{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T09:19:18Z","timestamp":1777454358700,"version":"3.51.4"},"reference-count":42,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2012,6,1]],"date-time":"2012-06-01T00:00:00Z","timestamp":1338508800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,6,1]],"date-time":"2012-06-01T00:00:00Z","timestamp":1338508800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2012,6,1]],"date-time":"2012-06-01T00:00:00Z","timestamp":1338508800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2012,6,1]],"date-time":"2012-06-01T00:00:00Z","timestamp":1338508800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2012,6,1]],"date-time":"2012-06-01T00:00:00Z","timestamp":1338508800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2012,6,1]],"date-time":"2012-06-01T00:00:00Z","timestamp":1338508800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2012,6,1]],"date-time":"2012-06-01T00:00:00Z","timestamp":1338508800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["BIO2007-66807"],"award-info":[{"award-number":["BIO2007-66807"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["PLE 2009-0101"],"award-info":[{"award-number":["PLE 2009-0101"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["SAF 2010-17167"],"award-info":[{"award-number":["SAF 2010-17167"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Behavioural Brain Research"],"published-print":{"date-parts":[[2012,6]]},"DOI":"10.1016\/j.bbr.2012.04.020","type":"journal-article","created":{"date-parts":[[2012,4,17]],"date-time":"2012-04-17T14:40:21Z","timestamp":1334673621000},"page":"225-232","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"title":["Long term behavioral effects of functional dopaminergic neurons generated from human neural stem cells in the rat 6-OH-DA Parkinson's disease model. Effects of the forced expression of BCL-XL"],"prefix":"10.1016","volume":"232","author":[{"given":"Tania","family":"Ramos-Moreno","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia G.","family":"Castillo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Mart\u00ednez-Serrano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbr.2012.04.020_bib0005","doi-asserted-by":"crossref","first-page":"1860","DOI":"10.1016\/j.yexcr.2009.03.011","article-title":"Generation and properties of a new human ventral mesencephalic neural stem cell line","volume":"315","author":"Villa","year":"2009","journal-title":"Experimental Cell Research"},{"key":"10.1016\/j.bbr.2012.04.020_bib0010","doi-asserted-by":"crossref","first-page":"9881","DOI":"10.1074\/jbc.M109.054312","article-title":"In vitro and in vivo enhanced generation of human A9 dopamine neurons from neural stem cells by Bcl-XL","volume":"285","author":"Courtois","year":"2010","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.bbr.2012.04.020_bib0015","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.tins.2004.12.006","article-title":"Cell transplantation in Parkinson's disease: how can we make it work","volume":"28","author":"Winkler","year":"2005","journal-title":"Trends in Neurosciences"},{"key":"10.1016\/j.bbr.2012.04.020_bib0020","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.tins.2007.12.001","article-title":"Critical issues of clinical human embryonic stem cell therapy for brain repair","volume":"31","author":"Li","year":"2008","journal-title":"Trends in Neurosciences"},{"key":"10.1016\/j.bbr.2012.04.020_bib0025","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.tips.2009.03.001","article-title":"Prospects of stem cell therapy for replacing dopamine neurons in Parkinson's disease","volume":"30","author":"Lindvall","year":"2009","journal-title":"Trends in Pharmacological Sciences"},{"key":"10.1016\/j.bbr.2012.04.020_bib0030","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1007\/s13311-011-0069-6","article-title":"Cell therapeutics in Parkinson's disease","volume":"8","author":"Lindvall","year":"2011","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.bbr.2012.04.020_bib0035","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/S0079-6123(10)84015-4","article-title":"Neural grafting in Parkinson's disease unraveling the mechanisms underlying graft-induced dyskinesia","volume":"184","author":"Lane","year":"2010","journal-title":"Progress in Brain Research"},{"key":"10.1016\/j.bbr.2012.04.020_bib0040","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/j.expneurol.2010.01.013","article-title":"Functional properties of the human ventral mesencephalic neural stem cell line hVM1","volume":"223","author":"Tonnesen","year":"2010","journal-title":"Experimental Neurology"},{"key":"10.1016\/j.bbr.2012.04.020_bib0045","doi-asserted-by":"crossref","first-page":"1908","DOI":"10.1111\/j.1471-4159.2009.06281.x","article-title":"Enhanced dopaminergic differentiation of human neural stem cells by synergistic effect of Bcl-xL and reduced oxygen tension","volume":"110","author":"Krabbe","year":"2009","journal-title":"Journal of Neurochemistry"},{"key":"10.1016\/j.bbr.2012.04.020_bib0050","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1007\/BF00271860","article-title":"Human fetal dopamine neurons grafted in a rat model of Parkinson's disease: immunological aspects, spontaneous and drug-induced behaviour, and dopamine release","volume":"70","author":"Brundin","year":"1988","journal-title":"Experimental Brain Research"},{"key":"10.1016\/j.bbr.2012.04.020_bib0055","first-page":"537","article-title":"Survival of expanded dopaminergic precursors is critical for clinical trials","volume":"1","author":"Brundin","year":"1998","journal-title":"Nature