{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T03:04:54Z","timestamp":1791255894928,"version":"4.1.0"},"reference-count":51,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2009,12,1]],"date-time":"2009-12-01T00:00:00Z","timestamp":1259625600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,12,1]],"date-time":"2009-12-01T00:00:00Z","timestamp":1259625600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2009,12,1]],"date-time":"2009-12-01T00:00:00Z","timestamp":1259625600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2009,12,1]],"date-time":"2009-12-01T00:00:00Z","timestamp":1259625600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2009,12,1]],"date-time":"2009-12-01T00:00:00Z","timestamp":1259625600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2009,12,1]],"date-time":"2009-12-01T00:00:00Z","timestamp":1259625600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2009,12,1]],"date-time":"2009-12-01T00:00:00Z","timestamp":1259625600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Behavioural Brain Research"],"published-print":{"date-parts":[[2009,12]]},"DOI":"10.1016\/j.bbr.2009.06.005","type":"journal-article","created":{"date-parts":[[2009,6,11]],"date-time":"2009-06-11T05:03:14Z","timestamp":1244696594000},"page":"206-211","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":156,"title":["Object location memory in mice: Pharmacological validation and further evidence of hippocampal CA1 participation"],"prefix":"10.1016","volume":"204","author":[{"given":"Fabr\u00edcio Luiz","family":"Assini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo","family":"Duzzioni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reinaldo Naoto","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbr.2009.06.005_bib1","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1037\/0735-7044.118.1.223","article-title":"Blockade of central cholinergic receptors impairs new learning and increases proactive interference in a word paired-associate memory task","volume":"118","author":"Atri","year":"2004","journal-title":"Behav Neurosci"},{"key":"10.1016\/j.bbr.2009.06.005_bib2","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/S0014-2999(00)00054-6","article-title":"Pre-training blocks the improving effect of tetrahydroaminoacridine and d-cycloserine on spatial navigation performance in aged rats","volume":"390","author":"Aura","year":"2000","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.bbr.2009.06.005_bib3","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1002\/hipo.20369","article-title":"Memory for spatial location and object\u2013place associations are differently processed by the hippocampal formation, parahippocampal areas TH\/TF and perirhinal cortex","volume":"18","author":"Bachevalier","year":"2008","journal-title":"Hippocampus"},{"key":"10.1016\/j.bbr.2009.06.005_bib4","doi-asserted-by":"crossref","first-page":"2260","DOI":"10.1111\/j.1460-9568.2007.05488.x","article-title":"Deficit of NMDA receptor activation in CA1 hippocampal area of aged rats is rescued by d-cycloserine","volume":"25","author":"Billard","year":"2007","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.bbr.2009.06.005_bib5","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1038\/nrn2335","article-title":"The hippocampus and memory: insights from spatial processing","volume":"3","author":"Bird","year":"2008","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.bbr.2009.06.005_bib6","first-page":"196","article-title":"The role of horizontal categorization in retroactive and proactive interference","volume":"49","author":"Blank","year":"2002","journal-title":"Exp Psychol"},{"key":"10.1016\/j.bbr.2009.06.005_bib7","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0165-0270(00)00348-4","article-title":"Time course and effective spread of lidocaine and tetrodotoxin delivered via microdialysis: an electrophysiological study in cerebral cortex","volume":"105","author":"Boehnke","year":"2001","journal-title":"J Neurosci Methods"},{"key":"10.1016\/j.bbr.2009.06.005_bib8","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1037\/0278-7393.20.1.51","article-title":"Reducing retroactive interference: an interference analysis","volume":"20","author":"Bower","year":"1994","journal-title":"J Exp Psychol Learn Mem Cogn"},{"key":"10.1016\/j.bbr.2009.06.005_bib9","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1037\/0735-7044.122.3.535","article-title":"Glutamate receptor-mediated restoration of experience-dependent place field expansion plasticity in aged rats","volume":"22","author":"Burke","year":"2008","journal-title":"Behav Neurosci"},{"key":"10.1016\/j.bbr.2009.06.005_bib10","doi-asserted-by":"crossref","first-page":"2135","DOI":"10.1038\/sj.npp.1300761","article-title":"Cholinesterase