{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T22:32:15Z","timestamp":1792708335274,"version":"4.5.0"},"reference-count":159,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2011,8,1]],"date-time":"2011-08-01T00:00:00Z","timestamp":1312156800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Behavioural Brain Research"],"published-print":{"date-parts":[[2011,8]]},"DOI":"10.1016\/j.bbr.2010.11.058","type":"journal-article","created":{"date-parts":[[2010,12,10]],"date-time":"2010-12-10T04:15:03Z","timestamp":1291954503000},"page":"555-563","source":"Crossref","is-referenced-by-count":935,"title":["The cholinergic system in aging and neuronal degeneration"],"prefix":"10.1016","volume":"221","author":[{"given":"Reinhard","family":"Schliebs","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Arendt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbr.2010.11.058_bib0005","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1007\/s00702-006-0579-2","article-title":"The significance of the cholinergic system in the brain during aging and in Alzheimer's disease","volume":"113","author":"Schliebs","year":"2006","journal-title":"J Neural Transm"},{"key":"10.1016\/j.bbr.2010.11.058_bib0010","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/S0149-7634(03)00070-8","article-title":"The cholinergic basal forebrain system during development and its influence on cognitive processes: important questions and potential answers","volume":"27","author":"Berger-Sweeney","year":"2003","journal-title":"Neurosci Behav Rev"},{"key":"10.1016\/j.bbr.2010.11.058_bib0015","series-title":"Brain cholinergic systems","first-page":"364","article-title":"The nucleus basalis of Meynert during aging and in dementing neuropsychiatric disorders","author":"Bigl","year":"1990"},{"key":"10.1016\/j.bbr.2010.11.058_bib0020","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1515\/REVNEURO.2002.13.2.95","article-title":"Functional recovery of cholinergic basal forebrain neurons under disease conditions: old problems, new solutions?","volume":"13","author":"H\u00e4rtig","year":"2002","journal-title":"Rev Neurosci"},{"key":"10.1016\/j.bbr.2010.11.058_bib0025","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1111\/j.1460-9568.1997.tb01349.x","article-title":"Analysis of cutaneous sensory neurons in transgenic mice lacking the low affinity neurotrophin receptor p75","volume":"9","author":"Bergmann","year":"1997","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.bbr.2010.11.058_bib0030","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1097\/00001756-199110000-00006","article-title":"NGF increases cortical acetylcholine release in rats with lesions of the nucleus basalis","volume":"2","author":"Dekker","year":"1991","journal-title":"Neuroreport"},{"key":"10.1016\/j.bbr.2010.11.058_bib0035","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0306-4522(85)90163-0","article-title":"Nerve growth factor increases choline acetyltransferase but not survival or fibre outgrowth of cultured fetal septal cholinergic neurons","volume":"14","author":"Hefti","year":"1985","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbr.2010.11.058_bib0040","doi-asserted-by":"crossref","first-page":"9231","DOI":"10.1073\/pnas.83.23.9231","article-title":"Continuous infusion of nerve growth factor prevents basal forebrain neuronal death after fimbria fornix transection","volume":"83","author":"Williams","year":"1986","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.bbr.2010.11.058_bib0045","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1002\/cne.903590405","article-title":"Nerve growth factor prevents apoptotic cell death in injured central cholinergic neurons","volume":"359","author":"Wilcox","year":"1995","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.bbr.2010.11.058_bib0050","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1523\/JNEUROSCI.20-02-00834.2000","article-title":"Nerve growth factor (NGF) augments cortical and hippocampal cholinergic functioning after p75NGF receptor-mediated deafferentation but impairs inhibitory avoidance and induces fear-related behaviors","volume":"20","author":"Winkler","year":"2000","journal-title":"J Neurosci"},{"key":"10.1016\/j.bbr.2010.11.058_bib0055","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/S0168-0102(98)00040-6","article-title":"Age-related changes in levels of brain-derived neurotrophic factor in selected brain regions of rats, normal mice and senescence-accelerated mice: a comparison to those of nerve growth factor and neurotrophin-3","volume":"31","author":"Katoh-Semba","year":"1998","journal-title":"Neurosci Res"},{"key":"10.1016\/j.bbr.2010.11.058_bib0060","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/0306-4522(94)90462-6","article-title":"Reduced transport of 125I-NGF by cholinergic neurons and downregulated TrkA expression in the medial septum of aged rats","volume":"62","author":"Cooper","year":"1994","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbr.2010.11.058_bib0065","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/0306-4522(96)00239-4","article-title":"Reduced retrograde labeling with fluorescent tracer accompanies neuronal atrophy of basal forebrain cholinergic neurons in aged rats","volume":"75","author":"DeLacalle","year":"1996","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbr.2010.11.058_bib0070","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1146\/annurev.neuro.24.1.1217","article-title":"Nerve growth factor signaling, neuroprotection, and neural repair","volume":"24","author":"Sofroniew","year":"2001","journal-title":"Annu Rev Neurosci"},{"key":"10.1016\/j.bbr.2010.11.058_bib0075","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1002\/ana.410300613","article-title":"Human nerve growth factor prevents degeneration of basal forebrain cholinergic neurons in primates","volume":"30","author":"Koliatsos","year":"1991","journal-title":"Ann Neurol"},{"key":"10.1016\/j.bbr.2010.11.058_bib0080","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1177\/096368970000900508","article-title":"Intraparenchymal NGF infusions rescue degenerating cholinergic neurons","volume":"9","author":"Tuszynski","year":"2000","journal-title":"Cell Transplant"},{"key":"10.1016\/j.bbr.2010.11.058_bib0085","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1002\/cne.903490110","article-title":"Implants of polymer-encapsulated human NGF-secreting cells in the nonhuman primate: rescue and sprouting of degenerating cholinergic basal forebrain neurons","volume":"349","author":"Emerich","year":"1994","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.bbr.2010.11.058_bib0090","first-page":"305","article-title":"Gene therapy