{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T18:31:40Z","timestamp":1790620300648,"version":"4.1.0"},"reference-count":69,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2010,10,1]],"date-time":"2010-10-01T00:00:00Z","timestamp":1285891200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,10,1]],"date-time":"2010-10-01T00:00:00Z","timestamp":1285891200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Behavioural Brain Research"],"published-print":{"date-parts":[[2010,10]]},"DOI":"10.1016\/j.bbr.2010.04.015","type":"journal-article","created":{"date-parts":[[2010,4,15]],"date-time":"2010-04-15T05:02:06Z","timestamp":1271307726000},"page":"179-186","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":66,"title":["Topical application of l-menthol induces heat analgesia, mechanical allodynia, and a biphasic effect on cold sensitivity in rats"],"prefix":"10.1016","volume":"212","author":[{"given":"Amanda H.","family":"Klein","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolyn M.","family":"Sawyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirela Iodi","family":"Carstens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merab G.","family":"Tsagareli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nana","family":"Tsiklauri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Carstens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbr.2010.04.015_bib1","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.neulet.2005.12.005","article-title":"Ca2+-dependent PKC activation mediates menthol-induced desensitization of transient receptor potential M8","volume":"397","author":"Abe","year":"2006","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.bbr.2010.04.015_bib2","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1093\/chemse\/bjm056","article-title":"Modulation of oral heat and cold pain by irritant chemicals","volume":"33","author":"Albin","year":"2008","journal-title":"Chem Senses"},{"key":"10.1016\/j.bbr.2010.04.015_bib3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1744-8069-1-36","article-title":"Detection of cold pain, cold allodynia and cold hyperalgesia in freely behaving rats","volume":"1","author":"Allchorne","year":"2005","journal-title":"Mol Pain"},{"key":"10.1016\/j.bbr.2010.04.015_bib4","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1038\/nature05910","article-title":"The menthol receptor TRPM8 is the principal detector of environmental cold","volume":"448","author":"Bautista","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.bbr.2010.04.015_bib5","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1038\/sj.bjp.0705652","article-title":"Characterization of the mouse cold-menthol receptor TRPM8 and vanilloid receptor type-1 VR1 using a fluorometric imaging plate reader (FLIPR) assay","volume":"141","author":"Behrendt","year":"2004","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.bbr.2010.04.015_bib6","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s00221-009-1797-2","article-title":"Converting cold into pain","volume":"196","author":"Belmonte","year":"2009","journal-title":"Exp Brain Res"},{"key":"10.1016\/j.bbr.2010.04.015_bib7","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1007\/s00403-005-0622-4","article-title":"How does the type of vehicle influence the in vitro skin absorption and elmination kinetics of terpenes?","volume":"297","author":"Cal","year":"2006","journal-title":"Arch Dermatol Res"},{"key":"10.1016\/j.bbr.2010.04.015_bib8","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1358\/mf.2009.31.4.1371197","article-title":"Skin disposition of d-camphor and l-menthol alone and together","volume":"31","author":"Cal","year":"2009","journal-title":"Methods Find Exp Clin Pharmacol"},{"key":"10.1016\/j.bbr.2010.04.015_bib9","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1007\/s002130100770","article-title":"Analgesia induced by chronic nicotine infusion in rats\u2014differences by gender and pain test","volume":"157","author":"Carstens","year":"2001","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.bbr.2010.04.015_bib10","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/0031-9384(95)02089-6","article-title":"Sensitization and desensitization to capsaicin and menthol in the oral cavity: interactions and individual differences","volume":"59","author":"Cliff","year":"1996","journal-title":"Physiol Behav"},{"key":"10.1016\/j.bbr.2010.04.015_bib11","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1016\/0031-9384(94)90338-7","article-title":"Sensory irritation and coolness produced by menthol: evidence for