{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T11:04:05Z","timestamp":1774868645242,"version":"3.50.1"},"reference-count":91,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Behavioural Brain Research"],"published-print":{"date-parts":[[2005,1]]},"DOI":"10.1016\/j.bbr.2004.05.024","type":"journal-article","created":{"date-parts":[[2004,7,21]],"date-time":"2004-07-21T17:57:43Z","timestamp":1090432663000},"page":"201-213","source":"Crossref","is-referenced-by-count":51,"title":["An intermittent, controlled-rate, slow progressive degeneration model of Parkinson\u2019s disease: antiparkinson effects of Sinemet and protective effects of methylphenidate"],"prefix":"10.1016","volume":"156","author":[{"given":"Sheila M.","family":"Fleming","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yvon","family":"Delville","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy","family":"Schallert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.bbr.2004.05.024_bib1","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1046\/j.1460-9568.2000.00896.x","article-title":"Evaluation of simple and complex sensorimotor behaviours in rats with a partial lesion of the dopaminergic nigrostriatal system","volume":"12","author":"Barneoud","year":"2000","journal-title":"Eur. J. Neurosci."},{"issue":"1","key":"10.1016\/j.bbr.2004.05.024_bib2","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/0166-4328(90)90122-U","article-title":"Functional subdivisions of the rat somatic sensorimotor cortex","volume":"39","author":"Barth","year":"1990","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbr.2004.05.024_bib3","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1002\/ana.1049","article-title":"Subclinical dopaminergic dysfunction in asymptomatic Parkinson\u2019s disease patients\u2019 relatives with a decreased sense of smell","volume":"50","author":"Berendse","year":"2001","journal-title":"Ann. Neurol."},{"issue":"4","key":"10.1016\/j.bbr.2004.05.024_bib4","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/0022-510X(73)90175-5","article-title":"Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations","volume":"20","author":"Bernheimer","year":"1973","journal-title":"J. Neurol. Sci."},{"issue":"12","key":"10.1016\/j.bbr.2004.05.024_bib5","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1038\/81834","article-title":"Chronic pesticide exposure reproduces features of Parkinson\u2019s disease","volume":"3","author":"Betarbet","year":"2000","journal-title":"Nat. Neurosci."},{"issue":"17","key":"10.1016\/j.bbr.2004.05.024_bib6","doi-asserted-by":"crossref","first-page":"6853","DOI":"10.1523\/JNEUROSCI.21-17-06853.2001","article-title":"Relationship between appearance of symptoms and the level of nigrostriatal degeneration in a progressive 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned macaque model of Parkinson\u2019s disease","volume":"21","author":"Bezard","year":"2001","journal-title":"J. Neurosci."},{"issue":"1","key":"10.1016\/j.bbr.2004.05.024_bib7","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0304-3940(97)00663-0","article-title":"Kinetics of nigral degeneration in a chronic model of MPTP-treated mice","volume":"234","author":"Bezard","year":"1997","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.bbr.2004.05.024_bib8","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1006\/exnr.1998.6995","article-title":"Absence of MPTP-induced neuronal death in mice lacking the dopamine transporter","volume":"155","author":"Bezard","year":"1999","journal-title":"Exp. Neurol."},{"issue":"12","key":"10.1016\/j.bbr.2004.05.024_bib9","doi-asserted-by":"crossref","first-page":"833","DOI":"10.2165\/00148581-200305120-00006","article-title":"Efficacy and safety of Ritalin LA, a new, once daily, extended-release dosage form of methylphenidate, in children with attention deficit hyperactivity disorder","volume":"5","author":"Biederman","year":"2003","journal-title":"Paediatr. Drugs"},{"key":"10.1016\/j.bbr.2004.05.024_bib10","doi-asserted-by":"crossref","first-page":"4546","DOI":"10.1073\/pnas.80.14.4546","article-title":"A primate model of parkinsonism: selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine","volume":"80","author":"Burns","year":"1983","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bbr.2004.05.024_bib11","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1002\/1531-8257(200101)16:1<33::AID-MDS1014>3.0.CO;2-W","article-title":"Discriminating mild parkinsonism: methods for epidemiological research","volume":"16","author":"Camicioli","year":"2001","journal-title":"Mov. Disord."