{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T05:29:01Z","timestamp":1789622941531,"version":"build-2803163510"},"reference-count":59,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Behavioural Brain Research"],"published-print":{"date-parts":[[2012,1]]},"DOI":"10.1016\/j.bbr.2011.08.044","type":"journal-article","created":{"date-parts":[[2011,9,7]],"date-time":"2011-09-07T04:14:26Z","timestamp":1315368866000},"page":"50-55","source":"Crossref","is-referenced-by-count":20,"title":["5-HT2A receptor activation in the dorsolateral septum facilitates inhibitory avoidance in the elevated T-maze"],"prefix":"10.1016","volume":"226","author":[{"given":"D.C.","family":"de Paula","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.S.","family":"Torricelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.R.","family":"Lopreato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.O.G.","family":"Nascimento","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.B.","family":"Viana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbr.2011.08.044_bib0005","series-title":"The neuropsychology of anxiety","author":"Gray","year":"1987"},{"key":"10.1016\/j.bbr.2011.08.044_bib0010","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/0006-8993(91)90975-2","article-title":"Septal unit activity during classical conditioning: a regional comparison","volume":"547","author":"Thomas","year":"1991","journal-title":"Brain Res"},{"key":"10.1016\/j.bbr.2011.08.044_bib0015","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.pbb.2004.10.018","article-title":"Effects of chlordiazepoxide on single-unit activity in the septal region of the freely moving rat: aversive vs. non-aversive contexts","volume":"80","author":"Thomas","year":"2005","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.bbr.2011.08.044_bib0020","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1016\/0031-9384(93)90362-J","article-title":"The role of the lateral septum in anxiolysis","volume":"53","author":"Yadin","year":"1993","journal-title":"Physiol Behav"},{"key":"10.1016\/j.bbr.2011.08.044_bib0025","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/S0031-9384(96)00138-2","article-title":"Lateral and medial septal lesions reduce anxiety in the plus-maze and probe-burying tests","volume":"60","author":"Menard","year":"1996","journal-title":"Physiol Behav"},{"key":"10.1016\/j.bbr.2011.08.044_bib0030","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.brainresrev.2004.04.009","article-title":"Regulation of affect by the lateral septum: implications for neuropsychiatry","volume":"46","author":"Sheehan","year":"2004","journal-title":"Brain Res Rev"},{"key":"10.1016\/j.bbr.2011.08.044_bib0035","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.pbb.2008.01.007","article-title":"5-HT1A receptors of the lateral septum regulate inhibitory avoidance but not escape behavior in rats","volume":"89","author":"Viana","year":"2008","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.bbr.2011.08.044_bib0040","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/0166-4328(93)90028-O","article-title":"Induction of Fos immunoreactivity in the brain by exposure to the elevated plus-maze","volume":"56","author":"Silveira","year":"1993","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.bbr.2011.08.044_bib0045","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/0006-8993(94)01451-M","article-title":"c-fos Immunoreactivity in the brain following electrical or chemical stimulation of the medial hypothalamus of freely moving rats","volume":"674","author":"Silveira","year":"1995","journal-title":"Brain Res"},{"key":"10.1016\/j.bbr.2011.08.044_bib0050","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/0361-9230(93)90225-Z","article-title":"Stress-induced c-fos expression in the rat brain: activation mechanism of sympathetic pathway","volume":"31","author":"Senba","year":"1993","journal-title":"Brain Res Bull"},{"key":"10.1016\/j.bbr.2011.08.044_bib0055","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1037\/0735-7044.114.2.337","article-title":"Using c-Fos immunocytochemistry to identify forebrain regions that may inhibit maternal behavior in rats","volume":"114","author":"Sheehan","year":"2000","journal-title":"Behav Neurosci"},{"key":"10.1016\/j.bbr.2011.08.044_bib0060","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1016\/S0306-4522(01)00150-6","article-title":"\u201cWhen a rat smells a cat\u201d: the distribution of Fos immunoreactivity in rat brain following exposure to a predatory odor","volume":"104","author":"Dielenberg","year":"2001","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbr.2011.08.044_bib0065","doi-asserted-by":"crossref","first-page":"3855","DOI":"10.1523\/JNEUROSCI.23-09-03855.2003","article-title":"Neural correlates of competing fear behaviors evoked by an innately aversive stimulus","volume":"23","author":"Mongeau","year":"2003","journal-title":"J Neurosci"},{"key":"10.1016\/j.bbr.2011.08.044_bib0070","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/j.biopsych.2003.10.021","article-title":"Neurobiological