selective desensitization of irritation","volume":"56","author":"Cliff","year":"1994","journal-title":"Physiol Behav"},{"key":"10.1016\/j.bbr.2010.04.015_bib12","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.neuron.2007.04.017","article-title":"Attenuated cold sensitivity in TRPM8 null mice","volume":"54","author":"Colburn","year":"2007","journal-title":"Neuron"},{"key":"10.1016\/j.bbr.2010.04.015_bib13","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1152\/jn.2001.86.2.856","article-title":"Differential projections of thermoreceptive and nociceptive lamina I trigeminothalamic and spinothalamic neurons in the cat","volume":"86","author":"Craig","year":"2001","journal-title":"J Neurophysiol"},{"key":"10.1016\/j.bbr.2010.04.015_bib14","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0031-9384(01)00431-0","article-title":"Oral irritant properties of menthol: sensitizing and desensitizing effects of repeated application and cross-desensitization to nicotine","volume":"73","author":"Dessirier","year":"2001","journal-title":"Physiol Behav"},{"key":"10.1016\/j.bbr.2010.04.015_bib15","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1523\/JNEUROSCI.3976-07.2008","article-title":"Visualizing cold spots: TRPM8-expressing sensory neurons and their projections","volume":"28","author":"Dhaka","year":"2008","journal-title":"J Neurosci"},{"key":"10.1016\/j.bbr.2010.04.015_bib16","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.neuron.2007.02.024","article-title":"TRPM8 is required for cold sensation in mice","volume":"54","author":"Dhaka","year":"2007","journal-title":"Neuron"},{"key":"10.1016\/j.bbr.2010.04.015_bib17","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1111\/j.2042-7158.1994.tb03871.x","article-title":"Menthol and related cooling compounds","volume":"46","author":"Eccles","year":"1994","journal-title":"J Pharm Pharmacol"},{"key":"10.1016\/j.bbr.2010.04.015_bib18","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0304-3940(01)02527-7","article-title":"Menthol: a natural analgesic compound","volume":"322","author":"Galeotti","year":"2002","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.bbr.2010.04.015_bib19","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1055\/s-2001-11515","article-title":"Local anaesthetic activity of (+) and (\u2212)-menthol","volume":"67","author":"Galeotti","year":"2001","journal-title":"Planta Med"},{"key":"10.1016\/j.bbr.2010.04.015_bib20","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/0304-3959(96)03104-1","article-title":"Enhanced withdrawal responses to heat and mechanical stimuli following intraplantar injection of capsaicin in rats","volume":"67","author":"Gilchrist","year":"1996","journal-title":"Pain"},{"key":"10.1016\/j.bbr.2010.04.015_bib21","doi-asserted-by":"crossref","first-page":"301","DOI":"10.3109\/08990229109144754","article-title":"Interactions between chemical and thermal cutaneous stimuli-inhibition (counterirritation) and integration","volume":"8","author":"Green","year":"1991","journal-title":"Somatosens Mot Res"},{"key":"10.1016\/j.bbr.2010.04.015_bib22","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1093\/chemse\/bjh184","article-title":"Lingual heat and cold sensitivity following exposure to capsaicin or menthol","volume":"30","author":"Green","year":"2005","journal-title":"Chem Senses"},{"key":"10.1016\/j.bbr.2010.04.015_bib23","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/0031-9384(86)90050-8","article-title":"Menthol inhbits the perception of warmth","volume":"38","author":"Green","year":"1986","journal-title":"Physiol Behav"},{"key":"10.1016\/j.bbr.2010.04.015_bib24","doi-asserted-by":"crossref","first-page":"235","DOI":"10.3109\/08990229209144774","article-title":"The sensory effects of l-menthol on human skin","volume":"9","author":"Green","year":"1992","journal-title":"Somatosens Mot Res"},{"key":"10.1016\/j.bbr.2010.04.015_bib25","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/S0031-9384(99)00221-8","article-title":"Menthol desensitization of capsaicin irritation: evidence of a short-term anti-nociceptive effect","volume":"68","author":"Green","year":"2000","journal-title":"Physiol Behav"},{"key":"10.1016\/j.bbr.2010.04.015_bib26","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1007\/s00221-002-1280-9","article-title":"Innocuous cooling can produce nociceptive sensations that are inhibited during dynamic mechanical contact","volume":"148","author":"Green","year":"2003","journal-title":"Exp Brain Res"},{"key":"10.1016\/j.bbr.2010.04.015_bib27","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.bbr.2006.10.013","article-title":"Thermal