{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T09:20:39Z","timestamp":1767864039938,"version":"3.49.0"},"reference-count":73,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2013,9,1]],"date-time":"2013-09-01T00:00:00Z","timestamp":1377993600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Behavioural Brain Research"],"published-print":{"date-parts":[[2013,9]]},"DOI":"10.1016\/j.bbr.2013.07.004","type":"journal-article","created":{"date-parts":[[2013,7,11]],"date-time":"2013-07-11T17:00:32Z","timestamp":1373562032000},"page":"103-112","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Repeated and chronic administration of Vardenafil or Sildenafil differentially affects emotional and socio-sexual behavior in mice"],"prefix":"10.1016","volume":"253","author":[{"given":"H.","family":"Dadomo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Parmigiani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Nicolini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Freschini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Gioiosa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.S.","family":"Patrelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Palanza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Volpi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.bbr.2013.07.004_bib0005","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1073\/pnas.0509972102","article-title":"PDE1B2 regulates cGMP and a subset of the phenotypic characteristics acquired upon macrophage differentiation from a monocyte","volume":"103","author":"Bender","year":"2006","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"3","key":"10.1016\/j.bbr.2013.07.004_bib0010","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.pharmthera.2005.07.003","article-title":"Cyclic nucleotide phosphodiesterase (PDE) superfamily: a new target for the development of specific therapeutic agents","volume":"109","author":"Lugnier","year":"2006","journal-title":"Pharmacology & Therapeutics"},{"key":"10.1016\/j.bbr.2013.07.004_bib0015","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1146\/annurev.biochem.76.060305.150444","article-title":"Biochemistry and physiology of cyclic nucleotide phosphocliesterases: essential components in cyclic nucleotide signaling","volume":"76","author":"Conti","year":"2007","journal-title":"Annual Review of Biochemistry"},{"issue":"3","key":"10.1016\/j.bbr.2013.07.004_bib0020","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1161\/01.RES.0000256354.95791.f1","article-title":"Overview of PDEs and their regulation","volume":"100","author":"Omori","year":"2007","journal-title":"Circulation Research"},{"issue":"5","key":"10.1016\/j.bbr.2013.07.004_bib0025","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1007\/s003450100221","article-title":"Phosphodiesterase 1 inhibition in the treatment of lower urinary tract dysfunction: From bench to bedside","volume":"19","author":"Truss","year":"2001","journal-title":"World Journal of Urology"},{"issue":"7","key":"10.1016\/j.bbr.2013.07.004_bib0030","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1021\/jm000081+","article-title":"N-3-substituted imidazoquinazolinones: potent and selective PDE5 inhibitors as potential agents for treatment of erectile dysfunction","volume":"43","author":"Rotella","year":"2000","journal-title":"Journal of Medicinal Chemistry"},{"key":"10.1016\/j.bbr.2013.07.004_bib0035","doi-asserted-by":"crossref","first-page":"S14","DOI":"10.1046\/j.1463-1326.2002.0040s2s14.x","article-title":"The pharmacology of cilostazol","volume":"4","author":"Schror","year":"2002","journal-title":"Diabetes Obesity & Metabolism"},{"issue":"1-2","key":"10.1016\/j.bbr.2013.07.004_bib0040","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.physbeh.2005.07.009","article-title":"Effects of long-term continuous exposure to light on memory and anxiety in mice","volume":"86","author":"Castro","year":"2005","journal-title":"Physiology and Behavior"},{"issue":"9454","key":"10.1016\/j.bbr.2013.07.004_bib0045","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0140-6736(05)17708-3","article-title":"Phosphodiesterase-4 inhibitors for asthma and chronic obstructive pulmonary disease","volume":"365","author":"Lipworth","year":"2005","journal-title":"Lancet"},{"issue":"20","key":"10.1016\/j.bbr.2013.07.004_bib0050","doi-asserted-by":"crossref","first-page":"2511","DOI":"10.2174\/138161206777698855","article-title":"Improving