{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T03:03:04Z","timestamp":1789354984646,"version":"build-2803163510"},"reference-count":45,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2011,2,1]],"date-time":"2011-02-01T00:00:00Z","timestamp":1296518400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Behavioural Brain Research"],"published-print":{"date-parts":[[2011,2]]},"DOI":"10.1016\/j.bbr.2010.10.014","type":"journal-article","created":{"date-parts":[[2010,10,26]],"date-time":"2010-10-26T08:46:18Z","timestamp":1288082778000},"page":"122-127","source":"Crossref","is-referenced-by-count":81,"title":["Hippocampal neurochemistry is involved in the behavioural effects of neonatal maternal separation and their reversal by post-weaning environmental enrichment: A magnetic resonance study"],"prefix":"10.1016","volume":"217","author":[{"given":"Jiao-jie","family":"Hui","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-jun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan-shan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guang-jun","family":"Xi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang-rong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gao-Jun","family":"Teng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin C.","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ed X.","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin-bin","family":"Nie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bao-ci","family":"Shan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling-jiang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gavin P.","family":"Reynolds","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbr.2010.10.014_bib0005","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/j.euroneuro.2010.08.010","article-title":"Adolescent escitalopram administration modifies neurochemical alterations in the hippocampus of maternally separated rats","volume":"20","author":"Hui","year":"2010","journal-title":"Eur Neuropsychopharmacol"},{"issue":"12","key":"10.1016\/j.bbr.2010.10.014_bib0010","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1002\/hipo.20586","article-title":"Effects of neonatal stress on markers of synaptic plasticity in the hippocampus: implications for spatial memory","volume":"19","author":"Aisa","year":"2009","journal-title":"Hippocampus"},{"key":"10.1016\/j.bbr.2010.10.014_bib0015","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1667\/RR0735.1","article-title":"Quantitative magnetic resonance spectroscopy reveals a potential relationship between radiation-induced changes in rat brain metabolites and cognitive impairment","volume":"168","author":"Atwood","year":"2007","journal-title":"Radiat Res"},{"key":"10.1016\/j.bbr.2010.10.014_bib0020","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1159\/000111347","article-title":"Multinuclear NMR studies on the energy metabolism of glial and neuronal cells","volume":"15","author":"Brand","year":"1993","journal-title":"Dev Neurosci"},{"key":"10.1016\/j.bbr.2010.10.014_bib0025","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/S0306-4522(02)00918-1","article-title":"Partial reversal of the effect of maternal care on cognitive function through environmental enrichment","volume":"118","author":"Bredy","year":"2003","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbr.2010.10.014_bib0030","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0006-3223(96)00162-X","article-title":"Magnetic resonance imaging-based measurement of hippocampal volume in posttraumatic stress disorder related to childhood physical and sexual abuse\u2014a preliminary report","volume":"41","author":"Bremner","year":"1997","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.bbr.2010.10.014_bib0035","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1176\/appi.ajp.160.5.924","article-title":"MRI and PET study of deficits in hippocampal structure and function in women with childhood sexual abuse and posttraumatic stress disorder","volume":"160","author":"Bremner","year":"2003","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.bbr.2010.10.014_bib0040","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1002\/jmri.21736","article-title":"MRI of late microstructural and metabolic alterations in radiation-induced brain injuries","volume":"29","author":"Chan","year":"2009","journal-title":"J Magn Reson Imaging"},{"key":"10.1016\/j.bbr.2010.10.014_bib0045","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1002\/nbm.1234","article-title":"Influence of measured and simulated basis sets on metabolite concentration estimates","volume":"21","author":"Cudalbu","year":"2008","journal-title":"NMR Biomed"},{"key":"10.1016\/j.bbr.2010.10.014_bib0050","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.neulet.2006.05.048","article-title":"Enriched environment experience overcomes the memory deficits and depressive-like behavior induced by early life stress","volume":"404","author":"Cui","year":"2006","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.bbr.2010.10.014_bib0055","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/S0031-9384(97)00042-5","article-title":"Diurnal variation in the effect of chronic mild stress on sucrose intake and preference","volume":"62","author":"D","year":"1997","journal-title":"Physiol Behav"},{"key":"10.1016\/j.bbr.2010.10.014_bib0060","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1176\/appi.ajp.157.7.1175","article-title":"N-Acetylaspartate concentration in the anterior cingulate of maltreated children and adolescents with