{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T18:03:02Z","timestamp":1791309782102,"version":"4.3.1"},"reference-count":84,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2009,7,1]],"date-time":"2009-07-01T00:00:00Z","timestamp":1246406400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Behavioural Brain Research"],"published-print":{"date-parts":[[2009,7]]},"DOI":"10.1016\/j.bbr.2009.02.021","type":"journal-article","created":{"date-parts":[[2009,3,4]],"date-time":"2009-03-04T04:53:50Z","timestamp":1236142430000},"page":"216-222","source":"Crossref","is-referenced-by-count":85,"title":["Differential actions of adenosine A1 and A2A antagonists on the effort-related effects of dopamine D2 antagonism"],"prefix":"10.1016","volume":"201","author":[{"given":"John D.","family":"Salamone","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew M.","family":"Farrar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Font","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vatsal","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devra E.","family":"Schlar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric J.","family":"Nunes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lyndsey E.","family":"Collins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas N.","family":"Sager","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbr.2009.02.021_bib1","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/S0306-4522(99)00004-4","article-title":"Nucleus accumbens dopamine depletions make rats more sensitive to high ratio requirements but do not impair primary food reinforcement","volume":"92","author":"Aberman","year":"1999","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbr.2009.02.021_bib2","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.neuropharm.2006.08.017","article-title":"Evidence for adenosine- and serotonin-mediated antihyperalgesic effects of cizolirtine in rats suffering from diabetic neuropathy","volume":"52","author":"Aubel","year":"2007","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bbr.2009.02.021_bib3","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1007\/s00213-007-0741-z","article-title":"Discrete neurochemical coding of distinguishable motivational processes: insights from nucleus accumbens control of feeding","volume":"191","author":"Baldo","year":"2007","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.bbr.2009.02.021_bib4","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1007\/s00213-006-0521-1","article-title":"Opioids for hedonic experience and dopamine to get ready for it","volume":"191","author":"Barbano","year":"2007","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.bbr.2009.02.021_bib5","doi-asserted-by":"crossref","first-page":"2384","DOI":"10.1038\/sj.npp.1301362","article-title":"Basal ganglia hypermetabolism and symptoms of fatigue during interferon-alpha therapy","volume":"32","author":"Capuron","year":"2007","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.bbr.2009.02.021_bib6","unstructured":"Collins LE, Galtieri DL, Hockemeyer J, M\u00fcller CE, Salamone JD. Systemic injections of the adenosine A2A antagonist MSX-3, but not of the adenosine A1 antagonist DPCPX, suppress the tremulous jaw movements induced by a cholinomimetic: possible relevance to parkinsonian tremor. Program No. 341.7 neuroscience meeting planner. 2008. Washington, DC: Society for Neuroscience; 2008. Online."},{"key":"10.1016\/j.bbr.2009.02.021_bib7","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S0166-4328(02)00292-9","article-title":"Nucleus accumbens dopamine and work requirements on interval schedules","volume":"137","author":"Correa","year":"2002","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.bbr.2009.02.021_bib8","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0166-4328(03)00178-5","article-title":"The adenosine A2A antagonist KF17837 reverses the locomotor suppression and tremulous jaw movements induced by haloperidol in rats: possible relevance to parkinsonism","volume":"148","author":"Correa","year":"2004","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.bbr.2009.02.021_bib9","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0166-4328(95)00151-4","article-title":"Nucleus accumbens dopamine depletions alter relative response allocation in a T-maze cost\/benefit task","volume":"74","author":"Cousins","year":"1996","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.bbr.2009.02.021_bib10","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/0091-3057(94)90460-X","article-title":"Nucleus accumbens dopamine depletions in rats affect relative response allocation in a novel cost\/benefit procedure","volume":"49","author":"Cousins","year":"1994","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.bbr.2009.02.021_bib11","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/0091-3057(93)90226-J","article-title":"Different effects of nucleus accumbens