{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T09:23:13Z","timestamp":1777627393772,"version":"3.51.4"},"reference-count":92,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2012,10,1]],"date-time":"2012-10-01T00:00:00Z","timestamp":1349049600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Behavioural Brain Research"],"published-print":{"date-parts":[[2012,10]]},"DOI":"10.1016\/j.bbr.2012.06.021","type":"journal-article","created":{"date-parts":[[2012,6,26]],"date-time":"2012-06-26T13:34:04Z","timestamp":1340717644000},"page":"137-148","source":"Crossref","is-referenced-by-count":78,"title":["Guanosine produces an antidepressant-like effect through the modulation of NMDA receptors, nitric oxide\u2013cGMP and PI3K\/mTOR pathways"],"prefix":"10.1016","volume":"234","author":[{"given":"Luis E.B.","family":"Bettio","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mauricio P.","family":"Cunha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josiane","family":"Budni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francis L.","family":"Pazini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c1gatha","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9 R.","family":"Colla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana L\u00facia S.","family":"Rodrigues","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbr.2012.06.021_bib0005","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/S0736-5748(00)00084-8","article-title":"Involvement of astrocytes in purine-mediated reparative processes in the brain","volume":"19","author":"Ciccarelli","year":"2001","journal-title":"International Journal of Developmental Neuroscience"},{"key":"10.1016\/j.bbr.2012.06.021_bib0010","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1007\/s10571-005-4939-5","article-title":"Guanosine enhances glutamate transport capacity in brain cortical slices","volume":"25","author":"Frizzo","year":"2005","journal-title":"Cellular and Molecular Neurobiology"},{"key":"10.1016\/j.bbr.2012.06.021_bib0015","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1002\/jnr.20327","article-title":"Effects of chronic administered guanosine on behavioral parameters and brain glutamate uptake in rats","volume":"79","author":"Vinad\u00e9","year":"2005","journal-title":"Journal of Neuroscience Research"},{"key":"10.1016\/j.bbr.2012.06.021_bib0020","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1002\/jnr.22681","article-title":"Neuroprotective effect of guanosine against glutamate-induced cell death in rat hippocampal slices is mediated by the phosphatidylinositol-3 kinase\/Akt\/glycogen synthase kinase 3\u03b2 pathway activation and inducible nitric oxide synthase inhibition","volume":"89","author":"Molz","year":"2011","journal-title":"Journal of Neuroscience Research"},{"key":"10.1016\/j.bbr.2012.06.021_bib0025","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/S0301-0082(99)00017-9","article-title":"Trophic effects of purines in neurons and glial cells","volume":"59","author":"Rathbone","year":"1999","journal-title":"Progress in Neurobiology"},{"key":"10.1016\/j.bbr.2012.06.021_bib0030","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1002\/(SICI)1098-1136(20000201)29:3<202::AID-GLIA2>3.0.CO;2-C","article-title":"Cultured astrocyte proliferation induced by extracellular guanosine involves endogenous adenosine and is raised by the co-presence of microglia","volume":"29","author":"Ciccarelli","year":"2000","journal-title":"Glia"},{"key":"10.1016\/j.bbr.2012.06.021_bib0035","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/S0006-8993(03)02506-X","article-title":"Extracellular conversion of guanine-based purines to guanosine specifically enhances astrocyte glutamate uptake","volume":"972","author":"Frizzo","year":"2003","journal-title":"Brain Research"},{"key":"10.1016\/j.bbr.2012.06.021_bib0040","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.expneurol.2009.09.027","article-title":"Glutamate, excitotoxicity, and programmed cell death in Parkinson disease","volume":"220","author":"Caudle","year":"2009","journal-title":"Experimental Neurology"},{"key":"10.1016\/j.bbr.2012.06.021_bib0045","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.jns.2008.06.029","article-title":"Neurodegeneration in multiple sclerosis: the role of oxidative stress and excitotoxicity","volume":"274","author":"Gonsette","year":"2008","journal-title":"Journal of the Neurological Sciences"},{"key":"10.1016\/j.bbr.2012.06.021_bib0050","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.pneurobio.2006.11.003","article-title":"N-methyl-d-aspartate (NMDA) receptor function and