{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T12:20:35Z","timestamp":1792153235784,"version":"4.4.0"},"reference-count":100,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2013,9,1]],"date-time":"2013-09-01T00:00:00Z","timestamp":1377993600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Behavioural Brain Research"],"published-print":{"date-parts":[[2013,9]]},"DOI":"10.1016\/j.bbr.2013.06.031","type":"journal-article","created":{"date-parts":[[2013,7,3]],"date-time":"2013-07-03T17:18:26Z","timestamp":1372871906000},"page":"68-77","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":94,"special_numbering":"C","title":["Cognitive, motor and tyrosine hydroxylase temporal impairment in a model of parkinsonism induced by reserpine"],"prefix":"10.1016","volume":"253","author":[{"given":"Jos\u00e9 R.","family":"Santos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o A.S.","family":"Cunha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aline L.","family":"Dierschnabel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clarissa L.C.","family":"Camp\u00ealo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anderson H.F.F.","family":"Le\u00e3o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anatildes F.","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rovena C.G.J.","family":"Engelberth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geison S.","family":"Iz\u00eddio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeferson S.","family":"Cavalcante","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa C.","family":"Ab\u00edlio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra M.","family":"Ribeiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Regina H.","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbr.2013.06.031_bib0005","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/S1474-4422(06)70471-9","article-title":"Epidemiology of Parkinson's disease","volume":"5","author":"De Lau","year":"2006","journal-title":"Lancet Neurology"},{"key":"10.1016\/j.bbr.2013.06.031_bib0010","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1212\/WNL.51.2_Suppl_2.S2","article-title":"Biochemical aspects of Parkinson's disease","volume":"51","author":"Hornykiewicz","year":"1998","journal-title":"Neurology"},{"key":"10.1016\/j.bbr.2013.06.031_bib0015","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1001\/archneur.64.1.20","article-title":"Circuits and circuit disorders of the basal ganglia","volume":"64","author":"De Long","year":"2007","journal-title":"Archives of Neurology"},{"key":"10.1016\/j.bbr.2013.06.031_bib0020","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/s00441-004-0975-6","article-title":"Parkinson's disease: clinical aspects","volume":"318","author":"Klockgether","year":"2004","journal-title":"Cell and Tissue Research"},{"key":"10.1016\/j.bbr.2013.06.031_bib0025","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1136\/jnnp.57.6.672","article-title":"Parkinson's disease","volume":"57","author":"Marsden","year":"1994","journal-title":"Journal of Neurology, Neurosurgery and Psychiatry"},{"key":"10.1016\/j.bbr.2013.06.031_bib0030","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1212\/01.wnl.0000338632.00552.cb","article-title":"Cognitive impairment in incident, untreated Parkinson disease: the Norwegian ParkWest study","volume":"72","author":"Aarsland","year":"2009","journal-title":"Neurology"},{"key":"10.1016\/j.bbr.2013.06.031_bib0035","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1111\/j.1468-1331.2009.02707.x","article-title":"Cognitive function in early Parkinson's disease: a population-based study","volume":"16","author":"Elgh","year":"2009","journal-title":"European Journal of Neurology"},{"key":"10.1016\/j.bbr.2013.06.031_bib0040","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.jns.2011.07.054","article-title":"Brain structural MRI correlates of cognitive dysfunctions in Parkinson's disease","volume":"310","author":"Ibarretxe-Bilbao","year":"2011","journal-title":"Journal of the Neurological Sciences"},{"key":"10.1016\/j.bbr.2013.06.031_bib0045","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.jns.2011.06.054","article-title":"Population-based case-control study of cognitive function in early Parkinson's disease (NEDICES)","volume":"310","author":"Benito-Le\u00f3n","year":"2011","journal-title":"Journal of the Neurological Sciences"},{"key":"10.1016\/j.bbr.2013.06.031_bib0050","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1002\/mds.23443","article-title":"Ventricular