and nociceptive sensations from menthol and their suppression by dynamic contact","volume":"176","author":"Green","year":"2007","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.bbr.2010.04.015_bib28","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/0304-3959(88)90026-7","article-title":"A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia","volume":"32","author":"Hargreaves","year":"1988","journal-title":"Pain"},{"key":"10.1016\/j.bbr.2010.04.015_bib29","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.pain.2006.01.026","article-title":"Psychophysical study of the effects of topical application of menthol in healthy volunteers","volume":"122","author":"Hatem","year":"2006","journal-title":"Pain"},{"key":"10.1016\/j.bbr.2010.04.015_bib30","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/j.1748-1716.1951.tb00824.x","article-title":"The effect of menthol on the thermoreceptors","volume":"24","author":"Hensel","year":"1951","journal-title":"Acta Physiol Scand"},{"key":"10.1016\/j.bbr.2010.04.015_bib31","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/S0304-3959(98)00017-7","article-title":"The cold plate as a test of nociceptive behaviors: description and application to the study of chronic neuropathic and inflammatory pain models","volume":"75","author":"Jasmin","year":"1998","journal-title":"Pain"},{"key":"10.1016\/j.bbr.2010.04.015_bib32","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/S0959-4388(03)00101-6","article-title":"Lessons from peppers and peppermint: the molecular logic of thermosensation","volume":"13","author":"Jordt","year":"2003","journal-title":"Curr Opin Neurobiol"},{"key":"10.1016\/j.bbr.2010.04.015_bib33","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.archoralbio.2006.09.001","article-title":"Effects of capsaicin and menthol on oral thermal sensory thresholds","volume":"52","author":"Kalantzis","year":"2007","journal-title":"Arch Oral Biol"},{"key":"10.1016\/j.bbr.2010.04.015_bib34","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1113\/jphysiol.2004.081059","article-title":"Thermosensitivity of the two-pore domain K+ channels TREK-2 and TRAAK","volume":"564","author":"Kang","year":"2005","journal-title":"J Physiol"},{"key":"10.1016\/j.bbr.2010.04.015_bib35","doi-asserted-by":"crossref","first-page":"9874","DOI":"10.1523\/JNEUROSCI.2221-07.2007","article-title":"Bimodal action of menthol on the transient receptor potential channel TRPA1","volume":"27","author":"Karashima","year":"2007","journal-title":"J Neurosci"},{"key":"10.1016\/j.bbr.2010.04.015_bib36","series-title":"Neuroscience meeting planner","article-title":"Effects of TRPM8 agonist menthol on thermal and mechanical sensitvity in rats","author":"Klein","year":"2009"},{"key":"10.1016\/j.bbr.2010.04.015_bib37","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.mcn.2006.05.005","article-title":"More than cool: promiscuous relationships of menthol and other sensory compounds","volume":"32","author":"Macpherson","year":"2006","journal-title":"Mol Cell Neurosci"},{"key":"10.1016\/j.bbr.2010.04.015_bib38","doi-asserted-by":"crossref","first-page":"12512","DOI":"10.1523\/JNEUROSCI.3752-06.2006","article-title":"Contribution of TRPM8 channels to cold transduction in primary sensory neurons and peripheral nerve terminals","volume":"26","author":"Madrid","year":"2006","journal-title":"J Neurosci"},{"key":"10.1016\/j.bbr.2010.04.015_bib39","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0169-409X(01)00158-2","article-title":"Veterinary drug delivery: potential for skin penetration enhancement","volume":"50","author":"Magnusson","year":"2001","journal-title":"Adv Drug Deliv Rev"},{"key":"10.1016\/j.bbr.2010.04.015_bib40","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1113\/jphysiol.2006.123059","article-title":"Bidirectional shifts of TRPM8 channel gating by temperature and chemical agents modulate the cold sensitivity of mammalian thermoreceptors","volume":"581","author":"Malkia","year":"2007","journal-title":"J Physiol (Lond)"},{"key":"10.1016\/j.bbr.2010.04.015_bib41","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1038\/nature719","article-title":"Identification of a cold receptor reveals a general role for TRP channels in thermosensation","volume":"416","author":"McKemy","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.bbr.2010.04.015_bib42","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1126\/science.1108609","article-title":"Impaired thermosensation in mice lacking TRPV3, a heat and camphor sensor in the