inhibitors ameliorate behavioral deficits induced by MK-801 in mice","volume":"30","author":"Csernansky","year":"2005","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.bbr.2009.06.005_bib11","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1101\/lm.81905","article-title":"Encoding, consolidation, and retrieval of contextual memory: differential involvement of dorsal CA3 and CA1 hippocampal subregions","volume":"12","author":"Daumas","year":"2005","journal-title":"Learn Mem"},{"key":"10.1016\/j.bbr.2009.06.005_bib12","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/S0079-6123(07)63040-4","article-title":"Hippocampal atrophy and disconnection in incipient and mild Alzheimer's disease","volume":"163","author":"deToledo-Morrell","year":"2007","journal-title":"Prog Brain Res"},{"key":"10.1016\/j.bbr.2009.06.005_bib13","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1007\/PL00005603","article-title":"Spontaneous object recognition and object location memory in rats, the effects of lesions in the cingulate cortices, the medial prefrontal cortex, the cingulum bundle and the fornix","volume":"113","author":"Ennaceur","year":"1997","journal-title":"Exp Brain Res"},{"key":"10.1016\/j.bbr.2009.06.005_bib14","doi-asserted-by":"crossref","first-page":"8046","DOI":"10.1523\/JNEUROSCI.1187-07.2007","article-title":"Mineralocorticoid receptor overexpression differentially modulates specific phases of spatial and nonspatial memory","volume":"27","author":"Ferguson","year":"2007","journal-title":"J Neurosci"},{"key":"10.1016\/j.bbr.2009.06.005_bib15","first-page":"93","article-title":"Animal models of different anxiety states","volume":"48","author":"File","year":"1995","journal-title":"Adv Biochem Psychopharmacol"},{"key":"10.1016\/j.bbr.2009.06.005_bib16","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.nlm.2007.04.003","article-title":"Estrogens and progestins enhance spatial learning of intact and ovariectomized rats in the object placement task","volume":"88","author":"Frye","year":"2007","journal-title":"Neurobiol Learn Mem"},{"key":"10.1016\/j.bbr.2009.06.005_bib17","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S1074-7427(03)00069-8","article-title":"Memory for objects and their locations: the role of the hippocampus in retention of object\u2013place associations","volume":"81","author":"Gilbert","year":"2004","journal-title":"Neurobiol Learn Mem"},{"key":"10.1016\/j.bbr.2009.06.005_bib18","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1002\/(SICI)1098-1063(1998)8:2<138::AID-HIPO6>3.0.CO;2-H","article-title":"Hippocampal lesions enhance configural learning by reducing proactive interference","volume":"8","author":"Han","year":"1998","journal-title":"Hippocampus"},{"key":"10.1016\/j.bbr.2009.06.005_bib19","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S0079-6123(03)45015-2","article-title":"High acetylcholine levels set circuit dynamics for attention and encoding and low acetylcholine levels set dynamics for consolidation","volume":"145","author":"Hasselmo","year":"2004","journal-title":"Prog Brain Res"},{"key":"10.1016\/j.bbr.2009.06.005_bib20","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1016\/j.conb.2006.09.002","article-title":"The role of acetylcholine in learning and memory","volume":"16","author":"Hasselmo","year":"2006","journal-title":"Curr Opin Neurobiol"},{"key":"10.1016\/j.bbr.2009.06.005_bib21","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1111\/j.1476-5381.1989.tb16865.x","article-title":"The cholinergic pharmacology of tetrahydroaminoacridine in vivo and in vitro","volume":"98","author":"Hunter","year":"1989","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.bbr.2009.06.005_bib22","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/0165-6147(89)90231-9","article-title":"Mechanism of action of scopolamine as an amnestic","volume":"10","author":"Izquierdo","year":"1989","journal-title":"Trends Pharmacol Sci"},{"key":"10.1016\/j.bbr.2009.06.005_bib23","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/S0031-9384(03)00171-9","article-title":"Assessment of spatial learning abilities of mice in a new circular maze","volume":"79","author":"Koopmans","year":"2003","journal-title":"Physiol Behav"},{"key":"10.1016\/j.bbr.2009.06.005_bib24","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.brainres.2008.01.019","article-title":"Blockade of NMDA receptors pre-training, but not post-training, impairs object displacement learning in the rat","volume":"1199","author":"Larkin","year":"2008","journal-title":"Brain Res"},{"key":"10.1016\/j.bbr.2009.06.005_bib25","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.nlm.2007.06.006","article-title":"Electrolytic lesions of