correlates of high (HAB) versus low anxiety-related behavior (LAB): differential Fos expression in HAB and LAB rats","volume":"55","author":"Salome","year":"2004","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.bbr.2011.08.044_bib0075","doi-asserted-by":"crossref","first-page":"2825","DOI":"10.1111\/j.1460-9568.2005.04107.x","article-title":"Effects of exposure to a predator on behaviour and serotonergic neurotransmission in different brain regions of C57b1\/6N mice","volume":"21","author":"Beekman","year":"2005","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.bbr.2011.08.044_bib0080","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.ygcen.2005.11.014","article-title":"Widespread tissue distribution and diverse functions of corticotropin-releasing factor and related peptides","volume":"146","author":"Boorse","year":"2006","journal-title":"Gen Comp Endocrinol"},{"key":"10.1016\/j.bbr.2011.08.044_bib0085","doi-asserted-by":"crossref","first-page":"2833","DOI":"10.1523\/JNEUROSCI.21-08-02833.2001","article-title":"Regulation of serotonin release in the lateral septum and striatum by corticotropin-releasing factor","volume":"21","author":"Price","year":"2001","journal-title":"J Neurosci"},{"key":"10.1016\/j.bbr.2011.08.044_bib0090","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1016\/S0278-5846(00)00129-9","article-title":"Hippocampal and septal injections of nicotine and 8-OH-DPAT distinguish among different animal tests of anxiety","volume":"24","author":"Cheeta","year":"2000","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"10.1016\/j.bbr.2011.08.044_bib0095","doi-asserted-by":"crossref","first-page":"3797","DOI":"10.1046\/j.1460-9568.2000.00246.x","article-title":"The role of 5-HT1A receptors in mediating the anxiogenic effects of nicotine following lateral septal administration","volume":"12","author":"Cheeta","year":"2000","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.bbr.2011.08.044_bib0100","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/0166-4328(93)90104-X","article-title":"Multiple serotonin mechanisms in animal models of anxiety: environmental, emotional and cognitive factors","volume":"58","author":"Handley","year":"1993","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.bbr.2011.08.044_bib0105","series-title":"Handbook of anxiety and fear","first-page":"11","article-title":"Theoretical approaches to the modeling of anxiety in animals","author":"McNaughton","year":"2008"},{"key":"10.1016\/j.bbr.2011.08.044_bib0110","series-title":"Biological psychiatry","first-page":"879","article-title":"Animal models of anxiety","author":"Graeff","year":"2002"},{"key":"10.1016\/j.bbr.2011.08.044_bib0115","first-page":"67","article-title":"The elevated T maze, a new experimental model of anxiety and memory: effect of diazepam","volume":"26","author":"Graeff","year":"1993","journal-title":"Braz J Med Biol Res"},{"key":"10.1016\/j.bbr.2011.08.044_bib0120","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/0091-3057(94)90067-1","article-title":"The elevated T-maze: a new animal model of anxiety and memory","volume":"49","author":"Viana","year":"1994","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.bbr.2011.08.044_bib0125","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/S0091-3057(99)00261-0","article-title":"Behavioral effects of acute and chronic imipramine in the elevated T-maze model of anxiety","volume":"65","author":"Teixeira","year":"2000","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.bbr.2011.08.044_bib0130","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S0166-4328(03)00151-7","article-title":"Antipanic-like effect of serotonin reuptake inhibitors in the elevated T-maze","volume":"147","author":"Poltronieri","year":"2003","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.bbr.2011.08.044_bib0135","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0149-7634(01)00009-4","article-title":"Mouse defensive behaviors: pharmacological and behavioral assays for anxiety and panic","volume":"25","author":"Blanchard","year":"2001","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1016\/j.bbr.2011.08.044_bib0140","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1007\/s002130050299","article-title":"Effect of imipramine treatments on the 5-HT1A-receptor-mediated inhibition of panic-like behaviours in rats","volume":"131","author":"Mongeau","year":"1997","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.bbr.2011.08.044_bib0145","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/0165-1781(95)02673-K","article-title":"Dorsal periaqueductal gray-induced aversion as a simulation of panic anxiety: elements of face and predictive validity","volume":"57","author":"Jenck","year":"1995","journal-title":"Psychiatry Res"},{"key":"10.1016\/j.bbr.2011.08.044_bib0150","series-title":"The neuropsychology of anxiety","author":"Gray","year":"2001"},{"key":"10.1016\/j.bbr.2011.08.044_bib0155","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.neubiorev.2004.03.005","article-title":"A