{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:26:36Z","timestamp":1792783596929,"version":"4.5.0"},"reference-count":21,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,2,1]],"date-time":"2014-02-01T00:00:00Z","timestamp":1391212800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"China 973","award":["2010CB529604"],"award-info":[{"award-number":["2010CB529604"]}]},{"name":"Grants-in-Aid for Scientific Research KAKENHI","award":["22500396"],"award-info":[{"award-number":["22500396"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Behavioural Brain Research"],"published-print":{"date-parts":[[2014,2]]},"DOI":"10.1016\/j.bbr.2013.10.033","type":"journal-article","created":{"date-parts":[[2013,10,28]],"date-time":"2013-10-28T13:32:15Z","timestamp":1382967135000},"page":"45-49","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Blockade of Cav2.1-mediated NMDA receptor signaling disrupts conditioned fear extinction"],"prefix":"10.1016","volume":"259","author":[{"given":"Kimie","family":"Niimi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanfei","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuro","family":"Yoshimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fu","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaochun","family":"Teng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoli","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weidong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eiki","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbr.2013.10.033_bib0005","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1111\/j.1460-9568.2010.07101.x","article-title":"Neuronal circuits of fear extinction","volume":"31","author":"Herry","year":"2010","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.bbr.2013.10.033_bib0010","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1038\/35021052","article-title":"Fear memories require protein synthesis in the amygdala for reconsolidation after retrieval","volume":"406","author":"Nader","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.bbr.2013.10.033_bib0015","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/S0896-6273(02)01064-4","article-title":"Behavioral and neural analysis of extinction","volume":"36","author":"Myers","year":"2001","journal-title":"Neuron"},{"key":"10.1016\/j.bbr.2013.10.033_bib0020","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/j.neuron.2007.02.021","article-title":"Consolidation of fear extinction requires NMDA receptor-dependent bursting in the ventromedial prefrontal cortex","volume":"53","author":"Burgos-Robles","year":"2007","journal-title":"Neuron"},{"key":"10.1016\/j.bbr.2013.10.033_bib0025","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1523\/JNEUROSCI.4639-08.2009","article-title":"Brain region-specific gene expression activation required for reconsolidation and extinction of contextual fear memory","volume":"29","author":"Mamiya","year":"2009","journal-title":"J Neurosci"},{"key":"10.1016\/j.bbr.2013.10.033_bib0030","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1111\/j.1476-5381.2009.00463.x","article-title":"Levetiracetam inhibits glutamate transmission through presynaptic P\/Q-type calcium channels on the granule cells of the dentate gyrus","volume":"158","author":"Lee","year":"2009","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.bbr.2013.10.033_bib0035","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0169-328X(94)00265-G","article-title":"Localization of mRNAs of voltage-dependent calcium channels: four subtypes of alpha 1- and beta-subunits in developing and mature rat brain","volume":"30","author":"Tanaka","year":"1995","journal-title":"Brain Res Mol Brain Res"},{"key":"10.1016\/j.bbr.2013.10.033_bib0040","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1111\/j.1460-9568.2011.07628.x","article-title":"Molecular basis of NMDA receptor functional diversity","volume":"33","author":"Paoletti","year":"2011","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.bbr.2013.10.033_bib0045","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1016\/j.neuron.2008.09.005","article-title":"Ca2+ channel regulation and presynaptic plasticity","volume":"59","author":"Catterall","year":"2008","journal-title":"Neuron"},{"key":"10.1016\/j.bbr.2013.10.033_bib0050","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.exger.2008.11.006","article-title":"Spatial learning deficit in aged heterozygous Cav2.1 channel mutant mice, rolling mouse Nagoya","volume":"44","author":"Takahashi","year":"2009","journal-title":"Exp