dorsal CA3 impair episodic-like memory in rats","volume":"89","author":"Li","year":"2008","journal-title":"Neurobiol Learn Mem"},{"key":"10.1016\/j.bbr.2009.06.005_bib26","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.neulet.2007.06.023","article-title":"Water T-maze, an improved method to assess spatial working memory in rats: pharmacological validation","volume":"422","author":"Locchi","year":"2007","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.bbr.2009.06.005_bib27","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.ejphar.2007.10.032","article-title":"Effects of selective inhibition of N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) on mice in learning and memory tasks","volume":"579","author":"Lukawski","year":"2008","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.bbr.2009.06.005_bib28","doi-asserted-by":"crossref","first-page":"2030","DOI":"10.1111\/j.1742-1241.2007.01602.x","article-title":"Neurobiology of depression: an integrated view of key findings","volume":"61","author":"Maletic","year":"2007","journal-title":"Int J Clin Pract"},{"key":"10.1016\/j.bbr.2009.06.005_bib29","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S0165-0270(98)00161-7","article-title":"Reversible inactivation of subcortical sites by drug injection","volume":"86","author":"Malpeli","year":"1999","journal-title":"J Neurosci Methods"},{"key":"10.1016\/j.bbr.2009.06.005_bib30","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1002\/hipo.20367","article-title":"A single application of MK801 causes symptoms of acute psychosis, deficits in spatial memory, and impairment of synaptic plasticity in rats","volume":"18","author":"Manahan-Vaughan","year":"2008","journal-title":"Hippocampus"},{"issue":"5451","key":"10.1016\/j.bbr.2009.06.005_bib31","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1126\/science.287.5451.248","article-title":"Memory\u2014a century of consolidation","volume":"287","author":"McGaugh","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.bbr.2009.06.005_bib32","doi-asserted-by":"crossref","first-page":"5394","DOI":"10.1523\/JNEUROSCI.5047-06.2007","article-title":"Connecting TNF-alpha signaling pathways to iNOS expression in a mouse model of Alzheimer's disease: relevance for the behavioral and synaptic deficits induced by amyloid beta protein","volume":"27","author":"Medeiros","year":"2007","journal-title":"J Neurosci"},{"key":"10.1016\/j.bbr.2009.06.005_bib33","doi-asserted-by":"crossref","first-page":"2829","DOI":"10.1111\/j.1460-9568.2006.04888.x","article-title":"Elements of a neurobiological theory of hippocampal function: the role of synaptic plasticity, synaptic tagging and schemas","volume":"23","author":"Morris","year":"2006","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.bbr.2009.06.005_bib34","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1002\/(SICI)1098-1063(1998)8:6<608::AID-HIPO3>3.0.CO;2-7","article-title":"Functional differentiation in the hippocampus","volume":"8","author":"Moser","year":"1998","journal-title":"Hippocampus"},{"key":"10.1016\/j.bbr.2009.06.005_bib35","doi-asserted-by":"crossref","first-page":"3916","DOI":"10.1523\/JNEUROSCI.13-09-03916.1993","article-title":"Spatial learning impairment parallels the magnitude of dorsal hippocampal lesions, but is hardly present following ventral lesions","volume":"13","author":"Moser","year":"1993","journal-title":"J Neurosci"},{"key":"10.1016\/j.bbr.2009.06.005_bib36","doi-asserted-by":"crossref","first-page":"9697","DOI":"10.1073\/pnas.92.21.9697","article-title":"Spatial learning with a minislab in the dorsal hippocampus","volume":"92","author":"Moser","year":"1995","journal-title":"Proc Natl Acad Sci"},{"key":"10.1016\/j.bbr.2009.06.005_bib37","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1101\/lm.41302","article-title":"Hippocampal damage and exploratory preferences in rats: memory for objects, places, and contexts","volume":"9","author":"Mumby","year":"2003","journal-title":"Learn Mem"},{"key":"10.1016\/j.bbr.2009.06.005_bib38","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.physbeh.2006.09.013","article-title":"Characteristics of object location memory in mice: behavioral and pharmacological studies","volume":"90","author":"Murai","year":"2007","journal-title":"Physiol Behav"},{"key":"10.1016\/j.bbr.2009.06.005_bib39","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1038\/nrn1385","article-title":"NMDA receptors, place cells and hippocampal spatial memory","volume":"5","author":"Nakazawa","year":"2004","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.bbr.2009.06.005_bib40","series-title":"The mouse brain in stereotaxic coordinates","author":"Paxinos","year":"2001"},{"key":"10.1016\/j.bbr.2009.06.005_bib41","doi-asserted-by":"crossref","first-page":"2500","DOI":"10.1002\/jps.10243","article-title":"A