two-dimensional neuropsychology of defense: fear\/anxiety and defensive distance","volume":"28","author":"McNaughton","year":"2004","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1016\/j.bbr.2011.08.044_bib0160","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.neubiorev.2003.12.004","article-title":"Serotonin, the periaqueductal gray and panic","volume":"28","author":"Graeff","year":"2004","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1016\/j.bbr.2011.08.044_bib0165","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbr.2007.10.018","article-title":"Different patterns of freezing behavior organized in the periaqueductal gray of rats: association with different types of anxiety","volume":"188","author":"Brand\u00e3o","year":"2008","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.bbr.2011.08.044_bib0170","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/0169-328X(94)90223-2","article-title":"Distribution of the serotonin 5-HT 2 receptor family mRNAs: comparison between 5-HT2A and 5-HT2C receptors","volume":"23","author":"Pompeiano","year":"1994","journal-title":"Mol Brain Res"},{"key":"10.1016\/j.bbr.2011.08.044_bib0175","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1002\/cne.903510304","article-title":"Comparative localization of serotonin1A, 1C, and 2 receptor subtype mRNAs in rat brain","volume":"351","author":"Wright","year":"1995","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.bbr.2011.08.044_bib0180","doi-asserted-by":"crossref","first-page":"11","DOI":"10.2174\/1568007043482598","article-title":"5-HT2 receptors","volume":"3","author":"Leysen","year":"2004","journal-title":"Curr Drug Targets CNS Neurol Disord"},{"key":"10.1016\/j.bbr.2011.08.044_bib0185","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1002\/(SICI)1096-9861(19990628)409:2<187::AID-CNE2>3.0.CO;2-P","article-title":"Cellular and subcellular distribution of the serotonin 5-HT2A receptor in the central nervous system of adult rat","volume":"409","author":"C\u00f3rnea-Herbert","year":"1999","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.bbr.2011.08.044_bib0190","first-page":"291","article-title":"Anxiolytic-like effects of DOI microinjections into the hippocampus (but not the amygdala nor the PAG) in the mice four plates test","volume":"188","author":"Mass\u00e9","year":"2008","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.bbr.2011.08.044_bib0195","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.bbr.2009.06.006","article-title":"Brain structures implicated in the four-plate test in na\u00efve and experienced Swiss mice using injection of diazepam and the 5-HT2A agonist DOI","volume":"204","author":"Petit-Demouli\u00e8re","year":"2009","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.bbr.2011.08.044_bib0200","doi-asserted-by":"crossref","first-page":"207","DOI":"10.2174\/1871524911006030207","article-title":"The dual role of serotonin in defense and the mode of action of antidepressants on generalized anxiety and panic disorders","volume":"10","author":"Graeff","year":"2010","journal-title":"Cent Nerv Syst Agents Med Chem"},{"key":"10.1016\/j.bbr.2011.08.044_bib0205","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.neuropharm.2010.09.001","article-title":"5-HT2C receptor regulation of defensive responses in the rat dorsal periaqueductal gray","volume":"60","author":"Yamashita","year":"2011","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bbr.2011.08.044_bib0210","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0166-4328(02)00399-6","article-title":"The dorsal raphe nucleus exerts opposed control on generalized anxiety and panic-related defensive responses in rats","volume":"142","author":"Sena","year":"2003","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.bbr.2011.08.044_bib0215","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.brainresbull.2004.06.007","article-title":"Involvement of 5-HT1A and 5-HT2 receptors of the dorsal periaqueductal gray in the regulation of the defensive behaviors generated by the elevated T-maze","volume":"64","author":"De Paula Soares","year":"2004","journal-title":"Brain Res Bull"},{"key":"10.1016\/j.bbr.2011.08.044_bib0220","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.bbr.2008.08.027","article-title":"Stimulation of 5-HT1A or 5-HT2A receptors in the ventrolateral periaqueductal gray causes anxiolytic-, but not panicolytic-like effect in rats","volume":"197","author":"De Paula Soares","year":"2009","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.bbr.2011.08.044_bib0225","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/0091-3057(93)90492-C","article-title":"Anxiogenic stimuli in the elevated plus-maze","volume":"44","author":"Treit","year":"1993","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.bbr.2011.08.044_bib0230","series-title":"The rat brain in stereotaxic