excitotoxicity in Huntington's disease","volume":"81","author":"Fan","year":"2007","journal-title":"Progress in Neurobiology"},{"key":"10.1016\/j.bbr.2012.06.021_bib0055","first-page":"322","article-title":"The role of excitotoxicity in neurodegeneration","volume":"43","author":"Sali\u0144ska","year":"2005","journal-title":"Folia Neuropathologica"},{"key":"10.1016\/j.bbr.2012.06.021_bib0060","first-page":"32","article-title":"The neuroprotective activity of guanosine involves the production of trophic factors and the outflow of purines from astrocytes","volume":"50","author":"Caciagli","year":"2000","journal-title":"Drug Development Research"},{"key":"10.1016\/j.bbr.2012.06.021_bib0065","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/0736-5748(95)00083-6","article-title":"GTP and guanosine synergistically enhance NGF-induced neurite outgrowth from PC12 cells","volume":"14","author":"Gysbers","year":"1996","journal-title":"International Journal of Developmental Neuroscience"},{"key":"10.1016\/j.bbr.2012.06.021_bib0070","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.neuint.2007.07.017","article-title":"Mechanism of guanosine-induced neuroprotection in rat hippocampal slices submitted to oxygen\u2013glucose deprivation","volume":"52","author":"Oleskovicz","year":"2008","journal-title":"Neurochemistry International"},{"key":"10.1016\/j.bbr.2012.06.021_bib0075","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.neuroscience.2011.03.022","article-title":"Guanosine is neuroprotective against oxygen\/glucose deprivation in hippocampal slices via large conductance Ca2-activated K+ channels, phosphatidilinositol-3 kinase\/protein kinase B pathway activation and glutamate uptake","volume":"183","author":"Dal-Cim","year":"2011","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbr.2012.06.021_bib0080","first-page":"297","article-title":"Guanosine protects human neuroblastoma cells from oxidative stress and toxicity induced by amyloid-beta peptide oligomers","volume":"24","author":"Tarozzi","year":"2010","journal-title":"Journal of Biological Regulators and Homeostatic Agents"},{"key":"10.1016\/j.bbr.2012.06.021_bib0085","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1002\/glia.20002","article-title":"The antiapoptotic effect of guanosine is mediated by the activation of the PI3-kinase\/AKT\/PKB pathway in cultured rat astrocytes","volume":"46","author":"Di Iorio","year":"2004","journal-title":"Glia"},{"key":"10.1016\/j.bbr.2012.06.021_bib0090","doi-asserted-by":"crossref","first-page":"720","DOI":"10.4049\/jimmunol.178.2.720","article-title":"Guanosine inhibits CD40 receptor expression and function induced by cytokines and beta amyloid in mouse microglia cells","volume":"178","author":"D\u2019Alimonte","year":"2007","journal-title":"Journal of Immunology"},{"key":"10.1016\/j.bbr.2012.06.021_bib0095","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0006-8993(03)02769-0","article-title":"Chronically administered guanosine is anticonvulsant, amnesic and anxiolytic in mice","volume":"977","author":"Vinad\u00e9","year":"2003","journal-title":"Brain Research"},{"key":"10.1016\/j.bbr.2012.06.021_bib0100","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1111\/j.1460-9568.1997.tb01427.x","article-title":"Sequential role of hippocampus and amygdala, entorhinal cortex and parietal cortex in formation and retrieval of memory for inhibitory avoidance in rats","volume":"9","author":"Izquierdo","year":"1997","journal-title":"European Journal of Neuroscience"},{"key":"10.1016\/j.bbr.2012.06.021_bib0105","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/j.1360-0443.2011.03576.x","article-title":"Ketamine use: a review","volume":"107","author":"Morgan","year":"2012","journal-title":"Addiction"},{"key":"10.1016\/j.bbr.2012.06.021_bib0110","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.brainres.2004.01.053","article-title":"Anticonvulsant effect of GMP depends on its conversion to guanosine","volume":"1005","author":"Soares","year":"2004","journal-title":"Brain Research"},{"key":"10.1016\/j.bbr.2012.06.021_bib0115","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.nlm.2005.10.006","article-title":"Amnesic effect of GMP depends on its conversion to guanosine","volume":"85","author":"Saute","year":"2006","journal-title":"Neurobiology of Learning and Memory"},{"key":"10.1016\/j.bbr.2012.06.021_bib0120","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.1097\/00001756-200006260-00008","article-title":"Acute treatments with GMP produce antidepressant-like effects in