and ventrolateral striatal dopamine depletions on instrumental response selection in the rat","volume":"46","author":"Cousins","year":"1993","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.bbr.2009.02.021_bib12","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1007\/BF02247489","article-title":"Pharmacological characterization of performance on a concurrent lever pressing\/feeding choice procedure: effects of dopamine antagonist, cholinomimetic, sedative and stimulant drugs","volume":"116","author":"Cousins","year":"1994","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.bbr.2009.02.021_bib13","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1007\/s00210-002-0613-3","article-title":"Localization of adenosine A2A-receptors in rat brain with [3H]ZM-241385","volume":"366","author":"DeMet","year":"2002","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"10.1016\/j.bbr.2009.02.021_bib14","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1017\/S1461145704004729","article-title":"The many faces of fatigue in major depressive disorder","volume":"8","author":"Demyttenaere","year":"2005","journal-title":"Int J Neuropsychopharmacol"},{"key":"10.1016\/j.bbr.2009.02.021_bib15","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.neuroscience.2007.12.034","article-title":"Forebrain circuitry involved in effort-related choice: injections of the GABAA agonist muscimol into ventral pallidum alters response allocation in food-seeking behavior","volume":"152","author":"Farrar","year":"2008","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbr.2009.02.021_bib16","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1007\/s00213-006-0554-5","article-title":"Adenosine A(2A) receptor antagonism reverses the effects of dopamine receptor antagonism on instrumental output and effort-related choice in the rat: implications for studies of psychomotor slowing","volume":"191","author":"Farrar","year":"2007","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.bbr.2009.02.021_bib17","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/s002130050380","article-title":"Adenosine\u2013dopamine interactions in the ventral striatum. Implications for the treatment of schizophrenia","volume":"133","author":"Ferr\u00e9","year":"1997","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.bbr.2009.02.021_bib18","doi-asserted-by":"crossref","first-page":"2391","DOI":"10.2741\/2852","article-title":"Adenosine A1\u2013A2A receptor heteromers: new targets for caffeine in the brain","volume":"13","author":"Ferre","year":"2008","journal-title":"Front Biosci"},{"key":"10.1016\/j.bbr.2009.02.021_bib19","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.parkreldis.2004.02.014","article-title":"Adenosine A2A\u2013dopamine D2 receptor\u2013receptor heteromers. Targets for neuro-psychiatric disorders","volume":"10","author":"Ferr\u00e9","year":"2004","journal-title":"Parkinsonism Relat Disord"},{"key":"10.1016\/j.bbr.2009.02.021_bib20","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/S0166-2236(97)01096-5","article-title":"Adenosine\u2013dopamine receptor\u2013receptor interactions as an integrative mechanism in the basal ganglia","volume":"20","author":"Ferr\u00e9","year":"1997","journal-title":"Trends Neurosci"},{"key":"10.1016\/j.bbr.2009.02.021_bib21","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/0306-4522(94)90521-5","article-title":"Antagonistic interaction between adenosine A2A receptors and dopamine D2 receptors in the ventral striopallidal system. Implications for the treatment of schizophrenia","volume":"63","author":"Ferr\u00e9","year":"1994","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbr.2009.02.021_bib22","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S1353-8020(00)00063-8","article-title":"Adenosine\/dopamine interaction: implications for the treatment of Parkinson's disease","volume":"7","author":"Ferr\u00e9","year":"2001","journal-title":"Parkinsonism Relat Disord"},{"key":"10.1016\/j.bbr.2009.02.021_bib23","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1111\/j.1471-4159.2007.05196.x","article-title":"An update on the mechanisms of the psychostimulant effects of caffeine","volume":"105","author":"Ferr\u00e9","year":"2008","journal-title":"J Neurochem"},{"key":"10.1016\/j.bbr.2009.02.021_bib24","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1093\/cercor\/bhj143","article-title":"Amygdala-prefrontal cortical circuitry regulates effort-based decision making","volume":"17","author":"Floresco","year":"2007","journal-title":"Cereb Cortex"},{"key":"10.1016\/j.bbr.2009.02.021_bib25","doi-asserted-by":"crossref","first-page":"1966","DOI":"10.1038\/sj.npp.1301565","article-title":"Dopaminergic and glutamatergic regulation of effort- and delay-based decision making","volume":"33","author":"Floresco","year":"2008","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.bbr.2009.02.021_bib26","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1007\/s00213-008-1174-z","article-title":"Intra-accumbens