{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T07:05:42Z","timestamp":1777791942973,"version":"3.51.4"},"reference-count":37,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2010,5,1]],"date-time":"2010-05-01T00:00:00Z","timestamp":1272672000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Behavioural Brain Research"],"published-print":{"date-parts":[[2010,5]]},"DOI":"10.1016\/j.bbr.2010.01.018","type":"journal-article","created":{"date-parts":[[2010,1,26]],"date-time":"2010-01-26T09:59:17Z","timestamp":1264499957000},"page":"80-84","source":"Crossref","is-referenced-by-count":43,"title":["Isolation rearing-induced deficits in contextual fear learning do not require CRF2 receptors"],"prefix":"10.1016","volume":"209","author":[{"given":"Jodi E.","family":"Gresack","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victoria B.","family":"Risbrough","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine N.","family":"Scott","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Coste","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary","family":"Stenzel-Poore","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark A.","family":"Geyer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan B.","family":"Powell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.bbr.2010.01.018_bib1","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s002210100746","article-title":"The ventral hippocampus and fear conditioning in rats. Different anterograde amnesias of fear after tetrodotoxin inactivation and infusion of the GABA(A) agonist muscimol","volume":"139","author":"Bast","year":"2001","journal-title":"Exp Brain Res"},{"issue":"10","key":"10.1016\/j.bbr.2010.01.018_bib2","doi-asserted-by":"crossref","first-page":"2894","DOI":"10.1111\/j.1460-9568.2006.05170.x","article-title":"Isolation rearing induces recognition memory deficits accompanied by cytoskeletal alterations in rat hippocampus","volume":"24","author":"Bianchi","year":"2006","journal-title":"Eur J Neurosci"},{"issue":"2","key":"10.1016\/j.bbr.2010.01.018_bib3","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1001\/archgenpsychiatry.2007.26","article-title":"Influence of child abuse on adult depression: moderation by the corticotropin-releasing hormone receptor gene","volume":"65","author":"Bradley","year":"2008","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.bbr.2010.01.018_bib4","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0079-6123(07)67012-5","article-title":"Structural and functional plasticity of the human brain in posttraumatic stress disorder","volume":"167","author":"Bremner","year":"2008","journal-title":"Prog Brain Res"},{"issue":"6","key":"10.1016\/j.bbr.2010.01.018_bib5","first-page":"417","article-title":"The role of the hippocampus in the pathophysiology of major depression","volume":"29","author":"Campbell","year":"2004","journal-title":"J Psychiatry Neurosci"},{"issue":"44","key":"10.1016\/j.bbr.2010.01.018_bib6","doi-asserted-by":"crossref","first-page":"15782","DOI":"10.1073\/pnas.0403975101","article-title":"Modulation of dendritic differentiation by corticotropin-releasing factor in the developing hippocampus","volume":"101","author":"Chen","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"issue":"4","key":"10.1016\/j.bbr.2010.01.018_bib7","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1038\/74255","article-title":"Abnormal adaptations to stress and impaired cardiovascular function in mice lacking corticotropin-releasing hormone receptor-2","volume":"24","author":"Coste","year":"2000","journal-title":"Nat Genet"},{"issue":"12","key":"10.1016\/j.bbr.2010.01.018_bib8","doi-asserted-by":"crossref","first-page":"3319","DOI":"10.1111\/j.1460-9568.2006.04864.x","article-title":"The CRF1 receptor antagonist, antalarmin, reverses isolation-induced up-regulation of dopamine D2 receptors in the amygdala and nucleus accumbens of fawn-hooded rats","volume":"23","author":"Djouma","year":"2006","journal-title":"Eur J Neurosci"},{"issue":"2","key":"10.1016\/j.bbr.2010.01.018_bib9","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S0896-6273(00)80775-8","article-title":"Why we think plasticity underlying Pavlovian fear conditioning occurs in the basolateral amygdala","volume":"23","author":"Fanselow","year":"1999","journal-title":"Neuron"},{"issue":"6","key":"10.1016\/j.bbr.2010.01.018_bib10","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1016\/j.neubiorev.2008.03.003","article-title":"Behavioural and neurochemical effects of post-weaning social isolation in rodents-relevance to developmental neuropsychiatric disorders","volume":"32","author":"Fone","year":"2008","journal-title":"Neurosci Biobehav Rev"},{"issue":"1","key":"10.1016\/j.bbr.2010.01.018_bib11","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/0091-3057(86)90266-2","article-title":"Multivariate assessment of locomotor behavior: pharmacological and behavioral analyses","volume":"25","author":"Geyer","year":"1986","journal-title":"Pharmacol Biochem Behav"},{"issue":"5","key":"10.1016\/j.bbr.2010.01.018_bib12","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.biopsych.2006.12.023","article-title":"Configural cue performance in identical twins discordant for posttraumatic stress disorder: theoretical implications for the role of hippocampal function","volume":"62","author":"Gilbertson","year":"2007","journal-title":"Biol Psychiatry"},{"issue":"7","key":"10.1016\/j.bbr.2010.01.018_bib13","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1007\/s00702-007-0627-6","article-title":"Deficits in parvalbumin and calbindin immunoreactive cells in the hippocampus of isolation reared rats","volume":"114","author":"Harte","year":"2007","journal-title":"J Neural Transm"},{"issue":"4","key":"10.1016\/j.bbr.2010.01.018_bib14","doi-asserted-by":"crossref","first-page":"453","DOI":"10.2174\/187152706777950684","article-title":"Corticotropin releasing factor (CRF) receptor signaling in the central nervous system: new molecular targets","volume":"5","author":"Hauger","year":"2006","journal-title":"CNS Neurol Disord Drug Targets"},{"issue":"4","key":"10.1016\/j.bbr.2010.01.018_bib15","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1016\/j.neuroscience.2007.10.001","article-title":"Activation of basolateral amygdala corticotropin-releasing factor 1 receptors modulates the consolidation of contextual fear","volume":"150","author":"Hubbard","year":"2007","journal-title":"Neuroscience"},{"issue":"3","key":"10.1016\/j.bbr.2010.01.018_bib16","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1111\/j.1471-4159.2007.05207.x","article-title":"Social isolation rearing-induced impairment of the hippocampal neurogenesis is associated with deficits in spatial memory and emotion-related behaviors in juvenile mice","volume":"105","author":"Ibi","year":"2008","journal-title":"J Neurochem"},{"issue":"5057","key":"10.1016\/j.bbr.2010.01.018_bib17","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1126\/science.1585183","article-title":"Modality-specific retrograde amnesia of fear","volume":"256","author":"Kim","year":"1992","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.bbr.2010.01.018_bib18","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1016\/S0014-4886(03)00248-6","article-title":"Modification of hippocampal neurogenesis and neuroplasticity by social environments","volume":"183","author":"Lu","year":"2003","journal-title":"Exp Neurol"},{"issue":"32","key":"10.1016\/j.bbr.2010.01.018_bib19","doi-asserted-by":"crossref","first-page":"9955","DOI":"10.1523\/JNEUROSCI.0854-09.2009","article-title":"Corticotropin-releasing factor receptor antagonism within the dorsal raphe nucleus reduces social anxiety-like behavior after early-life social isolation","volume":"29","author":"Lukkes","year":"2009","journal-title":"J Neurosci"},{"issue":"1","key":"10.1016\/j.bbr.2010.01.018_bib20","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.yhbeh.2008.10.014","article-title":"Adult rats exposed to early-life social isolation exhibit increased anxiety and conditioned fear behavior, and altered hormonal stress responses","volume":"55","author":"Lukkes","year":"2009","journal-title":"Horm Behav"},{"key":"10.1016\/j.bbr.2010.01.018_bib21","doi-asserted-by":"crossref","first-page":"18","DOI":"10.3389\/neuro.08.018.2009","article-title":"Consequences of post-weaning social isolation on anxiety behavior and related neural circuits in rodents","volume":"3","author":"Lukkes","year":"2009","journal-title":"Front Behav Neurosci"},{"issue":"2","key":"10.1016\/j.bbr.2010.01.018_bib22","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1037\/0735-7044.106.2.274","article-title":"Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning","volume":"106","author":"Phillips","year":"1992","journal-title":"Behav Neurosci"},{"issue":"4","key":"10.1016\/j.bbr.2010.01.018_bib23","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1007\/s00213-008-1081-3","article-title":"The postweaning social isolation in C57BL\/6 mice: preferential vulnerability in the male sex","volume":"197","author":"Pietropaolo","year":"2008","journal-title":"Psychopharmacology (Berl)"},{"issue":"2","key":"10.1016\/j.bbr.2010.01.018_bib24","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.bbr.2009.04.021","article-title":"Prepulse inhibition and genetic mouse models of schizophrenia","volume":"204","author":"Powell","year":"2009","journal-title":"Behav Brain Res"},{"issue":"12","key":"10.1016\/j.bbr.2010.01.018_bib25","doi-asserted-by":"crossref","first-page":"5016","DOI":"10.1523\/JNEUROSCI.19-12-05016.1999","article-title":"Modulation of learning and anxiety by corticotropin-releasing factor (CRF) and stress: differential roles of CRF receptors 1 and 2","volume":"19","author":"Radulovic","year":"1999","journal-title":"J