{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T23:17:55Z","timestamp":1790723875042,"version":"4.1.0"},"reference-count":29,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2004,8,1]],"date-time":"2004-08-01T00:00:00Z","timestamp":1091318400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Behavioural Brain Research"],"published-print":{"date-parts":[[2004,8]]},"DOI":"10.1016\/j.bbr.2003.12.013","type":"journal-article","created":{"date-parts":[[2004,2,6]],"date-time":"2004-02-06T10:17:37Z","timestamp":1076062657000},"page":"377-381","source":"Crossref","is-referenced-by-count":57,"title":["Chronic hyperhomocysteinemia provokes a memory deficit in rats in the Morris water maze task"],"prefix":"10.1016","volume":"153","author":[{"given":"Emilio Luiz","family":"Streck","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caren Serra","family":"Bavaresco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos Alexandre","family":"Netto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela Terezinha de Souza","family":"Wyse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbr.2003.12.013_BIB1","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1111\/j.1471-4159.1986.tb01780.x","article-title":"Differential changes in the content of amino acid neurotransmitters in discrete regions of the rat brain prior to the onset and during the course of homocysteine-induced seizures","volume":"46","author":"Allen","year":"1986","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bbr.2003.12.013_BIB2","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S0006-8993(00)02280-0","article-title":"Antioxidant-rich diets improve cerebellar physiology and motor learning in aged rats","volume":"866","author":"Bickford","year":"2000","journal-title":"Brain Res."},{"key":"10.1016\/j.bbr.2003.12.013_BIB3","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1093\/hmg\/7.3.371","article-title":"Huntingtin interacts with cystathionine beta-synthase","volume":"7","author":"Boutell","year":"1998","journal-title":"Hum. Mol. Genet"},{"key":"10.1016\/j.bbr.2003.12.013_BIB4","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/S0736-5748(00)00008-3","article-title":"Neurobehavioral aspects of antioxidants in aging","volume":"18","author":"Cantuti-Castewlvetri","year":"2000","journal-title":"Int. J. Dev. Neurosci."},{"key":"10.1016\/j.bbr.2003.12.013_BIB5","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/S0165-0173(01)00067-4","article-title":"Applications of the Morris water maze in the study of learning and memory","volume":"36","author":"D\u2019Hooge","year":"2001","journal-title":"Brain Res. Brain Res. Rev."},{"key":"10.1016\/j.bbr.2003.12.013_BIB6","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1023\/A:1005369109055","article-title":"Disorders of homocysteine metabolism","volume":"20","author":"Fowler","year":"1997","journal-title":"J. Inherit Metab. Dis."},{"key":"10.1016\/j.bbr.2003.12.013_BIB7","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/S0891-5849(99)00029-5","article-title":"The effect of cyst(e)ine on the auto-oxidation of homocysteine","volume":"27","author":"Hogg","year":"1999","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbr.2003.12.013_BIB8","first-page":"117","article-title":"Involvement of N-methyl-d-aspartate receptor and free radical in homocysteine-mediated toxicity on rat cerebellar granule cells in culture","volume":"216","author":"Kim","year":"1996","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.bbr.2003.12.013_BIB9","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1111\/j.1528-1157.1995.tb01611.x","article-title":"Seizures induced by homocysteine in rats during ontogenesis","volume":"36","author":"Kubov\u00e1","year":"1995","journal-title":"Epilepsia"},{"key":"10.1016\/j.bbr.2003.12.013_BIB10","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1159\/000007984","article-title":"Elevated plasma levels of homocysteine in Parkinson\u2019s disease","volume":"40","author":"Kuhn","year":"1998","journal-title":"Eur. Neurol."},{"key":"10.1016\/j.bbr.2003.12.013_BIB11","doi-asserted-by":"crossref","first-page":"5923","DOI":"10.1073\/pnas.94.11.5923","article-title":"Neurotoxicity associated with dual actions of homocysteine at the N-methyl-d-aspartate receptor","volume":"94","author":"Lipton","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbr.2003.12.013_BIB12","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0047-6374(01)00365-7","article-title":"Folic acid and homocysteine in age-related disease","volume":"1","author":"Mattson","year":"2002","journal-title":"Ageing. Res. Rev."},{"key":"10.1016\/j.bbr.2003.12.013_BIB13","first-page":"7","article-title":"The methionine-homocysteine cycle and its effects on cognitive diseases","volume":"8","author":"Miller","year":"2003","journal-title":"Altern. Med. Rev."},{"key":"10.1016\/j.bbr.2003.12.013_BIB14","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1038\/297681a0","article-title":"Place navigation impaired in rats with hippocampal lesions","volume":"297","author":"Morris","year":"1982","journal-title":"Nature"},{"key":"10.1016\/j.bbr.2003.12.013_BIB15","unstructured":"Mudd SH, Levy HL, Skovby F. Disorders of transulfuration. In: Scriver CR, Beaudet AL, Sly WS, Valle D, editors. The metabolic and molecular bases of inherited disease. 