memory: a role for phosphodiesterases","volume":"12","author":"Blokland","year":"2006","journal-title":"Current Pharmaceutical Design"},{"issue":"8","key":"10.1016\/j.bbr.2013.07.004_bib0055","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1038\/nrd2058","article-title":"Phosphodiesterases in the CNS: targets for drug development","volume":"5","author":"Menniti","year":"2006","journal-title":"Nature Reviews Drug Discovery"},{"issue":"2","key":"10.1016\/j.bbr.2013.07.004_bib0060","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1152\/physrev.00030.2010","article-title":"Mammalian cyclic nucleotide phosphodiesterases: molecular mechanisms and physiological functions","volume":"91","author":"Francis","year":"2011","journal-title":"Physiological Reviews"},{"key":"10.1016\/j.bbr.2013.07.004_bib0065","series-title":"Abstracts of Papers of the American Chemical Society","first-page":"234","article-title":"MEDI 266-structure based design of second generation long-acting PDE5 inhibitors","author":"Palmer","year":"2007"},{"issue":"4","key":"10.1016\/j.bbr.2013.07.004_bib0070","doi-asserted-by":"crossref","first-page":"405","DOI":"10.2174\/156802607779941288","article-title":"Design of second generation phosphodiesterase 5 inhibitors","volume":"7","author":"Palmer","year":"2007","journal-title":"Current Topics in Medicinal Chemistry"},{"issue":"1","key":"10.1016\/j.bbr.2013.07.004_bib0075","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1124\/mol.107.040212","article-title":"Conformational variations of both phosphodiesterase-5 and inhibitors provide the structural basis for the physiological effects of vardenafil and sildenafil","volume":"73","author":"Wang","year":"2008","journal-title":"Molecular Pharmacology"},{"issue":"6","key":"10.1016\/j.bbr.2013.07.004_bib0080","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1007\/s00345-005-0022-6","article-title":"Clinical update on phosphodiesterase type-5 inhibitors for erectile dysfunction","volume":"23","author":"Briganti","year":"2005","journal-title":"World Journal of Urology"},{"issue":"5","key":"10.1016\/j.bbr.2013.07.004_bib0085","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/ncpuro0186","article-title":"Drug insight: oral phosphodiesterase type 5 inhibitors for erectile dysfunction","volume":"2","author":"Briganti","year":"2005","journal-title":"Nature Clinical Practice Urology"},{"issue":"27","key":"10.1016\/j.bbr.2013.07.004_bib0090","doi-asserted-by":"crossref","first-page":"3459","DOI":"10.2174\/138161206778343118","article-title":"Phosphodiesterase 5 inhibitors \u2013 drug design and differentiation based on selectivity, pharmacokinetic and efficacy profiles","volume":"12","author":"Supuran","year":"2006","journal-title":"Current Pharmaceutical Design"},{"issue":"8","key":"10.1016\/j.bbr.2013.07.004_bib0095","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1111\/j.1742-1241.2006.01049.x","article-title":"Comparison of phosphodiesterase type 5 (PDE5) inhibitors","volume":"60","author":"Wright","year":"2006","journal-title":"International Journal of Clinical Practice"},{"issue":"3","key":"10.1016\/j.bbr.2013.07.004_bib0100","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1038\/sj.ijir.3901525","article-title":"Do vardenafil and tadalafil have advantages over sildenafil in the treatment of erectile dysfunction?","volume":"19","author":"Doggrell","year":"2007","journal-title":"International Journal of Impotence Research"},{"issue":"3","key":"10.1016\/j.bbr.2013.07.004_bib0105","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1038\/sj.ijir.3901522","article-title":"The role of pharmacokinetics and pharmacodynamics in phosphodiesterase-5 inhibitor therapy","volume":"19","author":"Mehrotra","year":"2007","journal-title":"International Journal of Impotence Research"},{"issue":"6953","key":"10.1016\/j.bbr.2013.07.004_bib0110","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1038\/nature01914","article-title":"Structure of the catalytic domain of human phosphodiesterase 5 with bound drug molecules","volume":"425","author":"Sung","year":"2003","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.bbr.2013.07.004_bib0115","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1016\/j.bcp.2004.05.015","article-title":"Differential inhibitor sensitivity between human recombinant and native photoreceptor cGMP-phosphodiesterases (PDE6s)","volume":"68","author":"Zhang","year":"2004","journal-title":"Biochemical