in the adult primate brain: intraparenchymal grafts of cells genetically modified to produce nerve growth factor prevent cholinergic neuronal degeneration","volume":"3","author":"Tuszynski","year":"1996","journal-title":"Gene Ther"},{"key":"10.1016\/j.bbr.2010.11.058_bib0095","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/0306-4522(95)00099-5","article-title":"Synaptic loss in cognitively impaired aged rats is ameliorated by chronic human nerve growth factor infusion","volume":"68","author":"Chen","year":"1995","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbr.2010.11.058_bib0100","doi-asserted-by":"crossref","first-page":"4815","DOI":"10.1523\/JNEUROSCI.14-08-04815.1994","article-title":"Human nerve growth factor improves spatial memory in aged but not in young rats","volume":"14","author":"Markowska","year":"1994","journal-title":"J Neurosci"},{"key":"10.1016\/j.bbr.2010.11.058_bib0105","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1159\/000017069","article-title":"Intracerebroventricular infusion of nerve growth factor in three patients with Alzheimer's disease","volume":"9","author":"Eriksdotter-J\u00f6nhagen","year":"1998","journal-title":"Dement Geriatr Cogn Disord"},{"key":"10.1016\/j.bbr.2010.11.058_bib0110","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1038\/nm1239","article-title":"A phase 1 clinical trial of nerve growth factor gene therapy for Alzheimer disease","volume":"11","author":"Tuszynski","year":"2005","journal-title":"Nat Med"},{"key":"10.1016\/j.bbr.2010.11.058_bib0115","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.expneurol.2008.10.004","article-title":"Long-term reversal of cholinergic neuronal decline in aged non-human primates by lentiviral NGF gene delivery","volume":"215","author":"Nagahara","year":"2009","journal-title":"Exp Neurol"},{"key":"10.1016\/j.bbr.2010.11.058_bib0120","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1007\/s11064-007-9497-4","article-title":"The place of choline acetyltransferase activity measurement in the \u201ccholinergic hypothesis\u201d of neurodegenerative diseases","volume":"33","author":"Contestabile","year":"2008","journal-title":"Neurochem Res"},{"key":"10.1016\/j.bbr.2010.11.058_bib0125","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/nrn1809","article-title":"Neural plasticity in the ageing brain","volume":"7","author":"Burke","year":"2006","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.bbr.2010.11.058_bib0130","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1038\/nrn1788","article-title":"Axon degeneration mechanisms: commonality amid diversity","volume":"6","author":"Coleman","year":"2005","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.bbr.2010.11.058_bib0135","doi-asserted-by":"crossref","first-page":"9926","DOI":"10.1073\/pnas.93.18.9926","article-title":"Preserved neuron number in the hippocampus of aged rats with spatial learning deficits","volume":"93","author":"Rapp","year":"1996","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.bbr.2010.11.058_bib0140","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/0197-4580(95)02032-2","article-title":"Memory impaired aged rats: no loss of principal hippocampal and subicular neurons","volume":"17","author":"Rasmussen","year":"1996","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.bbr.2010.11.058_bib0145","doi-asserted-by":"crossref","first-page":"4373","DOI":"10.1523\/JNEUROSCI.4289-03.2004","article-title":"Memory impairment in aged primates is associated with focal death of cortical neurons and atrophy of subcortical neurons","volume":"24","author":"Smith","year":"2004","journal-title":"J Neurosci"},{"key":"10.1016\/j.bbr.2010.11.058_bib0150","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.1016\/j.neurobiolaging.2007.04.001","article-title":"The length of hippocampal cholinergic fibres is reduced in the aging brain","volume":"29","author":"Ypsilanti","year":"2008","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.bbr.2010.11.058_bib0155","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1515\/REVNEURO.2006.17.6.581","article-title":"Cytoskeletal transport in the aging brain: focus on the cholinergic system","volume":"17","author":"Niewiadomska","year":"2006","journal-title":"Rev Neurosci"},{"key":"10.1016\/j.bbr.2010.11.058_bib0160","doi-asserted-by":"crossref","first-page":"7181","DOI":"10.1073\/pnas.0400285101","article-title":"Imaging correlates of brain function in monkeys and rats isolates a hippocampal subregion differentially vulnerable to aging","volume":"101","author":"Small","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.bbr.2010.11.058_bib0165","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.neulet.2006.11.040","article-title":"Age-dependent loss of NGF signaling in the rat basal forebrain is due to disrupted MAPK activation","volume":"413","author":"Williams","year":"2007","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.bbr.2010.11.058_bib0170","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1038\/nrn1886","article-title":"Aging and neuronal vulnerability","volume":"7","author":"Mattson","year":"2006","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.bbr.2010.11.058_bib0175","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/0304-3940(89)90391-1","article-title":"The pontomesencephalotegmental cholinergic system does not degenerate in Alzheimer's disease","volume":"96","author":"Woolf","year":"1989","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.bbr.2010.11.058_bib0180","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1016\/j.bcp.2005.05.019","article-title":"Brain cholinergic vulnerability: relevance to behavior and disease","volume":"70","author":"McKinney","year":"2005","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.bbr.2010.11.058_bib0185","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1038\/332448a0","article-title":"Cholinergic-rich brain transplants reverse alcohol-induced memory deficits","volume":"332","author":"Arendt","year":"1988","journal-title":"Nature"},{"key":"10.1016\/j.bbr.2010.11.058_bib0190","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1097\/00001756-200004070-00007","article-title":"Differential vulnerability of primary cultured cholinergic neurons to nitric oxide excess","volume":"11","author":"Fass","year":"2000","journal-title":"Neuroreport"},{"key":"10.1016\/j.bbr.2010.11.058_bib0195","doi-asserted-by":"crossref","first-page":"2157","DOI":"10.1046\/j.1471-4159.1995.65052157.x","article-title":"Altered cholinergicmetabolism in rat CNS following aluminum exposure: implications on learning performance","volume":"65","author":"Julka","year":"1995","journal-title":"J