PTSD","volume":"157","author":"De","year":"2000","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.bbr.2010.10.014_bib0065","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1001\/archpsyc.57.12.1115","article-title":"Magnetic resonance imaging volumes of the hippocampus and the amygdala in women with borderline personality disorder and early traumatization","volume":"57","author":"Driessen","year":"2000","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.bbr.2010.10.014_bib0070","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.yfrne.2006.02.001","article-title":"Hippocampal neuroplasticity induced by early-life stress: functional and molecular aspects","volume":"27","author":"Fenoglio","year":"2006","journal-title":"Front Neuroendocrinol"},{"key":"10.1016\/j.bbr.2010.10.014_bib0075","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbr.2006.08.016","article-title":"Therapeutic and protective effect of environmental enrichment against psychogenic and neurogenic stress","volume":"175","author":"Fox","year":"2006","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.bbr.2010.10.014_bib0080","doi-asserted-by":"crossref","first-page":"7840","DOI":"10.1523\/JNEUROSCI.22-18-07840.2002","article-title":"Environmental enrichment reverses the effects of maternal separation on stress reactivity","volume":"22","author":"Francis","year":"2002","journal-title":"J Neurosci"},{"key":"10.1016\/j.bbr.2010.10.014_bib0085","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1002\/mrm.1910290613","article-title":"Automatic, localized in vivo adjustment of all first- and second-order shim coils","volume":"29","author":"Gruetter","year":"1993","journal-title":"Magn Reson Med"},{"key":"10.1016\/j.bbr.2010.10.014_bib0090","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1016\/S0006-3223(01)01157-X","article-title":"The role of childhood trauma in the neurobiology of mood and anxiety disorders: preclinical and clinical studies","volume":"49","author":"Heim","year":"2001","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.bbr.2010.10.014_bib0095","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1007\/s002130100701","article-title":"Development of adult ethanol preference and anxiety as a consequence of neonatal maternal separation in Long Evans rats and reversal with antidepressant treatment","volume":"158","author":"Huot","year":"2001","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.bbr.2010.10.014_bib0100","doi-asserted-by":"crossref","first-page":"e4329","DOI":"10.1371\/journal.pone.0004329","article-title":"Enriched environment experience overcomes learning deficits and depressive-like behavior induced by juvenile stress","volume":"4","author":"Ilin","year":"2009","journal-title":"PLoS ONE"},{"key":"10.1016\/j.bbr.2010.10.014_bib0105","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.biopsych.2004.10.004","article-title":"Reduced size and abnormal asymmetry of parietal cortex in women with borderline personality disorder","volume":"57","author":"Irle","year":"2005","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.bbr.2010.10.014_bib0110","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.bbr.2006.03.023","article-title":"Effects of early weaning on anxiety and autonomic responses to stress in rats","volume":"171","author":"Ito","year":"2006","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.bbr.2010.10.014_bib0115","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0091-3057(02)00781-5","article-title":"Long-lasting changes in stress-induced corticosterone response and anxiety-like behaviors as a consequence of neonatal maternal separation in Long-Evans rats","volume":"73","author":"Kalinichev","year":"2002","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.bbr.2010.10.014_bib0120","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0166-4328(99)00172-2","article-title":"A volumetric MRI study of the hippocampus in type 1 and 2 alcoholism","volume":"109","author":"Laakso","year":"2000","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.bbr.2010.10.014_bib0125","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.nbd.2008.05.001","article-title":"Effects of enriched environment on animal models of neurodegenerative diseases and psychiatric disorders","volume":"31","author":"Laviola","year":"2008","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.bbr.2010.10.014_bib0130","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1111\/j.1460-9568.2004.03597.x","article-title":"Beneficial effects of enriched environment on adolescent rats from stressed pregnancies","volume":"20","author":"Laviola","year":"2004","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.bbr.2010.10.014_bib0135","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1016\/j.neuropharm.2008.12.005","article-title":"Early deprivation leads to long-term reductions in motivation for reward and 5-HT1A binding and both effects are reversed by fluoxetine","volume":"56","author":"Leventopoulos","year":"2009","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bbr.2010.10.014_bib0140","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0166-4328(02)00100-6","article-title":"Experience-dependent asymmetric variation in primate prefrontal morphology","volume":"136","author":"Lyons","year":"2002","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.bbr.2010.10.014_bib0145","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S0006-3223(01)01313-0","article-title":"Magnetic resonance spectroscopy: current and future applications in psychiatric research","volume":"51","author":"Lyoo","year":"2002","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.bbr.2010.10.014_bib0150","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.neures.2008.01.011","article-title":"Maternal