{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T13:36:36Z","timestamp":1761917796817},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,5,1]],"date-time":"2014-05-01T00:00:00Z","timestamp":1398902400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"crossref","award":["472958\/2011-9"],"award-info":[{"award-number":["472958\/2011-9"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Behavioural Brain Research"],"published-print":{"date-parts":[[2014,5]]},"DOI":"10.1016\/j.bbr.2014.02.015","type":"journal-article","created":{"date-parts":[[2014,2,21]],"date-time":"2014-02-21T18:46:13Z","timestamp":1393008373000},"page":"101-110","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Fish oil provides a sustained antiamnesic effect after acute, transient forebrain ischemia but not after chronic cerebral hypoperfusion in middle-aged rats"],"prefix":"10.1016","volume":"265","author":[{"given":"Emilene Dias Fiuza","family":"Ferreira","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e1ssia Val\u00e9rio","family":"Romanini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janaina Nicolau de","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isolde Terezinha Santos","family":"Previdelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvana Regina de","family":"Melo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R\u00fabia Maria Weffort de","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Humberto","family":"Milani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbr.2014.02.015_bib0005","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.physbeh.2013.06.001","article-title":"Fish oil provides robust and sustained memory recovery after cerebral ischemia: influence of treatment regimen","volume":"119","author":"Correia Bacarin","year":"2013","journal-title":"Physiol Behav"},{"issue":"1","key":"10.1016\/j.bbr.2014.02.015_bib0010","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1037\/h0077579","article-title":"Memory deficits associated with senescence: a neurophysiological and behavioral study in the rat","volume":"93","author":"Barnes","year":"1979","journal-title":"J Comp Physiol Psychol"},{"key":"10.1016\/j.bbr.2014.02.015_bib0015","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.bbr.2008.10.023","article-title":"The cognitive and histopathological effects of chronic 4-vessel occlusion in rats depend on the set of vessels occluded and the age of the animals","volume":"197","author":"Barros","year":"2009","journal-title":"Behav Brain Res"},{"issue":"1","key":"10.1016\/j.bbr.2014.02.015_bib0020","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1161\/01.STR.0000149620.74770.2e","article-title":"Docosahexaenoic acid complexed to albumin elicits high-grade ischemic neuroprotection","volume":"36","author":"Belayev","year":"2004","journal-title":"Stroke"},{"issue":"9","key":"10.1016\/j.bbr.2014.02.015_bib0025","doi-asserted-by":"crossref","first-page":"3121","DOI":"10.1161\/STROKEAHA.109.555979","article-title":"Robust docosahexaenoic acid-mediated neuroprotection in a rat model of transient, focal cerebral ischemia","volume":"40","author":"Belayev","year":"2009","journal-title":"Stroke"},{"key":"10.1016\/j.bbr.2014.02.015_bib0030","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.pbb.2007.07.001","article-title":"Tacrolimus (FK506) reduces hippocampal damage but fails to prevent learning and memory deficits after transient, global cerebral ischemia in rats","volume":"88","author":"Benetoli","year":"2007","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.bbr.2014.02.015_bib0035","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.pbb.2004.09.016","article-title":"Protective effect of chronic ethyl docosahexaenoate administration on brain injury in ischemic gerbils","volume":"79","author":"Cao","year":"2004","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.bbr.2014.02.015_bib0040","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.lfs.2005.04.083","article-title":"Chronic administration of ethyl docosahexaenoate decreases mortality and cerebral edema in ischemic gerbils","volume":"78","author":"Cao","year":"2005","journal-title":"Life Sci"},{"issue":"4","key":"10.1016\/j.bbr.2014.02.015_bib0045","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.jnutbio.2005.04.006","article-title":"Chronic administration of ethyl docosahexaenoate reduces gerbil brain eicosanoid productions following ischemia and reperfusion","volume":"17","author":"Cao","year":"2006","journal-title":"J