mice","volume":"11","author":"Eckeli","year":"2000","journal-title":"Neuroreport"},{"key":"10.1016\/j.bbr.2012.06.021_bib0125","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.tips.2009.09.002","article-title":"Glutamate-based antidepressants: 20 years on","volume":"30","author":"Skolnick","year":"2009","journal-title":"Trends in Pharmacological Sciences"},{"key":"10.1016\/j.bbr.2012.06.021_bib0130","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.ddstr.2008.10.003","article-title":"Future antidepressant targets: neurotrophic factors and related signaling cascades","volume":"5","author":"Schmidt","year":"2008","journal-title":"Drug Discovery Today: Therapeutic Strategies"},{"key":"10.1016\/j.bbr.2012.06.021_bib0135","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1016\/j.pnpbp.2010.06.013","article-title":"The role of glutamate on the action of antidepressants","volume":"35","author":"Hashimoto","year":"2011","journal-title":"Progress in Neuro-Psychopharmacology and Biological Psychiatry"},{"key":"10.1016\/j.bbr.2012.06.021_bib0140","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0896-6273(02)00653-0","article-title":"Neurobiology of depression","volume":"34","author":"Nestler","year":"2002","journal-title":"Neuron"},{"key":"10.1016\/j.bbr.2012.06.021_bib0145","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S0166-4328(03)00069-X","article-title":"Involvement of NMDA receptors and l-arginine-nitric oxide pathway in the antidepressant-like effects of zinc in mice","volume":"144","author":"Rosa","year":"2003","journal-title":"Behavioural Brain Research"},{"key":"10.1016\/j.bbr.2012.06.021_bib0150","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/S0166-4328(03)00069-X","article-title":"Glutamate and depression: clinical and preclinical studies","volume":"1003","author":"Paul","year":"2003","journal-title":"Annals of the New York Academy of Sciences"},{"key":"10.1016\/j.bbr.2012.06.021_bib0155","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1196\/annals.1300.016","article-title":"Zinc and depression. An update","volume":"57","author":"Nowak","year":"2005","journal-title":"Pharmacological Reports"},{"key":"10.1016\/j.bbr.2012.06.021_bib0160","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.bbr.2005.11.023","article-title":"Evidence for the involvement of l-arginine-nitric oxide-cyclic guanosine monophosphate pathway in the antidepressant-like effect of memantine in mice","volume":"168","author":"Almeida","year":"2006","journal-title":"Behavioural Brain Research"},{"key":"10.1016\/j.bbr.2012.06.021_bib0165","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.bbr.2005.11.023","article-title":"Cellular mechanisms underlying the antidepressant effects of ketamine: role of a-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors","volume":"63","author":"Maeng","year":"2008","journal-title":"Biological Psychiatry"},{"key":"10.1016\/j.bbr.2012.06.021_bib0170","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.biopsych.2007.05.028","article-title":"Evidence for the involvement of the monoaminergic system in the antidepressant-like effect of magnesium","volume":"33","author":"Cardoso","year":"2009","journal-title":"Progress in Neuro-Psychopharmacology and Biological Psychiatry"},{"key":"10.1016\/j.bbr.2012.06.021_bib0175","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/j.pnpbp.2008.11.007","article-title":"mTOR-dependent synapse formation underlies the rapid antidepressant effects of NMDA antagonists","volume":"329","author":"Li","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.bbr.2012.06.021_bib0180","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1126\/science.1190287","article-title":"A randomized trial of an N-methyl-d-aspartate antagonist in treatment-resistant major depression","volume":"63","author":"Zarate","year":"2006","journal-title":"Archives of General Psychiatry"},{"key":"10.1016\/j.bbr.2012.06.021_bib0185","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1001\/archpsyc.63.8.856","article-title":"Rapid resolution of suicidal ideation after a single infusion of an N-methyl-d-aspartate antagonist in patients with treatment-resistant major depressive disorder","volume":"71","author":"DiazGranados","year":"2010","journal-title":"Journal of Clinical Psychiatry"},{"key":"10.1016\/j.bbr.2012.06.021_bib0190","doi-asserted-by":"crossref","first-page":"35","DOI":"10.4088\/JCP.09m05327blu","article-title":"Signaling pathways underlying the rapid antidepressant actions of ketamine","volume":"62","author":"Duman","year":"2012","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bbr.2012.06.021_bib0195","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.neuropharm.2011.08.044","article-title":"Nitric