},{"issue":"2","key":"10.1016\/j.bbr.2004.05.024_bib12","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/0006-8993(91)90835-J","article-title":"Partial lesion of the substantia nigra: relation between extent of lesion and rotational behavior","volume":"553","author":"Carman","year":"1991","journal-title":"Brain Res."},{"key":"10.1016\/j.bbr.2004.05.024_bib13","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1038\/nrn877","article-title":"Animal models of neurological deficits: how relevant is the rat?","volume":"3","author":"Cenci","year":"2002","journal-title":"Nat. Rev. Neurosci."},{"issue":"2","key":"10.1016\/j.bbr.2004.05.024_bib14","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/S0306-4522(98)00217-6","article-title":"Biochemical and anatomical characterization of forepaw adjusting steps in rat models of Parkinson\u2019s disease: studies on medial forebrain bundle and striatal lesions","volume":"88","author":"Chang","year":"1999","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbr.2004.05.024_bib15","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1006\/exnr.1998.6887","article-title":"Behavioral and cellular protection of rat dopaminergic neurons by an adenoviral vector encoding glial cell line-derived neurotrophic factor","volume":"154","author":"Choi-Lundberg","year":"1998","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.bbr.2004.05.024_bib16","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1046\/j.1471-4159.2003.01657.x","article-title":"Neuroprotective effects of prior limb use in 6-hydroxydopamine-treated rats: possible role of GDNF","volume":"85","author":"Cohen","year":"2003","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bbr.2004.05.024_bib17","doi-asserted-by":"crossref","first-page":"1936","DOI":"10.1038\/sj.gt.3301033","article-title":"The differential effects of adenoviral vector mediated glial cell line-derived neurotrophic factor (GDNF) in the striatum vs substantia nigra of the aged parkinsonian rat","volume":"6","author":"Conner","year":"1999","journal-title":"Gene Ther."},{"key":"10.1016\/j.bbr.2004.05.024_bib18","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1006\/exnr.2001.7638","article-title":"Glial cell line-derived neurotrophic factor (GDNF) gene delivery protects dopaminergic terminals from degeneration","volume":"169","author":"Conner","year":"2001","journal-title":"Exp. Neurol."},{"issue":"1","key":"10.1016\/j.bbr.2004.05.024_bib19","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/0006-8993(93)90312-B","article-title":"Enhanced recovery of the nigrostriatal dopaminergic system in MPTP-treated mice following intrastriatal injection of basic fibroblast growth factor in relation to aging","volume":"621","author":"Date","year":"1993","journal-title":"Brain Res."},{"issue":"2","key":"10.1016\/j.bbr.2004.05.024_bib20","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1006\/exnr.2002.7891","article-title":"Modeling Parkinson\u2019s disease in rats: an evaluation of 6-OHDA lesions of the nigrostriatal pathway","volume":"175","author":"Deumens","year":"2002","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.bbr.2004.05.024_bib21","series-title":"Drug treatment issues in Parkinson\u2019s disease","first-page":"1","article-title":"Early detection of Parkinson\u2019s disease","author":"Di Paola","year":"2000"},{"issue":"1\/2","key":"10.1016\/j.bbr.2004.05.024_bib22","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0169-328X(99)00235-1","article-title":"Cocaine reward and MPTP toxicity: alteration by regional variant dopamine transporter overexpression","volume":"73","author":"Donovan","year":"1999","journal-title":"Brain Res. Mol. Brain Res."},{"key":"10.1016\/j.bbr.2004.05.024_bib23","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1007\/BF01485901","article-title":"Distribution of noradrenaline and dopamine (3-hydroxytyramine) in the human brain and their behavior in diseases of the extrapyramidal system","volume":"38","author":"Ehringer","year":"1960","journal-title":"Klin Wochenschr."},{"key":"10.1016\/j.bbr.2004.05.024_bib24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1749-6632.2003.tb07458.x","article-title":"Description of Parkinson\u2019s disease as a clinical syndrome","volume":"991","author":"Fahn","year":"2003","journal-title":"Ann. N. Y. Acad. Sci."