Nutr Biochem"},{"key":"10.1016\/j.bbr.2014.02.015_bib0050","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.brainres.2012.12.006","article-title":"Cerebral white matter injury and damage to myelin sheath following whole-brain ischemia","volume":"1495","author":"Chen","year":"2013","journal-title":"Brain Res"},{"key":"10.1016\/j.bbr.2014.02.015_bib0055","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1002\/jnr.20727","article-title":"Minocycline attenuates white matter damage in a rat model of chronic cerebral hypoperfusion","volume":"83","author":"Cho","year":"2006","journal-title":"J Neurosci Res"},{"issue":"1","key":"10.1016\/j.bbr.2014.02.015_bib0060","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.devbrainres.2004.05.004","article-title":"Temporal changes in cerebral antioxidant enzyme activities after ischemia and reperfusion in a rat focal brain ischemia model: effect of dietary fish oil","volume":"152","author":"Choi-Kwon","year":"2004","journal-title":"Brain Res Dev Brain Res"},{"issue":"1","key":"10.1016\/j.bbr.2014.02.015_bib0065","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0306-4522(98)00659-9","article-title":"Cerebral hypoperfusion yields capillary damage in the hippocampal CA1 area that correlates with spatial memory impairment","volume":"91","author":"De Jong","year":"1999","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbr.2014.02.015_bib0070","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/0006-8993(92)90132-S","article-title":"Chronic cerebrovascular insufficiency induces dementia-like deficits in aged rats","volume":"582","author":"de la Torre","year":"1992","journal-title":"Brain Res"},{"key":"10.1016\/j.bbr.2014.02.015_bib0075","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.jstrokecerebrovasdis.2008.11.014","article-title":"Carotid artery ultrasound and echocardiography testing to lower the prevalence of Alzheimer's disease","volume":"18","author":"de la Torre","year":"2009","journal-title":"J Stroke Cerebrovasc Dis"},{"key":"10.1016\/j.bbr.2014.02.015_bib0080","doi-asserted-by":"crossref","first-page":"367516","DOI":"10.1155\/2012\/367516","article-title":"Cardiovascular risk factors promote brain hypoperfusion leading to cognitive decline and dementia","volume":"2012","author":"de la Torre","year":"2012","journal-title":"Cardiovasc Psychiatry Neurol"},{"key":"10.1016\/j.bbr.2014.02.015_bib0085","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/S0301-0082(00)00068-X","article-title":"Cerebral microvascular pathology in aging and Alzheimer's disease","volume":"64","author":"Farkas","year":"2001","journal-title":"Prog Neurobiol"},{"key":"10.1016\/j.bbr.2014.02.015_bib0090","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1111\/j.1749-6632.2002.tb04800.x","article-title":"Systemic effects of dietary n-3 PUFA supplementation accompany changes of CNS parameters in cerebral hypoperfusion","volume":"977","author":"Farkas","year":"2002","journal-title":"Ann NY Acad Sci"},{"issue":"1","key":"10.1016\/j.bbr.2014.02.015_bib0095","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.brainresrev.2007.01.003","article-title":"Permanent, bilateral common carotid artery occlusion in the rat: a model for chronic cerebral hypoperfusion-related neurodegenerative diseases","volume":"54","author":"Farkas","year":"2007","journal-title":"Brain Res Rev"},{"key":"10.1016\/j.bbr.2014.02.015_bib0100","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1016\/j.nutres.2008.09.004","article-title":"Long-term treatment with fish oil prevents memory impairments but not hippocampal damage in rats subjected to transient, global cerebral ischemia","volume":"28","author":"Fernandes","year":"2008","journal-title":"Nutr Res"},{"key":"10.1016\/j.bbr.2014.02.015_bib0105","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1111\/j.1460-9568.2011.07824.x","article-title":"Middle-aged, but not young, rats develop cognitive\/impairment and cortical neurodegeneration following the four-vessel occlusion internal carotid artery model of chronic cerebral hypoperfusion","volume":"34","author":"Ferreira","year":"2011","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.bbr.2014.02.015_bib0110","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.brainresbull.2012.08.010","article-title":"Sildenafil provides sustained neuroprotection in the absence of learning recovery following the 4-vessel occlusion\/internal carotid artery model of chronic cerebral hypoperfusion in