oxide signaling in brain function, dysfunction, and dementia","volume":"16","author":"Steinert","year":"2010","journal-title":"Neuroscientist"},{"key":"10.1016\/j.bbr.2012.06.021_bib0200","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1177\/1073858410366481","article-title":"Nitric oxide and major depression","volume":"24","author":"Dhir","year":"2011","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.bbr.2012.06.021_bib0205","doi-asserted-by":"crossref","first-page":"5004","DOI":"10.1016\/j.niox.2011.02.002","article-title":"Vicious cycle involving Na+ channels, glutamate release, and NMDA receptor mediates delayed neurodegeneration through nitric oxide formation","volume":"16","author":"Strijbos","year":"1996","journal-title":"Journal of Neuroscience"},{"key":"10.1016\/j.bbr.2012.06.021_bib0210","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.pneurobio.2005.06.001","article-title":"The physiology and pathophysiology of nitric oxide in the brain","volume":"76","author":"Guix","year":"2005","journal-title":"Progress in Neurobiology"},{"key":"10.1016\/j.bbr.2012.06.021_bib0215","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1016\/j.bbagen.2011.07.010","article-title":"Protein S-nitrosylation: role for nitric oxide signaling in neuronal death","volume":"1820","author":"Shahani","year":"2012","journal-title":"Biochimica et Biophysica Acta"},{"key":"10.1016\/j.bbr.2012.06.021_bib0220","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/S0005-2728(99)00024-9","article-title":"Guanylate cyclase and the NO\/cGMP signaling pathway","volume":"1411","author":"Denninger","year":"1999","journal-title":"Biochimica et Biophysica Acta"},{"key":"10.1016\/j.bbr.2012.06.021_bib0225","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0005-2728(99)00024-9","article-title":"Increased plasma nitric oxide metabolites in suicide attempters","volume":"53","author":"Lee","year":"2006","journal-title":"Neuropsychobiology"},{"key":"10.1016\/j.bbr.2012.06.021_bib0230","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1159\/000092542","article-title":"Elevated plasma nitrate levels in depressive states","volume":"63","author":"Suzuki","year":"2001","journal-title":"Journal of Affective Disorders"},{"key":"10.1016\/j.bbr.2012.06.021_bib0235","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/S0165-0327(00)00164-6","article-title":"Serotonergic mediation of the antidepressant-like effects of nitric oxide synthase inhibitors","volume":"44","author":"Harkin","year":"2003","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bbr.2012.06.021_bib0240","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/S0028-3908(03)00030-3","article-title":"Involvement of nitric oxide\u2013cGMP pathway in the antidepressant-like effects of adenosine in the forced swimming test","volume":"8","author":"Kaster","year":"2005","journal-title":"International Journal of Neuropsychopharmacology"},{"key":"10.1016\/j.bbr.2012.06.021_bib0245","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1017\/S1461145705005316","article-title":"Inhibition of neuronal nitric oxide synthase in the rat hippocampus induces antidepressant-like effects","volume":"185","author":"Joca","year":"2006","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.bbr.2012.06.021_bib0250","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s00213-006-0326-2","article-title":"Antidepressant-like effect of folic acid: involvement of NMDA receptors and l-arginine\u2013nitric oxide\u2013cyclic guanosine monophosphate pathway","volume":"598","author":"Brocardo","year":"2008","journal-title":"European Journal of Pharmacology"},{"key":"10.1016\/j.bbr.2012.06.021_bib0255","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.ejphar.2008.08.033","article-title":"Behavioral despair in mice: a primary screening test for antidepressants","volume":"229","author":"Porsolt","year":"1977","journal-title":"Archives Internationales de Pharmacodynamie et de Therapie"},{"key":"10.1016\/j.bbr.2012.06.021_bib0260","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/BF00428203","article-title":"The tail suspension test: a new method for screening antidepressants in mice","volume":"85","author":"Steru","year":"1985","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.bbr.2012.06.021_bib0265","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1007\/BF00428203","article-title":"Involvement of nitric oxide\u2013cGMP pathway in the antidepressant-like effect of ascorbic acid in the tail suspension test","volume":"225","author":"Moretti","year":"2011","journal-title":"Behavioural Brain