{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T09:01:56Z","timestamp":1791277316927,"version":"4.1.0"},"reference-count":57,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2006,3,1]],"date-time":"2006-03-01T00:00:00Z","timestamp":1141171200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,3,1]],"date-time":"2006-03-01T00:00:00Z","timestamp":1141171200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Behavioural Brain Research"],"published-print":{"date-parts":[[2006,3]]},"DOI":"10.1016\/j.bbr.2005.10.014","type":"journal-article","created":{"date-parts":[[2005,12,22]],"date-time":"2005-12-22T18:49:55Z","timestamp":1135277395000},"page":"83-91","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":45,"title":["Inhibition of neprilysin by thiorphan (i.c.v.) causes an accumulation of amyloid \u03b2 and impairment of learning and memory"],"prefix":"10.1016","volume":"168","author":[{"given":"Akihiro","family":"Mouri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Bo","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuhisa","family":"Iwata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takaomi C.","family":"Saido","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dayong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min-Wei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukihiro","family":"Noda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshitaka","family":"Nabeshima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbr.2005.10.014_bib1","doi-asserted-by":"crossref","first-page":"13546","DOI":"10.1073\/pnas.93.24.13547","article-title":"Cognitive and neurobiologic markers of early Alzheimer's disease","volume":"93","author":"Albert","year":"1996","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.bbr.2005.10.014_bib2","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1007\/s00702-002-0807-3","article-title":"Possible increased risk for Alzheimer's disease associated with neprilysin gene","volume":"110","author":"Clarimon","year":"2003","journal-title":"J Neural Transm"},{"key":"10.1016\/j.bbr.2005.10.014_bib3","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0166-4328(96)00163-5","article-title":"Response learning of rats in a Morris water maze: involvement of the medical prefrontal cortex","volume":"85","author":"de Bruin","year":"1997","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.bbr.2005.10.014_bib4","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/0014-5793(93)81399-K","article-title":"Amyloidogenicity of rodent and human beta A4 sequences","volume":"324","author":"Dyrks","year":"1993","journal-title":"FEBS Lett"},{"key":"10.1016\/j.bbr.2005.10.014_bib5","doi-asserted-by":"crossref","first-page":"13909","DOI":"10.1073\/pnas.0404458101","article-title":"A nontransgenic mouse model shows inducible amyloid-\u03b2 (A\u03b2) peptide deposition and elucidates the role of apolipoprotein E in the amyloid cascade","volume":"101","author":"Dolev","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.bbr.2005.10.014_bib6","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1074\/jbc.C200642200","article-title":"Alzheimer's disease \u03b2-amyloid peptide is increased in mice deficient in endothelin-converting enzyme","volume":"278","author":"Eckman","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bbr.2005.10.014_bib7","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/0166-4328(96)00006-X","article-title":"Neurotoxic lesions of the perirhinal cortex do not mimic the behavioural effects of fornix transection in the rat","volume":"80","author":"Ennaceur","year":"1996","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.bbr.2005.10.014_bib8","doi-asserted-by":"crossref","first-page":"4162","DOI":"10.1073\/pnas.0230450100","article-title":"Insulin degrading enzyme regulates the levels of insulin, amyloid-\u03b2 protein, \u03b2-amyloid precursor protein intracellular domain in vivo","volume":"100","author":"Farris","year":"2003","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.bbr.2005.10.014_bib9","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/0197-4580(94)00155-3","article-title":"Age-related spatial reference and working memory deficits assessed in the water maze","volume":"16","author":"Frick","year":"1995","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.bbr.2005.10.014_bib10","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0168-0102(02)00015-9","article-title":"A\u03b2-degrading endopeptidase, neprilysin, in mouse brain: synaptic and axonal localization inversely correlating with A\u03b2 pathology","volume":"43","author":"Fukami","year":"2002","journal-title":"Neurosci Res"},{"key":"10.1016\/j.bbr.2005.10.014_bib11","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1001\/archneur.60.7.958","article-title":"Age but not diagnosis is the main predictor of plasma amyloid \u03b2-protein levels","volume":"60","author":"Fukumoto","year":"2003","journal-title":"Arch Neurol"},{"key":"10.1016\/j.bbr.2005.10.014_bib12","doi-asserted-by":"crossref","first-page":"4596","DOI":"10.1523\/JNEUROSCI.5517-03.2004","article-title":"Interaction