skin","volume":"307","author":"Moqrich","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.bbr.2010.04.015_bib43","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.ceca.2006.07.008","article-title":"Many cold sensitive peripheral neurons of the mouse do not express TRPM8 or TRPA1","volume":"41","author":"Munns","year":"2007","journal-title":"Cell Calcium"},{"key":"10.1016\/j.bbr.2010.04.015_bib44","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1097\/00001756-200506210-00015","article-title":"TRPA1 and TRPM8 activation in humans: effects of cinnamaldehyde and menthol","volume":"16","author":"Namer","year":"2005","journal-title":"NeuroReport"},{"key":"10.1016\/j.bbr.2010.04.015_bib45","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1152\/jn.00843.2002","article-title":"TRPM8 mRNA is expressed in a subset of cold-responsive trigeminal neurons from rat","volume":"90","author":"Nealen","year":"2003","journal-title":"J Neurophysiol"},{"key":"10.1016\/j.bbr.2010.04.015_bib46","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.pain.2007.12.015","article-title":"Principle components analysis of pain thresholds to thermal, electrical, and mechanical stimuli suggests a predominant common source of variance","volume":"138","author":"Neddermeyer","year":"2008","journal-title":"Pain"},{"key":"10.1016\/j.bbr.2010.04.015_bib47","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1038\/emboj.2009.57","article-title":"The mechano-activated K+ channels TRAAK and TREK-1 control both warm and cold perception","volume":"28","author":"Noel","year":"2009","journal-title":"EMBO J"},{"key":"10.1016\/j.bbr.2010.04.015_bib48","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/j.jaad.2007.04.008","article-title":"Menthol: a refreshing look at this ancient compound","volume":"57","author":"Patel","year":"2007","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.bbr.2010.04.015_bib49","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/S0092-8674(02)00652-9","article-title":"A TRP channel that senses cold stimuli and menthol","volume":"108","author":"Peier","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.bbr.2010.04.015_bib50","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1016\/j.cub.2006.07.061","article-title":"Analgesia mediated by the TRPM8 cold receptor in chronic neuropathic pain","volume":"16","author":"Proudfoot","year":"2006","journal-title":"Curr Biol"},{"key":"10.1016\/j.bbr.2010.04.015_bib51","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1007\/s00424-005-1437-z","article-title":"ThermoTRP channels and cold sensing: what are they really up to?","volume":"451","author":"Reid","year":"2005","journal-title":"Pflugers Arch"},{"key":"10.1016\/j.bbr.2010.04.015_bib52","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1113\/jphysiol.2002.024331","article-title":"A cold- and menthol-activated current in rat dorsal root ganglion neurones: properties and role in cold transduction","volume":"545","author":"Reid","year":"2002","journal-title":"J Physiol (Lond)"},{"key":"10.1016\/j.bbr.2010.04.015_bib53","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0304-3940(00)01694-3","article-title":"Cold transduction by inhibition of a background potassium conductance in rat primary sensory neurones","volume":"297","author":"Reid","year":"2001","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.bbr.2010.04.015_bib54","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1038\/35097164","article-title":"Physiology: cold current in thermoreceptive neurons","volume":"413","author":"Reid","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.bbr.2010.04.015_bib55","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1038\/nn1451","article-title":"PI(4,5)P-2 regulates the activation and desensitization of TRPM8 channels through the TRP domain","volume":"8","author":"Rohacs","year":"2005","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.bbr.2010.04.015_bib56","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/1744-8069-2-37","article-title":"Characterization of cold sensitivity and thermal preference using an operant orofacial assay","volume":"2","author":"Rossi","year":"2006","journal-title":"Mol Pain"},{"key":"10.1016\/j.bbr.2010.04.015_bib57","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0378-5173(94)00194-A","article-title":"Differences in enhancing effect of l-menthol, ethanol and their combination between hairless rat and human skin","volume":"113","author":"Sugibayashi","year":"1995","journal-title":"Int J Pharm"},{"issue":"3","key":"10.1016\/j.bbr.2010.04.015_bib58","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.neulet.2010.02.056","article-title":"Behavioral evidence of thermal hyperalgesia and mechanical allodynia induced by intradermal cinnamaldehyde in rats","volume":"473","author":"Tsagareli","year":"2010","journal-title":"Neurosci Lett."