{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T10:54:26Z","timestamp":1793012066756,"version":"4.5.0"},"reference-count":48,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2011,11,1]],"date-time":"2011-11-01T00:00:00Z","timestamp":1320105600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Behavioural Brain Research"],"published-print":{"date-parts":[[2011,11]]},"DOI":"10.1016\/j.bbr.2011.07.024","type":"journal-article","created":{"date-parts":[[2011,7,25]],"date-time":"2011-07-25T16:58:04Z","timestamp":1311613084000},"page":"328-333","source":"Crossref","is-referenced-by-count":62,"title":["Involvement of nitric oxide\u2013cGMP pathway in the antidepressant-like effect of ascorbic acid in the tail suspension test"],"prefix":"10.1016","volume":"225","author":[{"given":"Morgana","family":"Moretti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andiara Espindola de","family":"Freitas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josiane","family":"Budni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sinara Castellen Pereira","family":"Fernandes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grasiela de Oliveira","family":"Balen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana L\u00facia Severo","family":"Rodrigues","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbr.2011.07.024_bib0005","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1056\/NEJMra073096","article-title":"Major depressive disorder","volume":"358","author":"Belmaker","year":"2008","journal-title":"N Eng J Med"},{"key":"10.1016\/j.bbr.2011.07.024_bib0010","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1176\/appi.ajp.163.9.1561","article-title":"Prevalence and effects of mood disorders on work performance in a nationally representative sample of US workers","volume":"163","author":"Kessler","year":"2006","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.bbr.2011.07.024_bib0015","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1177\/1073858409336093","article-title":"The role of the tripartite glutamatergic synapse in the pathophysiology and therapeutics of mood disorders","volume":"15","author":"Machado-Vieira","year":"2009","journal-title":"Neuroscientist"},{"key":"10.1016\/j.bbr.2011.07.024_bib0020","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.brainresrev.2009.05.005","article-title":"Emerging role of glutamate in the pathophysiology of major depressive disorder","volume":"61","author":"Hashimoto","year":"2009","journal-title":"Brain Res Rev"},{"key":"10.1016\/j.bbr.2011.07.024_bib0025","doi-asserted-by":"crossref","unstructured":"Hashimoto K. The role of glutamate on the action of antidepressants. Prog Neuropsychopharmacol Biol Psychiatry; 2010: in press, doi:10.1016\/j.pnpbp.2010.06.013.","DOI":"10.1016\/j.pnpbp.2010.06.013"},{"key":"10.1016\/j.bbr.2011.07.024_bib0030","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1196\/annals.1300.016","article-title":"Glutamate and depression: clinical and preclinical studies","volume":"1003","author":"Paul","year":"2003","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.bbr.2011.07.024_bib0035","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1001\/archpsyc.63.8.856","article-title":"A randomized trial of an N-methyl-d-aspartate antagonist in treatment-resistant major depression","volume":"63","author":"Zarate","year":"2006","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.bbr.2011.07.024_bib0040","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.pnpbp.2009.01.004","article-title":"Ketamine treatment reverses behavioral and physiological alterations induced by chronic mild stress in rats","volume":"33","author":"Garcia","year":"2009","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"10.1016\/j.bbr.2011.07.024_bib0045","doi-asserted-by":"crossref","first-page":"079","DOI":"10.1038\/sj.bjp.0704569","article-title":"NO as a signalling molecule in the nervous system","volume":"135","author":"Esplugues","year":"2002","journal-title":"Brit J Pharmacol"},{"key":"10.1016\/j.bbr.2011.07.024_bib0050","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/S0005-2728(99)00024-9","article-title":"Guanylate cyclase and the NO\/cGMP signaling pathway","volume":"1411","author":"Denninger","year":"1999","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.bbr.2011.07.024_bib0055","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S0014-2999(99)00191-0","article-title":"Nitric oxide synthase inhibitors have antidepressant-like properties in mice 1. Acute treatments are active in the forced swim test","volume":"372","author":"Harkin","year":"1999","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.bbr.2011.07.024_bib0060","first-page":"3699","article-title":"Evidence for dual effects of nitric oxide in the forced swimming test and in the tail suspension test in mice","volume":"11","author":"da Silva","year":"2000","journal-title":"Neuro Report"},{"key":"10.1016\/j.bbr.2011.07.024_bib0065","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0304-3940(03)00306-9","article-title":"Melatonin exerts an antidepressant-like effect in the tail suspension test in mice: evidence for evidence for involvement of N-methyl-d-aspartate receptors and the l-arginine-nitric oxide pathway","volume":"343","author":"Mantovani","year":"2003","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.bbr.2011.07.024_bib0070","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.ejphar.2008.08.033","article-title":"Antidepressant-like effect of folic acid: involvement of NMDA receptors and l-arginine-nitric oxide-cyclic guanosine monophosphate pathway","volume":"598","author":"Brocardo","year":"2008","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.bbr.2011.07.024_bib0075","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1111\/j.1749-6632.1975.tb29266.x","article-title":"Synthesis