Pharmacology"},{"issue":"1","key":"10.1016\/j.bbr.2013.07.004_bib0120","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0378-1119(98)00303-5","article-title":"Isolation and characterization of cDNAs encoding PDE5A, a human cGMP-binding, cGMP-specific 3\u2032,5\u2032-cyclic nucleotide phosphodiesterase","volume":"216","author":"Loughney","year":"1998","journal-title":"Gene"},{"issue":"4","key":"10.1016\/j.bbr.2013.07.004_bib0125","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1152\/physrev.1995.75.4.725","article-title":"Cyclic-nucleotide phosphodiesterases \u2013 functional implications of multiple isoforms","volume":"75","author":"Beavo","year":"1995","journal-title":"Physiological Reviews"},{"issue":"9150","key":"10.1016\/j.bbr.2013.07.004_bib0130","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/S0140-6736(98)05473-7","article-title":"Retinal side-effects of sildenafil","volume":"353","author":"Vobig","year":"1999","journal-title":"Lancet"},{"issue":"10","key":"10.1016\/j.bbr.2013.07.004_bib0135","doi-asserted-by":"crossref","first-page":"2680","DOI":"10.1111\/j.1743-6109.2009.01410.x","article-title":"Phosphodiesterase type 5 inhibitors facilitate noncontact erections in male rats: site of action in the brain and mechanism of action","volume":"6","author":"Sanna","year":"2009","journal-title":"Journal of Sexual Medicine"},{"issue":"1","key":"10.1016\/j.bbr.2013.07.004_bib0140","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.bbr.2010.07.036","article-title":"Sildenafil counteracts the inhibitory effect of social subordination on competitive aggression and sexual motivation in male mice","volume":"216","author":"Dadomo","year":"2011","journal-title":"Behavioural Brain Research"},{"key":"10.1016\/j.bbr.2013.07.004_bib0145","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/S0306-4530(02)00039-2","article-title":"Individual housing induces altered immuno-endocrine responses to psychological stress in male mice","volume":"28","author":"Bartolomucci","year":"2003","journal-title":"Psychoneuroendocrinology"},{"issue":"3","key":"10.1016\/j.bbr.2013.07.004_bib0150","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1096\/fj.07-9574LSF","article-title":"Dose translation from animal to human studies revisited","volume":"22","author":"Reagan-Shaw","year":"2008","journal-title":"FASEB Journal"},{"issue":"February","key":"10.1016\/j.bbr.2013.07.004_bib0155","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1477-5751-8-3","article-title":"Evaluation of vardenafil for the treatment of subjective tinnitus: a controlled pilot study","volume":"8","author":"Mazurek","year":"2009","journal-title":"Journal of Negative Results in BioMedicine"},{"issue":"52","key":"10.1016\/j.bbr.2013.07.004_bib0160","first-page":"1","article-title":"The vicious cycle towards violence: focus on the negative feedback mechanisms of brain serotonin neurotransmission","volume":"3","author":"Natarajan","year":"2009","journal-title":"Frontiers in Behavioural Neuroscience"},{"issue":"3","key":"10.1016\/j.bbr.2013.07.004_bib0165","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/S0031-9384(01)00453-X","article-title":"Social status in mice: behavioral, endocrine and immune changes are context dependent","volume":"73","author":"Bartolomucci","year":"2001","journal-title":"Physiology & Behavior"},{"issue":"5","key":"10.1016\/j.bbr.2013.07.004_bib0170","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/j.physbeh.2004.09.005","article-title":"Aggressive behavior increases after termination of chronic sildenafil treatment in mice","volume":"83","author":"Hotchkiss","year":"2005","journal-title":"Physiology & Behavior"},{"issue":"3","key":"10.1016\/j.bbr.2013.07.004_bib0175","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1124\/pr.110.002907","article-title":"cGMP-dependent protein kinases and cGMP phosphodiesterases in nitric oxide and cGMP action","volume":"62","author":"Francis","year":"2010","journal-title":"Pharmacological Reviews"},{"issue":"May\u2013June (3)","key":"10.1016\/j.bbr.2013.07.004_bib0180","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1038\/sj.ijir.3901522","article-title":"The role of pharmacokinetics and pharmacodynamics in phosphodiesterase-5 inhibitor therapy","volume":"19","author":"Mehrotra","year":"2007","journal-title":"International Journal of Impotence Research"},{"key":"10.1016\/j.bbr.2013.07.004_bib0185","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1097\/00007691-200102000-00005","article-title":"Determination