},{"issue":"22","key":"10.1016\/j.bbr.2004.05.024_bib25","doi-asserted-by":"crossref","first-page":"9547","DOI":"10.1523\/JNEUROSCI.18-22-09547.1998","article-title":"Long-lasting induction of astrocytic basic fibroblast growth factor by repeated injections of amphetamine: blockade by concurrent treatment with glutamate antagonist","volume":"18","author":"Flores","year":"1998","journal-title":"J. Neurosci."},{"issue":"RC55","key":"10.1016\/j.bbr.2004.05.024_bib26","first-page":"1","article-title":"Requirement of endogenous basic fibroblast growth factor for sensitization to amphetamine","volume":"20","author":"Flores","year":"2000","journal-title":"J. Neurosci."},{"issue":"2","key":"10.1016\/j.bbr.2004.05.024_bib27","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/S0306-4522(00)00115-9","article-title":"Changes in astrocytic basic fibroblast growth factor expression during and after prolonged exposure to escalating doses of amphetamine","volume":"98","author":"Flores","year":"2000","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbr.2004.05.024_bib28","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/S0306-4522(03)00005-8","article-title":"A role for presynaptic mechanisms in the actions of nomifensine and haloperidol","volume":"118","author":"Garris","year":"2003","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbr.2004.05.024_bib29","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/978-3-7091-6842-4_7","article-title":"Mechanism of 6-hydroxydopamine neurotoxicity","volume":"50","author":"Glinka","year":"1997","journal-title":"J. Neural. Transm. Suppl."},{"issue":"Suppl 1","key":"10.1016\/j.bbr.2004.05.024_bib30","doi-asserted-by":"crossref","first-page":"S89","DOI":"10.1177\/070674370200601S11","article-title":"Guidelines and algorithms for the use of methylphenidate in children with attention-deficit\/hyperactivity disorder","volume":"6","author":"Greenhill","year":"2002","journal-title":"J. Attention Disord."},{"issue":"10","key":"10.1016\/j.bbr.2004.05.024_bib31","doi-asserted-by":"crossref","first-page":"2478","DOI":"10.1161\/01.STR.0000032302.91894.0F","article-title":"Behavioral tests after intracerebral hemorrhage in the rat","volume":"33","author":"Hua","year":"2002","journal-title":"Stroke"},{"issue":"2","key":"10.1016\/j.bbr.2004.05.024_bib32","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/0006-8993(91)90481-A","article-title":"Degeneration of the nigra DA neurons after 6-hydroxydopamine injection into the rat striatum","volume":"549","author":"Ichitani","year":"1991","journal-title":"Brain Res."},{"issue":"2","key":"10.1016\/j.bbr.2004.05.024_bib33","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1006\/exnr.1994.1205","article-title":"Biochemical and immunocytochemical changes induced by intrastriatal 6-hydroxydopamine injection in the rat nigrostriatal DA neuron system: evidence for cell death in the substantia nigra","volume":"130","author":"Ichitani","year":"1994","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.bbr.2004.05.024_bib34","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1002\/mds.870120502","article-title":"The dopamine transporter: a crucial component regulating dopamine transmission","volume":"12","author":"Jabor","year":"1997","journal-title":"Mov. Disord."},{"issue":"4 Suppl 1","key":"10.1016\/j.bbr.2004.05.024_bib35","doi-asserted-by":"crossref","first-page":"S19","DOI":"10.1212\/WNL.58.suppl_1.S19","article-title":"Levodopa strengths and weaknesses","volume":"58","author":"Jankovic","year":"2002","journal-title":"Neurology"},{"issue":"1\/2","key":"10.1016\/j.bbr.2004.05.024_bib36","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0166-4328(99)00068-6","article-title":"Akinesia postural abnormality after unilateral dopamine depletion","volume":"104","author":"Johnson","year":"1999","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbr.2004.05.024_bib37","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0166-4328(99)00113-8","article-title":"Early androgen treatment decreases cognitive functioning and catecholamine innervation of the frontal cortex in an animal model of ADHD","volume":"107","author":"King","year":"2000","journal-title":"Behav. Brain Res."},{"issue":"2","key":"10.1016\/j.bbr.2004.05.024_bib38","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1006\/exnr.1998.6848","article-title":"Characterization of behavioral and neurodegenerative changes following partial lesions of the nigrostriatal DA system induced by intrastriatal 6-hydroxydopamine in the rat","volume":"152","author":"Kirik","year":"1998","journal-title":"Exp. Neurol."