enlargement and mild cognitive impairment in early Parkinson's disease","volume":"26","author":"Dalaker","year":"2011","journal-title":"Movement Disorders"},{"key":"10.1016\/j.bbr.2013.06.031_bib0055","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1080\/13803390490515469","article-title":"Recognition memory in Parkinson's disease with and without dementia: evidence inconsistent with the retrieval deficit hypothesis","volume":"27","author":"Higginson","year":"2005","journal-title":"Journal of Clinical and Experimental Neuropsychology"},{"key":"10.1016\/j.bbr.2013.06.031_bib0060","doi-asserted-by":"crossref","first-page":"6351","DOI":"10.1523\/JNEUROSCI.23-15-06351.2003","article-title":"Cognitive impairments in early Parkinson's disease are accompanied by reductions in activity in frontostriatal neural circuitry","volume":"23","author":"Lewis","year":"2003","journal-title":"Journal of Neuroscience"},{"key":"10.1016\/j.bbr.2013.06.031_bib0065","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1136\/jnnp.2006.093146","article-title":"Attentional deficits affect activities of daily living in dementia-associated with Parkinson's disease","volume":"77","author":"Bronnick","year":"2006","journal-title":"Journal of Neurology, Neurosurgery and Psychiatry"},{"key":"10.1016\/j.bbr.2013.06.031_bib0070","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1038\/nrneurol.2012.34","article-title":"Parkinson disease: proteomic tools identify dementia biomarkers in PD","volume":"8","author":"Wood","year":"2012","journal-title":"Nature Reviews Neurology"},{"key":"10.1016\/j.bbr.2013.06.031_bib0075","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1602\/neurorx.2.3.484","article-title":"Toxin-induced models of Parkinson's disease","volume":"2","author":"Bove","year":"2005","journal-title":"NeuroRx"},{"key":"10.1016\/j.bbr.2013.06.031_bib0080","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/S0969-8051(02)00303-7","article-title":"Dual SPECT of dopamine system using [99mTc] TRODAT-1 and [123I]IBZM in normal and 6-OHDA-lesioned formosan rock monkeys","volume":"29","author":"Ma","year":"2002","journal-title":"Nuclear Medicine and Biology"},{"key":"10.1016\/j.bbr.2013.06.031_bib0085","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/0891-0618(95)00072-0","article-title":"Effects of unilateral 6-hydroxydopamine lesions on neuropeptide immunoreactivity in the basal ganglia of the common marmoset, Callithrix jacchus, a quantitative immunohistochemical analysis","volume":"9","author":"Roeling","year":"1995","journal-title":"Journal of Chemical Neuroanatomy"},{"key":"10.1016\/j.bbr.2013.06.031_bib0090","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0166-4328(01)00211-X","article-title":"Memory disruption in rats with nigral lesions induced by MPTP: a model for early Parkinson's disease amnesia","volume":"124","author":"Da Cunha","year":"2001","journal-title":"Behavioural Brain Research"},{"key":"10.1016\/j.bbr.2013.06.031_bib0095","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.expneurol.2006.02.002","article-title":"Rat model of Parkinson's disease: chronic central delivery of 1-methyl-4-phenylpyridinium (MPP+)","volume":"200","author":"Yazdani","year":"2006","journal-title":"Experimental Neurology"},{"key":"10.1016\/j.bbr.2013.06.031_bib0100","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1038\/81834","article-title":"Chronic systemic pesticide exposure reproduces features of Parkinson's disease","volume":"3","author":"Betarbet","year":"2000","journal-title":"Nature Neuroscience"},{"key":"10.1016\/j.bbr.2013.06.031_bib0105","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1089\/ars.2005.7.685","article-title":"Reactive oxygen and nitrogen species: weapons of neuronal destruction in models of Parkinson's disease","volume":"7","author":"Przedborski","year":"2005","journal-title":"Antioxidants and Redox Signalling"},{"key":"10.1016\/j.bbr.2013.06.031_bib0110","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/0091-3057(93)90203-6","article-title":"Vacuous jaw movements in rats induced by acute reserpine administration: interactions with different doses of apomorphine","volume":"46","author":"Baskin","year":"1993","journal-title":"Pharmacology Biochemistry and Behavior"},{"key":"10.1016\/j.bbr.2013.06.031_bib0115","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1016\/0028-3908(87)90110-9","article-title":"Pharmacological characteristics of tremor, rigidity and hypokinesia