of sildenafil citrate in plasma by high-performance liquid chromatography and a case for the potential interaction of grapefruit juice with sildenafil citrate","volume":"23","author":"Lee","year":"2001","journal-title":"Therapeutic Drug Monitoring"},{"key":"10.1016\/j.bbr.2013.07.004_bib0190","first-page":"613","article-title":"Simultaneous determination of sildenafil and N-desmethyl sildenafil in human plasma by highperformance liquid chromatography method using electrochemical detection with application to a pharmacokinetic study","volume":"43","author":"Al Ghazawi","year":"2007","journal-title":"Therapeutic Drug Monitoring"},{"key":"10.1016\/j.bbr.2013.07.004_bib0195","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1007\/978-94-009-2403-1_29","article-title":"Ethoexperimental analysis of different forms of intraspecific aggression in the house mouse (Mus musculus)","volume":"48","author":"Parmigiani","year":"1989","journal-title":"Ethoexperimental Approaches to the Study of Behavior"},{"issue":"April (4)","key":"10.1016\/j.bbr.2013.07.004_bib0200","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1016\/j.yhbeh.2013.02.016","article-title":"The effects of bisphenol A on emotional behavior depend upon the timing of exposure, age and gender in mice","volume":"63","author":"Gioiosa","year":"2013","journal-title":"Hormones and Behavior"},{"issue":"3","key":"10.1016\/j.bbr.2013.07.004_bib0205","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S0149-7634(01)00011-2","article-title":"A detailed ethological analysis of the mouse open field test: effects of diazepam, chlordiazepoxide and an extremely low frequency pulsed magnetic field","volume":"25","author":"Choleris","year":"2001","journal-title":"Neuroscience and Biobehavioral Reviews"},{"issue":"2","key":"10.1016\/j.bbr.2013.07.004_bib0210","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1038\/nrn1846","article-title":"New approaches to antidepressant drug discovery: beyond monoamines","volume":"7","author":"Berton","year":"2006","journal-title":"Nature Reviews Neuroscience"},{"issue":"1","key":"10.1016\/j.bbr.2013.07.004_bib0215","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0004265","article-title":"Stress and depression: preclinical research and clinical implications","volume":"4","author":"Bartolomucci","year":"2009","journal-title":"PLoS ONE"},{"issue":"January (1\u20132)","key":"10.1016\/j.bbr.2013.07.004_bib0220","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S0031-9384(00)00406-6","article-title":"Novelty seeking in periadolescent mice: sex differences and influence of intrauterine position","volume":"72","author":"Palanza","year":"2001","journal-title":"Physiology & Behavior"},{"issue":"4","key":"10.1016\/j.bbr.2013.07.004_bib0225","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0035538","article-title":"Mouse estrous cycle identification tool and images","volume":"7","author":"Byers","year":"2012","journal-title":"PLoS ONE"},{"issue":"1","key":"10.1016\/j.bbr.2013.07.004_bib0230","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1163\/156853971X00014","article-title":"Biological significance, genetics and evolutionary origin of variability in behaviour within and between inbred strains of mice (Mus musculus). A behaviour genetic study","volume":"38","author":"Van Oortmerssen","year":"1971","journal-title":"Behaviour"},{"key":"10.1016\/j.bbr.2013.07.004_bib0235","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1095\/biolreprod31.3.446","article-title":"Longitudinal studies of estrous cyclicity in aging C57BL\/6J mice. II. Cessation of cyclicity and the duration of persistent vaginal cornification","volume":"31","author":"Felicio","year":"1984","journal-title":"Biology of Reproduction"},{"key":"10.1016\/j.bbr.2013.07.004_bib0240","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.jhazmat.2009.03.131","article-title":"Subacute oral exposure to benzo[alpha]pyrene(B[alpha]P) increases aggressiveness and affects consummatory aspects of sexual behaviour in male mice","volume":"169","author":"Bouayed","year":"2009","journal-title":"Journal of Hazardous Materials"},{"issue":"3","key":"10.1016\/j.bbr.2013.07.004_bib0245","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1007\/s11011-012-9284-z","article-title":"Chronic treatment with the phosphodiesterase type 5 inhibitors sildenafil and tadalafil