},{"issue":"7","key":"10.1016\/j.bbr.2004.05.024_bib39","doi-asserted-by":"crossref","first-page":"4708","DOI":"10.1073\/pnas.062047599","article-title":"Reversal of motor impairments in parkinsonian rats by continuous intrastriatal delivery of l-DOPA using rAAV-mediated gene transfer","volume":"99","author":"Kirik","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"11","key":"10.1016\/j.bbr.2004.05.024_bib40","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1023\/A:1026025408742","article-title":"Motor enrichment and the induction of plasticity before or after brain injury","volume":"28","author":"Kleim","year":"2003","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.bbr.2004.05.024_bib41","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/exnr.2000.7463","article-title":"Delivery of a GDNF gene into the substantia nigra after a progressive 6-OHDA lesion maintains functional nigrostriatal connnections","volume":"166","author":"Kozlowski","year":"2000","journal-title":"Exp. Neurol."},{"issue":"16","key":"10.1016\/j.bbr.2004.05.024_bib42","doi-asserted-by":"crossref","first-page":"7264","DOI":"10.1523\/JNEUROSCI.22-16-07264.2002","article-title":"Exposure of adolescent rats to oral methylphenidate: preferential effects on extracellular norepinephrine and absence of sensitization and cross-sensitization to methamphetamine","volume":"22","author":"Kuczenski","year":"2002","journal-title":"J. Neurosci."},{"issue":"3","key":"10.1016\/j.bbr.2004.05.024_bib43","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/0024-3205(85)90059-1","article-title":"MPTP neurotoxicity: an overview and characterization of phases of toxicity","volume":"36","author":"Langston","year":"1985","journal-title":"Life Sci."},{"issue":"4587","key":"10.1016\/j.bbr.2004.05.024_bib44","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1126\/science.6823561","article-title":"Chronic parkinsonism in humans due to a product of meperidine-analog synthesis","volume":"219","author":"Langston","year":"1983","journal-title":"Science"},{"issue":"3","key":"10.1016\/j.bbr.2004.05.024_bib45","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/0306-4522(95)00571-4","article-title":"Dopaminergic neuronal degeneration and motor impairments following axon terminal lesion by intrastriatal 6-hydroxydopamine in the rat","volume":"72","author":"Lee","year":"1996","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbr.2004.05.024_bib46","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1002\/mds.870070203","article-title":"When did Ray Kennedy\u2019s Parkinson\u2019s disease begin?","volume":"7","author":"Lees","year":"1992","journal-title":"Mov. Disord."},{"issue":"6","key":"10.1016\/j.bbr.2004.05.024_bib47","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/0361-9230(96)00027-5","article-title":"Validation of a rodent model of Parkinson\u2019s disease: evidence of a therapeutic window for oral Sinemet","volume":"39","author":"Lindner","year":"1995","journal-title":"Brain Res. Bull."},{"issue":"1","key":"10.1016\/j.bbr.2004.05.024_bib48","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/0014-4886(95)90059-4","article-title":"Implantation of encapsulated catecholamine and GDNF-producing cells in rats with unilateral dopamine depletions and parkinsonian symptoms","volume":"132","author":"Lindner","year":"1996","journal-title":"Exp. Neurol."},{"issue":"1","key":"10.1016\/j.bbr.2004.05.024_bib49","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1006\/exnr.1997.6456","article-title":"Somatic delivery of catecholamines in the striatum attenuate parkinsonian symptoms and widen the therapeutic window of oral sinemet in rats","volume":"145","author":"Lindner","year":"1997","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.bbr.2004.05.024_bib50","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/0092-8674(92)90425-C","article-title":"A cDNA that suppresses MPP+ toxicity encodes a vesicular amine transporter","volume":"70","author":"Lui","year":"1992","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.bbr.2004.05.024_bib51","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1046\/j.0953-816x.2001.01843.x","article-title":"Pharmacological validation of behavioural measures of akinesia and dyskinesia in a rat model of Parkinson\u2019s disease","volume":"15","author":"Lundblad","year":"2002","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.bbr.2004.05.024_bib52","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1056\/NEJM199910213411717","article-title":"The freezing of time as a presenting symptom of Parkinson\u2019s disease","volume":"341","author":"Mazzoni","year":"1999","journal-title":"N. Engl. J. Med."