{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T02:09:57Z","timestamp":1791166197109,"version":"4.1.0"},"reference-count":55,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2007,2,1]],"date-time":"2007-02-01T00:00:00Z","timestamp":1170288000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Behavioural Brain Research"],"published-print":{"date-parts":[[2007,2]]},"DOI":"10.1016\/j.bbr.2006.10.027","type":"journal-article","created":{"date-parts":[[2006,12,5]],"date-time":"2006-12-05T12:11:14Z","timestamp":1165320674000},"page":"142-149","source":"Crossref","is-referenced-by-count":41,"title":["Neurobehavioural disorders in the infant reeler mouse model: Interaction of genetic vulnerability and consequences of maternal separation"],"prefix":"10.1016","volume":"177","author":[{"given":"Elisa","family":"Ognibene","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter","family":"Adriani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Macr\u00ec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Laviola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbr.2006.10.027_bib1","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/0031-9384(69)90179-6","article-title":"Effects of early experience on adrenocortical reactivity","volume":"4","author":"Ader","year":"1969","journal-title":"Physiol Behav"},{"key":"10.1016\/j.bbr.2006.10.027_bib2","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1038\/sj.mp.4000473","article-title":"Environment and vulnerability to major psychiatric illness\u2014a case control study of early parental loss in major depression, bipolar disorder and schizophrenia","volume":"4","author":"Agid","year":"1999","journal-title":"Mol Psychiatry"},{"issue":"4","key":"10.1016\/j.bbr.2006.10.027_bib3","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1007\/BF00432509","article-title":"Short-, medium-, and long-term effects of prenatal oxazepam on neurobehavioural development of mice","volume":"87","author":"Alleva","year":"1985","journal-title":"Psychopharmacology (Berl)"},{"issue":"1\/2","key":"10.1016\/j.bbr.2006.10.027_bib4","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0169-328X(02)00389-3","article-title":"A reeler mutant mouse with a new, spontaneous mutation in the reelin gene","volume":"105","author":"Andersen","year":"2002","journal-title":"Brain Res Mol Brain Res"},{"key":"10.1016\/j.bbr.2006.10.027_bib5","series-title":"Abstract national congress of the Italian society for neuroscience and joint Italian-Swedish neuroscience meeting Regina Isabella Congress Center Lacco Ameno","article-title":"Interaction between reelin and estrogens on Purkinje cells during development: a model of cerebellar pathology in autism and related disorders","author":"Assenza","year":"2006"},{"issue":"6998","key":"10.1016\/j.bbr.2006.10.027_bib6","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1038\/nature02725","article-title":"Developmental plasticity and human health","volume":"430","author":"Bateson","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.bbr.2006.10.027_bib7","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.ijdevneu.2004.10.004","article-title":"Three autism candidate genes: a synthesis of human genetic analysis with other disciplines","volume":"23","author":"Bartlett","year":"2005","journal-title":"Int J Dev Neurosci"},{"key":"10.1016\/j.bbr.2006.10.027_bib8","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0736-5748(98)00019-7","article-title":"Postnatal maternal separation during the SHRP enhances the adrenocortical response to novelty in adult rats by affecting feedback regulation in the CA1 hippocampal field","volume":"16","author":"Biagini","year":"1997","journal-title":"Int J Dev Neurosci"},{"key":"10.1016\/j.bbr.2006.10.027_bib9","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0166-4328(01)00277-7","article-title":"Ultrasonic vocalisation emitted by infant rodents: a tool for assessment of neurobehavioural development","volume":"125","author":"Branchi","year":"2001","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.bbr.2006.10.027_bib10","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1034\/j.1601-183X.2002.10301.x","article-title":"Transgenic and knock-out mouse pups: the growing need for behavioural analysis","volume":"3","author":"Branchi","year":"2002","journal-title":"Gen Brain Behav"},{"issue":"2\/3","key":"10.1016\/j.bbr.2006.10.027_bib11","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S0920-9964(03)00056-2","article-title":"Cognitive performance in schizophrenia patients assessed before and following the first psychotic episodi","volume":"65","author":"Caspi","year":"2003","journal-title":"Schizophr Res"},{"key":"10.1016\/j.bbr.2006.10.027_bib12","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1007\/s002130050435","article-title":"Sexual