induced by reserpine in rats","volume":"26","author":"Colpaert","year":"1987","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bbr.2013.06.031_bib0120","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/0014-2999(95)00200-5","article-title":"Antiparkinsonian action of dextramethorphan in the reserpine-treated mouse","volume":"280","author":"Kaur","year":"1995","journal-title":"European Journal of Pharmacology"},{"key":"10.1016\/j.bbr.2013.06.031_bib0125","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/S0091-3057(97)98984-X","article-title":"Effects of dopaminergic agents on reversal of reserpine-induced impairment in conditioned avoidance response in rats","volume":"58","author":"Nakagawa","year":"1997","journal-title":"Pharmacology Biochemistry and Behavior"},{"key":"10.1016\/j.bbr.2013.06.031_bib0130","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/0091-3057(95)00164-6","article-title":"Vacuous jaw movements induced by acute reserpine and low-dose apomorphine: possible model of parkinsonian tremor","volume":"53","author":"Salamone","year":"1996","journal-title":"Pharmacology Biochemistry and Behavior"},{"key":"10.1016\/j.bbr.2013.06.031_bib0135","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.brainres.2006.09.008","article-title":"Effects of reserpine on the plus-maze discriminative avoidance task: dissociation between memory and motor impairments","volume":"1122","author":"Carvalho","year":"2006","journal-title":"Brain Research"},{"key":"10.1016\/j.bbr.2013.06.031_bib0140","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1016\/j.pnpbp.2008.05.004","article-title":"Memory impairment induced by low doses of reserpine in rats: possible relationship with emotional processing deficits in Parkinson disease","volume":"32","author":"Fernandes","year":"2008","journal-title":"Progress in Neuro-Psychopharmacology and Biological Psychiatry"},{"key":"10.1016\/j.bbr.2013.06.031_bib0145","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/S1054-3589(08)60736-X","article-title":"Molecular pharmacology of the vesicular monoamine transporter","volume":"42","author":"Henry","year":"1998","journal-title":"Advances in Pharmacology"},{"key":"10.1016\/j.bbr.2013.06.031_bib0150","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1007\/s00213-002-1081-7","article-title":"Effects of melatonin on orofacial movements in rats","volume":"161","author":"Ab\u00edlio","year":"2002","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.bbr.2013.06.031_bib0155","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0278-5846(02)00340-8","article-title":"E attenuates reserpine-induced oral dyskinesia and striatal oxidized glutathione\/reduced glutathione ratio (GSSG\/GSH) enhancement in rats","volume":"27","author":"Ab\u00edlio","year":"2003","journal-title":"Progress in Neuro-Psychopharmacology and Biological Psychiatry"},{"key":"10.1016\/j.bbr.2013.06.031_bib0160","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0278-5846(01)00255-X","article-title":"The mitochondrial toxin 3-nitroproprionic acid aggravants reserpine induced oral dyskinesia in rats","volume":"26","author":"Calvente","year":"2002","journal-title":"Progress in Neuro-Psychopharmacology and Biological Psychiatry"},{"key":"10.1016\/j.bbr.2013.06.031_bib0165","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1001\/archpsyc.1991.01810360061009","article-title":"Oxygen free radicals and neuropsychiatric illness","volume":"48","author":"Lohr","year":"1991","journal-title":"Archives of General Psychiatry"},{"key":"10.1016\/j.bbr.2013.06.031_bib0170","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.bbr.2012.03.008","article-title":"Repeated treatment with a low dose of reserpine as a progressive model of Parkinson's disease","volume":"231","author":"Fernandes","year":"2012","journal-title":"Behavioural Brain Research"},{"issue":"12","key":"10.1016\/j.bbr.2013.06.031_bib0175","doi-asserted-by":"crossref","first-page":"7502","DOI":"10.1523\/JNEUROSCI.14-12-07502.1994","article-title":"Quantitative study of tyrosine hydroxylase protein levels with the somatic area of the rat locus coeruleus during postnatal development","volume":"14","author":"Bezin","year":"1994","journal-title":"Journal of Neuroscience"},{"key":"10.1016\/j.bbr.2013.06.031_bib0180","series-title":"The rat brain in stereotaxic coordinates","author":"Paxinos","year":"2005"},{"key":"10.1016\/j.bbr.2013.06.031_bib0185","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1136\/practneurol-2011-000132","article-title":"Improving