middle-aged rats","volume":"90","author":"Ferreira","year":"2013","journal-title":"Brain Res Bull"},{"issue":"3","key":"10.1016\/j.bbr.2014.02.015_bib0115","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1089\/neu.2011.2141","article-title":"Docosahexaenoic acid pretreatment confers protection and functional improvements after acute spinal cord injury in adult rats","volume":"29","author":"Figueroa","year":"2012","journal-title":"J Neurotrauma"},{"issue":"4","key":"10.1016\/j.bbr.2014.02.015_bib0120","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1097\/00005072-199207000-00001","article-title":"The evolution of brain infarcts: a review","volume":"51","author":"Garcia","year":"1992","journal-title":"J Neuropathol Exp Neurol"},{"issue":"3 Suppl","key":"10.1016\/j.bbr.2014.02.015_bib0125","doi-asserted-by":"crossref","first-page":"S111","DOI":"10.1161\/STROKEAHA.108.528877","article-title":"Current status of neuroprotection for cerebral ischemia: synoptic overview","volume":"40","author":"Ginsberg","year":"2009","journal-title":"Stroke"},{"key":"10.1016\/j.bbr.2014.02.015_bib0130","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.jacc.2009.02.084","article-title":"Omega-3 polyunsaturated fatty acids and cardiovascular diseases","volume":"54","author":"Lavie","year":"2009","journal-title":"J Am Coll Cardiol"},{"issue":"2","key":"10.1016\/j.bbr.2014.02.015_bib0135","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1097\/MCO.0b013e328342cba5","article-title":"Docosahexaenoic acid: brain accretion and roles in neuroprotection after brain hypoxia and ischemia","volume":"14","author":"Mayurasakorn","year":"2011","journal-title":"Curr Opin Clin Nutr Metab Care"},{"issue":"5","key":"10.1016\/j.bbr.2014.02.015_bib0140","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1002\/jnr.21925","article-title":"Intensity of chronic cerebral hypoperfusion determines white\/gray matter injury and cognitive\/motor dysfunction in mice","volume":"87","author":"Miki","year":"2009","journal-title":"J Neurosci Res"},{"issue":"2","key":"10.1016\/j.bbr.2014.02.015_bib0145","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1227\/NEU.0b013e3181ff692b","article-title":"Dietary supplementation with the omega-3 fatty acid docosahexaenoic acid in traumatic brain injury","volume":"68","author":"Mills","year":"2011","journal-title":"Neurosurgery"},{"key":"10.1016\/j.bbr.2014.02.015_bib0150","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/0306-4522(95)00427-0","article-title":"The chronic administration of docosahexaenoic acid reduces the spatial cognitive deficit following transient forebrain ischemia in rats","volume":"71","author":"Okada","year":"1996","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbr.2014.02.015_bib0155","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.jstrokecerebrovasdis.2009.11.016","article-title":"Eicosapentaenoic acid prevents memory impairment after ischemia by inhibiting inflammatory response and oxidative damage","volume":"20","author":"Okabe","year":"2011","journal-title":"J Stroke Cerebrovasc Dis"},{"key":"10.1016\/j.bbr.2014.02.015_bib0160","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.jneumeth.2003.08.012","article-title":"A novel version of the 8-arm radial maze: effects of cerebral ischemia on learning and memory","volume":"132","author":"Paganelli","year":"2004","journal-title":"J Neurosci Methods"},{"key":"10.1016\/j.bbr.2014.02.015_bib0165","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.bbr.2012.01.023","article-title":"Time-course of neurodegeneration and memory impairment following the 4-vessel occlusion\/internal carotid artery model of chronic cerebral hypoperfusion in middle-aged rats","volume":"229","author":"Pereira","year":"2012","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.bbr.2014.02.015_bib0170","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.physbeh.2008.07.020","article-title":"Dietary PUFA supplements reduce memory deficits but not CA1 ischemic injury in rats","volume":"95","author":"Plamondon","year":"2008","journal-title":"Physiol Behav"},{"issue":"5","key":"10.1016\/j.bbr.2014.02.015_bib0175","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1002\/ana.410110509","article-title":"Temporal profile of neuronal damage in a model of transient forebrain ischemia","volume":"11","author":"Pulsinelli","year":"1982","journal-title":"Ann Neurol"},{"key":"10.1016\/j.bbr.2014.02.015_bib0180","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/1056-8719(92)90016-T","article-title":"Prevention