Neurosci"},{"issue":"11","key":"10.1016\/j.bbr.2010.01.018_bib26","doi-asserted-by":"crossref","first-page":"2349","DOI":"10.1038\/sj.npp.1301161","article-title":"Differential contributions of dopamine D1, D2, and D3 receptors to MDMA-induced effects on locomotor behavior patterns in mice","volume":"31","author":"Risbrough","year":"2006","journal-title":"Neuropsychopharmacology"},{"issue":"36","key":"10.1016\/j.bbr.2010.01.018_bib27","doi-asserted-by":"crossref","first-page":"11436","DOI":"10.1523\/JNEUROSCI.23-36-11436.2003","article-title":"Mitogen-activated protein kinase signaling in the hippocampus and its modulation by corticotropin-releasing factor receptor 2: a possible link between stress and fear memory","volume":"23","author":"Sananbenesi","year":"2003","journal-title":"J Neurosci"},{"issue":"1\u20133","key":"10.1016\/j.bbr.2010.01.018_bib28","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0014-2999(03)01283-4","article-title":"The place of the hippocampus in fear conditioning","volume":"463","author":"Sanders","year":"2003","journal-title":"Eur J Pharmacol"},{"issue":"1\u20132","key":"10.1016\/j.bbr.2010.01.018_bib29","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/S0006-8993(03)03042-7","article-title":"Decreased dendritic spine density on prefrontal cortical and hippocampal pyramidal neurons in postweaning social isolation rats","volume":"983","author":"Silva-Gomez","year":"2003","journal-title":"Brain Res"},{"issue":"11","key":"10.1016\/j.bbr.2010.01.018_bib30","doi-asserted-by":"crossref","first-page":"3385","DOI":"10.1111\/j.1460-9568.2007.05592.x","article-title":"Differential activation of CRF receptor subtypes removes stress-induced memory deficit and anxiety","volume":"25","author":"Todorovic","year":"2007","journal-title":"Eur J Neurosci"},{"issue":"4\u20135","key":"10.1016\/j.bbr.2010.01.018_bib31","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1101\/lm.5.4.391","article-title":"Automated measurement of mouse freezing behavior and its use for quantitative trait locus analysis of contextual fear conditioning in (BALB\/cJ \u00d7 C57BL\/6J)F2 mice","volume":"5","author":"Valentinuzzi","year":"1998","journal-title":"Learn Mem"},{"issue":"2","key":"10.1016\/j.bbr.2010.01.018_bib32","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1002\/1096-9861(20001211)428:2<191::AID-CNE1>3.0.CO;2-U","article-title":"Distribution of mRNAs encoding CRF receptors in brain and pituitary of rat and mouse","volume":"428","author":"Van Pett","year":"2000","journal-title":"J Comp Neurol"},{"issue":"2","key":"10.1016\/j.bbr.2010.01.018_bib33","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0006-8993(99)01173-7","article-title":"Reduced synaptophysin immunoreactivity in the dentate gyrus of prepulse inhibition-impaired isolation-reared rats","volume":"824","author":"Varty","year":"1999","journal-title":"Brain Res"},{"issue":"1","key":"10.1016\/j.bbr.2010.01.018_bib34","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.bbr.2005.11.025","article-title":"Isolation rearing of mice induces deficits in prepulse inhibition of the startle response","volume":"169","author":"Varty","year":"2006","journal-title":"Behav Brain Res"},{"issue":"4","key":"10.1016\/j.bbr.2010.01.018_bib35","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1111\/j.1601-183X.2004.00106.x","article-title":"Long-term individual housing in C57BL\/6J and DBA\/2 mice: assessment of behavioral consequences","volume":"4","author":"Voikar","year":"2005","journal-title":"Genes Brain Behav"},{"issue":"3","key":"10.1016\/j.bbr.2010.01.018_bib36","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1006\/nlme.2001.4005","article-title":"Intrahippocampal scopolamine impairs both acquisition and consolidation of contextual fear conditioning","volume":"75","author":"Wallenstein","year":"2001","journal-title":"Neurobiol Learn Mem"},{"issue":"2","key":"10.1016\/j.bbr.2010.01.018_bib37","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.bbr.2003.10.015","article-title":"Effect of social isolation on stress-related behavioural and neuroendocrine state in the rat","volume":"152","author":"Weiss","year":"2004","journal-title":"Behav Brain Res"}],"container-title":["Behavioural Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432810000355?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432810000355?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T19:21:20Z","timestamp":1685388080000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166432810000355"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,5]]},"references-count":37,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,5]]}},"alternative-id":["S0166432810000355"],"URL":"https:\/\/doi.org\/10.1016\/j.bbr.2010.01.018","relation":{},"ISSN":["0166-4328"],"issn-type":[{"value":"0166-4328","type":"print"}],"subject":[],"published":{"date-parts":[[2010,5]]}}}