display anxiolytic effects in Flinders sensitive line rats","volume":"27","author":"Liebenberg","year":"2012","journal-title":"Metabolic Brain Disease"},{"issue":"2","key":"10.1016\/j.bbr.2013.07.004_bib0250","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/S0306-4522(02)00199-9","article-title":"Effects of two selective phosphodiesterase type 5 inhibitors, sildenafil and vardenafil, on object recognition memory and hippocampal cyclic GMP levels in the rat","volume":"113","author":"Prickaerts","year":"2002","journal-title":"Neuroscience"},{"issue":"3","key":"10.1016\/j.bbr.2013.07.004_bib0255","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.neubiorev.2005.02.002","article-title":"Pleiotropic contributions of nitric oxide to aggressive behavior","volume":"30","author":"Nelson","year":"2006","journal-title":"Neuroscience and Biobehavioral Reviews"},{"issue":"9","key":"10.1016\/j.bbr.2013.07.004_bib0260","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1007\/BF03401818","article-title":"Inhibition of neuronal nitric oxide synthase increases aggressive behavior in mice","volume":"3","author":"Demas","year":"1997","journal-title":"Molecular Medicine"},{"issue":"1","key":"10.1016\/j.bbr.2013.07.004_bib0265","first-page":"63","article-title":"Cerebrospinal fluid amine metabolites and cyclic nucleotides in human aggression proceedings","volume":"17","author":"Brown","year":"1981","journal-title":"Psychopharmacology Bulletin"},{"key":"10.1016\/j.bbr.2013.07.004_bib0270","first-page":"305","article-title":"Influence of cyclic nucleotides on defensive, offensive and predatory aggression in rodents","volume":"169","author":"Kantak","year":"1984","journal-title":"Progress in clinical and biological research"},{"issue":"12","key":"10.1016\/j.bbr.2013.07.004_bib0275","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/S0166-2236(00)01996-2","article-title":"Molecular basis of aggression","volume":"24","author":"Nelson","year":"2001","journal-title":"Trends in Neurosciences"},{"issue":"1","key":"10.1016\/j.bbr.2013.07.004_bib0280","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.neuropharm.2011.09.004","article-title":"Inhibition of iNOS induces antidepressant-like effects in mice: pharmacological and genetic evidence","volume":"62","author":"Montezuma","year":"2012","journal-title":"Neuropharmacology"},{"issue":"3","key":"10.1016\/j.bbr.2013.07.004_bib0285","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.pbb.2007.08.008","article-title":"Nitric oxide-mediated anxiolytic-like and antidepressant-like effects in animal models of anxiety and depression","volume":"88","author":"Spiacci","year":"2008","journal-title":"Pharmacology Biochemistry and Behavior"},{"issue":"3","key":"10.1016\/j.bbr.2013.07.004_bib0290","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.yhbeh.2003.02.002","article-title":"Interaction of nitric oxide and serotonin in aggressive behavior","volume":"44","author":"Chiavegatto","year":"2003","journal-title":"Hormones and Behavior"},{"issue":"4","key":"10.1016\/j.bbr.2013.07.004_bib0295","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1111\/j.1365-2613.2009.00660.x","article-title":"Chronic treatment with sildenafil stimulates Leydig cell and testosterone secretion","volume":"90","author":"Saraiva","year":"2009","journal-title":"International Journal of Experimental Pathology"},{"issue":"4","key":"10.1016\/j.bbr.2013.07.004_bib0300","first-page":"RA136","article-title":"Testosterone and aggressiveness","volume":"11","author":"Giammanco","year":"2005","journal-title":"Medical Science Monitor"},{"key":"10.1016\/j.bbr.2013.07.004_bib0305","series-title":"Novartis Foundation Symposium","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1002\/0470010703.ch6","article-title":"Genes for sex hormone receptors controlling mouse aggression","author":"Pfaff","year":"2005"},{"issue":"3","key":"10.1016\/j.bbr.2013.07.004_bib0310","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.neubiorev.2004.12.007","article-title":"Testosterone and human aggression: an evaluation of the challenge hypothesis","volume":"30","author":"Archer","year":"2006","journal-title":"Neuroscience and Biobehavioral Reviews"},{"issue":"4","key":"10.1016\/j.bbr.2013.07.004_bib0315","doi-asserted-by":"crossref","first-page":"A543","DOI":"10.1096\/fasebj.20.4.A543-c","article-title":"Potent inhibition of phosphodiesterase-5 (PDE5) by vardenafil, but not by sildenafil, tadalafil, or