the diagnostic accuracy in parkinsonism: a three-pronged approach","volume":"2","author":"Aerts","year":"2012","journal-title":"Practice in Neurology"},{"key":"10.1016\/j.bbr.2013.06.031_bib0190","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1056\/NEJMcp043908","article-title":"Clinical practice. Diagnosis and initial management of Parkinson's disease","volume":"353","author":"Nutt","year":"2005","journal-title":"New England Journal of Medicine"},{"key":"10.1016\/j.bbr.2013.06.031_bib0195","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1007\/s004150050168","article-title":"Drug-naive patients with Parkinson's disease in Hoehn and Yahr stages I and II show a bilateral decrease in striatal dopamine transporters as revealed by [123I]beta-CIT SPECT","volume":"245","author":"Tissingh","year":"1998","journal-title":"Journal of Neurology"},{"key":"10.1016\/j.bbr.2013.06.031_bib0200","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1111\/j.1749-6632.2009.03885.x","article-title":"Risk is in the air: an intranasal MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) rat model of Parkinson's disease","volume":"1170","author":"Prediger","year":"2009","journal-title":"Annals of the New York Academy of Sciences"},{"key":"10.1016\/j.bbr.2013.06.031_bib0205","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.brainresbull.2008.08.018","article-title":"Unilateral axonal or terminal injection of 6-hydroxydopamine causes rapid-onset nigrostriatal degeneration and contralateral motor impairments in the rat","volume":"77","author":"Grealish","year":"2008","journal-title":"Brain Research Bulletin"},{"key":"10.1016\/j.bbr.2013.06.031_bib0210","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbr.2005.02.023","article-title":"Behavioral characterization of a unilateral 6-OHDA-lesion model of Parkinson's disease in mice","volume":"162","author":"Iancu","year":"2005","journal-title":"Behavioural Brain Research"},{"key":"10.1016\/j.bbr.2013.06.031_bib0215","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/S0166-4328(02)00180-8","article-title":"Rotenone destroys dopaminergic neurons and induces parkinsonian symptoms in rats","volume":"136","author":"Alam","year":"2002","journal-title":"Behavioural Brain Research"},{"key":"10.1016\/j.bbr.2013.06.031_bib0220","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/0091-3057(93)90371-Y","article-title":"Effects of acute haloperidol and reserpine administration on vacuous jaw movements in three different age groups of rats","volume":"46","author":"Steinpreis","year":"1993","journal-title":"Pharmacology Biochemistry and Behavior"},{"key":"10.1016\/j.bbr.2013.06.031_bib0225","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1111\/j.1476-5381.2011.01426.x","article-title":"Animal models of Parkinson's disease: a source of novel treatments and clues to the cause of the disease","volume":"164","author":"Duty","year":"2011","journal-title":"British Journal of Pharmacology"},{"key":"10.1016\/j.bbr.2013.06.031_bib0230","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1046\/j.1471-4159.1995.65010192.x","article-title":"Biochemistry of somatodendritic dopamine release in substantia nigra: an in vivo comparison with striatal dopamine release","volume":"65","author":"Heeringa","year":"1995","journal-title":"Journal of Neurochemistry"},{"key":"10.1016\/j.bbr.2013.06.031_bib0235","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1037\/0735-7044.102.5.748","article-title":"The catalepsy test: its ups and downs","volume":"102","author":"Sanberg","year":"1988","journal-title":"Behavioral Neuroscience"},{"key":"10.1016\/j.bbr.2013.06.031_bib0240","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1212\/WNL.42.2.333","article-title":"Motor blocks in Parkinson's disease","volume":"42","author":"Giladi","year":"1992","journal-title":"Neurology"},{"key":"10.1016\/j.bbr.2013.06.031_bib0245","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1007\/s002130051146","article-title":"Actions of adenosine A2A receptor antagonist KW-6002 on drug-induced catalepsy and hypokinesia caused by reserpine or MPTP","volume":"147","author":"Shiozaki","year":"1999","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.bbr.2013.06.031_bib0250","first-page":"1264","article-title":"FK506 as effective adjunct to l-dopa in reserpine-induced catalepsy in rats","volume":"41","author":"Singh","year":"2003","journal-title":"Indian Journal of Experimental