between perirhinal and medial prefrontal cortex is required for temporal order but not recognition memory for objects in rats","volume":"24","author":"Hannesson","year":"2004","journal-title":"J Neurosci"},{"key":"10.1016\/j.bbr.2005.10.014_bib13","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/S0166-2236(96)01030-2","article-title":"Amyloid, the presents and Altzheimer's disease","volume":"20","author":"Hardy","year":"1997","journal-title":"Trends Neurosci"},{"key":"10.1016\/j.bbr.2005.10.014_bib14","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1126\/science.1072994","article-title":"The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics","volume":"297","author":"Hardy","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.bbr.2005.10.014_bib15","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/0304-3940(93)90106-U","article-title":"MK-801 increases endogenous acetylcholine release in the rat parietal cortex: a study using brain microdialysis","volume":"150","author":"Hasegawa","year":"1993","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.bbr.2005.10.014_bib16","doi-asserted-by":"crossref","first-page":"1746","DOI":"10.1136\/jnnp.2004.036574","article-title":"Polymorphisms in neprilysin gene affect the risk of Alzheimer's disease in Finnish patients","volume":"75","author":"Helisalmi","year":"2004","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.bbr.2005.10.014_bib17","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1046\/j.1471-4159.1996.66031113.x","article-title":"Dysfunction of cholinergic and dopaminergic neuronal systems in \u03b2-amyloid protein-infused rats","volume":"66","author":"Itoh","year":"1996","journal-title":"J Neurochem"},{"key":"10.1016\/j.bbr.2005.10.014_bib18","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0014-2999(96)00977-6","article-title":"Effects of metrifonate on memory impairment and cholinergic dysfunction in rats","volume":"322","author":"Itoh","year":"1997","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.bbr.2005.10.014_bib19","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.pharmthera.2005.03.010","article-title":"Metabolism of amyloid \u03b2 peptide and Alzheimer's disease","volume":"108","author":"Iwata","year":"2005","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.bbr.2005.10.014_bib20","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1523\/JNEUROSCI.4792-03.2004","article-title":"Presynaptic localization of neprilysin contributes to efficient clearance of amyloid-\u03b2 peptide in mouse brain","volume":"24","author":"Iwata","year":"2004","journal-title":"J Neurosci"},{"key":"10.1016\/j.bbr.2005.10.014_bib21","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/72237","article-title":"Identification of the major A\u03b21\u201342-degrading catabolic pathway in brain parenchyma: suppression leads to biochemical and pathological deposition","volume":"6","author":"Iwata","year":"2000","journal-title":"Nat Med"},{"key":"10.1016\/j.bbr.2005.10.014_bib22","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1002\/jnr.10390","article-title":"Region-specific reduction of A\u03b2-degrading endopeptidase, neprilysin, in mouse hippocampus upon aging","volume":"70","author":"Iwata","year":"2002","journal-title":"J Neurosci Res"},{"key":"10.1016\/j.bbr.2005.10.014_bib23","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1126\/science.1059946","article-title":"Metabolic regulation of brain A\u03b2 by neprilysin","volume":"292","author":"Iwata","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.bbr.2005.10.014_bib24","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1038\/npp.1994.7","article-title":"[Leu]enkephalin enhances active avoidance conditioning in rats and mice","volume":"10","author":"Janak","year":"1994","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.bbr.2005.10.014_bib25","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/0091-3057(90)90542-P","article-title":"Only tyrosine-containing metabolites of [Leu]enkephalin impair active avoidance conditioning in mice","volume":"37","author":"Janak","year":"1990","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.bbr.2005.10.014_bib26","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0304-3940(03)00898-X","article-title":"Human neprilysin is capable of degrading amyloid \u03b2 peptide not only in the monomeric form but also the pathological oligomeric form","volume":"350","author":"Kanemitsu","year":"2003","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.bbr.2005.10.014_bib27","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/j.cell.2005.01.015","article-title":"Environmental enrichment reduces A\u03b2 levels and amyloid deposition in transgenic mice","volume":"120","author":"Lazarov","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.bbr.2005.10.014_bib28","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1016\/S0896-6273(03)00787-6","article-title":"Enhanced proteolysis of \u03b2-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death","volume":"40","author":"Leissring","year":"2003","journal-title":"Neuron"},{"key":"10.1016\/j.bbr.2005.10.014_bib29","doi-asserted-by":"crossref","first-page":"1992","DOI":"10.1523\/JNEUROSCI.23-06-01992.2003","article-title":"Neprilysin