8th ed. New York: McGraw-Hill; 2001. p. 1279\u2013327."},{"key":"10.1016\/j.bbr.2003.12.013_BIB16","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/0306-4530(86)90005-3","article-title":"Differential effect of posttraining naloxone, beta-endorphin, leu-enkephalin and electroconvulsive shock administration upon memory of an open-field habituation and of a water-finding task","volume":"11","author":"Netto","year":"1986","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.bbr.2003.12.013_BIB17","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/0306-4522(93)90384-R","article-title":"Effects of fetal hippocampal field grafts on ischaemic-induced deficits in spatial navigation in the water maze","volume":"54","author":"Netto","year":"1993","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbr.2003.12.013_BIB18","first-page":"599","article-title":"In vitro effect of the cysteine metabolites homocysteic acid","volume":"19","author":"Parsons","year":"1998","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.bbr.2003.12.013_BIB19","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1023\/A:1019982223034","article-title":"Pretreatment with vitamins E and C prevent the impairment of memory caused by homocysteine administration in rats","volume":"17","author":"Reis","year":"2002","journal-title":"Metab. Brain Dis."},{"key":"10.1016\/j.bbr.2003.12.013_BIB20","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1056\/NEJMoa011613","article-title":"Plasma homocysteine as a risk factor for dementia and Alzheimer\u2019s disease","volume":"346","author":"Seshadri","year":"2002","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbr.2003.12.013_BIB21","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1023\/A:1021670607647","article-title":"Reduction of Na+, K+-ATPase activity in hippocampus of rats subjected to chemically induced hyperhomocysteinemia","volume":"27","author":"Streck","year":"2002","journal-title":"Neurochem Res."},{"key":"10.1016\/j.bbr.2003.12.013_BIB22","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1023\/A:1015594111778","article-title":"Inhibition of Na+, K+-ATPase activity by the metabolites accumulating in homocystinuria","volume":"17","author":"Streck","year":"2002","journal-title":"Metab. Brain Dis."},{"key":"10.1016\/j.bbr.2003.12.013_BIB23","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0925-4439(03)00019-X","article-title":"Impairment of energy metabolism in hippocampus of rats subjected to chemically-induced hyperhomocysteinemia","volume":"1637","author":"Streck","year":"2003","journal-title":"Biochim. Biophys. Acta."},{"key":"10.1016\/j.bbr.2003.12.013_BIB24","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1023\/A:1023815119931","article-title":"In vitro effect of homocysteine on some parameters of oxidative stress in rat hippocampus","volume":"18","author":"Streck","year":"2003","journal-title":"Metab. Brain Dis."},{"key":"10.1016\/j.bbr.2003.12.013_BIB25","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/S0197-0186(02)00230-9","article-title":"Brain energy metabolism is compromised by the metabolites accumulating in homocystinuria","volume":"43","author":"Streck","year":"2003","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.bbr.2003.12.013_BIB26","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1006\/nlme.1999.3948","article-title":"Sex differences and estropausal phase effects on water maze performance in aged rats","volume":"74","author":"Warren","year":"2000","journal-title":"Neurobiol. Learn Mem."},{"key":"10.1016\/j.bbr.2003.12.013_BIB27","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1080\/21548331.1997.11443510","article-title":"Homocysteine, oxidative stress, and vascular disease","volume":"32","author":"Welch","year":"1997","journal-title":"Hosp. Pract."},{"key":"10.1016\/j.bbr.2003.12.013_BIB28","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1046\/j.1471-4159.2001.00178.x","article-title":"Homocysteine potentiates copper- and amyloid beta peptide-mediated toxicity in primary neuronal cultures: possible risk factors in the Alzheimer\u2019s-type neurodegenerative pathways","volume":"76","author":"White","year":"2001","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bbr.2003.12.013_BIB29","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1023\/A:1021647329937","article-title":"Inhibition of Na+, K+-ATPase activity in hippocampus of rats subjected to acute administration of homocysteine is prevented by vitamins E and C treatment","volume":"27","author":"Wyse","year":"2002","journal-title":"Neurochem. Res."}],"container-title":["Behavioural Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432803004820?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432803004820?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,2,15]],"date-time":"2019-02-15T05:57:58Z","timestamp":1550210278000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166432803004820"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,8]]},"references-count":29,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2004,8]]}},"alternative-id":["S0166432803004820"],"URL":"https:\/\/doi.org\/10.1016\/j.bbr.2003.12.013","relation":{},"ISSN":["0166-4328"],"issn-type":[{"value":"0166-4328","type":"print"}],"subject":[],"published":{"date-parts":[[2004,8]]}}}