Neurochem"},{"key":"10.1016\/j.bbr.2010.11.058_bib0200","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/S0169-328X(98)00096-5","article-title":"Amyloid beta neurotoxicity in the cholinergic but not in the serotonergic phenotype of RN46A cells","volume":"57","author":"Olesen","year":"1998","journal-title":"Brain Res Mol Brain Res"},{"key":"10.1016\/j.bbr.2010.11.058_bib0205","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/s11011-006-9007-4","article-title":"Phenotype-dependent susceptibility of cholinergic neuroblastoma cells to neurotoxic inputs","volume":"21","author":"Szutowicz","year":"2006","journal-title":"Metab Brain Dis"},{"key":"10.1016\/j.bbr.2010.11.058_bib0210","doi-asserted-by":"crossref","first-page":"1874","DOI":"10.1016\/j.neurobiolaging.2007.04.024","article-title":"Aging elevates metabolic gene expression in brain cholinergic neurons","volume":"29","author":"Baskerville","year":"2008","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.bbr.2010.11.058_bib0215","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1016\/S0140-6736(76)91936-X","article-title":"Selective loss of central cholinergic neurons in Alzheimer's disease","volume":"2","author":"Davies","year":"1976","journal-title":"Lancet"},{"key":"10.1016\/j.bbr.2010.11.058_bib0220","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1093\/brain\/99.3.459","article-title":"Neurotransmitter-related enzymes and indices of hypoxia in senile dementia and other abiotrophies","volume":"99","author":"Bowen","year":"1976","journal-title":"Brain"},{"key":"10.1016\/j.bbr.2010.11.058_bib0225","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/0022-510X(77)90073-9","article-title":"Neurotransmitter enzyme abnormalities in senile dementia. Choline acetyltransferase and glutamic acid decarboxylase activities in necropsy brain tissue","volume":"34","author":"Perry","year":"1977","journal-title":"J Neurol Sci"},{"key":"10.1016\/j.bbr.2010.11.058_bib0230","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0140-6736(77)91780-9","article-title":"Necropsy evidence of central cholinergic deficits in senile dementia","volume":"1","author":"Perry","year":"1977","journal-title":"Lancet"},{"key":"10.1016\/j.bbr.2010.11.058_bib0235","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1046\/j.1471-4159.1995.64020749.x","article-title":"Neurochemical correlates of dementia severity in Alzheimer's disease: relative importance of the cholinergic deficits","volume":"64","author":"Bierer","year":"1995","journal-title":"J Neurochem"},{"key":"10.1016\/j.bbr.2010.11.058_bib0240","doi-asserted-by":"crossref","first-page":"265","DOI":"10.2174\/1381612043386473","article-title":"Functional neurochemistry of Alzheimer's disease","volume":"10","author":"Gsell","year":"2004","journal-title":"Curr Pharmacol Design"},{"key":"10.1016\/j.bbr.2010.11.058_bib0245","first-page":"303","article-title":"Neuroreceptor changes in Alzheimer disease","volume":"4","author":"Nordberg","year":"1992","journal-title":"Cerebrovasc Brain Met Rev"},{"key":"10.1016\/j.bbr.2010.11.058_bib0250","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1006\/exnr.2000.7397","article-title":"On neurodegenerative diseases, models, and treatment strategies: lessons learned and lessons forgotten a generation following the cholinergic hypothesis","volume":"163","author":"Bartus","year":"2000","journal-title":"Exp Neurol"},{"key":"10.1016\/j.bbr.2010.11.058_bib0255","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1586\/14737175.8.11.1703","article-title":"Cholinergic system during the progression of Alzheimer's disease: therapeutic implications","volume":"8","author":"Mufson","year":"2008","journal-title":"Exp Rev Neurother"},{"key":"10.1016\/j.bbr.2010.11.058_bib0260","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1136\/jnnp.74.1.113","article-title":"Brain acetylcholinesterase activity in mild cognitive impairment and early Alzheimer's disease","volume":"74","author":"Rinne","year":"2003","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.bbr.2010.11.058_bib0265","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1002\/1531-8249(200008)48:2<194::AID-ANA9>3.0.CO;2-X","article-title":"Progressive loss of cortical acetylcholinesterase activity in association with cognitive decline in Alzheimer's disease: a positron emission tomography study","volume":"48","author":"Shinotoh","year":"2000","journal-title":"Ann Neurol"},{"key":"10.1016\/j.bbr.2010.11.058_bib0270","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1001\/jama.281.15.1401","article-title":"Cholinergic markers in elderly patients with early signs of Alzheimer disease","volume":"281","author":"Davis","year":"1999","journal-title":"JAMA"},{"key":"10.1016\/j.bbr.2010.11.058_bib0275","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1212\/WNL.55.9.1278","article-title":"The decline in synapses and cholinergic activity is asynchronous in Alzheimer's disease","volume":"55","author":"Tiraboschi","year":"2000","journal-title":"Neurology"},{"key":"10.1016\/j.bbr.2010.11.058_bib0280","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1002\/(SICI)1096-9861(19990906)411:4<693::AID-CNE13>3.0.CO;2-D","article-title":"Preservation of nucleus basalis neurons containing choline acetyltransferase and the vesicular acetylcholine transporter in the elderly with mild cognitive impairment and early Alzheimer's disease","volume":"411","author":"Gilmor","year":"1999","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.bbr.2010.11.058_bib0285","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1002\/ana.10069","article-title":"Upregulation of choline acetyltransferase activity in hippocampus and frontal cortex of elderly subjects with mild cognitive impairment","volume":"51","author":"DeKosky","year":"2002","journal-title":"Ann Neurol"},{"key":"10.1016\/j.bbr.2010.11.058_bib0290","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1093\/jnen\/64.4.263","article-title":"The role of nerve growth factor receptors in cholinergic basal forebrain degeneration in prodromal Alzheimer disease","volume":"64","author":"Counts","year":"2005","journal-title":"J Neuropathol Exp Neurol"},{"key":"10.1016\/j.bbr.2010.11.058_bib0295","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1002\/1531-8249(20010201)49:2<202::AID-ANA40>3.0.CO;2-3","article-title":"Loss and atrophy of layer II entorhinal cortex neurons in elderly people with mild cognitive impairment","volume":"49","author":"Kordower","year":"2001","journal-title":"Ann Neurol"},{"key":"10.1016\/j.bbr.2010.11.058_bib0300","doi-asserted-by":"crossref","first-page":"4491","DOI":"10.1523\/JNEUROSCI.16-14-04491.1996","article-title":"Profound loss of layer II entorhinal cortex neurons