{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T00:00:17Z","timestamp":1790985617802,"version":"4.1.0"},"reference-count":53,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Behavioural Brain Research"],"published-print":{"date-parts":[[2012,1]]},"DOI":"10.1016\/j.bbr.2011.09.033","type":"journal-article","created":{"date-parts":[[2011,9,29]],"date-time":"2011-09-29T21:38:41Z","timestamp":1317332321000},"page":"386-396","source":"Crossref","is-referenced-by-count":95,"title":["Ethyl-eicosapentaenoate (E-EPA) attenuates motor impairments and inflammation in the MPTP-probenecid mouse model of Parkinson's disease"],"prefix":"10.1016","volume":"226","author":[{"given":"D.W.","family":"Luchtman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Q.","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbr.2011.09.033_bib0005","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/S0896-6273(03)00568-3","article-title":"Parkinson's disease: mechanisms and models","volume":"39","author":"Dauer","year":"2003","journal-title":"Neuron"},{"key":"10.1016\/j.bbr.2011.09.033_bib0010","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1159\/000119104","article-title":"A modern hypothesis: the distinct pathologies of dementia associated with Parkinson's disease versus Alzheimer's disease","volume":"25","author":"Farlow","year":"2008","journal-title":"Dement Geriatr Cogn Disord"},{"key":"10.1016\/j.bbr.2011.09.033_bib0015","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/s00441-004-0944-0","article-title":"Cellular pathology of Parkinson's disease: astrocytes, microglia and inflammation","volume":"318","author":"Teismann","year":"2004","journal-title":"Cell Tissue Res"},{"key":"10.1016\/j.bbr.2011.09.033_bib0020","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/0306-4522(90)90229-W","article-title":"Heterogeneity in the distribution and morphology of microglia","volume":"39","author":"Lawson","year":"1990","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbr.2011.09.033_bib0025","doi-asserted-by":"crossref","first-page":"2634","DOI":"10.1046\/j.1471-4159.1998.71062634.x","article-title":"Mice deficient in group IV cytosolic phospholipase A2 are resistant to MPTP neurotoxicity","volume":"71","author":"Klivenyi","year":"1998","journal-title":"J Neurochem"},{"key":"10.1016\/j.bbr.2011.09.033_bib0030","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1111\/j.1749-6632.2003.tb07482.x","article-title":"COX-2 and neurodegeneration in Parkinson's disease","volume":"991","author":"Teismann","year":"2003","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.bbr.2011.09.033_bib0035","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1002\/jnr.20599","article-title":"Loss of dopaminergic neurons by the induction of inducible nitric oxide synthase and cyclooxygenase-2 via CD 40: relevance to Parkinson's disease","volume":"81","author":"Okuno","year":"2005","journal-title":"J Neurosci Res"},{"key":"10.1016\/j.bbr.2011.09.033_bib0040","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.plefa.2006.05.012","article-title":"Polyunsaturated fatty acids and inflammation","volume":"75","author":"Calder","year":"2006","journal-title":"Prostaglandins Leukot Essent Fatty Acids"},{"key":"10.1016\/j.bbr.2011.09.033_bib0045","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.jns.2009.09.021","article-title":"Dietary fat intake and risk of Parkinson's disease: a case-control study in Japan","volume":"288","author":"Miyake","year":"2010","journal-title":"J Neurol Sci"},{"key":"10.1016\/j.bbr.2011.09.033_bib0050","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.ejphar.2010.09.046","article-title":"Ethyl-eicosapentaenoate modulates changes in neurochemistry and brain lipids induced by Parkinsonian neurotoxin 1-methyl-4-phenylpyridinium in mouse brain slices","volume":"649","author":"Meng","year":"2010","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.bbr.2011.09.033_bib0055","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1007\/s12017-008-8036-z","article-title":"Neurological benefits of omega-3 fatty acids","volume":"10","author":"Dyall","year":"2008","journal-title":"Neuromol Med"},{"key":"10.1016\/j.bbr.2011.09.033_bib0060","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/S0736-5748(00)00013-7","article-title":"Essential fatty acids and the brain: possible health implications","volume":"18","author":"Youdim","year":"2000","journal-title":"Int J Dev Neurosci"},{"key":"10.1016\/j.bbr.2011.09.033_bib0065","doi-asserted-by":"crossref","first-page":"10931","DOI":"10.1073\/pnas.0402342101","article-title":"Effects of dietary omega-3 polyunsaturated