Biology"},{"key":"10.1016\/j.bbr.2013.06.031_bib0255","first-page":"258","article-title":"Pharmacologic profile of n-palmitoylglycine. Its effect on reserpine and haloperidol catalepsy","volume":"134","author":"Vamvakid\u00e8s","year":"1995","journal-title":"Bollettino Chimico Farmaceutico"},{"key":"10.1016\/j.bbr.2013.06.031_bib0260","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/0006-8993(91)90710-D","article-title":"Neurochemical changes associated with the persistence of spontaneous oral dyskinesia in rats following chronic reserpine treatment","volume":"558","author":"Neisewander","year":"1991","journal-title":"Brain Research"},{"issue":"4","key":"10.1016\/j.bbr.2013.06.031_bib0265","doi-asserted-by":"crossref","first-page":"359","DOI":"10.2174\/187152712800792839","article-title":"Paradoxical sleep deprivation modulates tyrosine hydroxylase expression in the nigrostriatal pathway and attenuates motor deficits induced by dopaminergic depletion","volume":"11","author":"Lima","year":"2013","journal-title":"CNS & Neurological Disorders \u2013 Drug Targets"},{"key":"10.1016\/j.bbr.2013.06.031_bib0270","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.neuropharm.2004.04.003","article-title":"Important role of striatal catalase in aging and reserpine induced oral dyskinesia","volume":"47","author":"Ab\u00edlio","year":"2004","journal-title":"Neuropharmacology"},{"issue":"4","key":"10.1016\/j.bbr.2013.06.031_bib0275","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.pbb.2007.10.004","article-title":"Influence of chronic exercise on reserpine-induced oxidative stress in rats: behavioral and antioxidant evaluations","volume":"88","author":"Teixeira","year":"2008","journal-title":"Pharmacology Biochemistry and Behavior"},{"key":"10.1016\/j.bbr.2013.06.031_bib0280","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1146\/annurev.pa.36.040196.000503","article-title":"Oxidative stress in neurodegenerative diseases","volume":"36","author":"Simonian","year":"1996","journal-title":"Annual Review of Pharmacology and Toxicology"},{"key":"10.1016\/j.bbr.2013.06.031_bib0285","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.nbd.2012.10.011","article-title":"Mitochondrial dysfunction and oxidative stress in Parkinson's disease and monogenic parkinsonism","volume":"51","author":"Hauser","year":"2013","journal-title":"Neurobiology of Disease"},{"key":"10.1016\/j.bbr.2013.06.031_bib0290","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.1016\/j.neuroscience.2007.04.002","article-title":"Alpha-lipoic acid differently affects the reserpine-induced oxidative stress in the striatum and prefrontal cortex of rat brain","volume":"146","author":"Bilska","year":"2007","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbr.2013.06.031_bib0295","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0278-5846(02)00344-5","article-title":"Ebselen attenuates reserpine-induced orofacial dyskinesia and oxidative stress in rat striatum","volume":"27","author":"Burger","year":"2003","journal-title":"Progress in Neuro-Psychopharmacology and Biological Psychiatry"},{"key":"10.1016\/j.bbr.2013.06.031_bib0300","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.npep.2010.11.003","article-title":"The localization of brain sites of anxiogenic-like effects of urocortin-2","volume":"45","author":"Sk\u00f3rzewska","year":"2011","journal-title":"Neuropeptides"},{"key":"10.1016\/j.bbr.2013.06.031_bib0305","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1037\/h0059253","article-title":"Emotional behavioral in the rat. III: The relationship between emotionality and ambulatory activity","volume":"22","author":"Hall","year":"1936","journal-title":"Journal of Comparative Psychology"},{"key":"10.1016\/j.bbr.2013.06.031_bib0310","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S0149-7634(01)00011-2","article-title":"A detailed ethological analysis of the mouse open field test: effect of diazepam, chlordiazepoxide and an extremely low frequency pulsed magnetic field","volume":"25","author":"Choleris","year":"2001","journal-title":"Neuroscience and Behavioral Reviews"},{"key":"10.1016\/j.bbr.2013.06.031_bib0315","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1136\/jnnp.2010.213652","article-title":"Depression and anxiety related subtypes in Parkinson's disease","volume":"82","author":"Brown","year":"2011","journal-title":"Journal of Neurology, Neurosurgery and Psychiatry"},{"key":"10.1016\/j.bbr.2013.06.031_bib0320","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1046\/j.1468-1331.9.s3.6.x","article-title":"Depression