{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T19:06:57Z","timestamp":1790622417218,"version":"4.1.0"},"reference-count":78,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2011,9,1]],"date-time":"2011-09-01T00:00:00Z","timestamp":1314835200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Behavioural Brain Research"],"published-print":{"date-parts":[[2011,9]]},"DOI":"10.1016\/j.bbr.2011.04.036","type":"journal-article","created":{"date-parts":[[2011,4,28]],"date-time":"2011-04-28T18:35:40Z","timestamp":1304015740000},"page":"154-168","source":"Crossref","is-referenced-by-count":37,"title":["Individual differences in novelty-seeking predict differential responses to chronic antidepressant treatment through sex- and phenotype-dependent neurochemical signatures"],"prefix":"10.1016","volume":"223","author":[{"given":"Pothitos M.","family":"Pitychoutis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleftherios G.","family":"Pallis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hudu G.","family":"Mikail","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeta","family":"Papadopoulou-Daifoti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbr.2011.04.036_bib0005","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.jad.2004.09.008","article-title":"Gender differences in depression: findings from the STAR*D study","volume":"87","author":"Marcus","year":"2005","journal-title":"J Affect Disord"},{"key":"10.1016\/j.bbr.2011.04.036_bib0010","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1080\/10401230701653294","article-title":"Gender issues in depression","volume":"19","author":"Grigoriadis","year":"2007","journal-title":"Ann Clin Psychiatry"},{"key":"10.1016\/j.bbr.2011.04.036_bib0015","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1126\/science.308.5728.1574","article-title":"Sex and the suffering brain","volume":"308","author":"Holden","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.bbr.2011.04.036_bib0020","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/S0193-953X(03)00044-3","article-title":"Gender differences in depression and response to antidepressant treatment","volume":"26","author":"Sloan","year":"2003","journal-title":"Psychiatr Clin North Am"},{"key":"10.1016\/j.bbr.2011.04.036_bib0025","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.jpsychires.2008.07.002","article-title":"Sex differences in response to citalopram: a STAR*D report","volume":"43","author":"Young","year":"2009","journal-title":"J Psychiatr Res"},{"key":"10.1016\/j.bbr.2011.04.036_bib0030","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.pharmthera.2009.11.006","article-title":"Inter-individual differences in neurobiology as vulnerability factors for affective disorders: implications for psychopharmacology","volume":"125","author":"Harro","year":"2010","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.bbr.2011.04.036_bib0035","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.pharmthera.2006.07.002","article-title":"Differentiating antidepressants of the future: efficacy and safety","volume":"113","author":"Rosenzweig-Lipson","year":"2007","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.bbr.2011.04.036_bib0040","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S0193-953X(05)70283-5","article-title":"Definition and epidemiology of treatment-resistant depression","volume":"19","author":"Fava","year":"1996","journal-title":"Psychiatr Clin North Am"},{"key":"10.1016\/j.bbr.2011.04.036_bib0045","doi-asserted-by":"crossref","first-page":"2214","DOI":"10.2174\/138161210791792831","article-title":"Pharmacogenetic insights into depression and antidepressant response: does sex matter?","volume":"16","author":"Pitychoutis","year":"2010","journal-title":"Curr Pharm Des"},{"issue":"Suppl. 3","key":"10.1016\/j.bbr.2011.04.036_bib0050","first-page":"S235","article-title":"Individualized medicine \u2013 implementation of pharmacogenetic diagnostics in antidepressant drug treatment of major depressive disorders","volume":"36","author":"Kirchheiner","year":"2003","journal-title":"Pharmacopsychiatry"},{"key":"10.1016\/j.bbr.2011.04.036_bib0055","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/j.bbr.2007.10.010","article-title":"Individual responses to novelty are associated with differences in behavioral and neurochemical profiles","volume":"187","author":"Antoniou","year":"2008","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.bbr.2011.04.036_bib0060","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/j.neuroscience.2003.10.009","article-title":"Individual