Research"},{"key":"10.1016\/j.bbr.2012.06.021_bib0270","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbr.2011.07.024","article-title":"Melatonin exerts an antidepressant-like effect in the tail suspension test in mice: evidence for involvement of N-methyl-d-aspartate receptors and the l-arginine-nitric oxide pathway","volume":"343","author":"Mantovani","year":"2003","journal-title":"Neuroscience Letters"},{"key":"10.1016\/j.bbr.2012.06.021_bib0275","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1177\/0269881111424456","article-title":"Involvement of PI3K, GSK-3\u03b2 and PPAR\u03b3 in the antidepressant-like effect of folic acid in the forced swimming test in mice","volume":"26","author":"Budni","year":"2012","journal-title":"Journal of Psychopharmacology"},{"key":"10.1016\/j.bbr.2012.06.021_bib0280","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1007\/BF00181261","article-title":"The tail suspension test: ethical considerations","volume":"90","author":"Thierry","year":"1986","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.bbr.2012.06.021_bib0285","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/BF00181261","article-title":"Intra- and interstrain differences in models of behavioral despair","volume":"70","author":"Bai","year":"2001","journal-title":"Pharmacology Biochemistry and Behavior"},{"key":"10.1016\/j.bbr.2012.06.021_bib0290","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0091-3057(01)00599-8","article-title":"Oral administration of guanosine impairs inhibitory avoidance performance in rats and mice","volume":"81","author":"Vinad\u00e9","year":"2004","journal-title":"Neurobiology of Learning and Memory"},{"key":"10.1016\/j.bbr.2012.06.021_bib0295","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1016\/j.nlm.2003.12.003","article-title":"Mechanisms involved in the antinociception induced by systemic administration of guanosine in mice","volume":"159","author":"Schmidt","year":"2010","journal-title":"British Journal of Pharmacology"},{"key":"10.1016\/j.bbr.2012.06.021_bib0300","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1111\/j.1476-5381.2009.00597.x","article-title":"Systemic administration of guanosine promotes functional and histological improvement following an ischemic stroke in rats","volume":"1407","author":"Rathbone","year":"2011","journal-title":"Brain Research"},{"key":"10.1016\/j.bbr.2012.06.021_bib0305","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.brainres.2011.06.027","article-title":"Effects of ketamine on different types of anxiety\/fear and related memory in rats with lesions of the median raphe nucleus","volume":"431","author":"Babar","year":"2001","journal-title":"European Journal of Pharmacology"},{"key":"10.1016\/j.bbr.2012.06.021_bib0310","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1016\/S0014-2999(01)01340-1","article-title":"Ketamine activates the l-arginine\/nitric oxide\/cyclic guanosine monophosphate pathway to induce peripheral antinociception in rats","volume":"113","author":"Romero","year":"2011","journal-title":"Anesthesia and Analgesia"},{"key":"10.1016\/j.bbr.2012.06.021_bib0315","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1213\/ANE.0b013e3182285dda","article-title":"Inhibition of neuron-specific CREB dephosphorylation is involved in propofol and ketamine-induced neuroprotection against cerebral ischemic injuries of mice","volume":"37","author":"Shu","year":"2012","journal-title":"Neurochemical Research"},{"key":"10.1016\/j.bbr.2012.06.021_bib0320","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/s11064-011-0582-3","article-title":"Adaptation of the NMDA receptor in rat cortex following chronic electroconvulsive shock or imipramine","volume":"247","author":"Paul","year":"1993","journal-title":"European Journal of Pharmacology"},{"key":"10.1016\/j.bbr.2012.06.021_bib0325","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/0922-4106(93)90199-J","article-title":"Adaptation of cortical NMDA receptors by chronic treatment with specific serotonin reuptake inhibitors","volume":"342","author":"Nowak","year":"1998","journal-title":"European Journal of Pharmacology"},{"key":"10.1016\/j.bbr.2012.06.021_bib0330","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/S0014-2999(97)01589-6","article-title":"Effects of intravenous ketamine on explicit and implicit measures of suicidality in treatment-resistant depression","volume":"66","author":"Price","year":"2009","journal-title":"Biological Psychiatry"},{"key":"10.1016\/j.bbr.2012.06.021_bib0335","doi-asserted-by":"crossref","first-page":"4149","DOI":"10.1016\/j.biopsych.2009.04.029","article-title":"d-Serine is key determinant of glutamate