separation of rat pups increases the risk of developing depressive-like behavior after subsequent chronic stress by altering corticosterone and neurotrophin levels in the hippocampus","volume":"61","author":"Marais","year":"2008","journal-title":"Neurosci Res"},{"key":"10.1016\/j.bbr.2010.10.014_bib0155","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.pbb.2006.10.006","article-title":"Enhancement of endocannabinoid signalling during adolescence: modulation of impulsivity and long-term consequences on metabolic brain parameters in early maternally deprived rats","volume":"86","author":"Marco","year":"2007","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.bbr.2010.10.014_bib0160","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/S0006-3223(03)00004-0","article-title":"A magnetic resonance spectroscopic imaging study of adult nonhuman primates exposed to early-life stressors","volume":"54","author":"Mathew","year":"2003","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.bbr.2010.10.014_bib0165","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1038\/nn1290","article-title":"Early life experience alters response of adult neurogenesis to stress","volume":"7","author":"Mirescu","year":"2004","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.bbr.2010.10.014_bib0170","doi-asserted-by":"crossref","first-page":"3367","DOI":"10.1111\/j.1460-9568.2003.03070.x","article-title":"Environmental enrichment during adolescence reverses the effects of prenatal stress on play behaviour and HPA axis reactivity in rats","volume":"18","author":"Morley-Fletcher","year":"2003","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.bbr.2010.10.014_bib0175","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/j.neuroimage.2008.12.021","article-title":"Automatic cropping of MRI rat brain volumes using pulse coupled neural networks","volume":"45","author":"Murugavel","year":"2009","journal-title":"Neuroimage"},{"key":"10.1016\/j.bbr.2010.10.014_bib0180","series-title":"The rat brain in stereotaxic coordinates","author":"Paxinos","year":"1998"},{"key":"10.1016\/j.bbr.2010.10.014_bib0185","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.brainresrev.2009.07.002","article-title":"On whether the environmental enrichment may provide cognitive and brain reserves","volume":"61","author":"Petrosini","year":"2009","journal-title":"Brain Res Rev"},{"key":"10.1016\/j.bbr.2010.10.014_bib0190","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1038\/266730a0","article-title":"Depression: a new animal model sensitive to antidepressant treatments","volume":"266","author":"Porsolt","year":"1977","journal-title":"Nature"},{"key":"10.1016\/j.bbr.2010.10.014_bib0195","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1038\/sj.mp.4001036","article-title":"Early maternal deprivation reduces the expression of BDNF and NMDA receptor subunits in rat hippocampus","volume":"7","author":"Roceri","year":"2002","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.bbr.2010.10.014_bib0200","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1017\/S0954579401003029","article-title":"Early adverse experience as a developmental risk factor for later psychopathology: evidence from rodent and primate models","volume":"13","author":"Sanchez","year":"2001","journal-title":"Dev Psychopathol"},{"key":"10.1016\/j.bbr.2010.10.014_bib0205","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1001\/archgenpsychiatry.2009.52","article-title":"Early-life stress induces long-term morphologic changes in primate brain","volume":"66","author":"Spinelli","year":"2009","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.bbr.2010.10.014_bib0210","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1016\/j.neuroscience.2008.06.013","article-title":"Early life programming of hemispheric lateralization and synchronization in the adult medial prefrontal cortex","volume":"155","author":"Stevenson","year":"2008","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbr.2010.10.014_bib0215","doi-asserted-by":"crossref","first-page":"2072","DOI":"10.1176\/appi.ajp.159.12.2072","article-title":"Childhood trauma associated with smaller hippocampal volume in women with major depression","volume":"159","author":"Vythilingam","year":"2002","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.bbr.2010.10.014_bib0220","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1212\/WNL.42.9.1743","article-title":"Anatomic basis of amygdaloid and hippocampal volume measurement by magnetic resonance imaging","volume":"42","author":"Watson","year":"1992","journal-title":"Neurology"},{"key":"10.1016\/j.bbr.2010.10.014_bib0225","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1007\/BF00187257","article-title":"Reduction of sucrose preference by chronic unpredictable mild stress, and its restoration by a tricyclic antidepressant","volume":"93","author":"Willner","year":"1987","journal-title":"Psychopharmacology (Berl)"}],"container-title":["Behavioural Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432810006868?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432810006868?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,6,5]],"date-time":"2019-06-05T22:02:20Z","timestamp":1559772140000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166432810006868"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,2]]},"references-count":45,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,2]]}},"alternative-id":["S0166432810006868"],"URL":"https:\/\/doi.org\/10.1016\/j.bbr.2010.10.014","relation":{},"ISSN":["0166-4328"],"issn-type":[{"value":"0166-4328","type":"print"}],"subject":[],"published":{"date-parts":[[2011,2]]}}}