and some major functions of vitamin C in animals","volume":"258","author":"Chatterjee","year":"1975","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.bbr.2011.07.024_bib0080","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/0006-8993(90)90379-P","article-title":"Regulation of the NMDA receptor by redox phenomena: inhibitory role of ascorbate","volume":"537","author":"Majewska","year":"1990","journal-title":"Brain Res"},{"key":"10.1016\/j.bbr.2011.07.024_bib0085","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1097\/00001756-199011000-00004","article-title":"Ascorbic acid protects neurons from injury induced by glutamate and NMDA","volume":"1","author":"Majewska","year":"1990","journal-title":"Neuroreport"},{"key":"10.1016\/j.bbr.2011.07.024_bib0090","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/0301-0082(94)90052-3","article-title":"A vitamin as neuromodulator: ascorbate release into the extracellular fluid of the brain regulates dopaminergic and glutamatergic transmission","volume":"43","author":"Rebec","year":"1994","journal-title":"Prog Neurobiol"},{"key":"10.1016\/j.bbr.2011.07.024_bib0095","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.neulet.2005.02.032","article-title":"Evidence for the involvement of glutamatergic system in the antinociceptive effect of ascorbic acid","volume":"381","author":"Rosa","year":"2005","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.bbr.2011.07.024_bib0100","doi-asserted-by":"crossref","first-page":"2172","DOI":"10.1016\/j.lfs.2005.09.022","article-title":"Effect of acute and chronic MK-801 administration on extracellular glutamate and ascorbic acid release in the prefrontal cortex of freely moving mice on line with open-field behavior","volume":"78","author":"Zuo","year":"2006","journal-title":"Life Sci"},{"key":"10.1016\/j.bbr.2011.07.024_bib0105","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/j.freeradbiomed.2008.12.018","article-title":"Vitamin C function in the brain: vital role of the ascorbate transporter SVCT2","volume":"46","author":"Harrison","year":"2009","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.bbr.2011.07.024_bib0110","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/S0006-3223(02)01329-X","article-title":"High-dose ascorbic acid increases intercourse frequency and improves mood: a randomized controlled clinical trial","volume":"52","author":"Brody","year":"2002","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.bbr.2011.07.024_bib0115","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1542\/peds.65.4.862","article-title":"Antidepressant effect of vitamin C","volume":"65","author":"Cocchi","year":"1980","journal-title":"Pediatrics"},{"key":"10.1016\/j.bbr.2011.07.024_bib0120","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/j.pnpbp.2009.02.003","article-title":"Ascorbic acid administration produces an antidepressant-like effect: evidence for the involvement of monoaminergic neurotransmission","volume":"33","author":"Binfar\u00e9","year":"2009","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"10.1016\/j.bbr.2011.07.024_bib0125","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/BF00428203","article-title":"The tail suspension test: a new method for screening antidepressants in mice","volume":"85","author":"Steru","year":"1985","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.bbr.2011.07.024_bib0130","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.bbr.2005.11.023","article-title":"Evidence for the involvement of l-arginine-nitric oxide-cyclic guanosine monophosphate pathway in the antidepressant-like effect of memantine in mice","volume":"168","author":"Almeida","year":"2006","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.bbr.2011.07.024_bib0135","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.euroneuro.2007.07.011","article-title":"Nitric oxide involvement in the antidepressant-like effects of acute lithium administration in the mouse forced swimming test","volume":"18","author":"Ghasemi","year":"2008","journal-title":"Eur Neuropsychopharmacol"},{"key":"10.1016\/j.bbr.2011.07.024_bib0140","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1017\/S1461145705005316","article-title":"Involvement of nitric oxide-cGMP pathway in the antidepressant-like effects of adenosine in the forced swimming test","volume":"8","author":"Kaster","year":"2005","journal-title":"Int J Neuropsychopharmacol"},{"key":"10.1016\/j.bbr.2011.07.024_bib0145","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.ejphar.2007.05.002","article-title":"Possible involvement of l-arginine\u2013nitric oxide (NO)-cyclic guanosine monophosphate (cGMP) signaling pathway in the antidepressant-like activity of berberine chloride","volume":"569","author":"Kulkarni","year":"2007","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.bbr.2011.07.024_bib0150","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S0166-4328(03)00069-X","article-title":"Involvement of NMDA receptors and l-arginine-nitric oxide pathway in the antidepressant-like effects of zinc in mice","volume":"144","author":"Rosa","year":"2003","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.bbr.2011.07.024_bib0155","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/j.euroneuro.2010.07.011","article-title":"Involvement of NMDA receptors and l-arginine-nitric oxide-cyclic guanosine monophosphate pathway in the antidepressant-like effects of escitalopram in the forced swimming test","volume":"20","author":"Zomkowski","year":"2010","journal-title":"Eur Neuropsychopharmacol"},{"key":"10.1016\/j.bbr.2011.07.024_bib0160","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.bbr.2005.06.015","article-title":"A