toxicity in amyotrophic lateral sclerosis","volume":"26","author":"Sasabe","year":"2007","journal-title":"EMBO Journal"},{"key":"10.1016\/j.bbr.2012.06.021_bib0340","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1038\/sj.emboj.7601840","article-title":"Induction of serine racemase expression and d-serine release from microglia by secreted amyloid precursor protein (sAPP)","volume":"4","author":"Wu","year":"2007","journal-title":"Current Alzheimer Research"},{"key":"10.1016\/j.bbr.2012.06.021_bib0345","doi-asserted-by":"crossref","first-page":"996","DOI":"10.2174\/156720507781077241","article-title":"d-Serine, a selective glycine\/N-methyl-d-aspartate receptor agonist, antagonizes the antidepressant-like effects of magnesium and zinc in mice","volume":"60","author":"Poleszak","year":"2008","journal-title":"Pharmacological Reports"},{"key":"10.1016\/j.bbr.2012.06.021_bib0350","first-page":"164","article-title":"Possible involvement of nitric oxide (NO) signaling pathway in the antidepressant-like effect of MK-801(dizocilpine), a NMDA receptor antagonist in mouse forced swim test","volume":"46","author":"Dhir","year":"2008","journal-title":"Indian Journal of Experimental Biology"},{"key":"10.1016\/j.bbr.2012.06.021_bib0355","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.bbr.2011.05.035","article-title":"Involvement of AMPA receptor in both the rapid and sustained antidepressant-like effects of ketamine in animal models of depression","volume":"224","author":"Koike","year":"2011","journal-title":"Behavioural Brain Research"},{"key":"10.1016\/j.bbr.2012.06.021_bib0360","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1016\/j.bbr.2011.05.035","article-title":"Synergistic effect of uncompetitive NMDA receptor antagonists and antidepressant drugs in the forced swimming test in rats","volume":"42","author":"Rog\u00f3z","year":"2002","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bbr.2012.06.021_bib0365","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/S0028-3908(02)00055-2","article-title":"Involvement of NMDA receptors and l-arginine\u2013nitric oxide\u2013cyclic guanosine monophosphate pathway in the antidepressant-like effects of escitalopram in the forced swimming test","volume":"20","author":"Zomkowski","year":"2010","journal-title":"European Neuropsychopharmacology"},{"key":"10.1016\/j.bbr.2012.06.021_bib0370","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1016\/j.euroneuro.2010.07.011","article-title":"Linking molecules to mood: new insight into the biology of depression","volume":"167","author":"Krishnan","year":"2010","journal-title":"American Journal of Psychiatry"},{"key":"10.1016\/j.bbr.2012.06.021_bib0375","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1176\/appi.ajp.2009.10030434","article-title":"Targeting the glutamatergic system to develop novel, improved therapeutics for mood disorders","volume":"7","author":"Sanacora","year":"2008","journal-title":"Nature Reviews Drug Discovery"},{"key":"10.1016\/j.bbr.2012.06.021_bib0380","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1038\/nrd2462","article-title":"Molecular pathways associated with stress resilience and drug resistance in the chronic mild stress rat model of depression: a gene expression study","volume":"33","author":"Bergstrom","year":"2007","journal-title":"Journal of Molecular Neuroscience"},{"key":"10.1016\/j.bbr.2012.06.021_bib0385","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1007\/s12031-007-0065-9","article-title":"Transgenic mice overexpressing nNOS in the adult nervous system","volume":"51","author":"Packer","year":"2005","journal-title":"Cell and Molecular Biology"},{"key":"10.1016\/j.bbr.2012.06.021_bib0390","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S0014-2999(99)00191-0","article-title":"Nitric oxide synthase inhibitors have antidepressant-like properties in mice. Acute treatments are active in the forced swimming test","volume":"372","author":"Harkin","year":"1999","journal-title":"European Journal of Pharmacology"},{"key":"10.1016\/j.bbr.2012.06.021_bib0395","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0014-2999(99)00191-0","article-title":"Involvement of nitric oxide (NO) signaling pathway in the antidepressant action of bupropion, a dopamine reuptake inhibitor","volume":"568","author":"Dhir","year":"2007","journal-title":"European Journal of Pharmacology"},{"key":"10.1016\/j.bbr.2012.06.021_bib0400","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/j.ejphar.2007.04.028","article-title":"Involvement of l-arginine\u2013nitric oxide\u2013cyclic guanosine monophosphate pathway in the antidepressant-like effect