{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T23:09:42Z","timestamp":1790550582637,"version":"4.1.0"},"reference-count":38,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2011,6,1]],"date-time":"2011-06-01T00:00:00Z","timestamp":1306886400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Behavioural Brain Research"],"published-print":{"date-parts":[[2011,6]]},"DOI":"10.1016\/j.bbr.2011.01.018","type":"journal-article","created":{"date-parts":[[2011,1,20]],"date-time":"2011-01-20T09:31:03Z","timestamp":1295515863000},"page":"20-29","source":"Crossref","is-referenced-by-count":81,"title":["Inflammation modulates anxiety in an animal model of multiple sclerosis"],"prefix":"10.1016","volume":"220","author":[{"given":"Isabella","family":"Peruga","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Hartwig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Th\u00f6ne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard","family":"Hovemann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf","family":"Gold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"Juckel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf A.","family":"Linker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbr.2011.01.018_bib0005","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1080\/08039480802541765","article-title":"Disability from depression: the public health challenge to primary care","volume":"63","author":"Rost","year":"2009","journal-title":"Nord J Psychiatry"},{"key":"10.1016\/j.bbr.2011.01.018_bib0010","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1176\/ajp.152.6.833","article-title":"Stressful life events, genetic liability, and onset of an episode of major depression in women","volume":"152","author":"Kendler","year":"1995","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.bbr.2011.01.018_bib0015","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1016\/S0140-6736(08)61620-7","article-title":"Multiple sclerosis","volume":"372","author":"Compston","year":"2008","journal-title":"Lancet"},{"key":"10.1016\/j.bbr.2011.01.018_bib0020","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1001\/archneur.1984.04050210065016","article-title":"Behavioral disorders in multiple sclerosis, temporal lobe epilepsy, and amyotrophic lateral sclerosis. An epidemiologic study","volume":"41","author":"Schiffer","year":"1984","journal-title":"Arch. Neurol"},{"key":"10.1016\/j.bbr.2011.01.018_bib0025","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/S0033-3182(93)71902-7","article-title":"Increased depression in multiple sclerosis patients. A meta-analysis","volume":"34","author":"Schubert","year":"1993","journal-title":"Psychosomatics"},{"key":"10.1016\/j.bbr.2011.01.018_bib0030","doi-asserted-by":"crossref","first-page":"1862","DOI":"10.1176\/appi.ajp.159.11.1862","article-title":"Depressive symptoms and severity of illness in multiple sclerosis: epidemiologic study of a large community sample","volume":"159","author":"Chwastiak","year":"2002","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.bbr.2011.01.018_bib0035","first-page":"9","article-title":"Depression and multiple sclerosis: a potential way to understand the biology of major depressive illness","volume":"30","author":"Joffe","year":"2005","journal-title":"J Psychiatry Neurosci"},{"key":"10.1016\/j.bbr.2011.01.018_bib0040","first-page":"4","article-title":"Cascading effects of stressors and inflammatory immune system activation: implications for major depressive disorder","volume":"34","author":"Anisman","year":"2009","journal-title":"J Psychiatry Neurosci"},{"key":"10.1016\/j.bbr.2011.01.018_bib0045","doi-asserted-by":"crossref","first-page":"2800","DOI":"10.1093\/brain\/awm236","article-title":"Lesion genesis in a subset of patients with multiple sclerosis: a role for innate immunity?","volume":"130","author":"Marik","year":"2007","journal-title":"Brain"},{"key":"10.1016\/j.bbr.2011.01.018_bib0050","doi-asserted-by":"crossref","first-page":"133","DOI":"10.3109\/00207459809000656","article-title":"Serotonergic neuronal atrophy with synaptic inactivation, not axonal degeneration, are the main hallmarks of multiple sclerosis","volume":"95","author":"Sandyk","year":"1998","journal-title":"Int J Neurosci"},{"key":"10.1016\/j.bbr.2011.01.018_bib0055","doi-asserted-by":"crossref","first-page":"249","DOI":"10.3109\/00207459408986007","article-title":"The co-occurrence of multiple sclerosis and migraine headache: the serotoninergic link","volume":"76","author":"Sandyk","year":"1994","journal-title":"Int J Neurosci"},{"key":"10.1016\/j.bbr.2011.01.018_bib0060","doi-asserted-by":"crossref","first-page":"1894","DOI":"10.1016\/j.neuroscience.2009.09.025","article-title":"Interferon-gamma deficiency modifies the motor and co-morbid behavioral pathology and