segregation in infant mice: behavioural and neuroendocrine responses to d-amphetamine administration","volume":"134","author":"Cirulli","year":"1997","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.bbr.2006.10.027_bib13","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1002\/dev.420270505","article-title":"Behavioural and hormonal responses to stress in the newborn mouse: effects of maternal deprivation and chlordiazepoxide","volume":"27","author":"Cirulli","year":"1994","journal-title":"Dev Psychobiol"},{"key":"10.1016\/j.bbr.2006.10.027_bib14","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1006\/nbdi.2001.0436","article-title":"Dendritic spine hypoplasia and downregulation of reelin and GABAergic tone in schizophrenia vulnerability","volume":"8","author":"Costa","year":"2001","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.bbr.2006.10.027_bib15","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/S1471-4892(01)00121-7","article-title":"The heterozygote reeler mouse as a model for the development of a new generation of antipsychotics","volume":"2","author":"Costa","year":"2002","journal-title":"Curr Opin Pharmacol"},{"key":"10.1016\/j.bbr.2006.10.027_bib16","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1002\/dev.420150306","article-title":"Temporal organization of ultrasonic vocalizations in infant mice","volume":"15","author":"Elwood","year":"1982","journal-title":"Dev Psychobiol"},{"key":"10.1016\/j.bbr.2006.10.027_bib17","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1038\/sj.mp.4000783","article-title":"Reduction in reelin immunoreactivity in hippocampus of subjects with schizophrenia, bipolar disorders and major depression","volume":"5","author":"Fatemi","year":"2000","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.bbr.2006.10.027_bib18","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/S0959-4388(99)80016-6","article-title":"Maternal care and the development of stress responses","volume":"9","author":"Francis","year":"1999","journal-title":"Curr Opin Neurobiol"},{"key":"10.1016\/j.bbr.2006.10.027_bib19","doi-asserted-by":"crossref","DOI":"10.1098\/rspb.2004.3001","article-title":"Environmental influences during development and their later consequences for health and disease: implications for the interpretation of empirical studies","author":"Gluckman","year":"2005","journal-title":"Proc Biol Sci"},{"key":"10.1016\/j.bbr.2006.10.027_bib20","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1146\/annurev.psych.56.091103.070208","article-title":"Human development: biological and genetic processes","volume":"2","author":"Gottesman","year":"2005","journal-title":"Annu Rev Psychol"},{"key":"10.1016\/j.bbr.2006.10.027_bib21","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1016\/S0006-3223(01)01157-X","article-title":"The role of childhood trauma in the neurobiology of mood and anxiety disorders\u2014preclinical and clinical studies","volume":"49","author":"Heim","year":"2001","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.bbr.2006.10.027_bib22","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1176\/appi.ajp.158.4.575","article-title":"Altered pituitary\u2013adrenal axis responses to provocative challenge tests in adult survivors of childhood abuse","volume":"158","author":"Heim","year":"2001","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.bbr.2006.10.027_bib23","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1001\/jama.284.5.592","article-title":"Pituitary\u2013adrenal and autonomic responses to stress in women after sexual and physical abuse in childhood","volume":"284","author":"Heim","year":"2000","journal-title":"JAMA"},{"key":"10.1016\/j.bbr.2006.10.027_bib24","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/j.1651-2227.1994.tb13260.x","article-title":"Early relationships as regulators of infant physiology and behaviour","volume":"397","author":"Hofer","year":"1994","journal-title":"Acta Paediatr"},{"key":"10.1016\/j.bbr.2006.10.027_bib25","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1177\/070674370505001403","article-title":"Long-term outcome of patients with schizophrenia: a review","volume":"50","author":"Jobe","year":"2005","journal-title":"Can J Psychiatry"},{"key":"10.1016\/j.bbr.2006.10.027_bib26","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.1016\/S0149-7634(03)00004-6","article-title":"Brain development, sex differences and stress: implications for psychopathology","volume":"27","author":"Laviola","year":"2003","journal-title":"Neurosci Biobehav Rev"},{"issue":"3","key":"10.1016\/j.bbr.2006.10.027_bib27","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1007\/BF02244108","article-title":"Genetic differences in maternal behaviour patterns in mice administered phenobarbital during