responses to novelty predict qualitative differences in d-amphetamine-induced open field but not reward-related behaviors in rats","volume":"123","author":"Antoniou","year":"2004","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbr.2011.04.036_bib0065","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1177\/0269881108095914","article-title":"Sex-related differential response to clomipramine treatment in a rat model of depression","volume":"23","author":"Kokras","year":"2009","journal-title":"J Psychopharmacol"},{"key":"10.1016\/j.bbr.2011.04.036_bib0070","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.neulet.2009.08.011","article-title":"Antidepressants induce regionally discrete, sex-dependent changes in brain's glutamate content","volume":"464","author":"Kokras","year":"2009","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.bbr.2011.04.036_bib0075","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1017\/S1461145709990502","article-title":"Chronic antidepressant treatment exerts sexually dimorphic immunomodulatory effects in an experimental model of major depression: do females lack an advantage?","volume":"12","author":"Pitychoutis","year":"2009","journal-title":"Int J Neuropsychopharmacol"},{"key":"10.1016\/j.bbr.2011.04.036_bib0080","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.neulet.2010.07.084","article-title":"Fluoxetine treatment induces dose dependent alterations in depression associated behavior and neural plasticity in female mice","volume":"484","author":"Hodes","year":"2010","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.bbr.2011.04.036_bib0085","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1124\/jpet.109.158717","article-title":"Sex-specific effects of chronic fluoxetine treatment on neuroplasticity and pharmacokinetics in mice","volume":"332","author":"Hodes","year":"2010","journal-title":"J Pharm Exp Ther"},{"key":"10.1016\/j.bbr.2011.04.036_bib0090","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0278-5846(03)00177-5","article-title":"Gender differences in treatment response to sertraline versus imipramine in patients with nonmelancholic depressive disorders","volume":"28","author":"Baca","year":"2004","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"10.1016\/j.bbr.2011.04.036_bib0095","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1176\/appi.ajp.160.9.1643","article-title":"Are gender differences important for the clinical effects of antidepressants?","volume":"160","author":"Hildebrandt","year":"2003","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.bbr.2011.04.036_bib0100","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1038\/nrn1846","article-title":"New approaches to antidepressant drug discovery: beyond monoamines","volume":"7","author":"Berton","year":"2006","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.bbr.2011.04.036_bib0105","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1017\/S1461145709991003","article-title":"Individual differences in the effects of cannabinoids on motor activity, dopaminergic activity and DARPP-32 phosphorylation in distinct regions of the brain","volume":"13","author":"Polissidis","year":"2010","journal-title":"Int J Neuropsychopharmacol"},{"key":"10.1016\/j.bbr.2011.04.036_bib0110","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/j.neuroscience.2005.06.068","article-title":"Chronic mild stress impact: are females more vulnerable?","volume":"135","author":"Dalla","year":"2005","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbr.2011.04.036_bib0115","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/j.neuroscience.2004.04.044","article-title":"Sex differences in behavioral, neurochemical and neuroendocrine effects induced by the forced swim test in rats","volume":"126","author":"Drossopoulou","year":"2004","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbr.2011.04.036_bib0120","doi-asserted-by":"crossref","first-page":"171","DOI":"10.2174\/1381612053382250","article-title":"Animal models of depressive illness: the importance of chronic drug treatment","volume":"11","author":"Mitchell","year":"2005","journal-title":"Curr Pharm Des"},{"key":"10.1016\/j.bbr.2011.04.036_bib0125","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/j.neubiorev.2005.03.008","article-title":"Assessing substrates underlying the behavioral effects of antidepressants using the modified rat forced swimming