of venlafaxine in mice","volume":"31","author":"Dhir","year":"2007","journal-title":"Progress in Neuro-Psychopharmacology and Biological Psychiatry"},{"key":"10.1016\/j.bbr.2012.06.021_bib0405","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/j.pnpbp.2007.02.008","article-title":"Nitric oxide: first in a new class of neurotransmitters","volume":"257","author":"Snyder","year":"1992","journal-title":"Science"},{"key":"10.1016\/j.bbr.2012.06.021_bib0410","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1126\/science.1353273","article-title":"Cyclic nucleotide phosphodiesterases: functional implications of multiple isoforms","volume":"75","author":"Beavo","year":"1995","journal-title":"Physiological Reviews"},{"key":"10.1016\/j.bbr.2012.06.021_bib0415","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1101\/gad.11.6.701","article-title":"The PI 3-kinase\/Akt signaling pathway delivers an anti-apoptotic signal","volume":"11","author":"Kennedy","year":"1997","journal-title":"Genes and Development"},{"key":"10.1016\/j.bbr.2012.06.021_bib0420","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1101\/gad.11.6.701","article-title":"Long-term potentiation in dentate gyrus of the rat is inhibited by the phosphoinositide 3-kinase inhibitor, wortmannin","volume":"39","author":"Kelly","year":"2000","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bbr.2012.06.021_bib0425","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0028-3908(99)00169-0","article-title":"Neurotrophin signalling in health and disease","volume":"110","author":"Chao","year":"2006","journal-title":"Clinical Science"},{"key":"10.1016\/j.bbr.2012.06.021_bib0430","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1042\/CS20050163","article-title":"Impact of genetic variant BDNF (Val66Met) on brain structure and function","volume":"289","author":"Chen","year":"2008","journal-title":"Novartis Foundation Symposium"},{"key":"10.1016\/j.bbr.2012.06.021_bib0435","doi-asserted-by":"crossref","first-page":"2631","DOI":"10.1002\/9780470751251.ch14","article-title":"Phosphatidylinositol 3-kinase activation is required for stress protocol-induced modification of hippocampal synaptic plasticity","volume":"283","author":"Yang","year":"2008","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.bbr.2012.06.021_bib0440","doi-asserted-by":"crossref","first-page":"2324","DOI":"10.1074\/jbc.M706954200","article-title":"Lower phosphoinositide 3-kinase (PI 3-kinase) activity and differential expression levels of selective catalytic and regulatory PI3-kinase subunit isoforms in prefrontal cortex and hippocampus of suicide subjects","volume":"33","author":"Dwivedi","year":"2008","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.bbr.2012.06.021_bib0445","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/sj.npp.1301641","article-title":"MPP(+)-induced cytotoxicity in neuroblastoma cells: antagonism and reversal by guanosine","volume":"3","author":"Pettifer","year":"2007","journal-title":"Purinergic Signalling"},{"key":"10.1016\/j.bbr.2012.06.021_bib0450","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/s11302-007-9073-z","article-title":"mTOR signaling: at the crossroads of plasticity, memory and disease","volume":"33","author":"Hoeffer","year":"2010","journal-title":"Trends in Neurosciences"},{"key":"10.1016\/j.bbr.2012.06.021_bib0455","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1016\/j.tins.2009.11.003","article-title":"Neurotrophic effects of extracellular guanosine","volume":"27","author":"Rathbone","year":"2008","journal-title":"Nucleosides Nucleotides Nucleic Acids"},{"key":"10.1016\/j.bbr.2012.06.021_bib0460","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1080\/15257770802143913","article-title":"Evidence for the existence of a specific G protein-coupled receptor activated by guanosine","volume":"6","author":"Volpini","year":"2011","journal-title":"ChemMedChem"}],"container-title":["Behavioural Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432812004342?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432812004342?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,6,30]],"date-time":"2019-06-30T08:32:04Z","timestamp":1561883524000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166432812004342"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10]]},"references-count":92,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,10]]}},"alternative-id":["S0166432812004342"],"URL":"https:\/\/doi.org\/10.1016\/j.bbr.2012.06.021","relation":{},"ISSN":["0166-4328"],"issn-type":[{"value":"0166-4328","type":"print"}],"subject":[],"published":{"date-parts":[[2012,10]]}}}