pregnancy","volume":"102","author":"Laviola","year":"1990","journal-title":"Psychopharmacology (Berl)"},{"issue":"3","key":"10.1016\/j.bbr.2006.10.027_bib28","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1007\/s00213-006-0426-z","article-title":"Paradoxical effects of prenatal acetilcholinesterase blockade on neurobehavioural development and drug-induced stereotipies in reeler mice","volume":"187","author":"Laviola","year":"2006","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.bbr.2006.10.027_bib29","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1515\/REVNEURO.2000.11.4.383","article-title":"Long-term bio-behavioural effects of maternal separation in the rat: consistent or confusing?","volume":"11","author":"Lehmann","year":"2000","journal-title":"Rev Neurosci"},{"key":"10.1016\/j.bbr.2006.10.027_bib30","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/S0197-4580(01)00320-7","article-title":"Comparison of maternal separation and early handling in terms of neurobehavioural effects in aged rats","volume":"23","author":"Lehmann","year":"2002","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.bbr.2006.10.027_bib31","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1126\/science.126.3270.405","article-title":"Infantile experience and resistance to physiological stress","volume":"126","author":"Levine","year":"1957","journal-title":"Science"},{"key":"10.1016\/j.bbr.2006.10.027_bib32","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0031-9384(67)90011-X","article-title":"Physiological and behavioural effects of infantile stimulation","volume":"2","author":"Levine","year":"1967","journal-title":"Physiol Behav"},{"key":"10.1016\/j.bbr.2006.10.027_bib33","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1126\/science.277.5332.1659","article-title":"Maternal care, hippocampal glucocorticoid receptors, and hypothalamic\u2013pituitary\u2013adrenal responses to stress","volume":"277","author":"Liu","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.bbr.2006.10.027_bib34","doi-asserted-by":"crossref","first-page":"3477","DOI":"10.1073\/pnas.051614698","article-title":"Downregulation of dendritic spine and glutamic acid decarboxylase 67 expressions in reelin haploinsufficient reeler mouse","volume":"98","author":"Liu","year":"2001","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.bbr.2006.10.027_bib35","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1111\/j.1460-9568.2004.03541.x","article-title":"Dissociation in the effects of neonatal maternal separations on maternal care and the offspring's HPA and fear responses in rats","volume":"20","author":"Macr\u00ec","year":"2004","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.bbr.2006.10.027_bib36","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.anbehav.2006.03.029","article-title":"Effects of variation in postnatal maternal environment on maternal behaviour and fear and stress responses in rats","volume":"73","author":"Macr\u00ec","year":"2007","journal-title":"Anim Behav"},{"key":"10.1016\/j.bbr.2006.10.027_bib37","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.yhbeh.2006.06.015","article-title":"Developmental plasticity of HPA and fear responses in rats: a critical review of the maternal mediation hypothesis","volume":"50","author":"Macr\u00ec","year":"2006","journal-title":"Horm Behav"},{"key":"10.1016\/j.bbr.2006.10.027_bib38","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/BF02246414","article-title":"Retarded acquisition and reduced expression of conditioned locomotor activity in adult rats following repeated maternal separation: effects of prefeeding, d-amphetamine, dopamine antagonists and clonidine","volume":"126","author":"Matthews","year":"1996","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.bbr.2006.10.027_bib39","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1146\/annurev.neuro.24.1.1161","article-title":"Maternal care, gene expression, and the transmission of individual differences in stress reactivity across generations","volume":"24","author":"Meaney","year":"2001","journal-title":"Ann Rev Neurosci"},{"key":"10.1016\/j.bbr.2006.10.027_bib40","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/0166-4328(87)90041-6","article-title":"Sex difference in ultrasound distress call by rat pups","volume":"25","author":"Naito","year":"1987","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.bbr.2006.10.027_bib41","doi-asserted-by":"crossref","unstructured":"Ognibene E, Adriani W, Granstrem O, Pieretti S, La viola G. Impulsivity\u2013anxiety-related behaviour and profiles of morphine-induced analgesia in heterozygous reeler mice, Brain Res, in press, doi:10.1016\/j.brainres.2006.11.007.","DOI":"10.1016\/j.brainres.2006.11.007"},{"key":"10.1016\/j.bbr.2006.10.027_bib42","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1385\/MN:28:1:1","article-title":"The