{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T06:10:10Z","timestamp":1791180610722,"version":"4.1.0"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2013,8,1]],"date-time":"2013-08-01T00:00:00Z","timestamp":1375315200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior (CAPES)"},{"name":"unda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","award":["10\/13460-1"],"award-info":[{"award-number":["10\/13460-1"]}]},{"DOI":"10.13039\/501100001807","name":"FAPESP","doi-asserted-by":"crossref","award":["09\/50940-4"],"award-info":[{"award-number":["09\/50940-4"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002322","name":"CAPES","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003593","name":"CNPq","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]},{"name":"NAPNA\/USP"},{"name":"Hospital S\u00edrio-Liban\u00eas"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Behavioural Brain Research"],"published-print":{"date-parts":[[2013,8]]},"DOI":"10.1016\/j.bbr.2013.05.019","type":"journal-article","created":{"date-parts":[[2013,5,20]],"date-time":"2013-05-20T12:00:40Z","timestamp":1369051240000},"page":"211-221","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":44,"special_numbering":"C","title":["Antinociception induced by motor cortex stimulation: Somatotopy of behavioral response and profile of neuronal activation"],"prefix":"10.1016","volume":"250","author":[{"given":"Nubia R.M.","family":"Fran\u00e7a","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elaine F.","family":"Toniolo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriano C.","family":"Franciosi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adilson S.","family":"Alves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel C.","family":"de Andrade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erich T.","family":"Fonoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz R.","family":"Britto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camila S.","family":"Dale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbr.2013.05.019_bib0005","doi-asserted-by":"crossref","first-page":"315","DOI":"10.3109\/02699059009026185","article-title":"Deep-brain stimulation in a persistent vegetative state: follow-up results and criteria for selection of candidates","volume":"4","author":"Tsubokawa","year":"1990","journal-title":"Brain Injury"},{"key":"10.1016\/j.bbr.2013.05.019_bib0010","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1590\/S0004-282X2010000600018","article-title":"Motor cortex electric stimulation for the treatment of neuropathic pain","volume":"68","author":"Fagundes-Pereyra","year":"2010","journal-title":"Arquivos de Neuro-Psiquiatria"},{"issue":"4","key":"10.1016\/j.bbr.2013.05.019_bib0015","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/S0987-7053(01)00260-X","article-title":"Interventional neurophysiology for pain control: duration of pain relief following repetitive transcranial magnetic stimulation of the motor cortex","volume":"31","author":"Lefaucheur","year":"2001","journal-title":"Neurophysiolie Clinique"},{"issue":"6","key":"10.1016\/j.bbr.2013.05.019_bib0020","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1093\/brain\/awp035","article-title":"Motor cortex stimulation for the treatment of refractory peripheral neuropathic pain","volume":"132","author":"Lefaucheur","year":"2009","journal-title":"Brain"},{"key":"10.1016\/j.bbr.2013.05.019_bib0025","first-page":"150","article-title":"Motor cortex stimulation as treatment of trigeminal neuropathic pain","volume":"58","author":"Meyerson","year":"1993","journal-title":"Acta Neurochirurgica Supplement"},{"key":"10.1016\/j.bbr.2013.05.019_bib0030","first-page":"54","article-title":"Treatment of deafferentation pain by chronic stimulation of the motor cortex: report of a series of 20 cases","volume":"68","author":"Nguyen","year":"1997","journal-title":"Acta Neurochirurgica Supplement"},{"issue":"3","key":"10.1016\/j.bbr.2013.05.019_bib0035","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1159\/000324895","article-title":"Pain relief and functional recovery in patients with complex regional pain syndrome after motor cortex stimulation","volume":"89","author":"Fonoff","year":"2011","journal-title":"Stereotactic and Functional