fatty acids on brain gene expression","volume":"101","author":"Kitajka","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.bbr.2011.09.033_bib0070","doi-asserted-by":"crossref","first-page":"93","DOI":"10.2174\/138161206780574579","article-title":"PPAR-gamma agonists as regulators of microglial activation and brain inflammation","volume":"12","author":"Bernardo","year":"2006","journal-title":"Curr Pharm Des"},{"key":"10.1016\/j.bbr.2011.09.033_bib0075","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.plefa.2006.07.006","article-title":"Omega-3 fatty acids and rodent behavior","volume":"75","author":"Fedorova","year":"2006","journal-title":"Prostaglandins Leukot Essent Fatty Acids"},{"key":"10.1016\/j.bbr.2011.09.033_bib0080","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.disamonth.2007.05.002","article-title":"Current pharmacotherapeutic treatment options in Parkinson's disease","volume":"53","author":"Rezak","year":"2007","journal-title":"Dis Mon"},{"key":"10.1016\/j.bbr.2011.09.033_bib0085","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1096\/fj.07-9677com","article-title":"Beneficial effects of dietary omega-3 polyunsaturated fatty acid on toxin-induced neuronal degeneration in an animal model of Parkinson's disease","volume":"22","author":"Bousquet","year":"2008","journal-title":"FASEB J"},{"key":"10.1016\/j.bbr.2011.09.033_bib0090","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1016\/j.pnpbp.2009.07.018","article-title":"Modulation of brain-derived neurotrophic factor as a potential neuroprotective mechanism of action of omega-3 fatty acids in a Parkinsonian animal model","volume":"33","author":"Bousquet","year":"2009","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"10.1016\/j.bbr.2011.09.033_bib0095","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.neures.2009.11.006","article-title":"Evaluation of chronic omega-3 fatty acids supplementation on behavioral and neurochemical alterations in 6-hydroxydopamine-lesion model of Parkinson's disease","volume":"66","author":"Delattre","year":"2010","journal-title":"Neurosci Res"},{"key":"10.1016\/j.bbr.2011.09.033_bib0100","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.jnutbio.2008.12.015","article-title":"Effects of eicosapentaenoic acid on synaptic plasticity, fatty acid profile and phosphoinositide 3-kinase signaling in rat hippocampus and differentiated PC12 cells","volume":"21","author":"Kawashima","year":"2010","journal-title":"J Nutr Biochem"},{"key":"10.1016\/j.bbr.2011.09.033_bib0105","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/S0920-9964(00)00083-9","article-title":"Two double-blind placebo-controlled pilot studies of eicosapentaenoic acid in the treatment of schizophrenia","volume":"49","author":"Peet","year":"2010","journal-title":"Schizophr Res"},{"key":"10.1016\/j.bbr.2011.09.033_bib0110","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.plefa.2009.01.005","article-title":"Rapid beta-oxidation of eicosapentaenoic acid in mouse brain: an in situ study","volume":"80","author":"Chen","year":"2009","journal-title":"Prostaglandins Leukot Essent Fatty Acids"},{"key":"10.1016\/j.bbr.2011.09.033_bib0115","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1194\/jlr.M300526-JLR200","article-title":"Omega-3 fatty acid ethyl-eicosapentaenoate, but not soybean oil, attenuates memory impairment induced by central IL-1beta administration","volume":"45","author":"Song","year":"2004","journal-title":"J Lipid Res"},{"key":"10.1016\/j.bbr.2011.09.033_bib0120","doi-asserted-by":"crossref","first-page":"1984","DOI":"10.1194\/jlr.M300217-JLR200","article-title":"Effects of dietary n-3 or n-6 fatty acids on interleukin-1beta-induced anxiety, stress, and inflammatory responses in rats","volume":"44","author":"Song","year":"2003","journal-title":"J Lipid Res"},{"key":"10.1016\/j.bbr.2011.09.033_bib0125","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1093\/jn\/138.5.954","article-title":"Long-chain polyunsaturated fatty acids modulate interleukin-1beta-induced changes in behavior, monoaminergic neurotransmitters, and brain inflammation in rats","volume":"138","author":"Song","year":"2008","journal-title":"J Nutr"},{"key":"10.1016\/j.bbr.2011.09.033_bib0130","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1038\/sj.mp.4001462","article-title":"Ethyl-eicosapentaenoic acid ingestion prevents corticosterone-mediated memory impairment induced by central administration of interleukin-1beta in rats","volume":"9","author":"Song","year":"2004","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.bbr.2011.09.033_bib0135","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.physbeh.2009.04.021","article-title":"Behavior, neurotransmitters