neurobiological context of autism","volume":"28","author":"Persico","year":"2003","journal-title":"Mol Neurobiol"},{"key":"10.1016\/j.bbr.2006.10.027_bib43","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.bbr.2003.10.033","article-title":"The heterozygous reeler mouse: behavioural phenotype","volume":"153","author":"Podhorna","year":"2003","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.bbr.2006.10.027_bib44","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.nlm.2005.11.001","article-title":"Cognitive disruption and altered hippocampus synaptic function in Reelin haploinsufficient mice","volume":"85","author":"Qiu","year":"2006","journal-title":"Neurobiol Learn Memory"},{"key":"10.1016\/j.bbr.2006.10.027_bib45","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0041-008X(03)00229-1","article-title":"Developmental exposure to chlorpyrifos alters reactivity to environmental and social cues in adolescent mice","author":"Ricceri","year":"2003","journal-title":"Toxicol Appl Pharmacol"},{"issue":"5","key":"10.1016\/j.bbr.2006.10.027_bib46","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/S0018-506X(03)00063-1","article-title":"Anxiety and fear behaviours in adult male and female C57BL\/6 mice are modulated by maternal separation","volume":"43","author":"Romeo","year":"2003","journal-title":"Hormones Behav"},{"key":"10.1016\/j.bbr.2006.10.027_bib47","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1037\/0735-7044.117.6.1257","article-title":"Behavioural phenotype of the reeler mutant mouse: effects of Reln gene dosage and social isolation","volume":"6","author":"Salinger","year":"2003","journal-title":"Behav Neurosci"},{"key":"10.1016\/j.bbr.2006.10.027_bib48","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/0361-9230(94)90115-5","article-title":"IGF-I and IGF-I24-41 but not IGF-I57-70 affect somatic and neurobehavioural development of newborn male mice","author":"Santucci","year":"1994","journal-title":"Brain Res Bull"},{"key":"10.1016\/j.bbr.2006.10.027_bib49","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1111\/j.1365-2826.2006.01482.x","article-title":"Metabolic signals modulate hypothalamic\u2013pituitary\u2013adrenal axis activation during maternal separation of the neonatal mouse","volume":"18","author":"Schmidt","year":"2006","journal-title":"J Neuroendocrinol"},{"key":"10.1016\/j.bbr.2006.10.027_bib50","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0006-3223(98)00281-9","article-title":"The reduced neuropil hypothesis: a circuit based model of schizophrenia","volume":"45","author":"Selemon","year":"1999","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.bbr.2006.10.027_bib51","series-title":"Parental care: evolution, mechanism, and adaptive significance","first-page":"243","article-title":"Somatosensation and maternal care in Norway rats","author":"Stern","year":"1996"},{"key":"10.1016\/j.bbr.2006.10.027_bib52","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1038\/nrn1113","article-title":"Reelin and brain development","volume":"4","author":"Tissir","year":"2003","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.bbr.2006.10.027_bib53","doi-asserted-by":"crossref","first-page":"17095","DOI":"10.1073\/pnas.262658999","article-title":"An epigenetic mouse model for molecular and behavioural neuropathologies related to schizophrenia vulnerability","volume":"99","author":"Tremolizzo","year":"2002","journal-title":"Proc Natl Acad Sci"},{"key":"10.1016\/j.bbr.2006.10.027_bib54","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/0165-6147(91)90616-Z","article-title":"The infant rat separation paradigm: a novel test for novel anxiolytics","volume":"12","author":"Winslow","year":"1991","journal-title":"Trends Pharmacol Sci"},{"key":"10.1016\/j.bbr.2006.10.027_bib55","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.pbb.2004.03.021","article-title":"Sexually dimorphic effects of postnatal allopregnanolone on the development of anxiety behaviour after early deprivation","volume":"78","author":"Zimmerberg","year":"2004","journal-title":"Pharmacol Biochem Behav"}],"container-title":["Behavioural Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432806005870?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432806005870?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,4,22]],"date-time":"2019-04-22T18:22:53Z","timestamp":1555957373000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166432806005870"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,2]]},"references-count":55,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,2]]}},"alternative-id":["S0166432806005870"],"URL":"https:\/\/doi.org\/10.1016\/j.bbr.2006.10.027","relation":{},"ISSN":["0166-4328"],"issn-type":[{"value":"0166-4328","type":"print"}],"subject":[],"published":{"date-parts":[[2007,2]]}}}