Neurosurgery"},{"key":"10.1016\/j.bbr.2013.05.019_bib0040","doi-asserted-by":"crossref","first-page":"393","DOI":"10.3171\/jns.1993.78.3.0393","article-title":"Chronic motor cortex stimulation in patients with thalamic pain","volume":"78","author":"Tsubokawa","year":"1993","journal-title":"Journal of Neurosurgery"},{"key":"10.1016\/j.bbr.2013.05.019_bib0045","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.pain.2005.07.020","article-title":"Motor cortex stimulation for refractory neuropathic pain: four year outcome and predictors of efficacy","volume":"118","author":"Nuti","year":"2005","journal-title":"Pain"},{"key":"10.1016\/j.bbr.2013.05.019_bib0050","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0188-4409(00)00078-3","article-title":"Motor cortex stimulation in the treatment of central and neuropathic pain","volume":"31","author":"Nguyen","year":"2000","journal-title":"Archives of Medical Research"},{"key":"10.1016\/j.bbr.2013.05.019_bib0055","first-page":"283","article-title":"The effect of motor cortex stimulation in deafferentated rats","volume":"26","author":"Rusina","year":"2005","journal-title":"Neuro Endocrinology Letters"},{"key":"10.1016\/j.bbr.2013.05.019_bib0060","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S0024-3205(00)00525-7","article-title":"Somatosensory cortex stimulation-evoked analgesia in rats: potentiation by NO synthase inhibition","volume":"66","author":"Kuroda","year":"2000","journal-title":"Life Sciences"},{"key":"10.1016\/j.bbr.2013.05.019_bib0065","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.brainres.2004.12.043","article-title":"Spinal dorsal horn neuron response to mechanical stimuli is decreased by electrical stimulation of the primary motor cortex","volume":"1036","author":"Senapati","year":"2005","journal-title":"Brain Research"},{"key":"10.1016\/j.bbr.2013.05.019_bib0070","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.brainres.2005.07.044","article-title":"Electrical stimulation of the primary somatosensory cortex inhibits spinal dorsal horn neuron activity","volume":"1057","author":"Senapati","year":"2005","journal-title":"Brain Research"},{"key":"10.1016\/j.bbr.2013.05.019_bib0075","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1016\/j.pain.2011.02.025","article-title":"Motor cortex stimulation reduces hyperalgesia in an animal model of central pain","volume":"152","author":"Lucas","year":"2011","journal-title":"Pain"},{"key":"10.1016\/j.bbr.2013.05.019_bib0080","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1007\/s00221-007-1158-y","article-title":"Motor cortex stimulation in rats with chronic constriction injury","volume":"185","author":"Vacul\u00edn","year":"2008","journal-title":"Experimental Brain Research"},{"key":"10.1016\/j.bbr.2013.05.019_bib0085","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.bbr.2008.07.027","article-title":"Antinociception induced by epidural motor cortex stimulation in naive conscious rats is mediated by the opioid system","volume":"196","author":"Fonoff","year":"2009","journal-title":"Behavioural Brain Research"},{"key":"10.1016\/j.bbr.2013.05.019_bib0090","first-page":"268","article-title":"Transdural motor cortex stimulation reverses neuropathic pain in rats: A profile of neuronal activation","volume":"15","author":"Pagano","year":"2011","journal-title":"European Journal of Pain"},{"key":"10.1016\/j.bbr.2013.05.019_bib0095","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/S0304-3959(03)00209-4","article-title":"Motor cortex stimulation for central and neuropathic pain: current status","volume":"104","author":"Brown","year":"2003","journal-title":"Pain"},{"key":"10.1016\/j.bbr.2013.05.019_bib0100","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/S0304-3959(99)00114-1","article-title":"Electrical stimulation of motor cortex for pain control: a combined PET-scan and electrophysiological study","volume":"83","author":"Garcia-Larrea","year":"1999","journal-title":"Pain"},{"key":"10.1016\/j.bbr.2013.05.019_bib0105","doi-asserted-by":"crossref","first-page":"S71","DOI":"10.1016\/j.neuroimage.2007.05.062","article-title":"Motor cortex stimulation for neuropathic pain: from phenomenology to mechanisms","volume":"37","author":"Garcia-Larrea","year":"2007","journal-title":"Neuroimage"},{"key":"10.1016\/j.bbr.2013.05.019_bib0110","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.neulet.2010.04.014","article-title":"Roles