},{"issue":"2","key":"10.1016\/j.bbr.2004.05.024_bib53","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1006\/nbdi.2002.0507","article-title":"Environmental risk factors and Parkinson\u2019s disease: selective degeneration of nigral dopaminergic neurons caused by the herbicide paraquat","volume":"10","author":"McCormack","year":"2002","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.bbr.2004.05.024_bib54","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1006\/exnr.1998.7008","article-title":"Immunochemical analysis of vesicular monoamine transporter (VMAT2) protein in Parkinson\u2019s disease","volume":"156","author":"Miller","year":"1999","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.bbr.2004.05.024_bib55","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/S0165-6147(99)01379-6","article-title":"Dopamine transporter and neuronal injury","volume":"20","author":"Miller","year":"1999","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.bbr.2004.05.024_bib56","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1002\/1531-8257(200005)15:3<467::AID-MDS1007>3.0.CO;2-#","article-title":"Early detection of probable idiopathic Parkinson\u2019s disease: development of a diagnostic test battery","volume":"15","author":"Montgomery","year":"2000","journal-title":"Mov. Disord."},{"issue":"11 Suppl 2","key":"10.1016\/j.bbr.2004.05.024_bib57","first-page":"11","article-title":"Motor complications associated with chronic levodopa therapy in Parkinson\u2019s disease","volume":"39","author":"Obeso","year":"1989","journal-title":"Neurology"},{"issue":"5 Pt 2","key":"10.1016\/j.bbr.2004.05.024_bib58","doi-asserted-by":"crossref","first-page":"3863","DOI":"10.1523\/JNEUROSCI.15-05-03863.1995","article-title":"Forelimb akinesia in the rat Parkinson model: differential effects of DA agonists and nigral transplants as assessed by a new stepping test","volume":"15","author":"Olsson","year":"1995","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbr.2004.05.024_bib59","series-title":"The rat brain in stereotaxic coordinates","author":"Paxinos","year":"1998"},{"issue":"10","key":"10.1016\/j.bbr.2004.05.024_bib60","doi-asserted-by":"crossref","first-page":"4246","DOI":"10.1523\/JNEUROSCI.13-10-04246.1993","article-title":"Dopamine transporter expression confers cytotoxicity to low doses of the parkinsonism-inducing neurotoxin 1-methyl-4-phenylpyridinium","volume":"13","author":"Pifl","year":"1993","journal-title":"J. Neurosci."},{"issue":"3\/4","key":"10.1016\/j.bbr.2004.05.024_bib61","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/BF01249445","article-title":"Time course of nigrostriatal degeneration in parkinson\u2019s disease. A detailed study of influential factors in human brain amine analysis","volume":"38","author":"Riederer","year":"1976","journal-title":"J. Neural Transm."},{"key":"10.1016\/j.bbr.2004.05.024_bib62","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/0165-0173(93)90013-P","article-title":"The neural basis of drug craving: an incentive-sensitization theory of addiction","volume":"1","author":"Robinson","year":"1993","journal-title":"Brain Res. Rev."},{"issue":"1","key":"10.1016\/j.bbr.2004.05.024_bib63","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1046\/j.1360-0443.2001.9611038.x","article-title":"Incentive-sensitization addiction","volume":"96","author":"Robinson","year":"2001","journal-title":"Addiction"},{"key":"10.1016\/j.bbr.2004.05.024_bib64","doi-asserted-by":"crossref","first-page":"8491","DOI":"10.1523\/JNEUROSCI.17-21-08491.1997","article-title":"Persistent structural modifications in nucleus accumbens and prefrontal cortex neurons produced by previous experience with amphetamine","volume":"17","author":"Robinson","year":"1997","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbr.2004.05.024_bib65","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1046\/j.1460-9568.1999.00576.x","article-title":"Alterations in the morphology of dendrites and dendritic spines in the nucleus accumbens and prefrontal cortex following repeated treatment with amphetamine or cocaine","volume":"11","author":"Robinson","year":"1999","journal-title":"Eur. J. Neurosci."