Nanotechnology"},{"key":"10.1016\/j.bbr.2012.04.020_bib0060","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.bbrc.2008.06.022","article-title":"One year survival and significant reversal of motor deficits in parkinsonian rats transplanted with hESC derived dopaminergic neurons","volume":"373","author":"Geeta","year":"2008","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"10.1016\/j.bbr.2012.04.020_bib0065","series-title":"The rat brain in stereotaxic coordinates","author":"Paxinos","year":"1986"},{"key":"10.1016\/j.bbr.2012.04.020_bib0070","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/0165-0270(91)90048-5","article-title":"The staircase test: a measure of independent forelimb reaching and grasping abilities in rats","volume":"36","author":"Montoya","year":"1991","journal-title":"Journal of Neuroscience Methods"},{"key":"10.1016\/j.bbr.2012.04.020_bib0075","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/S0028-3908(00)00005-8","article-title":"CNS plasticity and assessment of forelimb sensorimotor outcome in unilateral rat models of stroke, cortical ablation, parkinsonism and spinal cord injury","volume":"39","author":"Schallert","year":"2000","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bbr.2012.04.020_bib0080","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.neuroscience.2008.03.048","article-title":"Recovery of functional deficits following early donor age ventral mesencephalic grafts in a rat model of Parkinson's disease","volume":"154","author":"Torres","year":"2008","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbr.2012.04.020_bib0085","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/nprot.2006.2","article-title":"T-maze alternation in the rodent","volume":"1","author":"Deacon","year":"2006","journal-title":"Nature Protocols"},{"key":"10.1016\/j.bbr.2012.04.020_bib0090","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1101\/lm.2123811","article-title":"Contributions of dorsal striatal subregions to spatial alternation behavior","volume":"18","author":"Moussa","year":"2011","journal-title":"Learning & Memory"},{"key":"10.1016\/j.bbr.2012.04.020_bib0095","doi-asserted-by":"crossref","first-page":"1880","DOI":"10.1038\/sj.cdd.4402205","article-title":"Bcl-XL modulates the differentiation of immortalized human neural stem cells","volume":"14","author":"Liste","year":"2007","journal-title":"Cell Death and Differentiation"},{"key":"10.1016\/j.bbr.2012.04.020_bib0100","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1126\/science.571147","article-title":"Brain grafts reduce motor abnormalities produced by destruction of nigrostriatal dopamine system","volume":"204","author":"Perlow","year":"1979","journal-title":"Science"},{"key":"10.1016\/j.bbr.2012.04.020_bib0105","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1126\/science.2105529","article-title":"Grafts of fetal dopamine neurons survive and improve motor function in Parkinson's disease","volume":"247","author":"Lindvall","year":"1990","journal-title":"Science"},{"key":"10.1016\/j.bbr.2012.04.020_bib0110","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/nature00900","article-title":"Dopamine neurons derived from embryonic stem cells function in an animal model of Parkinson's disease","volume":"418","author":"Kim","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.bbr.2012.04.020_bib0115","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1038\/mt.2009.148","article-title":"Conditions for tumor-free and dopamine neuron-enriched grafts after transplanting human ES cell-derived neural precursor cells","volume":"17","author":"Ko","year":"2009","journal-title":"Molecular Therapy"},{"key":"10.1016\/j.bbr.2012.04.020_bib0120","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/0306-4522(93)90237-A","article-title":"Dopaminergic grafts implanted into the neonatal or adult striatum: comparative effects on rotation and paw reaching deficits induced by subsequent unilateral nigrostriatal lesions in adulthood","volume":"54","author":"Abrous","year":"1993","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbr.2012.04.020_bib0125","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1177\/096368970000900206","article-title":"Complex sensorimotor behavioral changes after terminal striatal 6-OHDA lesion and transplantation of dopaminergic embryonic micrografts","volume":"9","author":"Rodter","year":"2000","journal-title":"Cell Transplantation"},{"key":"10.1016\/j.bbr.2012.04.020_bib0130","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1002\/cne.1098","article-title":"Comparison of unilateral and bilateral intrastriatal 6-hydroxydopamine-induced axon terminal lesions: evidence for interhemispheric functional coupling of the two nigrostriatal pathways","volume":"432","author":"Roedter","year":"2001","journal-title":"Journal of Comparative Neurology"},{"key":"10.1016\/j.bbr.2012.04.020_bib0135","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.neuroscience.2005.01.016","article-title":"Training specificity, graft development and graft-mediated functional recovery in a rodent model of Huntington's disease","volume":"132","author":"Dobrossy","year":"2005","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbr.2012.04.020_bib0140","doi-asserted-by":"crossref","first-page":"257","DOI":"10.3727\/000000003108746812","article-title":"The role of pretraining on skilled forelimb use in an animal model of Huntington's disease","volume":"12","author":"Fricker-Gates","year":"2003","journal-title":"Cell Transplantation"},{"key":"10.1016\/j.bbr.2012.04.020_bib0145","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1016\/j.neuropharm.2009.01.019","article-title":"Evaluation of D2 and D3 dopamine receptor selective compounds on l-dopa-dependent