gene transfer reduces human amyloid pathology in transgenic mice","volume":"23","author":"Marr","year":"2003","journal-title":"J Neurosci"},{"key":"10.1016\/j.bbr.2005.10.014_bib30","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1016\/0306-4522(86)90113-2","article-title":"An immunohistochemical study of endopeptidase-24.11 (\u201cenkephalinase\u201d) in the pig nervous system","volume":"18","author":"Matsas","year":"1986","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbr.2005.10.014_bib31","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/0165-0270(84)90007-4","article-title":"Developments of a water\u2013maze procedure for studying spatial learning in the rat","volume":"11","author":"Morris","year":"1984","journal-title":"J Neurosci Methods"},{"key":"10.1016\/j.bbr.2005.10.014_bib32","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/S0304-3940(03)00902-9","article-title":"Thiorphan-induced neprilysin inhibition raises amyloid \u03b2 levels in rabbit cortex and cerebrospinal fluid","volume":"350","author":"Newell","year":"2003","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.bbr.2005.10.014_bib33","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1254\/jjp.60.51","article-title":"Continuous infusion of \u03b2-amyloid protein into the rat cerebral ventricle induces learning impairment and neuronal and morphological degeneration","volume":"73","author":"Nitta","year":"1997","journal-title":"Jpn J Pharmacol"},{"key":"10.1016\/j.bbr.2005.10.014_bib34","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/0304-3940(94)90239-9","article-title":"\u03b2-Amyloid protein-induced Alzheimer's disease animal model","volume":"170","author":"Nitta","year":"1994","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.bbr.2005.10.014_bib35","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/BF01244936","article-title":"Development of plasticity of brain function with repeated trainings and passage of time after basal forebrain lesions in rats","volume":"93","author":"Nitta","year":"1993","journal-title":"J Neural Transm Gen Sect"},{"key":"10.1016\/j.bbr.2005.10.014_bib36","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/0014-2999(93)90616-P","article-title":"Effects of oral administration of a stimulator for nerve growth factor synthesis in basal forebrain-lesioned rats","volume":"250","author":"Nitta","year":"1993","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.bbr.2005.10.014_bib37","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1007\/s007020170025","article-title":"Memory deficits and increased emotionality induced by \u03b2-amyloid (25\u201335) are correlated with the reduced acetylcholine release and altered phorbol dibutyrate binding in the hippocampus","volume":"108","author":"Olariu","year":"2001","journal-title":"J Neural Transm"},{"key":"10.1016\/j.bbr.2005.10.014_bib38","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1111\/j.1432-1033.1993.tb19893.x","article-title":"Human and rodent Alzheimer beta-amyloid peptides acquire distinct conformations in membrane-mimicking solvents","volume":"211","author":"Otvos","year":"1993","journal-title":"Eur J Biochem"},{"key":"10.1016\/j.bbr.2005.10.014_bib39","series-title":"The rat brain in stereotaxic coordinates","author":"Paxinos","year":"1986"},{"key":"10.1016\/j.bbr.2005.10.014_bib40","doi-asserted-by":"crossref","first-page":"8979","DOI":"10.1073\/pnas.150091797","article-title":"A systematic exploration of the influence of the protein stability on amyloid fibril formation in vitro","volume":"97","author":"Ramirez-Alvarado","year":"2000","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.bbr.2005.10.014_bib41","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S0031-6997(25)00449-1","article-title":"Neutral endopeptidase 24.11: structure, inhibition, and experimental and clinical pharmacology","volume":"45","author":"Roques","year":"1993","journal-title":"Pharmacol Rev"},{"key":"10.1016\/j.bbr.2005.10.014_bib42","series-title":"A\u03b2 metabolism and Alzheimer's disease","first-page":"1","article-title":"Overview-A\u03b2 metabolism: from Alzheimer research to brain aging control","author":"Saido","year":"2003"},{"key":"10.1016\/j.bbr.2005.10.014_bib43","series-title":"A\u03b2 metabolism and Alzheimer's disease","first-page":"61","article-title":"Proteolytic degradation of A\u03b2 by neprilysin and other peptidases","author":"Saido","year":"2003"},{"key":"10.1016\/j.bbr.2005.10.014_bib44","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1038\/nm1206","article-title":"Somatostatin regulates brain amyloid \u03b2 peptide A\u03b242 through modulation of proteolytic degradation","volume":"11","author":"Saito","year":"2005","journal-title":"Nat Med"},{"key":"10.1016\/j.bbr.2005.10.014_bib45","first-page":"E1","article-title":"Alzheimer's disease, neuropeptides, neuropeptidase, and amyloid-\u03b2 peptide metabolism","volume":"3","author":"Saito","year":"2003","journal-title":"Sci Aging