and inflammation in three regimens of the MPTP mouse model of Parkinson's disease","volume":"98","author":"Luchtman","year":"2009","journal-title":"Physiol Behav"},{"key":"10.1016\/j.bbr.2011.09.033_bib0140","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/S0306-4522(01)00295-0","article-title":"Mouse model of Parkinsonism: a comparison between subacute MPTP and chronic MPTP\/probenecid treatment","volume":"106","author":"Petroske","year":"2001","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbr.2011.09.033_bib0145","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/S0006-8993(96)01162-6","article-title":"Drug-free evaluation of rat models of Parkinsonism and nigral grafts using a new automated rotarod test","volume":"749","author":"Rozas","year":"1997","journal-title":"Brain Res"},{"key":"10.1016\/j.bbr.2011.09.033_bib0150","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.pbb.2006.02.007","article-title":"Effects of taurine on rat behaviors in three anxiety models","volume":"83","author":"Kong","year":"2006","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.bbr.2011.09.033_bib0155","first-page":"435","article-title":"A simple quantitative bradykinesia test in MPTP-treated mice","volume":"50","author":"Ogawa","year":"1985","journal-title":"Res Commun Chem Pathol Pharmacol"},{"key":"10.1016\/j.bbr.2011.09.033_bib0160","doi-asserted-by":"crossref","first-page":"1902","DOI":"10.1111\/j.1460-9568.2007.05812.x","article-title":"Non-motor behavioural impairments in parkin-deficient mice","volume":"26","author":"Zhu","year":"2007","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.bbr.2011.09.033_bib0165","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/S1074-7427(03)00008-X","article-title":"Evidence for the substantia nigra pars compacta as an essential component of a memory system independent of the hippocampal memory system","volume":"79","author":"Da Cunha","year":"2003","journal-title":"Neurobiol Learn Mem"},{"issue":"3","key":"10.1016\/j.bbr.2011.09.033_bib0170","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/s11689-010-9049-0","article-title":"Hippocampus specific iron deficiency alters competition and cooperation between developing memory systems","volume":"2","author":"Carlson","year":"2010","journal-title":"J Neurodev Disord"},{"key":"10.1016\/j.bbr.2011.09.033_bib0175","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.jneumeth.2008.08.007","article-title":"Lipopolysaccharide-induced increases in cytokines in discrete mouse brain regions are detectable using Luminex xMAP technology","volume":"175","author":"Datta","year":"2008","journal-title":"J Neurosci Methods"},{"key":"10.1016\/j.bbr.2011.09.033_bib0180","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/0304-3940(96)13091-3","article-title":"Effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and 5,7-dihydroxytryptamine on the locomotor activity and striatal amines in C57BL\/6 mice","volume":"218","author":"Chia","year":"1996","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.bbr.2011.09.033_bib0185","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/S0969-9961(03)00108-6","article-title":"Behavioral changes are not directly related to striatal monoamine levels, number of nigral neurons, or dose of Parkinsonian toxin MPTP in mice","volume":"14","author":"Rousselet","year":"2003","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.bbr.2011.09.033_bib0190","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1152\/jn.2001.85.3.1270","article-title":"Adrenergic hyperactivity and metanephrine excess in the nucleus accumbens after prefrontocortical dopamine depletion","volume":"85","author":"Espejo","year":"2001","journal-title":"J Neurophysiol"},{"key":"10.1016\/j.bbr.2011.09.033_bib0195","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1007\/s12640-009-9091-4","article-title":"Neuroprotective effect of PACAP on translational control alteration and cognitive decline in MPTP Parkinsonian mice","volume":"17","author":"Deguil","year":"2010","journal-title":"Neurotox Res"},{"key":"10.1016\/j.bbr.2011.09.033_bib0200","first-page":"10","article-title":"Restorative effect of endurance exercise on behavioral deficits in the chronic mouse model of Parkinson's disease with severe neurodegeneration","volume":"20","author":"Pothakos","year":"2009","journal-title":"BMC Neurosci"},{"key":"10.1016\/j.bbr.2011.09.033_bib0205","series-title":"Parkinson's disease: diagnosis and clinical