injections of the adenosine A(2A) agonist CGS 21680 affect effort-related choice behavior in rats","volume":"199","author":"Font","year":"2008","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.bbr.2009.02.021_bib27","doi-asserted-by":"crossref","first-page":"S19","DOI":"10.1212\/01.WNL.0000095206.44418.5C","article-title":"Receptor heteromerization in adenosine A2A receptor signaling: relevance for striatal function and Parkinson's disease","volume":"61","author":"Fuxe","year":"2003","journal-title":"Neurology"},{"key":"10.1016\/j.bbr.2009.02.021_bib28","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.physbeh.2007.05.034","article-title":"Adenosine receptor\u2013dopamine receptor interactions in the basal ganglia and their relevance for brain function","volume":"92","author":"Fuxe","year":"2007","journal-title":"Physiol Behav"},{"key":"10.1016\/j.bbr.2009.02.021_bib29","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0014-2999(97)00040-X","article-title":"Motor depressant effects mediated by dopamine D2 and adenosine A2A receptors in the nucleus accumbens and the caudate-putamen","volume":"323","author":"Hauber","year":"1997","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.bbr.2009.02.021_bib30","unstructured":"Hauber W, Sommer S. Prefrontostriatal circuitry regulates effort-related decision making. Cereb Cortex; in press."},{"key":"10.1016\/j.bbr.2009.02.021_bib31","doi-asserted-by":"crossref","first-page":"18091","DOI":"10.1074\/jbc.M107731200","article-title":"Coaggregation, cointernalization, and codesensitization of adenosine A2A receptors and dopamine D2 receptors","volume":"277","author":"Hillion","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bbr.2009.02.021_bib32","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.bbr.2006.12.020","article-title":"Injections of the selective adenosine A2A antagonist MSX-3 into the nucleus accumbens core attenuate the locomotor suppression induced by haloperidol in rats","volume":"178","author":"Ishiwari","year":"2007","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.bbr.2009.02.021_bib33","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/0014-2999(89)90571-2","article-title":"Direct autoradiographic localization of adenosine A2A receptors in the rat brain using the A2A-selective agonist, [3H]CGS 21680","volume":"168","author":"Jarvis","year":"1989","journal-title":"Eur J Pharmacol"},{"issue":"Suppl. 1","key":"10.1016\/j.bbr.2009.02.021_bib34","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1097\/00019052-200312001-00002","article-title":"Dopamine agonists, receptor selectivity and dyskinesia induction in Parkinson's disease","volume":"16","author":"Jenner","year":"2003","journal-title":"Curr Opin Neurol"},{"key":"10.1016\/j.bbr.2009.02.021_bib35","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1517\/13543784.14.6.729","article-title":"A novel adenosine A2A receptor antagonist, for the treatment of Parkinson's disease","volume":"14","author":"Jenner","year":"2005","journal-title":"Expert Opin Investig Drugs"},{"key":"10.1016\/j.bbr.2009.02.021_bib36","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/j.physbeh.2005.08.066","article-title":"Corticostriatal-hypothalamic circuitry and food motivation: integration of energy, action and reward","volume":"86","author":"Kelley","year":"2005","journal-title":"Physiol Behav"},{"key":"10.1016\/j.bbr.2009.02.021_bib37","series-title":"Design and analysis: a researcher's handbook","author":"Keppel","year":"1991"},{"key":"10.1016\/j.bbr.2009.02.021_bib38","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/s002130000505","article-title":"Role of nucleus accumbens dopamine D1 and D2 receptors in instrumental and Pavlovian paradigms of conditioned reward","volume":"152","author":"Koch","year":"2000","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.bbr.2009.02.021_bib39","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1016\/j.pnpbp.2008.01.012","article-title":"Involvement of the adenosine A1 and A2A receptors in the antidepressant-like effect of zinc in the forced swimming test","volume":"32","author":"Lobato","year":"2008","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"10.1016\/j.bbr.2009.02.021_bib40","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.pain.2007.01.013","article-title":"The antinociceptive effect of 2-chloro-2\u2032-C-methyl-N6-cyclopentyladenosine (2\u2032-Me-CCPA), a highly selective adenosine A1 receptor agonist, in the rat","volume":"131","author":"Maione","year":"2007","journal-title":"Pain"},{"key":"10.1016\/j.bbr.2009.02.021_bib41","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1016\/j.bbi.2007.12.009","article-title":"IFN-alpha-induced motor slowing is associated with increased depression and fatigue in patients with chronic hepatitis