Knowl Environ"},{"key":"10.1016\/j.bbr.2005.10.014_bib46","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1159\/000076351","article-title":"Association of the neprilysin gene with susceptibility to late-onset Alzheimer's disease","volume":"17","author":"Sakai","year":"2004","journal-title":"Dement Geriatr Cogn Disord"},{"key":"10.1016\/j.bbr.2005.10.014_bib47","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0304-3940(97)00660-5","article-title":"Opioid-related changes in nociceptive threshold and in tissue levels of enkephalins after target disruption of the gene for neutral endopeptidase (EC 3.4.24.11) in mice","volume":"234","author":"Saria","year":"1997","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.bbr.2005.10.014_bib48","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1146\/annurev.pharmtox.43.100901.140248","article-title":"Alzheimer's disease: molecular understanding predicts amyloid-based therapeutics","volume":"43","author":"Selkoe","year":"2003","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"10.1016\/j.bbr.2005.10.014_bib49","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0014-2999(98)00344-6","article-title":"NC-1900, an active fragment analog of arginine vasopressin, improves learning and memory deficits induced by \u03b2-amyloid protein in rats","volume":"352","author":"Tanaka","year":"1998","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.bbr.2005.10.014_bib50","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/sj.mp.4001240","article-title":"Tyrosine nitration of a synaptic protein synaptophysin contributes to amyloid \u03b2-peptide-induced cholinergic dysfunction","volume":"8","author":"Tran","year":"2003","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.bbr.2005.10.014_bib51","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1096\/fasebj.11.5.9141502","article-title":"Mammalian membrane metallopeptidases: NEP, ECE, KELL, and PEX","volume":"11","author":"Turner","year":"1997","journal-title":"FASEB J"},{"key":"10.1016\/j.bbr.2005.10.014_bib52","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/0304-3940(95)12161-7","article-title":"Changes in ciliary neurotrophic factor content in the rat brain after continuous intracerebroventricular infusion of \u03b2-amyloid (1\u201340) protein","volume":"201","author":"Yamada","year":"1995","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.bbr.2005.10.014_bib53","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S0014-2999(98)00166-6","article-title":"Propentofylline improves learning and memory deficits in rats induced by \u03b2-amyloid protein-(1\u201340)","volume":"349","author":"Yamada","year":"1998","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.bbr.2005.10.014_bib54","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/sj.bjp.0702309","article-title":"Improvement by nefiracetam of \u03b2-amyloid-(1\u201342)-induced learning and memory impairments in rats","volume":"126","author":"Yamada","year":"1999","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.bbr.2005.10.014_bib55","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0304-3940(00)01675-X","article-title":"Reduced neprilysin in high plaque areas of Alzheimer brain: a possible relationship to deficient degradation of \u03b2-amyloid peptide","volume":"297","author":"Yasojima","year":"2001","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.bbr.2005.10.014_bib56","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0006-8993(01)03008-6","article-title":"Relationship between \u03b2 amyloid peptide generating molecules and neprilysin in Alzheimer disease and normal brain","volume":"919","author":"Yasojima","year":"2001","journal-title":"Brain Res"},{"key":"10.1016\/j.bbr.2005.10.014_bib57","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/0166-4328(94)90055-8","article-title":"The effects of perirhinal cortical lesions on spatial reference memory in the rat","volume":"63","author":"Wiig","year":"1994","journal-title":"Behav Brain Res"}],"container-title":["Behavioural Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432805004584?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432805004584?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T12:54:13Z","timestamp":1759064053000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166432805004584"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,3]]},"references-count":57,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006,3]]}},"alternative-id":["S0166432805004584"],"URL":"https:\/\/doi.org\/10.1016\/j.bbr.2005.10.014","relation":{},"ISSN":["0166-4328"],"issn-type":[{"value":"0166-4328","type":"print"}],"subject":[],"published":{"date-parts":[[2006,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inhibition of neprilysin by thiorphan (i.c.v.) causes an accumulation of amyloid \u03b2 and impairment of learning and memory","name":"articletitle","label":"Article Title"},{"value":"Behavioural Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbr.2005.10.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2005 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}