},{"key":"10.1016\/j.bbr.2010.04.015_bib59","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.brainres.2005.01.019","article-title":"Differential activation of trigeminal C or A\u03b4 nociceptors by infrared diode laser in rats: behavioral evidence","volume":"1037","author":"Tzabazis","year":"2005","journal-title":"Brain Res"},{"key":"10.1016\/j.bbr.2010.04.015_bib60","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.ejpain.2007.07.001","article-title":"Mechanisms involved in potentiation of transient receptor potential vanilloid 1 responses by ethanol","volume":"12","author":"Vetter","year":"2008","journal-title":"Eur J Pain"},{"key":"10.1016\/j.bbr.2010.04.015_bib61","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1038\/nn809","article-title":"Specificity of cold thermotransduction is determined by differential ionic channel expression","volume":"5","author":"Viana","year":"2002","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.bbr.2010.04.015_bib62","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1038\/nature02732","article-title":"The principle of temperature-dependent gating in cold- and heat-sensitive TRP channels","volume":"430","author":"Voets","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.bbr.2010.04.015_bib63","series-title":"Veterinary applications of skin penetration enhancers","year":"1993"},{"key":"10.1016\/j.bbr.2010.04.015_bib64","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1111\/j.1526-4637.2007.00290.x","article-title":"The effect of menthol on cold allodynia in patients with neuropathic pain","volume":"9","author":"Wasner","year":"2008","journal-title":"Pain Med"},{"key":"10.1016\/j.bbr.2010.04.015_bib65","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1093\/brain\/awh134","article-title":"Topical menthol\u2014a human model for cold pain by activation and sensitization of C nociceptors","volume":"127","author":"Wasner","year":"2004","journal-title":"Brain"},{"key":"10.1016\/j.bbr.2010.04.015_bib66","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1111\/j.1476-5381.2009.00167.x","article-title":"Primary afferents with TRPM8 and TRPA1 profiles target distinct populations of rat superficial dorsal horn neurones","volume":"157","author":"Wrigley","year":"2009","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.bbr.2010.04.015_bib67","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/BF02530092","article-title":"Effect of topically applied menthol on thermal, pain and itch sensations and biophysical properties of the skin","volume":"288","author":"Yosipovitch","year":"1996","journal-title":"Arch Dermatol Res"},{"key":"10.1016\/j.bbr.2010.04.015_bib68","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.neulet.2007.10.008","article-title":"Cross-desensitization of responses of rat trigeminal subnucleus caudalis neurons to cinnamaldehyde and menthol","volume":"430","author":"Zanotto","year":"2008","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.bbr.2010.04.015_bib69","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1152\/jn.00996.2006","article-title":"Neurons in superficial trigeminal subnucleus caudalis responsive to oral cooling, menthol, and other irritant stimuli","volume":"97","author":"Zanotto","year":"2007","journal-title":"J Neurophysiol"}],"container-title":["Behavioural Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432810002780?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432810002780?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T12:58:11Z","timestamp":1759064291000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166432810002780"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,10]]},"references-count":69,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2010,10]]}},"alternative-id":["S0166432810002780"],"URL":"https:\/\/doi.org\/10.1016\/j.bbr.2010.04.015","relation":{},"ISSN":["0166-4328"],"issn-type":[{"value":"0166-4328","type":"print"}],"subject":[],"published":{"date-parts":[[2010,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Topical application of l-menthol induces heat analgesia, mechanical allodynia, and a biphasic effect on cold sensitivity in rats","name":"articletitle","label":"Article Title"},{"value":"Behavioural Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbr.2010.04.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}