neurochemical changes provoked by the pesticide paraquat","volume":"164","author":"Litteljohn","year":"2009","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbr.2011.01.018_bib0065","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1093\/brain\/awl075","article-title":"Understanding pathogenesis and therapy of multiple sclerosis via animal models: 70 years of merits and culprits in experimental autoimmune encephalomyelitis research","volume":"129","author":"Gold","year":"2006","journal-title":"Brain"},{"key":"10.1016\/j.bbr.2011.01.018_bib0070","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1002\/ana.21719","article-title":"Lower motor neuron loss in multiple sclerosis and experimental autoimmune encephalomyelitis","volume":"66","author":"Vogt","year":"2009","journal-title":"Ann Neurol"},{"key":"10.1016\/j.bbr.2011.01.018_bib0075","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.nbd.2008.01.001","article-title":"Pattern of axonal injury in murine myelin oligodendrocyte glycoprotein induced experimental autoimmune encephalomyelitis: implications for multiple sclerosis","volume":"30","author":"Herrero-Herranz","year":"2008","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.bbr.2011.01.018_bib0080","doi-asserted-by":"crossref","first-page":"S11","DOI":"10.1212\/WNL.45.6_Suppl_6.S11","article-title":"Cytokine-producing cells in experimental autoimmune encephalomyelitis and multiple sclerosis","volume":"45","author":"Olsson","year":"1995","journal-title":"Neurology"},{"key":"10.1016\/j.bbr.2011.01.018_bib0085","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/S0889-1591(02)00010-7","article-title":"Experimental autoimmune encephalomyelitis-associated behavioral syndrome as a model of \u2018depression due to multiple sclerosis\u2019","volume":"16","author":"Pollak","year":"2002","journal-title":"Brain, Behav. Immun."},{"key":"10.1016\/j.bbr.2011.01.018_bib0090","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0165-5728(99)00257-X","article-title":"Behavioral aspects of experimental autoimmune encephalomyelitis","volume":"104","author":"Pollak","year":"2000","journal-title":"J Neuroimmunol"},{"key":"10.1016\/j.bbr.2011.01.018_bib0095","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1038\/nm0602-620","article-title":"CNTF is a major protective factor in demyelinating CNS disease: a neurotrophic cytokine as modulator in neuroinflammation","volume":"8","author":"Linker","year":"2002","journal-title":"Nat Med"},{"key":"10.1016\/j.bbr.2011.01.018_bib0100","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/S0006-8993(98)01258-X","article-title":"Behavioral phenotyping of transgenic and knockout mice: experimental design and evaluation of general health, sensory functions, motor abilities, and specific behavioral tests","volume":"835","author":"Crawley","year":"1999","journal-title":"Brain Res"},{"key":"10.1016\/j.bbr.2011.01.018_bib0105","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1016\/j.biopsych.2005.02.010","article-title":"Anxious and hyperactive phenotype following brief ischemic episodes in mice","volume":"57","author":"Winter","year":"2005","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.bbr.2011.01.018_bib0110","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.bbr.2010.04.036","article-title":"Lesion of the medial prefrontal cortex and the subthalamic nucleus selectively affect depression-like behavior in rats","volume":"213","author":"Klein","year":"2010","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.bbr.2011.01.018_bib0115","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.brainresprot.2005.09.002","article-title":"Learned helplessness: validity and reliability of depressive-like states in mice","volume":"16","author":"Chourbaji","year":"2005","journal-title":"Brain Res Brain Res Protoc"},{"key":"10.1016\/j.bbr.2011.01.018_bib0120","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1097\/FBP.0b013e3282d28f6f","article-title":"The anxiolytic-like effects of allopregnanolone vary as a function of intracerebral microinfusion site: the amygdala, medial prefrontal cortex, or hippocampus","volume":"18","author":"Engin","year":"2007","journal-title":"Behav Pharmacol"},{"key":"10.1016\/j.bbr.2011.01.018_bib0125","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1176\/appi.ajp.159.7.1112","article-title":"Hippocampal changes in patients with a first episode of major depression","volume":"159","author":"Frodl","year":"2002","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.bbr.2011.01.018_bib0130","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1038\/sj.npp.1301281","article-title":"Reduced anxiety and depression-like behaviors in mice lacking GABA transporter subtype 