of the rostroventromedial medulla and the spinal 5-HT1A receptor in descending antinociception induced by motor cortex stimulation in the neuropathic rat","volume":"476","author":"Viisanen","year":"2010","journal-title":"Neuroscience Letters"},{"key":"10.1016\/j.bbr.2013.05.019_bib0115","doi-asserted-by":"crossref","first-page":"2359","DOI":"10.1016\/j.pain.2012.08.002","article-title":"Motor cortex stimulation and analgesia: possible pathways and Mechanisms","volume":"153","author":"Pagano","year":"2012","journal-title":"Pain"},{"key":"10.1016\/j.bbr.2013.05.019_bib0120","first-page":"1117","article-title":"Cortical stimulation for central pain","volume":"83","author":"Canavero","year":"1995","journal-title":"Journal of Neurosurgery"},{"key":"10.1016\/j.bbr.2013.05.019_bib0125","doi-asserted-by":"crossref","first-page":"1900","DOI":"10.1111\/j.1460-9568.2007.05389.x","article-title":"Inhibitory effect of voluntary movement preparation on cutaneous heat pain and laser-evoked potentials","volume":"25","author":"Le Pera","year":"2007","journal-title":"European Journal of Neuroscience"},{"key":"10.1016\/j.bbr.2013.05.019_bib0130","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S1090-3801(02)00124-6","article-title":"Segmental and plurisegmental modulation of pressure pain thresholds during static muscle contractions in healthy individuals","volume":"7","author":"Kosek","year":"2003","journal-title":"European Journal of Pain"},{"key":"10.1016\/j.bbr.2013.05.019_bib0135","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/0304-3959(83)90201-4","article-title":"Ethical guidelines for investigations of experimental pain in conscious animals","volume":"16","author":"Zimmermann","year":"1983","journal-title":"Pain"},{"key":"10.1016\/j.bbr.2013.05.019_bib0140","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.bbr.2009.03.018","article-title":"Functional mapping of the motor cortex of the rat using transdural electrical stimulation","volume":"202","author":"Fonoff","year":"2009","journal-title":"Behavioural Brain Research"},{"key":"10.1016\/j.bbr.2013.05.019_bib0145","first-page":"209","article-title":"A method for measurement of analgesic activity on inflamed tissue","volume":"111","author":"Randall","year":"1957","journal-title":"Archives Internationales de Pharmacodynamie et de Th\u00e9rapie"},{"key":"10.1016\/j.bbr.2013.05.019_bib0150","first-page":"270","article-title":"Gabapentin antinociception in mice with acute herpetic pain induced by herpes simplex virus infection","volume":"296","author":"Takasaki","year":"2001","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"key":"10.1016\/j.bbr.2013.05.019_bib0155","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/0091-3057(94)00291-P","article-title":"Modulation of morphine antinociception by the brain-penetrating H2 antagonist zolantidine: detailed characterization in five nociceptive test systems","volume":"50","author":"Nalwalk","year":"1995","journal-title":"Pharmacology, biochemistry, and behavior"},{"key":"10.1016\/j.bbr.2013.05.019_bib0160","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/S0165-0173(98)00018-6","article-title":"Inducible and constitutive transcription factors in the mammalian nervous system: control of gene expression by Jun, Fos and Krox, and CREB\/ATF proteins","volume":"28","author":"Herdegen","year":"1998","journal-title":"Brain Research Reviews"},{"issue":"12","key":"10.1016\/j.bbr.2013.05.019_bib0165","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1038\/nrn2947","article-title":"Neuronal circuitry for pain processing in the dorsal horn","volume":"11","author":"Todd","year":"2010","journal-title":"Nature Reviews Neuroscience"},{"key":"10.1016\/j.bbr.2013.05.019_bib0170","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0166-4328(02)00197-3","article-title":"Predatory hunting and exposure to a live predator induce opposite patterns of Fos immunoreactivity in the PAG","volume":"138","author":"Comoli","year":"2003","journal-title":"Behavioural Brain Research"},{"key":"10.1016\/j.bbr.2013.05.019_bib0175","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/BF01628049","article-title":"Anatomical basis of rat brachial plexus reconstruction","volume":"14","author":"Bertelli","year":"1992","journal-title":"Surgical Radiologic