C","volume":"22","author":"Majer","year":"2008","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.bbr.2009.02.021_bib42","first-page":"55","article-title":"Participation of adenosine system in the ketamine-induced motor activity in mice","volume":"57","author":"Mandryk","year":"2005","journal-title":"Pharmacol Rep"},{"key":"10.1016\/j.bbr.2009.02.021_bib43","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1016\/S0022-3565(24)37508-1","article-title":"Pharmacological characterization of a simple behavioral response mediated selectively by central adenosine A1 receptors, using in vivo and in vitro techniques","volume":"285","author":"Marston","year":"1998","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.bbr.2009.02.021_bib44","doi-asserted-by":"crossref","first-page":"9037","DOI":"10.1523\/JNEUROSCI.1525-08.2008","article-title":"Nucleus accumbens adenosine A2A receptors regulate exertion of effort by acting on the ventral striatopallidal pathway","volume":"28","author":"Mingote","year":"2008","journal-title":"J Neuroscience"},{"key":"10.1016\/j.bbr.2009.02.021_bib45","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1111\/j.1460-9568.2005.03972.x","article-title":"Ratio and time requirements on operant schedules: effort-related effects of nucleus accumbens dopamine depletions","volume":"21","author":"Mingote","year":"2005","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.bbr.2009.02.021_bib46","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/s100720170052","article-title":"Interaction between dopamine and adenosine A2A receptors as a basis for the treatment of Parkinson's disease","volume":"22","author":"Morelli","year":"2002","journal-title":"Neurol Sci"},{"key":"10.1016\/j.bbr.2009.02.021_bib47","unstructured":"Mott AM, Nunes EJ, Collins LE, Port RG, Sink KS, Hockemeyer J, et al. The adenosine A2A MSX-3 reverses the effects of the dopamine antagonist haloperidol on effort-related decision making in a t-maze cost\/benefit procedure. Psychopharmacology; in press."},{"key":"10.1016\/j.bbr.2009.02.021_bib48","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1007\/s00213-006-0502-4","article-title":"Tonic dopamine: opportunity costs and the control of response vigor","volume":"191","author":"Niv","year":"2007","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.bbr.2009.02.021_bib49","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/S0091-3057(01)00524-X","article-title":"D1 or D2 antagonism in nucleus accumbens core or dorsomedial shell suppresses lever pressing for food but leads to compensatory increases in chow consumption","volume":"69","author":"Nowend","year":"2001","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.bbr.2009.02.021_bib50","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1007\/s00213-005-0240-z","article-title":"The effect of the adenosine A2A antagonist KW-6002 on motor and motivational processes in the rat","volume":"184","author":"O\u2019Neill","year":"2006","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.bbr.2009.02.021_bib51","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1007\/s00213-006-0626-6","article-title":"Calculating utility: preclinical evidence for cost-benefit analysis by mesolimbic dopamine","volume":"191","author":"Phillips","year":"2007","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.bbr.2009.02.021_bib52","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/S0893-133X(98)00051-7","article-title":"Involvement of adenosine A2A receptors in the induction of c-fos expression by clozapine and haloperidol","volume":"20","author":"Pinna","year":"1999","journal-title":"Neuropsychopharmacol"},{"key":"10.1016\/j.bbr.2009.02.021_bib53","doi-asserted-by":"crossref","first-page":"3259","DOI":"10.1016\/j.lfs.2005.04.029","article-title":"New therapies for the treatment of Parkinson's disease: adenosine A2A receptor antagonists","volume":"77","author":"Pinna","year":"2005","journal-title":"Life Sci"},{"key":"10.1016\/j.bbr.2009.02.021_bib54","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.bbr.2004.10.017","article-title":"Blockade of adenosine A2A receptors reverses short-term social memory impairments in spontaneously hypertensive rats","volume":"159","author":"Prediger","year":"2005","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.bbr.2009.02.021_bib55","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.neulet.2004.11.049","article-title":"Modulation of short-term social memory in rats by adenosine A1 and A(2A) receptors","volume":"376","author":"Prediger","year":"2005","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.bbr.2009.02.021_bib56","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1007\/s00213-006-0528-7","article-title":"A role for mesencephalic dopamine in activation: commentary on Berridge (2006)","volume":"191","author":"Robbins","year":"2007","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.bbr.2009.02.021_bib57","series-title":"The mesolimbic dopamine system: from motivation to