coordinates","author":"Paxinos","year":"1998"},{"key":"10.1016\/j.bbr.2011.08.044_bib0235","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1097\/01.fbp.0000179280.05654.5a","article-title":"Chronic imipramine treatment sensitizes 5-HT1A and 5-HT2A receptors in the dorsal periaqueductal gray matter: evidence from the elevated T-maze test of anxiety","volume":"16","author":"Zanoveli","year":"2005","journal-title":"Behav Pharmacol"},{"key":"10.1016\/j.bbr.2011.08.044_bib0240","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1016\/j.bbr.2010.09.016","article-title":"Facilitation of 5-HT(2A\/2C)-mediated neurotransmission in the ventromedial hypothalamic nucleus decreases anxiety in the elevated T-maze","volume":"216","author":"Silva","year":"2011","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.bbr.2011.08.044_bib0245","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.euroneuro.2006.11.002","article-title":"Effect of GABAergic ligands on the anxiolytic-like activity of DOI (5-HT2A\/2C agonist) in the four-plate test","volume":"17","author":"Mass\u00e9","year":"2007","journal-title":"Eur Neuropsychopharmacology"},{"key":"10.1016\/j.bbr.2011.08.044_bib0250","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/0014-2999(96)00325-1","article-title":"5-HT2A receptor antagonists inhibit potassium stimulated-aminobutyric acid release in rat frontal cortex","volume":"309","author":"Cozzi","year":"1996","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.bbr.2011.08.044_bib0255","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0304-3940(02)00182-9","article-title":"Co-localization of 5-HT2A-receptor- and GABA immunoreactivity in neurones in the periaqueductal grey matter of the rat","volume":"326","author":"Griffiths","year":"2002","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.bbr.2011.08.044_bib0260","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.brainres.2004.03.016","article-title":"Chemical identity of 5-HT2A receptor immunoreactive neurons of the rat septal complex and dorsal hippocampus","volume":"1010","author":"Luttgen","year":"2004","journal-title":"Brain Res"},{"key":"10.1016\/j.bbr.2011.08.044_bib0265","series-title":"Psychopharmacology: the fourth generation of progress","first-page":"1451","article-title":"Electrophysiology of serotonin receptor subtypes and signal transduction pathways","author":"Aghajanian","year":"1995"},{"key":"10.1016\/j.bbr.2011.08.044_bib0270","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/S0091-3057(01)00746-8","article-title":"Molecular, pharmacological and functional diversity of 5-HT receptors","volume":"71","author":"Hoyer","year":"2002","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.bbr.2011.08.044_bib0275","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/336170a0","article-title":"GABA-containing neurons in the septum control inhibitory interneurons in the hippocampus","volume":"336","author":"Freund","year":"1988","journal-title":"Nature"},{"key":"10.1016\/j.bbr.2011.08.044_bib0280","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1007\/BF02245806","article-title":"Anxiogenic-like effect of infusing 1-(3-chlorophenyl) piperazine (mCPP) into the hippocampus","volume":"100","author":"Whitton","year":"1990","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.bbr.2011.08.044_bib0285","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1097\/00008877-200402000-00005","article-title":"Anxiogenic effects in the rat elevated plus-maze of 5-HT(2C) agonists into ventral but not dorsal hippocampus","volume":"15","author":"Alves","year":"2004","journal-title":"Behav Pharmacol"},{"key":"10.1016\/j.bbr.2011.08.044_bib0290","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.bbr.2006.12.003","article-title":"Anxiogenic-like effects of mCPP microinfusions into the amygdala (but not dorsal or ventral hippocampus) in mice exposed to elevated plus-maze","volume":"178","author":"Corn\u00e9lio","year":"2007","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.bbr.2011.08.044_bib0295","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1017\/S1461145711000873","article-title":"Serotonin-2C receptors in the basolateral nucleus of the amygdala mediate the anxiogenic effect of acute imipramine and fluoxetine administration","volume":"14","author":"Vicente","year":"2011","journal-title":"Int J Neuropsychopharmacol"}],"container-title":["Behavioural Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432811006516?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432811006516?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,6,14]],"date-time":"2019-06-14T21:59:10Z","timestamp":1560549550000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166432811006516"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,1]]},"references-count":59,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,1]]}},"alternative-id":["S0166432811006516"],"URL":"https:\/\/doi.org\/10.1016\/j.bbr.2011.08.044","relation":{},"ISSN":["0166-4328"],"issn-type":[{"value":"0166-4328","type":"print"}],"subject":[],"published":{"date-parts":[[2012,1]]}}}