},{"issue":"3","key":"10.1016\/j.bbr.2004.05.024_bib66","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1002\/1098-2396(20010301)39:3<257::AID-SYN1007>3.0.CO;2-1","article-title":"Cocaine self-administration alters the morphology of dendrites and dendritic spines in the nucleus accumbens and neocortex","volume":"39","author":"Robinson","year":"2001","journal-title":"Synapse"},{"issue":"5 Pt 1","key":"10.1016\/j.bbr.2004.05.024_bib67","doi-asserted-by":"crossref","first-page":"2687","DOI":"10.1523\/JNEUROSCI.14-05-02687.1994","article-title":"Time course of recovery of extracellular dopamine following partial damage to the nigrostriatal dopamine system","volume":"14","author":"Robinson","year":"1994","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbr.2004.05.024_bib68","doi-asserted-by":"crossref","first-page":"8705","DOI":"10.1523\/JNEUROSCI.22-19-08705.2002","article-title":"Methylphenidate redistributes vesicular monoamine transporter-2: role of dopamine receptors","volume":"22","author":"Sandoval","year":"2002","journal-title":"J. Neurosci."},{"issue":"2","key":"10.1016\/j.bbr.2004.05.024_bib69","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/0306-4522(94)90605-X","article-title":"Progressive degeneration in nigrostriatal dopamine neurons following intrastriatal terminal lesions with 6-hydroxydopamine: a combined retrograde tracing and immunocytochemical study in the rat","volume":"59","author":"Sauer","year":"1994","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbr.2004.05.024_bib70","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1111\/j.1749-6632.1988.tb32972.x","article-title":"Aging-dependent emergence of sensorimotor dysfunction in rats recovered from dopamine depletion sustained early in life","volume":"515","author":"Schallert","year":"1988","journal-title":"Ann. N. Y. Acad. Sci."},{"issue":"5","key":"10.1016\/j.bbr.2004.05.024_bib71","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/S0028-3908(00)00005-8","article-title":"CNS plasticity and assessment of forelimb sensorimotor outcome in unilateral rat models of stroke, cortical ablation, parkinsonism and spinal cord injury","volume":"39","author":"Schallert","year":"2000","journal-title":"Neuropharmacology"},{"issue":"1","key":"10.1016\/j.bbr.2004.05.024_bib72","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/0006-8993(86)90261-1","article-title":"Recovery of function after brain damage: severe and chronic disruption by diazepam","volume":"379","author":"Schallert","year":"1986","journal-title":"Brain Res."},{"key":"10.1016\/j.bbr.2004.05.024_bib73","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1097\/00004647-200011000-00001","article-title":"Experience-associated structural events, subependymal proliferation activity, and functional recovery after injury to the central nervous system: a review","volume":"20","author":"Schallert","year":"2000","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.bbr.2004.05.024_bib74","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1155\/NP.1992.332","article-title":"A clinically relevant unilateral rat model of parkinsonian akinesia","volume":"3","author":"Schallert","year":"1992","journal-title":"J. Neural Transplant Plast."},{"key":"10.1016\/j.bbr.2004.05.024_bib75","series-title":"Central nervous system diseases","article-title":"Intervention strategies for degeneration of DA neurons in parkinsonism: optimizing behavioral assessment of outcome","author":"Schallert","year":"2000"},{"issue":"3","key":"10.1016\/j.bbr.2004.05.024_bib76","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/0091-3057(82)90452-X","article-title":"Tactile extinction: distinguishing between sensorimotor and motor asymmetries in rats with unilateral nigrostriatal damage","volume":"16","author":"Schallert","year":"1982","journal-title":"Pharmacol. Biochem. Behav."},{"issue":"5","key":"10.1016\/j.bbr.2004.05.024_bib77","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/0091-3057(83)90019-9","article-title":"Posture-independent sensorimotor analysis of inter-hemispheric receptor asymmetries in neostriatum","volume":"18","author":"Schallert","year":"1983","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.bbr.2004.05.024_bib78","series-title":"Neuromethods (series 1: neurochemistry), general neurochemical techniques","first-page":"343","article-title":"Neurotransmitter-selective brain lesions","author":"Schallert","year":"1985"},{"issue":"2","key":"10.1016\/j.bbr.2004.05.024_bib79","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/S0006-8993(00)02900-0","article-title":"Fibroblast growth factor-2-producing fibroblasts protect the nigrostriatal dopaminergic system from 6-hydroxydopamine","volume":"883","author":"Shults","year":"2000","journal-title":"Brain Res."