test","volume":"29","author":"Cryan","year":"2005","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1016\/j.bbr.2011.04.036_bib0130","doi-asserted-by":"crossref","first-page":"2309","DOI":"10.1016\/S0028-3908(00)00077-0","article-title":"Chronic clomipramine alters presynaptic 5-HT(1B) and postsynaptic 5-HT(1A) receptor sensitivity in rat hypothalamus and hippocampus, respectively","volume":"39","author":"Newman","year":"2000","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bbr.2011.04.036_bib0135","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/S0197-0186(00)00123-6","article-title":"Cortical 5-HT(1A) receptor downregulation by antidepressants in rat brain","volume":"38","author":"Srinivas","year":"2001","journal-title":"Neurochem Int"},{"key":"10.1016\/j.bbr.2011.04.036_bib0140","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0304-3940(99)00058-0","article-title":"Chronic but not acute clomipramine alters the effect of NMDA receptor regulation of dopamine release in rat frontal cortex","volume":"262","author":"Pallotta","year":"1999","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.bbr.2011.04.036_bib0145","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1037\/0735-7044.119.1.127","article-title":"Aged and adult rats compared in acquisition and extinction of escape from the water maze: focus on individual differences","volume":"119","author":"Topic","year":"2005","journal-title":"Behav Neurosci"},{"key":"10.1016\/j.bbr.2011.04.036_bib0150","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/S0306-4522(99)00158-X","article-title":"High versus low reactivity to a novel environment: behavioural, pharmacological and neurochemical assessments","volume":"93","author":"Thiel","year":"1999","journal-title":"Neuroscience"},{"issue":"Suppl. 1","key":"10.1016\/j.bbr.2011.04.036_bib0155","doi-asserted-by":"crossref","first-page":"S26","DOI":"10.1016\/j.pain.2007.10.014","article-title":"Studying sex and gender differences in pain and analgesia: a consensus report","volume":"132","author":"Greenspan","year":"2007","journal-title":"Pain"},{"key":"10.1016\/j.bbr.2011.04.036_bib0160","doi-asserted-by":"crossref","first-page":"303","DOI":"10.14310\/horm.2002.1211","article-title":"The impact of the hormonal milieu and stress-associated hypothalamic dopaminergic activation on the rapid compensatory adrenal growth in cycling female rats","volume":"7","author":"Sfikakis","year":"2008","journal-title":"Hormones (Athens)"},{"key":"10.1016\/j.bbr.2011.04.036_bib0165","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.pbb.2008.03.008","article-title":"The effects of novelty-seeking phenotypes and sex differences on acquisition of cocaine self-administration in selectively bred high-responder and low-responder rats","volume":"90","author":"Davis","year":"2008","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.bbr.2011.04.036_bib0170","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.brainres.2008.09.063","article-title":"Modest effects of repeated fluoxetine on estrous cyclicity and sexual behavior in Sprague Dawley female rats","volume":"1245","author":"Maswood","year":"2008","journal-title":"Brain Res"},{"key":"10.1016\/j.bbr.2011.04.036_bib0175","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/s00213-006-0613-y","article-title":"Hyperalgesia, low-anxiety, and impairment of avoidance learning in neonatal caffeine-treated rats","volume":"191","author":"Pan","year":"2007","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.bbr.2011.04.036_bib0180","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1016\/j.neuroscience.2009.01.072","article-title":"Neurochemical and behavioral alterations in an inflammatory model of depression: sex differences exposed","volume":"159","author":"Pitychoutis","year":"2009","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbr.2011.04.036_bib0185","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1038\/266730a0","article-title":"Depression: a new animal model sensitive to antidepressant treatments","volume":"266","author":"Porsolt","year":"1977","journal-title":"Nature"},{"key":"10.1016\/j.bbr.2011.04.036_bib0190","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1002\/art.23446","article-title":"Glutamate levels and activity of the T cell voltage-gated potassium Kv1.3 channel in patients with systemic lupus erythematosus","volume":"58","author":"Poulopoulou","year":"2008","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.bbr.2011.04.036_bib0195","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.pnpbp.2003.11.018","article-title":"Central monoamines and their role in major