abnormal involuntary movements in rats","volume":"56","author":"Kumar","year":"2009","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bbr.2012.04.020_bib0150","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0091-3057(97)00467-X","article-title":"Cyclosporine A affects open field behavior in DA rats","volume":"60","author":"von Horsten","year":"1998","journal-title":"Pharmacology Biochemistry and Behavior"},{"key":"10.1016\/j.bbr.2012.04.020_bib0155","doi-asserted-by":"crossref","first-page":"2052","DOI":"10.1016\/S0041-1345(98)00537-5","article-title":"Comparison of serum lipids, lipoproteins, and fibrinogen in patients with kidney transplantation and hemodialysis","volume":"30","author":"Demirag","year":"1998","journal-title":"Transplantation Proceedings"},{"key":"10.1016\/j.bbr.2012.04.020_bib0160","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1038\/nature07202","article-title":"Integration of metabolism and inflammation by lipid-activated nuclear receptors","volume":"454","author":"Bensinger","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.bbr.2012.04.020_bib0165","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.cbi.2010.06.011","article-title":"Chronic treatment with cyclosporine affects systemic purinergic parameters, homocysteine levels and vascular disturbances in rats","volume":"188","author":"Bohmer","year":"2010","journal-title":"Chemico-Biological Interactions"},{"key":"10.1016\/j.bbr.2012.04.020_bib0170","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1093\/ajcn\/55.1.131","article-title":"The pathogenesis of homocysteinemia: interruption of the coordinate regulation by S-adenosylmethionine of the remethylation and transsulfuration of homocysteine","volume":"55","author":"Selhub","year":"1992","journal-title":"American Journal of Clinical Nutrition"},{"key":"10.1016\/j.bbr.2012.04.020_bib0175","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/0091-3057(92)90172-C","article-title":"Parkinson's disease-like effects of S-adenosyl-l-methionine: effects of l-dopa","volume":"43","author":"Charlton","year":"1992","journal-title":"Pharmacology Biochemistry and Behavior"},{"key":"10.1016\/j.bbr.2012.04.020_bib0180","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/0163-1047(93)90950-M","article-title":"S-adenosyl-l-methionine decreases motor activity in the rat: similarity to Parkinson's disease-like symptoms","volume":"59","author":"Crowell","year":"1993","journal-title":"Behavioral and Neural Biology"},{"key":"10.1016\/j.bbr.2012.04.020_bib0185","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1038\/nature10648","article-title":"Dopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson's disease","volume":"480","author":"Kriks","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.bbr.2012.04.020_bib0190","doi-asserted-by":"crossref","first-page":"941","DOI":"10.3181\/0707-MR-193","article-title":"Current management of the cognitive dysfunction in Parkinson's disease: how far have we come?","volume":"233","author":"Vale","year":"2008","journal-title":"Experimental Biology & Medicine (Maywood)"},{"key":"10.1016\/j.bbr.2012.04.020_bib0195","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1023\/A:1020736131907","article-title":"The lesion of the rat substantia nigra pars compacta dopaminergic neurons as a model for Parkinson's disease memory disabilities","volume":"22","author":"Da Cunha","year":"2002","journal-title":"Cellular and Molecular Neurobiology"},{"key":"10.1016\/j.bbr.2012.04.020_bib0200","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0361-9230(02)00754-2","article-title":"Impaired learning in a spatial working memory version and in a cued version of the water maze in rats with MPTP-induced mesencephalic dopaminergic lesions","volume":"58","author":"Miyoshi","year":"2002","journal-title":"Brain Research Bulletin"},{"key":"10.1016\/j.bbr.2012.04.020_bib0205","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.biopsycho.2006.01.005","article-title":"Functions of frontostriatal systems in cognition: comparative neuropsychopharmacological studies in rats, monkeys and humans","volume":"73","author":"Chudasama","year":"2006","journal-title":"Biological Psychology"},{"key":"10.1016\/j.bbr.2012.04.020_bib0210","doi-asserted-by":"crossref","first-page":"10786","DOI":"10.1523\/JNEUROSCI.3208-04.2004","article-title":"The generation of dopaminergic neurons by human neural stem cells is enhanced by Bcl-XL, both in vitro and in vivo","volume":"24","author":"Liste","year":"2004","journal-title":"Journal of Neuroscience"}],"container-title":["Behavioural Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016643281200280X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016643281200280X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T13:03:24Z","timestamp":1759064604000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S016643281200280X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,6]]},"references-count":42,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,6]]}},"alternative-id":["S016643281200280X"],"URL":"https:\/\/doi.org\/10.1016\/j.bbr.2012.04.020","relation":{},"ISSN":["0166-4328"],"issn-type":[{"value":"0166-4328","type":"print"}],"subject":[],"published":{"date-parts":[[2012,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Long term behavioral effects of functional dopaminergic neurons generated from human neural stem cells in the rat 6-OH-DA Parkinson's disease model. Effects of the forced expression of BCL-XL","name":"articletitle","label":"Article Title"},{"value":"Behavioural Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbr.2012.04.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}