action","first-page":"599","article-title":"Behavioral pharmacology of dopamine systems: a new synthesis","author":"Salamone","year":"1991"},{"key":"10.1016\/j.bbr.2009.02.021_bib58","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1007\/s00213-001-0994-x","article-title":"Dopamine antagonists alter response allocation but do not suppress appetite for food in rats: contrast between the effects of SKF 83566, raclopride and fenfluramine on a concurrent choice task","volume":"160","author":"Salamone","year":"2002","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.bbr.2009.02.021_bib59","doi-asserted-by":"crossref","first-page":"3594","DOI":"10.2741\/2952","article-title":"Tremorolytic effects of adenosine A2A antagonists: implications for parkinsonism","volume":"13","author":"Salamone","year":"2008","journal-title":"Front Biosci"},{"key":"10.1016\/j.bbr.2009.02.021_bib60","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0166-4328(02)00282-6","article-title":"Motivational views of reinforcement: implications for understanding the behavioral functions of nucleus accumbens dopamine","volume":"137","author":"Salamone","year":"2002","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.bbr.2009.02.021_bib61","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1007\/s00213-006-0668-9","article-title":"Effort-related functions of nucleus accumbens dopamine and associated forebrain circuits","volume":"191","author":"Salamone","year":"2007","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.bbr.2009.02.021_bib62","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1124\/jpet.102.035063","article-title":"Accumbens dopamine and the regulation of effort in food-seeking behavior: implications for studies of natural motivation and psychiatry","volume":"305","author":"Salamone","year":"2003","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.bbr.2009.02.021_bib63","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.coph.2004.09.004","article-title":"Beyond the reward hypothesis: alternative functions of nucleus accumbens dopamine","volume":"5","author":"Salamone","year":"2005","journal-title":"Curr Opin Pharmacol"},{"key":"10.1016\/j.bbr.2009.02.021_bib64","doi-asserted-by":"crossref","first-page":"267","DOI":"10.2174\/157340006776875914","article-title":"Nucleus accumbens dopamine and the forebrain circuitry involved in behavioral activation and effort-related decision making: implications for understanding anergia and psychomotor slowing in depression","volume":"2","author":"Salamone","year":"2006","journal-title":"Curr Psychiat Rev"},{"key":"10.1016\/j.bbr.2009.02.021_bib65","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/0166-4328(94)90108-2","article-title":"Anhedonia or anergia? Effects of haloperidol and nucleus accumbens dopamine depletion on instrumental response selection in a T-maze cost\/benefit procedure","volume":"65","author":"Salamone","year":"1994","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.bbr.2009.02.021_bib66","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/S0149-7634(96)00017-6","article-title":"Behavioral functions of nucleus accumbens dopamine: empirical and conceptual problems with the anhedonia hypothesis","volume":"21","author":"Salamone","year":"1997","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1016\/j.bbr.2009.02.021_bib67","doi-asserted-by":"crossref","first-page":"S130","DOI":"10.1016\/j.parkreldis.2008.04.017","article-title":"Dopamine\/adenosine interactions related to locomotion and tremor in animal models: possible relevance to parkinsonism","volume":"14","author":"Salamone","year":"2008","journal-title":"Parkinsonism Relat Disord"},{"key":"10.1016\/j.bbr.2009.02.021_bib68","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1007\/BF02245659","article-title":"Haloperidol and nucleus accumbens dopamine depletion suppress lever pressing for food but increase free food consumption in a novel food choice procedure","volume":"104","author":"Salamone","year":"1991","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.bbr.2009.02.021_bib69","series-title":"The nucleus accumbens: neurotransmitters and related behaviours","first-page":"195","article-title":"Nucleus accumbens and the neurochemical interactions regulating effort-related processes","author":"Salamone","year":"2008"},{"key":"10.1016\/j.bbr.2009.02.021_bib70","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1111\/j.1471-4159.1991.tb08257.x","article-title":"Striatal restricted adenosine A2A receptor (RDC8) is expressed by enkephalin but not by substance P neurons: an in situ hybridization histochemistry study","volume":"57","author":"Schiffmann","year":"1991","journal-title":"J Neurochem"},{"key":"10.1016\/j.bbr.2009.02.021_bib71","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1037\/0735-7044.119.6.1687","article-title":"Involvement of catecholamine neurotransmission in the rat anterior cingulate in effort-related decision