in Parkinson's disease","volume":"9","author":"Burn","year":"2002","journal-title":"European Journal of Neurology"},{"key":"10.1016\/j.bbr.2013.06.031_bib0325","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.ncl.2004.06.008","article-title":"Anxiety, depression, and psychosis in Parkinson's disease: unmet needs and treatment challenges","volume":"22","author":"Chen","year":"2004","journal-title":"Neurologic Clinics"},{"key":"10.1016\/j.bbr.2013.06.031_bib0330","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1002\/mds.22760","article-title":"Anxious and depressive symptoms in Parkinson's disease: the French cross-sectional DoPaMiP study","volume":"25","author":"N\u00e8gre-Pag\u00e8s","year":"2010","journal-title":"Movement Disorders"},{"key":"10.1016\/j.bbr.2013.06.031_bib0335","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1002\/mds.1099","article-title":"Comorbidity of the nonmotor symptoms of Parkinson's disease","volume":"16","author":"Shulman","year":"2001","journal-title":"Movement Disorders"},{"key":"10.1016\/j.bbr.2013.06.031_bib0340","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1176\/jnp.17.3.310","article-title":"Prevalence and treatment of depression in Parkinson's disease","volume":"17","author":"Veazey","year":"2005","journal-title":"Journal of Neuropsychiatry and Clinical Neurosciences"},{"key":"10.1016\/j.bbr.2013.06.031_bib0345","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1136\/jnnp-2011-300043","article-title":"Psychosis associated to Parkinson's disease in the early stages: relevance of cognitive decline and depression","volume":"83","author":"Morgante","year":"2012","journal-title":"Journal of Neurology, Neurosurgery and Psychiatry"},{"key":"10.1016\/j.bbr.2013.06.031_bib0350","doi-asserted-by":"crossref","first-page":"8103","DOI":"10.1523\/JNEUROSCI.1495-09.2009","article-title":"Nonmotor symptoms of Parkinson's disease revealed in an animal model with reduced monoamine storage capacity","volume":"29","author":"Taylor","year":"2009","journal-title":"Journal of Neuroscience"},{"key":"10.1016\/j.bbr.2013.06.031_bib0355","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1016\/S0278-5846(01)00333-5","article-title":"Evaluation of the face validity of reserpine administration as an animal model of depression-Parkinson's disease association","volume":"26","author":"Skalisz","year":"2002","journal-title":"Progress in Neuro-Psychopharmacology and Biological Psychiatry"},{"key":"10.1016\/j.bbr.2013.06.031_bib0360","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1016\/j.neuroscience.2008.08.035","article-title":"Emotional, cognitive and neurochemical alterations in a premotor stage model of Parkinson's disease","volume":"156","author":"Tadaiesky","year":"2008","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbr.2013.06.031_bib0365","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1097\/00002826-200401000-00009","article-title":"Dopamineric hypersensitivity in patients with Parkinson disease and migraine","volume":"27","author":"Cubo","year":"2004","journal-title":"Clinical Neuropharmacology"},{"key":"10.1016\/j.bbr.2013.06.031_bib0370","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/S0006-8993(02)02961-X","article-title":"Hypersensitiviy of dopamine transmission in the rat striatum after treatment with the NMDA receptor antagonist amantadine","volume":"949","author":"Peeters","year":"2002","journal-title":"Brain Research"},{"key":"10.1016\/j.bbr.2013.06.031_bib0375","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1023\/A:1020736131907","article-title":"The lesion of the rat substantia nigra pars compacta dopaminergic neurons as a model for Parkinson's disease memory disabilities","volume":"22","author":"Da Cunha","year":"2002","journal-title":"Cellular and Molecular Neurobiology"},{"key":"10.1016\/j.bbr.2013.06.031_bib0380","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/S1074-7427(03)00008-X","article-title":"Evidence for the substantia nigra pars compacta as an essential component of memory system independent of hippocampal memory system","volume":"79","author":"Da Cunha","year":"2003","journal-title":"Neurobiology of Learning and Memory"},{"key":"10.1016\/j.bbr.2013.06.031_bib0385","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/1055-8330(95)90014-4","article-title":"Cognitive deficits precede motor deficits in a slowly progressing model of parkinsonism in the