occurs in very mild Alzheimer's disease","volume":"16","author":"G\u00f3mez-Isla","year":"1996","journal-title":"J Neurosci"},{"key":"10.1016\/j.bbr.2010.11.058_bib0305","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1515\/REVNEURO.2001.12.3.195","article-title":"Molecules involved in reactive sprouting in the hippocampus","volume":"12","author":"Savaskan","year":"2001","journal-title":"Rev Neurosci"},{"key":"10.1016\/j.bbr.2010.11.058_bib0310","doi-asserted-by":"crossref","first-page":"340","DOI":"10.2174\/156720507781788855","article-title":"Cholinotrophic molecular substrates of mild cognitive impairment in the elderly","volume":"4","author":"Mufson","year":"2007","journal-title":"Curr Alzheimer Res"},{"key":"10.1016\/j.bbr.2010.11.058_bib0315","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0301-0082(02)00079-5","article-title":"Alzheimer's disease and the basal forebrain cholinergic system: relations to \u03b2-amyloid peptides, cognition, and treatment strategies","volume":"68","author":"Auld","year":"2002","journal-title":"Prog Neurobiol"},{"key":"10.1016\/j.bbr.2010.11.058_bib0320","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1002\/neu.10102","article-title":"Nicotinic receptors in aging and dementia","volume":"53","author":"Picciotto","year":"2002","journal-title":"J Neurobiol"},{"key":"10.1016\/j.bbr.2010.11.058_bib0325","doi-asserted-by":"crossref","first-page":"351","DOI":"10.2174\/156720507781788774","article-title":"NGF-cholinergic dependency in brain aging. MCI and Alzheimer's disease","volume":"4","author":"Cuello","year":"2007","journal-title":"Curr Alzheimer Res"},{"key":"10.1016\/j.bbr.2010.11.058_bib0330","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.neurobiolaging.2004.12.005","article-title":"Inhibition of hippocampal function in mild cognitive impairment: targeting the cholinergic hypothesis","volume":"27","author":"Gr\u00f6n","year":"2006","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.bbr.2010.11.058_bib0335","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1093\/brain\/awh671","article-title":"Cholinergic challenge in Alzheimer patients and mild cognitive impairment differentially affects hippocampal activation \u2013 a pharmacological fMRI study","volume":"129","author":"Goekoop","year":"2006","journal-title":"Brain"},{"key":"10.1016\/j.bbr.2010.11.058_bib0340","doi-asserted-by":"crossref","first-page":"112","DOI":"10.2174\/156720509787602915","article-title":"M1 agonists as a potential disease-modifying therapy for Alzheimer's disease","volume":"6","author":"Caccamo","year":"2009","journal-title":"Curr Alzheimer Res"},{"key":"10.1016\/j.bbr.2010.11.058_bib0345","doi-asserted-by":"crossref","first-page":"83","DOI":"10.2174\/156720509787602924","article-title":"Advances in Alzheimer therapy: understanding pharmacological approaches to the disease","volume":"6","author":"Mart\u00ednez","year":"2009","journal-title":"Curr Alzheimer Res"},{"key":"10.1016\/j.bbr.2010.11.058_bib0350","doi-asserted-by":"crossref","first-page":"86","DOI":"10.2174\/156720509787602861","article-title":"Cholinesterase inhibitors and beyond","volume":"6","author":"Pepeu","year":"2009","journal-title":"Curr Alzheimer Res"},{"key":"10.1016\/j.bbr.2010.11.058_bib0355","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/BF00697388","article-title":"Loss of neurons in the nucleus basalis of Meynert in Alzheimer's disease, paralysis agitans and Korsakoff's disease","volume":"61","author":"Arendt","year":"1983","journal-title":"Acta Neuropathol (Berl)"},{"key":"10.1016\/j.bbr.2010.11.058_bib0360","first-page":"185","article-title":"Morphological substrates of mental dysfunctions in Lewy body disease: an update","volume":"59","author":"Jellinger","year":"2000","journal-title":"J Neural Transm Suppl"},{"key":"10.1016\/j.bbr.2010.11.058_bib0365","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1002\/ana.410130304","article-title":"Basal forebrain neurons in the dementia of Parkinson disease","volume":"13","author":"Whitehouse","year":"1983","journal-title":"Ann Neurol"},{"key":"10.1016\/j.bbr.2010.11.058_bib0370","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/BF00689832","article-title":"Neurone loss in the nucleus basalis of Meynert in Creutzfeldt\u2013Jakob disease","volume":"65","author":"Arendt","year":"1984","journal-title":"Acta Neuropathol (Berl)"},{"key":"10.1016\/j.bbr.2010.11.058_bib0375","first-page":"173","article-title":"Impairment in memory function and neurodegenerative changes in the cholinergic basal forebrain system induced by chronic intake of ethanol","volume":"44","author":"Arendt","year":"1994","journal-title":"J Neural Transm Suppl"},{"key":"10.1016\/j.bbr.2010.11.058_bib0380","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1001\/archneur.60.12.1745","article-title":"Cortical cholinergic function is more severely affected in Parkinsonian dementia than in Alzheimer's disease: an in vivo positron tomography study","volume":"60","author":"Bohnen","year":"2003","journal-title":"Arch Neurol"},{"key":"10.1016\/j.bbr.2010.11.058_bib0385","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1124\/jpet.102.041616","article-title":"The cholinergic hypothesis of age and Alzheimer's disease-related cognitive deficits: recent challenges and their implications for novel drug development","volume":"306","author":"Terry","year":"2003","journal-title":"J Pharmacol Exp Ther"},{"issue":"Pt 1","key":"10.1016\/j.bbr.2010.11.058_bib0390","first-page":"189","article-title":"Cognitive sequelae of head injury: involvement of basal forebrain and associated structures","volume":"128","author":"Salmond","year":"2005","journal-title":"Brain"},{"key":"10.1016\/j.bbr.2010.11.058_bib0395","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.ijdevneu.2009.10.001","article-title":"Effects of lateral fluid percussion injury on cholinergic markers in the newborn piglet brain","volume":"28","author":"Donat","year":"2010","journal-title":"Int J Dev Neurosci"},{"key":"10.1016\/j.bbr.2010.11.058_bib0400","doi-asserted-by":"crossref","first-page":"241","DOI":"10.2174\/1567205043331992","article-title":"Alzheimer's disease: interactions between cholinergic functions and \u03b2-amyloid","volume":"1","author":"Yan","year":"2004","journal-title":"Curr Alzheimer Res"},{"key":"10.1016\/j.bbr.2010.11.058_bib0405","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1111\/j.1749-6632.1999.tb07845.x","article-title":"Neurotoxicity and oxidative damage of \u03b2-amyloid 1\u201342 versus \u03b2-amyloid 1\u201340 in the mouse cerebral cortex","volume":"893","author":"Klein","year":"1999","journal-title":"Ann NY Acad