depression","volume":"28","author":"Elhwuegi","year":"2004","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"10.1016\/j.bbr.2011.04.036_bib0200","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1016\/0006-2952(85)90484-8","article-title":"Monoamine metabolites: their relationship and lack of relationship to monoaminergic neuronal activity","volume":"34","author":"Commissiong","year":"1985","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.bbr.2011.04.036_bib0205","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0022-3565(25)39040-3","article-title":"Dopamine autoreceptors modulate the in vivo release of dopamine in the frontal, cingulate and entorhinal cortices","volume":"242","author":"Altar","year":"1987","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.bbr.2011.04.036_bib0210","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/0006-8993(89)91637-5","article-title":"Monoamine and metabolite levels in the prefrontal cortex and the mesolimbic forebrain following neonatal lesions of the ventral tegmental area","volume":"479","author":"Kalsbeek","year":"1989","journal-title":"Brain Res"},{"key":"10.1016\/j.bbr.2011.04.036_bib0215","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1007\/s00213-004-1959-7","article-title":"Fluvoxamine, a selective serotonin reuptake inhibitor, suppresses tetrahydrobiopterin levels and dopamine as well as serotonin turnover in the mesoprefrontal system of mice","volume":"177","author":"Miura","year":"2005","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.bbr.2011.04.036_bib0220","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1111\/j.1471-4159.1990.tb04559.x","article-title":"Development of monoaminergic neurotransmitters in fetal and postnatal rat brain: analysis by HPLC with electrochemical detection","volume":"55","author":"Herregodts","year":"1990","journal-title":"J Neurochem"},{"key":"10.1016\/j.bbr.2011.04.036_bib0225","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1007\/s005400170018","article-title":"Antinociceptive efficacy of antidepressants: assessment of five antidepressants and four monoamine receptors in rats","volume":"15","author":"Otsuka","year":"2001","journal-title":"J Anesth"},{"key":"10.1016\/j.bbr.2011.04.036_bib0230","doi-asserted-by":"crossref","first-page":"4886","DOI":"10.1523\/JNEUROSCI.17-12-04886.1997","article-title":"Inhibition of stress-induced neuroendocrine and behavioral responses in the rat by prepro-thyrotropin-releasing hormone 178-199","volume":"17","author":"McGivern","year":"1997","journal-title":"J Neurosci"},{"key":"10.1016\/j.bbr.2011.04.036_bib0235","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1159\/000119305","article-title":"Novelty-seeking in rats \u2013 biobehavioral characteristics and possible relationship with the sensation-seeking trait in man","volume":"34","author":"Dellu","year":"1996","journal-title":"Neuropsychobiology"},{"key":"10.1016\/j.bbr.2011.04.036_bib0240","doi-asserted-by":"crossref","first-page":"6983","DOI":"10.1523\/JNEUROSCI.20-18-06983.2000","article-title":"Neurobiological correlates of individual differences in novelty-seeking behavior in the rat: differential expression of stress-related molecules","volume":"20","author":"Kabbaj","year":"2000","journal-title":"J Neurosci"},{"key":"10.1016\/j.bbr.2011.04.036_bib0245","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1007\/s00213-009-1552-1","article-title":"Individual differences in the sensitivity to serotonergic drugs: a pharmacobehavioural approach using rats selected on the basis of their response to novelty","volume":"205","author":"Verheij","year":"2009","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.bbr.2011.04.036_bib0250","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1007\/s11926-005-0018-7","article-title":"Individual differences in pain responses","volume":"7","author":"Fillingim","year":"2005","journal-title":"Curr Rheumatol Rep"},{"key":"10.1016\/j.bbr.2011.04.036_bib0255","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S1090-3801(03)00065-X","article-title":"The tridimensional personality theory and pain: harm avoidance and reward dependence traits correlate with pain perception in healthy volunteers","volume":"8","author":"Pud","year":"2004","journal-title":"Eur J Pain"},{"key":"10.1016\/j.bbr.2011.04.036_bib0260","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.brainres.2007.02.050","article-title":"Locomotor response to novelty as a predictor of reactivity to aversive stimuli in the rat","volume":"1149","author":"White","year":"2007","journal-title":"Brain