monkey","volume":"4","author":"Schneider","year":"1995","journal-title":"Neurodegeneration"},{"key":"10.1016\/j.bbr.2013.06.031_bib0390","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.jneumeth.2005.04.005","article-title":"Comparison of bilaterally 6-OHDAand MPTP-lesioned rats as models of the early phase of Parkinson's disease: histological, neurochemical, motor and memory alterations","volume":"148","author":"Ferro","year":"2005","journal-title":"Journal of Neuroscience Methods"},{"key":"10.1016\/j.bbr.2013.06.031_bib0395","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1017\/S1461145701002619","article-title":"l-Dopa restores striatal dopamine level but fails to reverse MPTP-induced memory deficits in rats","volume":"4","author":"Gevaerd","year":"2001","journal-title":"International Journal of Neuropsychopharmacology"},{"key":"10.1016\/j.bbr.2013.06.031_bib0400","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0166-4328(98)00160-0","article-title":"Incomplete nigrostriatal dopaminergic cell loss and partial reductions in striatal dopamine produce akinesia, rigidity, tremor and cognitive deficits in middle-aged rats","volume":"102","author":"Lindner","year":"1999","journal-title":"Behavioural Brain Research"},{"key":"10.1016\/j.bbr.2013.06.031_bib0405","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0361-9230(02)00754-2","article-title":"Impaired learning in a spatial working memory version and in a cued version of the water maze in rats with MPTP-induced mesencephalic dopaminergic lesions","volume":"58","author":"Miyoshi","year":"2002","journal-title":"Brain Research Bulletin"},{"key":"10.1016\/j.bbr.2013.06.031_bib0410","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1016\/j.neubiorev.2008.04.004","article-title":"Object recognition memory: neurobiological mechanisms of encoding, consolidation and retrieval","volume":"32","author":"Winters","year":"2008","journal-title":"Neuroscience and Biobehavioral Reviews"},{"issue":"5","key":"10.1016\/j.bbr.2013.06.031_bib0415","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1002\/hipo.22097","article-title":"The medial and lateral entorhinal cortex both contribute to contextual and item recognition memory: a test of the binding of items and context model","volume":"23","author":"Hunsaker","year":"2013","journal-title":"Hippocampus"},{"key":"10.1016\/j.bbr.2013.06.031_bib0420","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/0306-4522(92)90099-N","article-title":"Mesostriatal and mesolimbic dopamine uptake binding sites are reduced in Parkinson's disease and progressive supranuclear palsy: a quantitative autoradiographic study using [3H]mazindol","volume":"49","author":"Chinaglia","year":"1992","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbr.2013.06.031_bib0425","first-page":"943","article-title":"Mesolimbic and mesocortical pathways in Parkinson disease","volume":"59","author":"Yokochi","year":"2007","journal-title":"Brain Nerve"},{"key":"10.1016\/j.bbr.2013.06.031_bib0430","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.brainresbull.2011.05.009","article-title":"Alterations of emotion, cognition and firing activity of the basolateral nucleus of the amygdala after partial bilateral lesions of the nigrostriatal pathway in rats","volume":"85","author":"Chen","year":"2011","journal-title":"Brain Research Bulletin"},{"key":"10.1016\/j.bbr.2013.06.031_bib0435","first-page":"829","article-title":"Evaluation of dopaminergic presynaptic function by [F-18] DOPA PET","volume":"47","author":"Kato","year":"2007","journal-title":"Rinsho Shinkeigaku"},{"key":"10.1016\/j.bbr.2013.06.031_bib0440","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.bbr.2012.04.022","article-title":"Differential roles of the dorsal hippocampal regions in the acquisition of spatial and temporal aspects of episodic-like memory","volume":"232","author":"Barbosa","year":"2012","journal-title":"Behavioural Brain Research"},{"key":"10.1016\/j.bbr.2013.06.031_bib0445","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1007\/s12640-009-9087-0","article-title":"Single intranasal administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in C57BL\/6 mice models early preclinical phase of Parkinson's disease","volume":"17","author":"Prediger","year":"2010","journal-title":"Neurotoxicity Research"},{"key":"10.1016\/j.bbr.2013.06.031_bib0450","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.brainres.2009.10.070","article-title":"Noradrenergic lesion of the locus coeruleus increases apomorphine-induced circling