Sci"},{"key":"10.1016\/j.bbr.2010.11.058_bib0410","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1111\/j.1471-4159.2006.04426.x","article-title":"A\u03b2 oligomers \u2013 a decade of discovery","volume":"101","author":"Walsh","year":"2007","journal-title":"J Neurochem"},{"key":"10.1016\/j.bbr.2010.11.058_bib0415","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/nn1372","article-title":"Natural oligomers of the amyloid-\u03b2 protein specifically disrupt cognitive function","volume":"8","author":"Cleary","year":"2005","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.bbr.2010.11.058_bib0420","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1002\/1531-8249(199912)46:6<860::AID-ANA8>3.0.CO;2-M","article-title":"Soluble pool of A\u03b2 amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease","volume":"46","author":"McLean","year":"1999","journal-title":"Ann Neurol"},{"key":"10.1016\/j.bbr.2010.11.058_bib0425","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1007\/s11064-005-6962-9","article-title":"Basal forebrain cholinergic dysfunction in Alzheimer's disease \u2013 interrelationship with \u03b2-amyloid, inflammation and neurotrophin signaling","volume":"30","author":"Schliebs","year":"2005","journal-title":"Neurochem Res"},{"key":"10.1016\/j.bbr.2010.11.058_bib0430","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0006-8993(02)03262-6","article-title":"Impairment of cholinergic neurotransmission in adult and aged transgenic Tg2576 mouse brain expressing the Swedish mutation of human beta-amyloid precursor protein","volume":"953","author":"Apelt","year":"2002","journal-title":"Brain Res"},{"key":"10.1016\/j.bbr.2010.11.058_bib0435","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/S0006-8993(03)02658-1","article-title":"Degeneration of \u03b2-amyloid-associated cholinergic structures in transgenic APPSW mice","volume":"977","author":"L\u00fcth","year":"2003","journal-title":"Brain Res"},{"key":"10.1016\/j.bbr.2010.11.058_bib0440","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.ijdevneu.2003.08.001","article-title":"Alterations in cholinergic and non-cholinergic neurotransmitter receptor densities in transgenic Tg2576 mouse brain with \u03b2-amyloid plaque pathology","volume":"21","author":"Klingner","year":"2003","journal-title":"Int J Dev Neurosci"},{"key":"10.1016\/j.bbr.2010.11.058_bib0445","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.ijdevneu.2005.11.010","article-title":"Muscarinic acetylcholine receptor inhibition in transgenic Alzheimer-like Tg2576 mice by scopolamine favours the amyloidogenic route of processing of amyloid precursor protein","volume":"24","author":"Liskowsky","year":"2006","journal-title":"Int J Dev Neurosci"},{"key":"10.1016\/j.bbr.2010.11.058_bib0450","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/s00702-002-0772-x","article-title":"Cortical glucose metabolism is altered in aged transgenic Tg2576 mice that demonstrate Alzheimer plaque pathology","volume":"110","author":"Bigl","year":"2003","journal-title":"J Neural Transm"},{"key":"10.1016\/j.bbr.2010.11.058_bib0455","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0079-6123(03)45012-7","article-title":"Cholinergic modulation of the cortical microvascular bed","volume":"145","author":"Hamel","year":"2004","journal-title":"Prog Brain Res"},{"key":"10.1016\/j.bbr.2010.11.058_bib0460","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1161\/01.STR.0000014421.15948.67","article-title":"Alzheimer disease as a vascular disorder: nosological evidence","volume":"33","author":"De la Torre","year":"2002","journal-title":"Stroke"},{"key":"10.1016\/j.bbr.2010.11.058_bib0465","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/S0197-4580(00)00125-1","article-title":"The role of cerebral ischemia in Alzheimer's disease","volume":"21","author":"Kalaria","year":"2000","journal-title":"Neurobiol Aging"},{"issue":"Suppl. 1","key":"10.1016\/j.bbr.2010.11.058_bib0470","first-page":"63","article-title":"Role of cholinergic system in \u03b2-amyloid related changes of perivascular innervation of cerebral microvessels in transgenic Tg2576 Alzheimer-like mice","volume":"101","author":"Kouznetsova","year":"2007","journal-title":"J Neurochem"},{"key":"10.1016\/j.bbr.2010.11.058_bib0475","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.ijdevneu.2009.06.011","article-title":"Vascular endothelial growth factor (VEGF) affects processing of the amyloid precursor protein and \u03b2-amyloidogenesis in brain slice cultures derived from transgenic Tg2576 mouse brain","volume":"27","author":"B\u00fcrger","year":"2009","journal-title":"Int J Dev Neurosci"},{"key":"10.1016\/j.bbr.2010.11.058_bib0480","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.1111\/j.1471-4159.2006.04015.x","article-title":"Cholinotoxicity mediated by soluble oligomers of \u03b2-amyloid(1\u201342) differs from cholinotoxic effects of oxidative stress as revealed by gene expression analysis","volume":"98","author":"Heinitz","year":"2006","journal-title":"J Neurochem"},{"key":"10.1016\/j.bbr.2010.11.058_bib0485","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.ijdevneu.2008.01.004","article-title":"Oligomeric \u03b2-amyloid(1\u201342) induces the expression of Alzheimer disease-relevant proteins in cholinergic SN56.B5.G4 cells as revealed by proteomic analysis","volume":"26","author":"J\u00f6rchel","year":"2008","journal-title":"Int J Dev Neurosci"},{"key":"10.1016\/j.bbr.2010.11.058_bib0490","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/S0169-328X(00)00031-0","article-title":"Quantitative assessment of nicotinic acetylcholine receptor proteins in the cerebral cortex of Alzheimer patients","volume":"76","author":"Burghaus","year":"2000","journal-title":"Mol Brain Res"},{"key":"10.1016\/j.bbr.2010.11.058_bib0495","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/S0306-4522(03)00460-3","article-title":"Protein and mRNA levels of nicotinic receptors in brain of tobacco using controls and patients with Alzheimer's disease","volume":"122","author":"Mousavi","year":"2003","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbr.2010.11.058_bib0500","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1046\/j.1471-4159.1999.0731635.x","article-title":"Alpha4 but not alpha3 and alpha7 nicotinic acetylcholine receptor subunits are lost from the temporal cortex in Alzheimer's disease","volume":"73","author":"Martin-Ruiz","year":"1999","journal-title":"J Neurochem"},{"key":"10.1016\/j.bbr.2010.11.058_bib0505","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0304-3940(98)00794-0","article-title":"Immunohistochemical localization of nicotinic beta2 and alpha4 receptor subunits in normal human brain and individuals with Lewy body and Alzheimer's disease: preliminary observations","volume":"256","author":"Sparks","year":"1998","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.bbr.2010.11.058_bib0510","doi-asserted-by":"crossref","first-page":"207","DOI":"10.3233\/JAD-1999-14-503","article-title":"Nicotinic acetylcholine receptors in Alzheimer's disease","volume":"1","author":"Wevers","year":"1999","journal-title":"J Alzheimers Dis"},{"key":"10.1016\/j.bbr.2010.11.058_bib0515","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1111\/j.1471-4159.1992.tb09752.x","article-title":"Comparative alterations of nicotinic and muscarinic binding sites in Alzheimer's and Parkinson's diseases","volume":"58","author":"Aubert","year":"1992","journal-title":"J Neurochem"},{"key":"10.1016\/j.bbr.2010.11.058_bib0520","doi-asserted-by":"crossref","first-page":"1948","DOI":"10.1111\/j.1471-4159.1986.tb13113.x","article-title":"Characterization of L-[3H]nicotine binding in human cerebral cortex: comparison between Alzheimer's disease and the normal","volume":"47","author":"Flynn","year":"1986","journal-title":"J Neurochem"},{"key":"10.1016\/j.bbr.2010.11.058_bib0525","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/S0169-328X(99)00030-3","article-title":"Regional distribution of nicotinic receptor subunit mRNAs in human brain: comparison between Alzheimer and normal brain","volume":"66","author":"Hellstr\u00f6m-Lindahl","year":"1999","journal-title":"Mol Brain Res"},{"key":"10.1016\/j.bbr.2010.11.058_bib0530","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/S0006-3223(00)01125-2","article-title":"Nicotinic receptor abnormalities of Alzheimer's disease: therapeutic implications","volume":"49","author":"Nordberg","year":"2001","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.bbr.2010.11.058_bib0535","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/0306-4522(94)00410-7","article-title":"Alteration in nicotine binding sites in Parkinson's disease. Lewy body dementia and Alzheimer's disease: possible index of early neuropathology","volume":"64","author":"Perry","year":"1995","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbr.2010.11.058_bib0540","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/0006-8993(91)90588-M","article-title":"A postmortem study of brain nicotinic receptors in Parkinson's and Alzheimer's disease","volume":"547","author":"Rinne","year":"1991","journal-title":"Brain Res"},{"key":"10.1016\/j.bbr.2010.11.058_bib0545","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1111\/j.1471-4159.1986.tb12960.x","article-title":"Changes in nicotinic and muscarinic cholinergic receptors in Alzheimer-type dementia","volume":"46","author":"Shimohama","year":"1986","journal-title":"J Neurochem"},{"key":"10.1016\/j.bbr.2010.11.058_bib0550","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1002\/jnr.490270314","article-title":"Nicotinic acetylcholine receptor subtypes in human frontal cortex: changes in Alzheimer's disease","volume":"27","author":"Sugaya","year":"1990","journal-title":"J Neurosci Res"},{"key":"10.1016\/j.bbr.2010.11.058_bib0555","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1124\/pr.108.000562","article-title":"Nicotinic acetylcholine receptor signaling: roles in Alzheimer's disease and amyloid neuroprotection","volume":"61","author":"Buckingham","year":"2009","journal-title":"Pharmacol Rev"},{"key":"10.1016\/j.bbr.2010.11.058_bib0560","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1007\/s007020100017","article-title":"Suppressed expression of nicotinic acetylcholine receptors by nanomolar \u03b2-amyloid peptides in PC12 cells","volume":"108","author":"Guan","year":"2001","journal-title":"J Neural Transm"},{"key":"10.1016\/j.bbr.2010.11.058_bib0565","doi-asserted-by":"crossref","first-page":"4734","DOI":"10.1073\/pnas.081553598","article-title":"\u03b2-Amyloid peptide blocks the response of \u03b17-containing nicotinic receptors on hippocampal neurons","volume":"98","author":"Liu","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.bbr.2010.11.058_bib0570","doi-asserted-by":"crossref","first-page":"5626","DOI":"10.1074\/jbc.275.8.5626","article-title":"\u03b2-Amyloid(1-42) binds to \u03b17 nicotinic acetylcholine receptor with high affinity. Implications for Alzheimer's disease pathology","volume":"275","author":"Wang","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bbr.2010.11.058_bib0575","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1046\/j.1471-4159.2000.0751155.x","article-title":"Amyloid peptide A\u03b2(1-42) binds selectively and with picomolar affinity to \u03b17 nicotinic acetylcholine receptors","volume":"75","author":"Wang","year":"2000","journal-title":"J Neurochem"},{"key":"10.1016\/j.bbr.2010.11.058_bib0580","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S0306-4522(01)00460-2","article-title":"Intracellular accumulation of \u03b2-amyloid(1-42) in neurons is facilitated by the \u03b17 nicotinic acetylcholine receptor in Alzheimer's disease","volume":"110","author":"Nagele","year":"2002","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbr.2010.11.058_bib0585","doi-asserted-by":"crossref","first-page":"3046","DOI":"10.1073\/pnas.0408500102","article-title":"Chronic nicotine administration exacerbates tau pathology in a transgenic model of Alzheimer's disease","volume":"102","author":"Oddo","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.bbr.2010.11.058_bib0590","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/j.neuint.2005.02.007","article-title":"Oxidative stress induced by \u03b2-amyloid peptide(1\u201342) is involved in the altered composition of cellular membrane lipids and the decreased expression of nicotinic receptors in human SH-SY5Y neuroblastoma cells","volume":"46","author":"Qi","year":"2005","journal-title":"Neurochem Int"},{"key":"10.1016\/j.bbr.2010.11.058_bib0595","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1002\/jnr.10496","article-title":"Loss of nicotinic receptors induced by \u03b2-amyloid peptides in PC12 cells: possible mechanism involving lipid peroxidation","volume":"71","author":"Guan","year":"2003","journal-title":"J Neurosci Res"},{"key":"10.1016\/j.bbr.2010.11.058_bib0600","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1046\/j.1471-4159.2003.02296.x","article-title":"\u03b17-nicotinic acetylcholine receptors mediate an A\u03b2(1\u201342)-induced increase in the level of acetylcholinesterase in primary cortical neurones","volume":"88","author":"Fodero","year":"2004","journal-title":"J Neurochem"},{"key":"10.1016\/j.bbr.2010.11.058_bib0605","doi-asserted-by":"crossref","first-page":"4125","DOI":"10.1523\/JNEUROSCI.21-12-04125.2001","article-title":"\u03b2-Amyloid activates the mitogen-activated protein kinase