Res"},{"key":"10.1016\/j.bbr.2011.04.036_bib0265","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0166-4328(02)00089-X","article-title":"Individual response profiles of male Wistar rats in animal models for anxiety and depression","volume":"136","author":"Ho","year":"2002","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.bbr.2011.04.036_bib0270","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1007\/s00213-008-1126-7","article-title":"Inter-individual differences in novelty-seeking behavior in rats predict differential responses to desipramine in the forced swim test","volume":"198","author":"Jama","year":"2008","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.bbr.2011.04.036_bib0275","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1016\/S0006-3223(98)00156-5","article-title":"Interindividual differences in active and passive behaviors in the forced-swimming test: implications for animal models of psychopathology","volume":"45","author":"Taghzouti","year":"1999","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.bbr.2011.04.036_bib0280","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1111\/j.1742-7843.2009.00516.x","article-title":"Sex differences in animal models of depression and antidepressant response","volume":"106","author":"Dalla","year":"2010","journal-title":"Basic Clin Pharmacol Toxicol"},{"key":"10.1016\/j.bbr.2011.04.036_bib0285","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1007\/s002130051156","article-title":"Serotonergic mediation of the effects of fluoxetine, but not desipramine, in the rat forced swimming test","volume":"147","author":"Page","year":"1999","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.bbr.2011.04.036_bib0290","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1016\/S0022-3565(24)36846-6","article-title":"Interaction between the forced swimming test and fluoxetine treatment on extracellular 5-hydroxytryptamine and 5-hydroxyindoleacetic acid in the rat","volume":"282","author":"Kirby","year":"1997","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.bbr.2011.04.036_bib0295","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/j.neuroscience.2008.03.007","article-title":"Repeated administration of imipramine attenuates glutamatergic transmission in rat frontal cortex","volume":"153","author":"Tokarski","year":"2008","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbr.2011.04.036_bib0300","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.ejphar.2008.10.049","article-title":"Forced swimming and imipramine modify plasma and brain amino acid concentrations in mice","volume":"602","author":"Murakami","year":"2009","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.bbr.2011.04.036_bib0305","doi-asserted-by":"crossref","first-page":"2088","DOI":"10.1073\/pnas.88.6.2088","article-title":"Corticosterone levels determine individual vulnerability to amphetamine self-administration","volume":"88","author":"Piazza","year":"1991","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.bbr.2011.04.036_bib0310","first-page":"11","article-title":"Involvement and role of antidepressant drugs of the hypothalamic\u2013pituitary\u2013adrenal axis and glucocorticoid receptor function","volume":"30","author":"Nikisch","year":"2009","journal-title":"Neuroendocrinol Lett"},{"key":"10.1016\/j.bbr.2011.04.036_bib0315","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/S0278-5846(01)00297-4","article-title":"The effects of stress exposure on the hypothalamic\u2013pituitary\u2013adrenal axis, thymus, thyroid hormones and glucose levels","volume":"26","author":"Kioukia-Fougia","year":"2002","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"10.1016\/j.bbr.2011.04.036_bib0320","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.ejphar.2005.08.012","article-title":"Stressors affect the response of male and female rats to clomipramine in a model of behavioral despair (forced swim test)","volume":"520","author":"Consoli","year":"2005","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.bbr.2011.04.036_bib0325","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/0091-3057(95)02166-3","article-title":"Psychosocial stress in tree shrews: clomipramine counteracts behavioral and endocrine changes","volume":"54","author":"Fuchs","year":"1996","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.bbr.2011.04.036_bib0330","doi-asserted-by":"crossref","first-page":"3012","DOI":"10.1210\/en.2003-0097","article-title":"Effects of long-term voluntary exercise on the mouse hypothalamic-pituitary-adrenocortical