making","volume":"119","author":"Schweimer","year":"2005","journal-title":"Behav Neurosci"},{"key":"10.1016\/j.bbr.2009.02.021_bib72","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1007\/s00213-007-0988-4","article-title":"Cannabinoid CB1 antagonists and dopamine antagonists produce different effects on a task involving response allocation and effort-related choice in food-seeking behavior","volume":"196","author":"Sink","year":"2008","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.bbr.2009.02.021_bib73","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/S0091-3057(97)00544-3","article-title":"The role of nucleus accumbens dopamine in lever pressing and response allocation: effects of 6-OHDA injected into core and dorsomedial shell","volume":"59","author":"Sokolowski","year":"1998","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.bbr.2009.02.021_bib74","doi-asserted-by":"crossref","first-page":"7","DOI":"10.4088\/JCP.v63n0102","article-title":"The psychopharmacology of energy and fatigue","volume":"63","author":"Stahl","year":"2002","journal-title":"J Clin Psychiatry"},{"key":"10.1016\/j.bbr.2009.02.021_bib75","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/S0301-0082(99)00011-8","article-title":"Distribution, biochemistry and function of striatal adenosine A2A receptors","volume":"59","author":"Svenningsson","year":"1999","journal-title":"Prog Neurobiol"},{"key":"10.1016\/j.bbr.2009.02.021_bib76","doi-asserted-by":"crossref","first-page":"2614","DOI":"10.2741\/2870","article-title":"Adenosine receptor antagonists for cognitive dysfunction: a review of animal studies","volume":"13","author":"Takahashi","year":"2008","journal-title":"Front Biosci"},{"key":"10.1016\/j.bbr.2009.02.021_bib77","first-page":"139","article-title":"DEPRES II (depression research in European society II): a patient survey of the symptoms, disability and current management of depression in the community","volume":"14","author":"Tylee","year":"1999","journal-title":"Int Clin Psychopharmacol"},{"key":"10.1016\/j.bbr.2009.02.021_bib78","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.bbr.2006.03.035","article-title":"Rats assess costs and benefits according to an internal standard","volume":"171","author":"Van den Bos","year":"2006","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.bbr.2009.02.021_bib79","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1007\/s00213-008-1214-8","article-title":"The effects of adenosine A2A receptor antagonists on haloperidol-induced movement disorders in primates","volume":"200","author":"Varty","year":"2008","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.bbr.2009.02.021_bib80","doi-asserted-by":"crossref","first-page":"6475","DOI":"10.1523\/JNEUROSCI.23-16-06475.2003","article-title":"Functional specialization within medial frontal cortex of the anterior cingulate for evaluating effort-related decisions","volume":"23","author":"Walton","year":"2003","journal-title":"J Neurosci"},{"key":"10.1016\/j.bbr.2009.02.021_bib81","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1016\/j.neunet.2006.03.005","article-title":"Weighing up the benefits of work: behavioral and neural analyses of effort-related decision making","volume":"19","author":"Walton","year":"2006","journal-title":"Neural Netw"},{"key":"10.1016\/j.bbr.2009.02.021_bib82","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1002\/syn.1070","article-title":"SCH 58261, an A2A adenosine receptor antagonist, counteracts parkinsonian-like muscle rigidity in rats","volume":"41","author":"Wardas","year":"2001","journal-title":"Synapse"},{"key":"10.1016\/j.bbr.2009.02.021_bib83","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1007\/s00213-008-1396-0","article-title":"The adenosine A2A antagonist MSX-3 reverses the effort-related effects of dopamine blockade: differential interaction with D1 and D2 family antagonists","volume":"203","author":"Worden","year":"2009","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.bbr.2009.02.021_bib84","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.nic.2007.08.001","article-title":"Mood disorders","volume":"17","author":"Yurgelun-Todd","year":"2007","journal-title":"Neuroimaging Clin N Am"}],"container-title":["Behavioural Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432809001089?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432809001089?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,7]],"date-time":"2025-02-07T19:10:15Z","timestamp":1738955415000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166432809001089"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,7]]},"references-count":84,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2009,7]]}},"alternative-id":["S0166432809001089"],"URL":"https:\/\/doi.org\/10.1016\/j.bbr.2009.02.021","relation":{},"ISSN":["0166-4328"],"issn-type":[{"value":"0166-4328","type":"print"}],"subject":[],"published":{"date-parts":[[2009,7]]}}}