management.","first-page":"195","article-title":"Neurochemistry","author":"Rabey","year":"2002"},{"key":"10.1016\/j.bbr.2011.09.033_bib0210","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0304-3940(98)00198-0","article-title":"Sprouting of the serotonergic afferents into striatum after selective lesion of the dopaminergic system by MPTP in adult mice","volume":"245","author":"Rozas","year":"1998","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.bbr.2011.09.033_bib0215","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.nbd.2008.07.015","article-title":"Memory, mood, dopamine, and serotonin in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned mouse model of basal ganglia injury","volume":"32","author":"Vu\u010dkovi\u0107","year":"2008","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.bbr.2011.09.033_bib0220","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/cercor\/bhm026","article-title":"D1 but not D5 dopamine receptors are critical for LTP, spatial learning, and LTP-Induced arc and zif268 expression in the hippocampus","volume":"18","author":"Granado","year":"2008","journal-title":"Cereb Cortex"},{"key":"10.1016\/j.bbr.2011.09.033_bib0225","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1111\/j.1460-9568.2009.06657.x","article-title":"PPARgamma-mediated neuroprotection in a chronic mouse model of Parkinson's disease","volume":"29","author":"Schintu","year":"2009","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.bbr.2011.09.033_bib0230","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1111\/j.1471-4159.2004.02399.x","article-title":"Genetic ablation of tumor necrosis factor-alpha (TNF-alpha) and pharmacological inhibition of TNF-synthesis attenuates MPTP toxicity in mouse striatum","volume":"89","author":"Ferger","year":"2004","journal-title":"J Neurochem"},{"key":"10.1016\/j.bbr.2011.09.033_bib0235","doi-asserted-by":"crossref","first-page":"3328","DOI":"10.1523\/JNEUROSCI.5321-06.2007","article-title":"Involvement of interferon-gamma in microglial-mediated loss of dopaminergic neurons","volume":"27","author":"Mount","year":"2007","journal-title":"J Neurosci"},{"key":"10.1016\/j.bbr.2011.09.033_bib0240","doi-asserted-by":"crossref","first-page":"117","DOI":"10.55782\/ane-2003-1461","article-title":"Dynamics of expression of the mRNA for cytokines and inducible nitric synthase in a murine model of the Parkinson's disease","volume":"63","author":"Ciesielska","year":"2003","journal-title":"Acta Neurobiol Exp"},{"key":"10.1016\/j.bbr.2011.09.033_bib0245","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.neuint.2005.12.002","article-title":"Postmortem brain fatty acid profile of levodopa-treated Parkinson disease patients and Parkinsonian monkeys","volume":"48","author":"Julien","year":"2006","journal-title":"Neurochem Int"},{"key":"10.1016\/j.bbr.2011.09.033_bib0250","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1046\/j.1460-9568.2003.02408.x","article-title":"The mouse MPTP model: gene expression changes in dopaminergic neurons","volume":"317","author":"K\u00fchn","year":"2003","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.bbr.2011.09.033_bib0255","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.2174\/138161208784480153","article-title":"Nonsteroidal anti-inflammatory drugs in experimental Parkinsonian models and Parkinson's disease","volume":"14","author":"Asanuma","year":"2008","journal-title":"Curr Pharm Des"},{"key":"10.1016\/j.bbr.2011.09.033_bib0260","doi-asserted-by":"crossref","first-page":"S7","DOI":"10.1186\/ar1793","article-title":"Balancing the gastrointestinal benefits and risks of nonselective NSAIDs","volume":"7","author":"Peura","year":"2005","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.bbr.2011.09.033_bib0265","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1017\/S0029665107005587","article-title":"Signals generating anorexia during acute illness","volume":"66","author":"Langhans","year":"2007","journal-title":"Proc Nutr Soc"}],"container-title":["Behavioural Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432811007066?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432811007066?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,4,13]],"date-time":"2024-04-13T02:12:10Z","timestamp":1712974330000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166432811007066"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,1]]},"references-count":53,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,1]]}},"alternative-id":["S0166432811007066"],"URL":"https:\/\/doi.org\/10.1016\/j.bbr.2011.09.033","relation":{},"ISSN":["0166-4328"],"issn-type":[{"value":"0166-4328","type":"print"}],"subject":[],"published":{"date-parts":[[2012,1]]}}}