axis","volume":"144","author":"Droste","year":"2003","journal-title":"Endocrinology"},{"key":"10.1016\/j.bbr.2011.04.036_bib0335","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1017\/S1461145710000465","article-title":"Of depression and immunity: does sex matter?","volume":"13","author":"Pitychoutis","year":"2010","journal-title":"Int J Neuropsychopharmacol"},{"key":"10.1016\/j.bbr.2011.04.036_bib0340","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0022-3956(98)00036-3","article-title":"Temperament and character inventory (TCI) and depression","volume":"33","author":"Hansenne","year":"1999","journal-title":"J Psychiatr Res"},{"key":"10.1016\/j.bbr.2011.04.036_bib0345","doi-asserted-by":"crossref","first-page":"150","DOI":"10.4306\/pi.2009.6.3.150","article-title":"Comparison of clinical features and personality dimensions between patients with major depressive disorder and normal control","volume":"6","author":"Hur","year":"2009","journal-title":"Psychiatry Investig"},{"key":"10.1016\/j.bbr.2011.04.036_bib0350","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1016\/j.neubiorev.2009.05.009","article-title":"The HR\/LR model: further evidence as an animal model of sensation seeking","volume":"33","author":"Blanchard","year":"2009","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1016\/j.bbr.2011.04.036_bib0355","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1007\/s00213-006-0445-9","article-title":"Age and sex differences in the locomotor effect of repeated methylphenidate in rats classified as high or low novelty responders","volume":"188","author":"Wooters","year":"2006","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.bbr.2011.04.036_bib0360","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/2042-6410-2-3","article-title":"Effects of a selectively bred novelty-seeking phenotype on the motivation to take cocaine in male and female rats","volume":"2","author":"Cummings","year":"2011","journal-title":"Biol Sex Differ"},{"key":"10.1016\/j.bbr.2011.04.036_bib0365","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/0165-0327(94)90149-X","article-title":"Temperament predicts clomipramine and desipramine response in major depression","volume":"30","author":"Joyce","year":"1994","journal-title":"J Affect Disord"},{"key":"10.1016\/j.bbr.2011.04.036_bib0370","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0165-0327(97)00030-X","article-title":"Serotonergic autoreceptor blockade in the reduction of antidepressant latency: personality variables and response to paroxetine and pindolol","volume":"44","author":"Tome","year":"1997","journal-title":"J Affect Disord"},{"key":"10.1016\/j.bbr.2011.04.036_bib0375","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1176\/appi.ajp.159.3.359","article-title":"Personality pathology and treatment outcome in major depression: a review","volume":"159","author":"Mulder","year":"2002","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.bbr.2011.04.036_bib0380","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1176\/appi.ajp.157.9.1445","article-title":"Gender differences in treatment response to sertraline versus imipramine in chronic depression","volume":"157","author":"Kornstein","year":"2000","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.bbr.2011.04.036_bib0385","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1038\/465690a","article-title":"Males still dominate animal studies","volume":"465","author":"Zucker","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.bbr.2011.04.036_bib0390","doi-asserted-by":"crossref","first-page":"581","DOI":"10.2217\/fnl.10.28","article-title":"Antidepressant pharmacotherapy: focus on sex differences in neuroimmunopharmacological crossroads","volume":"5","author":"Pitychoutis","year":"2010","journal-title":"Future Neurol"}],"container-title":["Behavioural Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432811003469?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432811003469?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,5]],"date-time":"2025-03-05T09:03:48Z","timestamp":1741165428000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166432811003469"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,9]]},"references-count":78,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,9]]}},"alternative-id":["S0166432811003469"],"URL":"https:\/\/doi.org\/10.1016\/j.bbr.2011.04.036","relation":{},"ISSN":["0166-4328"],"issn-type":[{"value":"0166-4328","type":"print"}],"subject":[],"published":{"date-parts":[[2011,9]]}}}