1","volume":"32","author":"Liu","year":"2007","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.bbr.2011.01.018_bib0135","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1016\/j.biopsych.2008.11.029","article-title":"Inflammation and its discontents: the role of cytokines in the pathophysiology of major depression","volume":"65","author":"Miller","year":"2009","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.bbr.2011.01.018_bib0140","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1111\/j.1460-9568.2007.05792.x","article-title":"CNS-irrelevant T-cells enter the brain, cause blood-brain barrier disruption but no glial pathology","volume":"26","author":"Smorodchenko","year":"2007","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.bbr.2011.01.018_bib0145","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0920-9964(00)00139-0","article-title":"Impact of prepulse characteristics on the detection of sensorimotor gating deficits in schizophrenia","volume":"49","author":"Braff","year":"2001","journal-title":"Schizophrenia Res"},{"key":"10.1016\/j.bbr.2011.01.018_bib0150","doi-asserted-by":"crossref","first-page":"3649","DOI":"10.1002\/jnr.22155","article-title":"Serotonin transporter, 5-HT1A receptor, and behavior in DBA\/2J mice in comparison with four inbred mouse strains","volume":"87","author":"Popova","year":"2009","journal-title":"J Neurosci Res"},{"key":"10.1016\/j.bbr.2011.01.018_bib0155","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.jad.2006.01.022","article-title":"Normal prepulse inhibition and habituation of acoustic startle response in suicidal depressive patients without psychotic symptoms","volume":"92","author":"Quednow","year":"2006","journal-title":"J Affec Disord"},{"key":"10.1016\/j.bbr.2011.01.018_bib32","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1038\/labinvest.2010.6","article-title":"Hippocampal CA1 atrophy and synaptic loss during experimental autoimmune encephalomyelitis, EAE","volume":"90","author":"Ziehn","year":"2010","journal-title":"Lab Invest"},{"key":"10.1016\/j.bbr.2011.01.018_bib0160","doi-asserted-by":"crossref","unstructured":"Mangiardi M, Crawford DK, Xia X, Du S, Simon-Freeman R, Voskuhl RR, et al. An animal model of cortical and callosal pathology in multiple sclerosis. Brain Pathol, doi:10.1111\/j.1750-3639.2010.00444.x, in press.","DOI":"10.1111\/j.1750-3639.2010.00444.x"},{"key":"10.1016\/j.bbr.2011.01.018_bib0165","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1089\/jir.1998.18.415","article-title":"The development of autoimmune encephalomyelitis provoked by myelin oligodendrocyte glycoprotein is associated with an upregulation of both proinflammatory and immunoregulatory cytokines in the central nervous system","volume":"18","author":"Okuda","year":"1998","journal-title":"J Interferon Cytokine Res"},{"key":"10.1016\/j.bbr.2011.01.018_bib0170","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1080\/07853890310004075","article-title":"Cytokines, stress and depressive illness: brain\u2013immune interactions","volume":"35","author":"Anisman","year":"2003","journal-title":"Ann Med"},{"key":"10.1016\/j.bbr.2011.01.018_bib0175","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.jchromb.2005.01.008","article-title":"Simple and rapid determination of serotonin and catecholamines in biological tissue using high-performance liquid chromatography with electrochemical detection","volume":"818","author":"Patel","year":"2005","journal-title":"J Chromatogr B Analyt Technol Biomed Life Sci"},{"key":"10.1016\/j.bbr.2011.01.018_bib0180","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.1038\/sj.npp.1301029","article-title":"The proinflammatory cytokines interleukin-1beta and tumor necrosis factor-alpha activate serotonin transporters","volume":"31","author":"Zhu","year":"2006","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.bbr.2011.01.018_bib0185","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0165-5728(02)00002-4","article-title":"Catecholamine levels in peripheral blood lymphocytes from multiple sclerosis patients","volume":"124","author":"Rajda","year":"2002","journal-title":"J Neuroimmunol"}],"container-title":["Behavioural Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432811000441?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432811000441?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,6,8]],"date-time":"2019-06-08T00:40:54Z","timestamp":1559954454000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166432811000441"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,6]]},"references-count":38,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,6]]}},"alternative-id":["S0166432811000441"],"URL":"https:\/\/doi.org\/10.1016\/j.bbr.2011.01.018","relation":{},"ISSN":["0166-4328"],"issn-type":[{"value":"0166-4328","type":"print"}],"subject":[],"published":{"date-parts":[[2011,6]]}}}