},{"issue":"13","key":"10.1016\/j.bbr.2004.05.024_bib80","doi-asserted-by":"crossref","first-page":"5102","DOI":"10.1523\/JNEUROSCI.20-13-05102.2000","article-title":"Striatal responses to partial dopaminergic lesion: evidence for compensatory sprouting","volume":"20","author":"Song","year":"2000","journal-title":"J. Neurosci."},{"issue":"2","key":"10.1016\/j.bbr.2004.05.024_bib81","first-page":"329","article-title":"In vitro studies of striatal vesicles containing the vesicular monoamine transporter (VMAT2): rat versus mouse differences in sequestration of 1-methyl-4-phenylpyridium","volume":"293","author":"Staal","year":"2000","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"6","key":"10.1016\/j.bbr.2004.05.024_bib82","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1037\/h0037638","article-title":"Effects on homeostasis of intraventricular injections of 6-hydroxydopamine in rats","volume":"86","author":"Stricker","year":"1974","journal-title":"J. Comp. Physiol. Psychol."},{"issue":"12","key":"10.1016\/j.bbr.2004.05.024_bib83","doi-asserted-by":"crossref","first-page":"4427","DOI":"10.1523\/JNEUROSCI.21-12-04427.2001","article-title":"Forced limb-use effects on behavioral and neurochemical effects of 6-hydroxydopamine","volume":"21","author":"Tillerson","year":"2001","journal-title":"J. Neurosci."},{"issue":"15","key":"10.1016\/j.bbr.2004.05.024_bib84","doi-asserted-by":"crossref","first-page":"6790","DOI":"10.1523\/JNEUROSCI.22-15-06790.2002","article-title":"Forced nonuse in unilateral parkinsonian rats exacerbates injury","volume":"22","author":"Tillerson","year":"2002","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbr.2004.05.024_bib85","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1111\/j.1365-201X.1971.tb11001.x","article-title":"Adipsia and aphagia after 6-hydroxydopamine induced degeneration of the nigro-striatal dopamine system","volume":"367","author":"Ungerstedt","year":"1971","journal-title":"Acta Physiol. Scand. Suppl."},{"issue":"3","key":"10.1016\/j.bbr.2004.05.024_bib86","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/0006-8993(70)90187-3","article-title":"Quantitative recording of rotational behavior in rats after 6-hydroxy-dopamine lesions of the nigrostriatal dopamine system","volume":"24","author":"Ungerstedt","year":"1970","journal-title":"Brain Res."},{"issue":"1","key":"10.1016\/j.bbr.2004.05.024_bib87","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S0024-3205(99)00225-8","article-title":"Methylphenidate and cocaine have a similar in vivo potency to block dopamine transporters in the human brain","volume":"65","author":"Volkow","year":"1999","journal-title":"Life Sci."},{"issue":"10","key":"10.1016\/j.bbr.2004.05.024_bib88","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1176\/ajp.155.10.1325","article-title":"DA transporter occupancies in the human brain induced by therapeutic doses of oral methylphenidate","volume":"155","author":"Volkow","year":"1998","journal-title":"Am. J. Psychiatry"},{"issue":"Suppl 2","key":"10.1016\/j.bbr.2004.05.024_bib89","doi-asserted-by":"crossref","first-page":"II 103","DOI":"10.1007\/PL00022910","article-title":"Preclinical (premotor) Parkinson\u2019s disease","volume":"247","author":"Wolters","year":"2000","journal-title":"J. Neurol."},{"key":"10.1016\/j.bbr.2004.05.024_bib90","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0006-8993(02)02311-9","article-title":"Chronic social stress during puberty enhances tyrosine hydroxylase immunoreactivity within the limbic system in golden hamsters","volume":"933","author":"Wommack","year":"2002","journal-title":"Brain Res."},{"issue":"4","key":"10.1016\/j.bbr.2004.05.024_bib91","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1007\/BF01975133","article-title":"Supersensitivity after intraventricular 6-hydroxydopamine: relation to dopamine depletion","volume":"36","author":"Zigmond","year":"1973","journal-title":"Experientia"}],"container-title":["Behavioural Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432804001901?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432804001901?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,4,29]],"date-time":"2023-04-29T01:39:36Z","timestamp":1682732376000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166432804001901"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,1]]},"references-count":91,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2005,1]]}},"alternative-id":["S0166432804001901"],"URL":"https:\/\/doi.org\/10.1016\/j.bbr.2004.05.024","relation":{},"ISSN":["0166-4328"],"issn-type":[{"value":"0166-4328","type":"print"}],"subject":[],"published":{"date-parts":[[2005,1]]}}}