cascade via hippocampal \u03b17 nicotinic acetylcholine receptors: in vitro and in vivo mechanisms related to Alzheimer's disease","volume":"21","author":"Dineley","year":"2001","journal-title":"J Neurosci"},{"key":"10.1016\/j.bbr.2010.11.058_bib0610","doi-asserted-by":"crossref","first-page":"25056","DOI":"10.1074\/jbc.M200066200","article-title":"\u03b2-Amyloid peptide activates \u03b17 nicotinic acetylcholine receptors expressed in Xenopus oocytes","volume":"277","author":"Dineley","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bbr.2010.11.058_bib0615","doi-asserted-by":"crossref","first-page":"RC120","DOI":"10.1523\/JNEUROSCI.21-01-j0003.2001","article-title":"\u03b2-Amyloid (1\u201342) peptide directly modulates nicotinic receptors in the rat hippocampal slice","volume":"21","author":"Pettit","year":"2001","journal-title":"J Neurosci"},{"key":"10.1016\/j.bbr.2010.11.058_bib0620","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/S0006-291X(02)00429-1","article-title":"The inhibitory and facilitatory actions of amyloid-\u03b2 peptides on nicotinic Ach receptors and AMPA receptors","volume":"294","author":"Tozaki","year":"2002","journal-title":"Biochem Biophys Res Commun"},{"issue":"Pt 1","key":"10.1016\/j.bbr.2010.11.058_bib0625","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1113\/jphysiol.2002.035436","article-title":"Amyloid \u03b2(1\u201342) peptide alters the gating of human and mouse \u03b1-bungarotoxin-sensitive nicotinic receptors","volume":"547","author":"Grassi","year":"2003","journal-title":"J Physiol"},{"key":"10.1016\/j.bbr.2010.11.058_bib0630","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1002\/neu.10203","article-title":"Differential physiologic responses of \u03b17 nicotinic acetylcholine receptors to \u03b2-amyloid1\u201340 and \u03b2-amyloid1\u201342","volume":"55","author":"Lee","year":"2003","journal-title":"J Neurobiol"},{"key":"10.1016\/j.bbr.2010.11.058_bib0635","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/BF02680013","article-title":"The cholinergic neuronal phenotype in Alzheimer's disease","volume":"15","author":"Blusztajn","year":"2000","journal-title":"Metab Brain Dis"},{"key":"10.1016\/j.bbr.2010.11.058_bib0640","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.mehy.2009.09.011","article-title":"Alpha7 neuronal nicotinic receptors: the missing link to understanding Alzheimer's etiopathology?","volume":"74","author":"Bencherif","year":"2010","journal-title":"Med Hypotheses"},{"key":"10.1016\/j.bbr.2010.11.058_bib0645","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1111\/j.1471-4159.2008.05483.x","article-title":"Role of GSK-3beta activation and alpha7 nAChRs in Abeta(1\u201342)-induced tau phosphorylation in PC12 cells","volume":"106","author":"Hu","year":"2008","journal-title":"J Neurochem"},{"key":"10.1016\/j.bbr.2010.11.058_bib0650","doi-asserted-by":"crossref","first-page":"8805","DOI":"10.1523\/JNEUROSCI.6159-08.2009","article-title":"Deletion of the \u03b17 nicotinic acetylcholine receptor gene improves cognitive deficits and synaptic pathology in a mouse model of Alzheimer's disease","volume":"29","author":"Dziewczapolski","year":"2009","journal-title":"J Neurosci"},{"key":"10.1016\/j.bbr.2010.11.058_bib0655","doi-asserted-by":"crossref","first-page":"10703","DOI":"10.1073\/pnas.91.22.10703","article-title":"Expression of the low-affinity nerve growth factor receptor enhances beta-amyloid peptide toxicity","volume":"91","author":"Rabizadeh","year":"1994","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.bbr.2010.11.058_bib0660","doi-asserted-by":"crossref","first-page":"7720","DOI":"10.1074\/jbc.M110929200","article-title":"Amyloid \u03b2 binds trimers as well as monomers of the 75-kDa neurotrophin receptor and activates receptor signaling","volume":"277","author":"Yaar","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bbr.2010.11.058_bib0665","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1002\/(SICI)1097-4547(19981215)54:6<798::AID-JNR7>3.0.CO;2-T","article-title":"Beta-amyloid binds to p57NTR and activates NFkappaB in human neuroblastoma cells","volume":"54","author":"Kuner","year":"1998","journal-title":"J Neurosci Res"},{"key":"10.1016\/j.bbr.2010.11.058_bib0670","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1084\/jem.20011797","article-title":"Role of p75 neurotrophin receptor in the neurotoxicity by beta-amyloid peptides and synergistic effect of inflammatory cytokines","volume":"195","author":"Perini","year":"2002","journal-title":"J Exp Med"},{"key":"10.1016\/j.bbr.2010.11.058_bib0675","doi-asserted-by":"crossref","first-page":"3941","DOI":"10.1523\/JNEUROSCI.0350-08.2008","article-title":"\u03b2-Amyloid(1\u201342) induces neuronal death through the p75 neurotrophin receptor","volume":"28","author":"Sotthibundhu","year":"2008","journal-title":"J Neurosci"},{"key":"10.1016\/j.bbr.2010.11.058_bib0680","doi-asserted-by":"crossref","first-page":"10627","DOI":"10.1523\/JNEUROSCI.0620-09.2009","article-title":"The p75 neurotrophin receptor promotes amyloid-\u03b2(1\u201342)-induced neuritic dystrophy in vitro and in vivo","volume":"29","author":"Knowles","year":"2009","journal-title":"J Neurosci"},{"key":"10.1016\/j.bbr.2010.11.058_bib0685","doi-asserted-by":"crossref","first-page":"7551","DOI":"10.1523\/JNEUROSCI.21-19-07551.2001","article-title":"\u03b2-Amyloid induces neuronal apoptosis via a mechanism that involves the c-Jun N-terminal kinase pathway and the induction of Fas ligand","volume":"21","author":"Morishima","year":"2001","journal-title":"J Neurosci"},{"key":"10.1016\/j.bbr.2010.11.058_bib0690","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1111\/j.1471-4159.2004.02513.x","article-title":"Molecular characterization of neurohybrid cell death induced by Alzheimer's amyloid-\u03b2 peptides via p75NTR\/PLAIDD","volume":"90","author":"Hashimoto","year":"2004","journal-title":"J Neurochem"},{"key":"10.1016\/j.bbr.2010.11.058_bib0695","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1111\/j.1365-2990.2007.00844.x","article-title":"A cyclic peptide that binds p75(NTR) protects neurones from \u03b2 amyloid (1\u201340)-induced cell death","volume":"33","author":"Yaar","year":"2007","journal-title":"Neuropathol Appl Neurobiol"},{"key":"10.1016\/j.bbr.2010.11.058_bib0700","doi-asserted-by":"crossref","first-page":"4044","DOI":"10.1073\/pnas.83.11.4044","article-title":"Microtubule-associated protein tau (tau) is a major antigenic component of paired helical filaments in Alzheimer disease","volume":"83","author":"Kosik","year":"1986","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.bbr.2010.11.058_bib0705","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1126\/science.1899488","article-title":"A68: a major subunit of paired helical filaments and derivatized forms of normal Tau","volume":"251","author":"Lee","year":"1991","journal-title":"Science"},{"key":"10.1016\/j.bbr.2010.11.058_bib0710","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.bbadis.2004.08.007","article-title":"Mutations causing neurodegenerative tauopathies","volume":"1739","author":"Goedert","year":"2005","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.bbr.2010.11.058_bib0715","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1046\/j.1471-4159.2000.740777.x","article-title":"Increased levels of tau protein in SH-SY5Y cells after treatment with cholinesterase inhibitors and nicotinic agonists","volume":"74","author":"Hellstr\u00f6m-Lindahl","year":"2000","journal-title":"J Neurochem"},{"key":"10.1016\/j.bbr.2010.11.058_bib0720","doi-asserted-by":"crossref","first-page":"31547","DOI":"10.1074\/jbc.M212532200","article-title":"\u03b17 nicotinic acetylcholine receptors mediate \u03b2-amyloid peptide-induced tau protein phosphorylation","volume":"278","author":"Wang","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bbr.2010.11.058_bib0725","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1016\/j.neurobiolaging.2003.08.012","article-title":"Amyloid deposition precedes tangle formation in a triple transgenic model of Alzheimer's disease","volume":"24","author":"Oddo","year":"2003","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.bbr.2010.11.058_bib0730","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.neuron.2005.01.040","article-title":"Intraneuronal A\u03b2 causes the onset of early Alzheimer's disease-related cognitive deficits in transgenic mice","volume":"45","author":"Billings","year":"2005","journal-title":"Neuron"},{"key":"10.1016\/j.bbr.2010.11.058_bib0735","doi-asserted-by":"crossref","first-page":"8843","DOI":"10.1523\/JNEUROSCI.2868-05.2005","article-title":"Lipopolysaccharide-induced inflammation exacerbates tau pathology by a cyclin-dependent kinase 5-mediated pathway in a transgenic model of Alzheimer's disease","volume":"25","author":"Kitazawa","year":"2005","journal-title":"J Neurosci"},{"key":"10.1016\/j.bbr.2010.11.058_bib0740","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1023\/A:1020952704398","article-title":"Gene expression profiles of cholinergic nucleus basalis neurons in Alzheimer's disease","volume":"27","author":"Mufson","year":"2002","journal-title":"Neurochem Res"},{"key":"10.1016\/j.bbr.2010.11.058_bib0745","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1101\/lm.69204","article-title":"The cholinergic lesion of Alzheime\u0155s disease: pivotal factor or side show","volume":"11","author":"Mesulam","year":"2004","journal-title":"Learn Mem"},{"key":"10.1016\/j.bbr.2010.11.058_bib0750","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1212\/01.wnl.0000256373.39415.b1","article-title":"Cortical biochemistry in MCI and Alzheimer disease: lack of correlation with clinical diagnosis","volume":"68","author":"Forman","year":"2007","journal-title":"Neurology"},{"key":"10.1016\/j.bbr.2010.11.058_bib0755","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.nurx.2006.05.007","article-title":"Single cell gene expression profiling in Alzheimer's disease","volume":"3","author":"Ginsberg","year":"2006","journal-title":"NeuroRx"},{"key":"10.1016\/j.bbr.2010.11.058_bib0760","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/0896-6273(89)90210-9","article-title":"Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease","volume":"3","author":"Goedert","year":"1989","journal-title":"Neuron"},{"key":"10.1016\/j.bbr.2010.11.058_bib0765","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1002\/j.1460-2075.1989.tb03390.x","article-title":"Cloning and sequencing of the cDNA encoding an isoform of microtubule-associated protein tau containing four tandem repeats: differential expression of tau protein mRNAs in human brain","volume":"8","author":"Goedert","year":"1989","journal-title":"EMBO J"},{"key":"10.1016\/j.bbr.2010.11.058_bib0770","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1111\/j.1471-4159.2005.03641.x","article-title":"Shift in the ratio of three-repeat tau and four-repeat tau mRNAs in individual cholinergic basal forebrain neurons in mild cognitive impairment and Alzheimer's disease","volume":"96","author":"Ginsberg","year":"2006","journal-title":"J Neurochem"},{"key":"10.1016\/j.bbr.2010.11.058_bib0775","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1097\/NEN.0b013e31816a1df3","article-title":"Cholinergic neuronal and axonal abnormalities are present early in aging and in Alzheimer disease","volume":"67","author":"Geula","year":"2008","journal-title":"J Neuropathol Exp Neurol"},{"key":"10.1016\/j.bbr.2010.11.058_bib0780","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1007\/s004019900178","article-title":"Evolution of Alzheimer's disease-related cytoskeletal changes in the basal nucleus of Meynert","volume":"100","author":"Sassin","year":"2000","journal-title":"Acta Neuropathol"},{"key":"10.1016\/j.bbr.2010.11.058_bib0785","doi-asserted-by":"crossref","first-page":"152","DOI":"10.2174\/156720509787602843","article-title":"Early Tau pathology involving the septo-hippocampal pathway in a Tau transgenic model: relevance to Alzheimer's disease","volume":"6","author":"Belarbi","year":"2009","journal-title":"Curr Alzheimer Res"},{"key":"10.1016\/j.bbr.2010.11.058_bib0790","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.neuint.2008.06.005","article-title":"Interactions between the amyloid and cholinergic mechanisms in Alzheimer's disease","volume":"53","author":"P\u00e1k\u00e1ski","year":"2008","journal-title":"Neurochem Int"},{"key":"10.1016\/j.bbr.2010.11.058_bib0795","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1002\/ana.21955","article-title":"Relationship between atrophy and \u03b2-amyloid deposition in Alzheimer disease","volume":"67","author":"Ch\u00e9telat","year":"2010","journal-title":"Ann Neurol"}],"container-title":["Behavioural Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432810007837?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432810007837?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T18:47:25Z","timestamp":1711997245000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166432810007837"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,8]]},"references-count":159,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2011,8]]}},"alternative-id":["S0166432810007837"],"URL":"https:\/\/doi.org\/10.1016\/j.bbr.2010.11.058","relation":{},"ISSN":["0166-4328"],"issn-type":[{"value":"0166-4328","type":"print"}],"subject":[],"published":{"date-parts":[[2011,8]]}}}