Gerontol"},{"key":"10.1016\/j.bbr.2013.10.033_bib0055","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1016\/S0196-9781(98)00058-8","article-title":"Peptide N- and P\/Q-type Ca2+ blockers inhibit stimulant-induced hyperactivity in mice","volume":"19","author":"Ogura","year":"1998","journal-title":"Peptides"},{"key":"10.1016\/j.bbr.2013.10.033_bib0060","doi-asserted-by":"crossref","first-page":"4787","DOI":"10.1523\/JNEUROSCI.5491-03.2004","article-title":"Memory reconsolidation and extinction have distinct temporal and biochemical signatures","volume":"24","author":"Suzuki","year":"2004","journal-title":"J Neurosci"},{"key":"10.1016\/j.bbr.2013.10.033_bib0065","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1254\/jjp.80.351","article-title":"Role of glutamate receptors and voltage-dependent calcium channels in glutamate toxicity in energy-compromised cortical neurons","volume":"80","author":"Kimura","year":"1999","journal-title":"Jpn J Pharmacol"},{"key":"10.1016\/j.bbr.2013.10.033_bib0070","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/sj.npp.1301555","article-title":"Neural mechanisms of extinction learning and retrieval","volume":"33","author":"Quirk","year":"2008","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.bbr.2013.10.033_bib0075","doi-asserted-by":"crossref","first-page":"5654","DOI":"10.1523\/JNEUROSCI.20-15-05654.2000","article-title":"Reduced voltage sensitivity of activation of P\/Q-type calcium channels is associated with the ataxic mouse mutation rolling Nagoya (tg(rol))","volume":"20","author":"Mori","year":"2000","journal-title":"J Neurosci"},{"key":"10.1016\/j.bbr.2013.10.033_bib0080","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.bbr.2010.04.030","article-title":"Impairment of spatial short-term memory following acute administration of the NMDA receptor antagonist in heterozygous rolling Nagoya mice carrying the Cav2.1alpha1 mutation","volume":"213","author":"Takahashi","year":"2010","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.bbr.2013.10.033_bib0085","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1038\/npp.2010.184","article-title":"Dissociable roles of prelimbic and infralimbic cortices, ventral hippocampus, and basolateral amygdala in the expression and extinction of conditioned fear","volume":"36","author":"Sierra-Mercado","year":"2010","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.bbr.2013.10.033_bib0090","doi-asserted-by":"crossref","first-page":"8474","DOI":"10.1523\/JNEUROSCI.0378-09.2009","article-title":"Sustained conditioned responses in prelimbic prefrontal neurons are correlated with fear expression and extinction failure","volume":"29","author":"Burgos-Robles","year":"2009","journal-title":"J Neurosci"},{"key":"10.1016\/j.bbr.2013.10.033_bib0095","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1038\/nature07167","article-title":"Amygdala intercalated neurons are required for expression of fear extinction","volume":"454","author":"Likhtik","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.bbr.2013.10.033_bib0100","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1101\/lm.1080108","article-title":"Distinct contributions of the basolateral amygdala and the medial prefrontal cortex to learning and relearning extinction of context conditioned fear","volume":"15","author":"Laurent","year":"2008","journal-title":"Learn Memory"},{"key":"10.1016\/j.bbr.2013.10.033_bib0105","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1101\/lm.1920810","article-title":"Activation of the infralimbic cortex in a fear context enhances extinction learning","volume":"17","author":"Thompson","year":"2010","journal-title":"Learn Memory"}],"container-title":["Behavioural Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432813006487?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432813006487?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,7,31]],"date-time":"2019-07-31T07:47:49Z","timestamp":1564559269000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166432813006487"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2]]},"references-count":21,"alternative-id":["S0166432813006487"],"URL":"https:\/\/doi.org\/10.1016\/j.bbr.2013.10.033","relation":{},"ISSN":["0166-4328"],"issn-type":[{"value":"0166-4328","type":"print"}],"subject":[],"published":{"date-parts":[[2014,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Blockade of Cav2.1-mediated NMDA receptor signaling disrupts conditioned fear extinction","name":"articletitle","label":"Article Title"},{"value":"Behavioural Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbr.2013.10.033","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}