IBMX requires an intact GAF b domain","volume":"20","author":"Blount","year":"2006","journal-title":"FASEB Journal"},{"issue":"30","key":"10.1016\/j.bbr.2013.07.004_bib0320","doi-asserted-by":"crossref","first-page":"21469","DOI":"10.1074\/jbc.M512527200","article-title":"Multiple conformations of phosphodiesterase-5 \u2013 implications for enzyme function and drug development","volume":"281","author":"Wang","year":"2006","journal-title":"Journal of Biological Chemistry"},{"issue":"4","key":"10.1016\/j.bbr.2013.07.004_bib0325","first-page":"812","article-title":"Chronic sildenafil (Viagra) administration reduces anxiety in intact and castrated male rats","volume":"20","author":"Solis","year":"2008","journal-title":"Psicothema"},{"key":"10.1016\/j.bbr.2013.07.004_bib0330","doi-asserted-by":"crossref","unstructured":"Verbeek MEM, Boon A, Drent PJ, Inventors. Exploration, aggressive behavior and dominance in pair-wise confrontations of juvenile male great tits. Patent Part 11\u201312; September 1996.","DOI":"10.1163\/156853996X00314"},{"issue":"3","key":"10.1016\/j.bbr.2013.07.004_bib0335","doi-asserted-by":"crossref","DOI":"10.1002\/1098-2337(1988)14:3<195::AID-AB2480140305>3.0.CO;2-G","article-title":"Social-dominance and individual aggressiveness","volume":"14","author":"Blanchard","year":"1988","journal-title":"Aggressive Behavior"},{"key":"10.1016\/j.bbr.2013.07.004_bib0340","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0079-6123(08)60196-X","article-title":"Neuroendocrine states and behavioral and physiological stress responses","volume":"72","author":"Bohus","year":"1987","journal-title":"Progress in Brain Research"},{"issue":"4","key":"10.1016\/j.bbr.2013.07.004_bib0345","first-page":"653","article-title":"Augmentation of the NO-cGMP cascade induces anxiogenic-like effect in mice","volume":"54","author":"Volke","year":"2003","journal-title":"Journal of Physiology and Pharmacology: an Official Journal of the Polish Physiological Society"},{"issue":"8","key":"10.1016\/j.bbr.2013.07.004_bib0350","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1016\/j.pnpbp.2009.08.012","article-title":"Involvement of NO-cGMP pathway in anti-anxiety effect of aminoguanidine in stressed mice","volume":"33","author":"Gilhotra","year":"2009","journal-title":"Progress in Neuro-Psychopharmacology and Biological Psychiatry"},{"issue":"4","key":"10.1016\/j.bbr.2013.07.004_bib0355","doi-asserted-by":"crossref","first-page":"213","DOI":"10.5213\/inj.2010.14.4.213","article-title":"Vardenafil enhances oxytocin expression in the paraventricular nucleus without sexual stimulation","volume":"14","author":"Shin","year":"2010","journal-title":"International Neurourology Journal"},{"issue":"1","key":"10.1016\/j.bbr.2013.07.004_bib0360","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1113\/jphysiol.2007.139303","article-title":"Blockade of phosphodiesterase type 5 enhances rat neurohypophysial excitability and electrically evoked oxytocin release","volume":"584","author":"Zhang","year":"2007","journal-title":"Journal of Physiology (London)"},{"issue":"3","key":"10.1016\/j.bbr.2013.07.004_bib0365","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/S0091-3057(02)00744-X","article-title":"Modulatory activity of sildenafil on copulatory behaviour of both intact and castrated male rats","volume":"72","author":"Ottani","year":"2002","journal-title":"Pharmacology Biochemistry and Behavior"}],"container-title":["Behavioural Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432813004038?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432813004038?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,2,28]],"date-time":"2022-02-28T13:18:50Z","timestamp":1646054330000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166432813004038"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,9]]},"references-count":73,"alternative-id":["S0166432813004038"],"URL":"https:\/\/doi.org\/10.1016\/j.bbr.2013.07.004","relation":{},"ISSN":["0166-4328"],"issn-type":[{"value":"0166-4328","type":"print"}],"subject":[],"published":{"date-parts":[[2013,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Repeated and chronic administration of Vardenafil or Sildenafil differentially affects emotional and socio-sexual behavior in mice","name":"articletitle","label":"Article Title"},{"value":"Behavioural Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbr.2013.07.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}