proposal of decision tree to screen putative antidepressants using forced swim and tail suspension tests","volume":"164","author":"Bourin","year":"2005","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.bbr.2011.07.024_bib0165","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/S0165-6147(02)02017-5","article-title":"Assessing antidepressant activity in rodents: recent developments and future needs","volume":"23","author":"Cryan","year":"2002","journal-title":"Trends Pharmacol Sci"},{"key":"10.1016\/j.bbr.2011.07.024_bib0170","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1002\/hup.178","article-title":"How valuable are animal models in defining antidepressant activity?","volume":"16","author":"Bourin","year":"2001","journal-title":"Hum Psychopharmacol"},{"key":"10.1016\/j.bbr.2011.07.024_bib0175","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/35072566","article-title":"Research treatment approaches to depression","volume":"2","author":"Wong","year":"2001","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.bbr.2011.07.024_bib0180","doi-asserted-by":"crossref","first-page":"125","DOI":"10.3109\/hrp.7.3.125","article-title":"NMDA agonists and antagonists as probes of glutamatergic dysfunction and pharmacotherapies in neuropsychiatric disorders","volume":"7","author":"Krystal","year":"1999","journal-title":"Harv Rev Psychiatry"},{"key":"10.1016\/j.bbr.2011.07.024_bib0185","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1038\/sj.mp.4001551","article-title":"Glutamate as a therapeutic target in psychiatric disorders","volume":"9","author":"Javitt","year":"2004","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.bbr.2011.07.024_bib0190","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1038\/nrd2462","article-title":"Targeting the glutamatergic system to develop novel, improved therapeutics for mood disorders","volume":"7","author":"Sanacora","year":"2008","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.bbr.2011.07.024_bib0195","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0014-2999(99)00330-1","article-title":"Antidepressants for the new millennium","volume":"375","author":"Skolnick","year":"1999","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.bbr.2011.07.024_bib0200","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/S0165-6147(00)89077-X","article-title":"NMDA receptor redox sites: are they targets for selective neuronal protection?","volume":"16","author":"Gozlan","year":"1995","journal-title":"Trends Pharmacol Sci"},{"key":"10.1016\/j.bbr.2011.07.024_bib0205","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s002139900316","article-title":"Antidepressant-like effects of 7-nitroindazole in the forced swimming test in rats","volume":"149","author":"Yildiz","year":"2000","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.bbr.2011.07.024_bib0210","first-page":"587","article-title":"Effect of NOS inhibitor on forced swim test and neurotransmitters turnover in the mouse brain","volume":"53","author":"Karolewicz","year":"2001","journal-title":"Pol J Pharmacol"},{"key":"10.1016\/j.bbr.2011.07.024_bib0215","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/S0028-3908(03)00030-3","article-title":"Serotonergic mediation of the antidepressant-like effects of nitric oxide synthase inhibitors","volume":"44","author":"Harkin","year":"2003","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bbr.2011.07.024_bib0220","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0166-4328(02)00312-1","article-title":"Antidepressant and anxiolytic-like effects of selective neuronal NOS inhibitor 1-(2-trifluoromethylphenyl)-imidazole in mice","volume":"140","author":"Volke","year":"2003","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.bbr.2011.07.024_bib0225","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.bbr.2010.11.027","article-title":"The antidepressant action of imipramine and venlafaxine involves suppression of nitric oxide synthesis","volume":"218","author":"Krass","year":"2011","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.bbr.2011.07.024_bib0230","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1111\/j.1471-4159.2007.04914.x","article-title":"Neuronal nitric oxide synthase contributes to chronic stress-induced depression by suppressing hippocampal neurogenesis","volume":"103","author":"Zhou","year":"2007","journal-title":"J Neurochem"},{"key":"10.1016\/j.bbr.2011.07.024_bib0235","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/j.pnpbp.2007.02.008","article-title":"Involvement of l-arginine-nitric oxide cyclic guanosine monophosphate pathway in the antidepressant-like effect of venlafaxine in mice","volume":"31","author":"Dhir","year":"2007","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"10.1016\/j.bbr.2011.07.024_bib0240","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1172\/JCI117683","article-title":"cGMP inhibition of heart phosphodiesterase: is it clinically relevant?","volume":"95","author":"Beavo","year":"1995","journal-title":"J Clin Invest"}],"container-title":["Behavioural Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432811005420?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432811005420?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,4,9]],"date-time":"2024-04-09T02:01:43Z","timestamp":1712628103000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166432811005420"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,11]]},"references-count":48,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,11]]}},"alternative-id":["S0166432811005420"],"URL":"https:\/\/doi.org\/10.1016\/j.bbr.2011.07.024","relation":{},"ISSN":["0166-4328"],"issn-type":[{"value":"0166-4328","type":"print"}],"subject":[],"published":{"date-parts":[[2011,11]]}}}