signal transduction pharmacodynamic model of the kinetics of the parasympathomimetic activity of low-dose scopolamine and atropine in rats","volume":"91","author":"Perlstein","year":"2002","journal-title":"J Pharm Sci"},{"key":"10.1016\/j.bbr.2009.06.005_bib42","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.bbr.2006.11.032","article-title":"Differential susceptibility following beta-amyloid peptide-(1\u201340) administration in C57BL\/6 and Swiss albino mice: evidence for a dissociation between cognitive deficits and the glutathione system response","volume":"177","author":"Prediger","year":"2007","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.bbr.2009.06.005_bib43","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0166-4328(02)00272-3","article-title":"Glutamate receptor function in learning and memory","volume":"140","author":"Riedel","year":"2003","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.bbr.2009.06.005_bib44","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/S1074-7427(03)00063-7","article-title":"Cholinergic modulation of the hippocampus during encoding and retrieval","volume":"80","author":"Rogers","year":"2003","journal-title":"Neurobiol Learn Mem"},{"key":"10.1016\/j.bbr.2009.06.005_bib45","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.neulet.2005.01.049","article-title":"The cannabinoid antagonist SR141716A facilitates memory acquisition and consolidation in the mouse elevated T-maze","volume":"380","author":"Takahashi","year":"2005","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.bbr.2009.06.005_bib46","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/S0022-3565(25)23251-7","article-title":"Kinetics of MK-801 and its effect on quinolinic acid-induced seizures and neurotoxicity in rats","volume":"249","author":"Vezzani","year":"1989","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.bbr.2009.06.005_bib47","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.nlm.2008.01.008","article-title":"Estradiol or diarylpropionitrile administration to wild type, but not estrogen receptor beta knockout, mice enhances performance in the object recognition and object placement tasks","volume":"89","author":"Walf","year":"2008","journal-title":"Neurobiol Learn Mem"},{"key":"10.1016\/j.bbr.2009.06.005_bib48","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/0014-2999(94)90132-5","article-title":"Effect of the glycine\/NMDA receptor partial agonist, d-cycloserine, on seizure threshold and some pharmacodynamic effects of MK-801 in mice","volume":"257","author":"Wla\u017a","year":"1994","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.bbr.2009.06.005_bib49","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0091-3057(96)00133-5","article-title":"Effects of d-cycloserine and aniracetam on spatial learning in rats with entorhinal cortex lesions","volume":"56","author":"Zajaczkowski","year":"1997","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.bbr.2009.06.005_bib50","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1254\/jphs.FP0061457","article-title":"Chotosan, a kampo formula, ameliorates chronic cerebral hypoperfusion-induced deficits in object recognition behaviors and central cholinergic systems in mice","volume":"103","author":"Zhao","year":"2007","journal-title":"J Pharmacol Sci"},{"key":"10.1016\/j.bbr.2009.06.005_bib51","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1007\/s00213-007-0816-x","article-title":"NMDA receptor modulation by d-cycloserine promotes episodic-like memory in mice","volume":"193","author":"Zlomuzica","year":"2007","journal-title":"Psychopharmacology"}],"container-title":["Behavioural Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432809003593?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432809003593?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T12:59:32Z","timestamp":1759064372000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166432809003593"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,12]]},"references-count":51,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2009,12]]}},"alternative-id":["S0166432809003593"],"URL":"https:\/\/doi.org\/10.1016\/j.bbr.2009.06.005","relation":{},"ISSN":["0166-4328"],"issn-type":[{"value":"0166-4328","type":"print"}],"subject":[],"published":{"date-parts":[[2009,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Object location memory in mice: Pharmacological validation and further evidence of hippocampal CA1 participation","name":"articletitle","label":"Article Title"},{"value":"Behavioural Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbr.2009.06.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}