7604(97)00027-2","article-title":"Brief post-hypoxic-ischemic hypothermia markedly delays neonatal brain injury","volume":"19","author":"Trescher","year":"1997","journal-title":"Brain Dev."},{"key":"10.1016\/j.bbr.2003.08.018_BIB32","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1097\/00000542-199508000-00013","article-title":"Temperature changes of \u22651\u00b0C alter functional neurologic outcome and histopathology in a canine model of complete cerebral ischemia","volume":"83","author":"Wass","year":"1995","journal-title":"Anesthesiology"},{"key":"10.1016\/j.bbr.2003.08.018_BIB33","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1203\/00006450-199310000-00029","article-title":"Influence of mild hypothermia on hypoxic-ischemic brain damage in the immature rat","volume":"34","author":"Yager","year":"1993","journal-title":"Pediatr Res."}],"container-title":["Behavioural Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432803003048?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432803003048?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,1,26]],"date-time":"2023-01-26T00:11:09Z","timestamp":1674691869000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166432803003048"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,5]]},"references-count":33,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2004,5]]}},"alternative-id":["S0166432803003048"],"URL":"https:\/\/doi.org\/10.1016\/j.bbr.2003.08.018","relation":{},"ISSN":["0166-4328"],"issn-type":[{"value":"0166-4328","type":"print"}],"subject":[],"published":{"date-parts":[[2004,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of hypothermia and hyperthermia on attentional and spatial learning deficits following neonatal hypoxia-ischemic insult in rats","name":"articletitle","label":"Article Title"},{"value":"Behavioural Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbr.2003.08.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2003 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}