of ischemia induced cerebral hypothermia by controlling the environmental temperature","volume":"27","author":"Seif el Nasr","year":"1992","journal-title":"J Pharmacol Toxicol Methods"},{"issue":"9","key":"10.1016\/j.bbr.2014.02.015_bib0185","doi-asserted-by":"crossref","first-page":"e74631","DOI":"10.1371\/journal.pone.0074631","article-title":"The ins and outs of the BCCAo model for chronic hypoperfusion: a multimodal and longitudinal MRI approach","volume":"8","author":"Soria","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.bbr.2014.02.015_bib0190","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.jnutbio.2009.11.003","article-title":"Mechanisms of n-3 fatty acid-mediated development and maintenance of learning memory performance","volume":"21","author":"Su","year":"2010","journal-title":"J Nutr Biochem"},{"issue":"5","key":"10.1016\/j.bbr.2014.02.015_bib0195","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1111\/j.1747-4949.2012.00770.x","article-title":"Neuroprotection for ischaemic stroke: translation from the bench to the bedside","volume":"7","author":"Sutherland","year":"2012","journal-title":"Int J Stroke"},{"key":"10.1016\/j.bbr.2014.02.015_bib0200","first-page":"425281","article-title":"Acute microvascular changes after subarachnoid hemorrhage and transient global cerebral ischemia","volume":"2013","author":"Tso","year":"2013","journal-title":"Stroke Res Treat"},{"issue":"1","key":"10.1016\/j.bbr.2014.02.015_bib0205","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0006-8993(98)00126-7","article-title":"Dose-dependent, protective effect of FK506 against white matter changes in the rat brain after chronic cerebral ischemia","volume":"792","author":"Wakita","year":"1998","journal-title":"Brain Res"},{"issue":"1","key":"10.1016\/j.bbr.2014.02.015_bib0210","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0006-8993(01)03223-1","article-title":"Axonal damage and demyelination in the white matter after chronic cerebral hypoperfusion in the rat","volume":"924","author":"Wakita","year":"2002","journal-title":"Brain Res"},{"key":"10.1016\/j.bbr.2014.02.015_bib0215","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1089\/neu.2010.1348","article-title":"Docosahexaenoic acid prevents white matter damage after spinal cord injury","volume":"27","author":"Ward","year":"2010","journal-title":"J Neurotrauma"},{"issue":"2","key":"10.1016\/j.bbr.2014.02.015_bib0220","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/S0006-8993(02)02695-1","article-title":"The effect of n-3 polyunsaturated fatty acid-rich diets on cognitive and cerebrovascular parameters in chronic cerebral hypoperfusion","volume":"947","author":"de Wilde","year":"2002","journal-title":"Brain Res"},{"issue":"2","key":"10.1016\/j.bbr.2014.02.015_bib0225","doi-asserted-by":"crossref","first-page":"e56233","DOI":"10.1371\/journal.pone.0056233","article-title":"n-3 fatty acid rich triglyceride emulsions are neuroprotective after cerebral hypoxic-ischemic injury in neonatal mice","volume":"8","author":"Williams","year":"2013","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.bbr.2014.02.015_bib0230","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.neuron.2008.01.003","article-title":"The blood\u2013brain barrier in health and chronic neurodegenerative disorders","volume":"57","author":"Zlokovic","year":"2008","journal-title":"Neuron"}],"container-title":["Behavioural Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432814000904?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432814000904?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,6]],"date-time":"2018-10-06T08:53:45Z","timestamp":1538816025000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166432814000904"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5]]},"references-count":46,"alternative-id":["S0166432814000904"],"URL":"https:\/\/doi.org\/10.1016\/j.bbr.2014.02.015","relation":{},"ISSN":["0166-4328"],"issn-type":[{"type":"print","value":"0166-4328"}],"subject":[],"published":{"date-parts":[[2014,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Fish oil provides a sustained antiamnesic effect after acute, transient forebrain ischemia but not after chronic cerebral hypoperfusion in middle-aged rats","name":"articletitle","label":"Article Title"},{"value":"Behavioural Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbr.2014.02.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}