behavior and the firing activity of substantia nigra pars reticulata neurons in a rat model of Parkinson's disease","volume":"1310","author":"Wang","year":"2010","journal-title":"Brain Research"},{"key":"10.1016\/j.bbr.2013.06.031_bib0455","doi-asserted-by":"crossref","first-page":"781","DOI":"10.3109\/15622975.2010.491127","article-title":"Serotonergic neurotransmission in early Parkinson's disease: a pilot study to assess implications for depression in this disorder","volume":"11","author":"Beucke","year":"2010","journal-title":"World Journal of Biological Psychiatry"},{"key":"10.1016\/j.bbr.2013.06.031_bib0460","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/0006-8993(84)90117-3","article-title":"Adrenergic receptors in Parkinson's disease","volume":"322","author":"Cash","year":"1984","journal-title":"Brain Research"},{"key":"10.1016\/j.bbr.2013.06.031_bib0465","doi-asserted-by":"crossref","first-page":"2330","DOI":"10.2174\/092986707781745550","article-title":"Noradrenaline in Parkinson's disease: from disease progression to current therapeutics","volume":"14","author":"Fornai","year":"2007","journal-title":"Current Medicinal Chemistry"},{"key":"10.1016\/j.bbr.2013.06.031_bib0470","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/S0149-7634(00)00028-2","article-title":"The role of the locus coeruleus in the development of Parkinson's disease","volume":"24","author":"Gesi","year":"2000","journal-title":"Neuroscience and Biobehavioral Reviews"},{"key":"10.1016\/j.bbr.2013.06.031_bib0475","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.pneurobio.2011.08.004","article-title":"The serotonergic system in Parkinson's disease","volume":"95","author":"Huot","year":"2011","journal-title":"Progress in Neurobiology"},{"issue":"1","key":"10.1016\/j.bbr.2013.06.031_bib0480","first-page":"231","article-title":"Effects of reserpine on extracellular caudate dopamine and hippocampus norepinephrine responses to amphetamine and cocaine: mechanistic and behavioral considerations","volume":"274","author":"Florin","year":"1995","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"issue":"4","key":"10.1016\/j.bbr.2013.06.031_bib0485","doi-asserted-by":"crossref","first-page":"1860","DOI":"10.1016\/j.neuroscience.2010.06.061","article-title":"Reserpine cause biphasic nociceptive sensitivity alteration in conjunction with brain biogenic amine tones in rats","volume":"169","author":"Oe","year":"2010","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbr.2013.06.031_bib0490","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/0169-328X(95)00278-Z","article-title":"Dopamine transporter (Dat) and synaptic vesicle amine transporter (VMAT2) gene expression in the substantia nigra of control and Parkinson's disease","volume":"36","author":"Harrington","year":"1996","journal-title":"Brain Research: Molecular Brain Research"},{"key":"10.1016\/j.bbr.2013.06.031_bib0495","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1002\/ana.410410417","article-title":"Immunochemical analysis of dopamine transporter protein in Parkinson's disease","volume":"41","author":"Miller","year":"1997","journal-title":"Annals of Neurology"},{"key":"10.1016\/j.bbr.2013.06.031_bib0500","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1006\/exnr.1998.7008","article-title":"Immunochemical analysis of vesicular monoamine transporter (VMAT2) protein in Parkinson's disease","volume":"156","author":"Miller","year":"1999","journal-title":"Experimental Neurology"}],"container-title":["Behavioural Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016643281300394X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016643281300394X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,7,16]],"date-time":"2019-07-16T21:49:36Z","timestamp":1563313776000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S016643281300394X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,9]]},"references-count":100,"alternative-id":["S016643281300394X"],"URL":"https:\/\/doi.org\/10.1016\/j.bbr.2013.06.031","relation":{},"ISSN":["0166-4328"],"issn-type":[{"value":"0166-4328","type":"print"}],"subject":[],"published":{"date-parts":[[2013,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cognitive, motor and tyrosine hydroxylase temporal impairment in a model of parkinsonism induced by reserpine","name":"articletitle","label":"Article Title"},{"value":"Behavioural Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbr.2013.06.031","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}