Anatomy"},{"key":"10.1016\/j.bbr.2013.05.019_bib0180","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.pain.2008.01.016","article-title":"Species and strain differences in rodent sciatic nerve anatomy: implications for studies of neuropathic pain","volume":"136","author":"Rigaud","year":"2008","journal-title":"Pain"},{"key":"10.1016\/j.bbr.2013.05.019_bib0185","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.expneurol.2012.04.023","article-title":"Tail spasms in rat spinal cord injury: changes in interneuronal connectivity","volume":"236","author":"Kapitza","year":"2012","journal-title":"Experimental Neurology"},{"issue":"5","key":"10.1016\/j.bbr.2013.05.019_bib0190","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1590\/S0100-879X2003000500002","article-title":"Anatomical connections of the periaqueductal gray: specific neural substrates for different kinds of fear","volume":"36","author":"Vianna","year":"2003","journal-title":"Brazilian Journal of Medical and Biological Research"},{"key":"10.1016\/j.bbr.2013.05.019_bib0195","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0301-0082(96)00021-4","article-title":"Activation of c-Fos in the brain","volume":"50","author":"Herrera","year":"1996","journal-title":"Progress in Neurobiology"},{"key":"10.1016\/j.bbr.2013.05.019_bib0200","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/S0197-0186(96)00136-2","article-title":"Egr transcription factors in the nervous system","volume":"31","author":"Beckmann","year":"1997","journal-title":"Neurochemistry International"},{"key":"10.1016\/j.bbr.2013.05.019_bib0205","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/0896-6273(90)90106-P","article-title":"The regulation and function of c-fos and other immediate early genes in the nervous system","volume":"4","author":"Sheng","year":"1990","journal-title":"Neuron"},{"key":"10.1016\/j.bbr.2013.05.019_bib0210","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/S0891-0618(01)00119-3","article-title":"The chemical architecture of the rat's periaqueductal gray based on acetylcholinesterase histochemistry: a quantitative and qualitative study","volume":"21","author":"Ruiz-Torner","year":"2001","journal-title":"Journal of Chemical Neuroanatomy"},{"key":"10.1016\/j.bbr.2013.05.019_bib0215","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1002\/cne.903130113","article-title":"Specific temporal and spatial distribution of Jun, Fos, and Krox-24 proteins in spinal neurons following noxious transsynaptic stimulation","volume":"313","author":"Herdegen","year":"1991","journal-title":"The Journal of Comparative Neurology"},{"key":"10.1016\/j.bbr.2013.05.019_bib0220","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/0306-4522(93)90439-M","article-title":"Spinal and hindbrain structures involved in visceroception and visceronociception as revealed by the expression of Fos, Jun and Krox-24 proteins","volume":"55","author":"Lanteri-Minet","year":"1993","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbr.2013.05.019_bib0225","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/S0079-6123(08)61871-3","article-title":"A Columnar organization in the midbrain periaqueductal gray and the integration of emotional expression","volume":"107","author":"Bandler","year":"1996","journal-title":"Progress in Brain Research"}],"container-title":["Behavioural Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432813002908?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432813002908?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,15]],"date-time":"2018-10-15T19:00:46Z","timestamp":1539630046000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166432813002908"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,8]]},"references-count":45,"alternative-id":["S0166432813002908"],"URL":"https:\/\/doi.org\/10.1016\/j.bbr.2013.05.019","relation":{},"ISSN":["0166-4328"],"issn-type":[{"value":"0166-4328","type":"print"}],"subject":[],"published":{"date-parts":[[2013,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Antinociception induced by motor cortex stimulation: Somatotopy of behavioral response and profile of neuronal activation","name":"articletitle","label":"Article Title"},{"value":"Behavioural Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbr.2013.05.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}